Published Aug. 12 (EPO); Aug. 6 (WO)

Abbott LabsWO 98/33926

Lung transcribed genes

Abbott Park, Ill.

Lung transcribed genes, encoded proteins, antibodies, modulators; for diagnosing and treating lung diseases.

AjinomotoEPO 857 788

Phosphorylating nucleosides biochemically

Tokyo

Thermostable acid phosphatases, transformed microorganisms; for enzymatically phosphorylating nucleosides.

AmgenWO 98/33922

Neurotrophic factor

Thousand Oaks, Calif.

Neurotrophic factor, encoding gene sequences, production methods; for modulating B- and T-cell responses.

Bio-Rad LabsWO 98/33898

Blood amino acid analysis

Hercules, Calif.

Enzymatic conversion of phenylalanine and tyrosine followed by chromatography; for whole blood analysis of amino acids.

BiognostikWO 98/33904

Antisense oligo preparation

Gottingen, Germany

Methods for preparing antisense oligonucleotides containing between 8 and 12 elements.

British Technol. GroupWO 98/33906

Anti-nematode proteins

London

Proteins and their amidated derivatives that are active against nematode worms, encoding genes.

Burnham Inst.WO 98/33816

Acetyl coenzyme-A transporter proteins

La Jolla, Calif.

Acetyl coenzyme-A transporter proteins, encoding genes, antibodies; for diagnostics and therapeutics.

California, Univ. ofWO 98/33918

Bone morphogenic protein antagonist

Oakland, Calif.

Bone morphogenic protein antagonist, encoding gene sequences, production methods, modulators.

CNRS (Natl. Ctr. Sci. Res.)WO 98/33929

Adenovirus receptor polypeptides

Paris

Polypeptides derived from adenovirus receptors, encoding genes; for transfection and virus binding control.

CSIRO (Comm. Sci. & Ind. Res. Org.)WO 98/33903

Tissue-specific expression vectors

Campbell, Australia

Vectors having steroid-responsive promoters from specific tissues and SV40 enhancers; for directed gene expression.

Cosmix Molec. BiologicalsWO 98/33901

Combinatorial gene libraries

Braunscheig, Germany

Combinatorial libraries derived from gene banks, phage display technology; for identifying protein ligands.

DNAVec Res.WO 98/33899

Liver-targeted transgenics

Ibaraki, Japan

Transgenics having a diphtheria toxin-epidermal growth factor fused gene selectively expressed in liver cells.

EnzonWO 98/33519

Arginine deiminase

Piscataway, N.J.

Mycoplasma arginine deiminase, encoding gene, non-antigenic conjugates; for increased blood circulation half-life.

GenentechWO 98/33924

O-fucosyltransferase

S. San Francisco

O-fucosyltransferase, encoding gene, production and purification methods.

Genetics Inst.WO 98/33916

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Hammatsu PhotonicsWO 98/33902

Light-aided molecular separation

Shizuoka, Japan

Separation of biological substances by immobilizing samples on a light-sensitive photoresist substrate.

HoechstEPO 857 781

Endoglin promoter

Frankfurt, Germany

Functional promoter region of the human endoglin gene; for expression vectors [in German].

Human Genome SciencesWO 98/33912

Myelin oligodendrocyte protein

Rockville, Md.

Myelin oligodendrocyte glycoprotein-like protein, encoding gene sequences, production method; for treating cancer.

Human Genome SciencesWO 98/33915

Breast cancer-specific gene

Rockville, Md.

Breast cancer-specific gene, encoded protein, production method; for detecting and treating breast cancer.

Human Genome SciencesWO 98/33920

Tissue factor pathway inhibitor

Rockville, Md.

Tissue factor pathway inhibitor, encoding gene, production method; for detecting and treating hemostasis disorders.

Imperial CollegeWO 98/33923

Reduced lipid A toxicity

London

Mutants of the Salmonella msbB and htrB genes resulting in loss of function; for reduced lipid A toxicity.

Incyte PharmaWO 98/33908

Human C5a-like receptor

Palo Alto, Calif.

Human C5a-like receptor, fragments, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/33909

Human ATPase inhibitor protein

Palo Alto, Calif.

Human ATPase inhibitor protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/33910

Human proline-rich protein

Palo Alto, Calif.

Human proline-rich protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/33911

Human nuclear movement protein

Palo Alto, Calif.

Human nuclear movement protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/33913

Human integral membrane protein

Palo Alto, Calif.

Human integral membrane protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/33921

Human cystatin-like protein

Palo Alto, Calif.

Human cystatin-like protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Isis InnovationWO 98/33905

Potassium-ATP channel

Oxford, U.K.

Potassium-ATP channel protein subunit; for identifying channel function modulators.

IxsysWO 98/33919

Vitaxin antibodies

San Diego

Recombinant humanized antibodies to Vitaxin fragments, encoding gene sequences.

Japan Sci. & Technol.WO 98/33900

Improved function proteins

Saitama, Japan

Computer-based method for predicting protein functional sites; for constructing improved function proteins.

Johns Hopkins Univ.WO 98/33887

GDF-8 transgenics

Baltimore

Transgenics having growth differentiation factor (GDF)-8 genes, antibodies, antisense; for increased muscle tissue.

Lab Molec. BiophotonicsWO 98/33897

Fluorescent transcription monitoring

Shizuoka, Japan

Monitoring of transcriptional synthesis of RNA using oligo probes having fluorescent markers.

Ludwig Inst.WO 98/33917

VEGF-3 and mutants

New York

Vascular endothelial growth factor (VEGF)-3, fragments, mutants, encoding gene sequences, production methods.

Mass. Gen. Hosp.WO 98/33809

Gene expression imaging

Boston, Mass.

Recombinant peptide chelates for co-expression with therapeutic genes; for expression confirmation by imaging.

Max Delbruck Ctr. Molec. Med.WO 98/33937

Mu-opioid receptor gene

Berlin, Germany

Genomic sequence of the mu-opioid receptor gene, variants, polymorphisms, and mutations.

Rochester, Univ. ofWO 98/33914

Anticancer fusion proteins

Rochester, N.Y.

Antibody-cytokine fusion proteins; for inducing antitumor immune responses to breast and ovarian cancer.

Sagami Chemical Res. Ctr.EPO 857 732

Gastrointestinal hormone

Sagamihara, Japan

Human gastrointestinal hormone, a PEC 60-like protein, secreted by the stomach, encoding gene.

Sloan-Kettering Inst.WO 98/33518

Thymidylate synthetase mutants

New York

Mutated thymidylate synthetase, encoding gene sequences, vectors, host cells, expression system.

SmithKline BeechamEPO 857 782

DD-1 polypeptides

Philadelphia

DD-1 polypeptides, encoding gene sequences, production method; for treating neurodegenerative diseases.

SmithKline BeechamEPO 857 785 & 786

Staphylococcus antibacterials

Philadelphia

Staphylococcus aureus RNA-dependent amidotransferase B and C, encoding gene sequences; for antibacterials.

SmithKline BeechamEPO 857 787

Staphylococcus antibacterials

Philadelphia

Staphylococcus aureus histidine kinase, encoding gene sequences, production method; for antibacterials.

Sumitomo ElectricEPO 857 780

Liver cancer proteins

Osaka, Japan

Liver proteins having elevated expression in cancer, encoding genes, antibodies; for diagnostic assays.

Takara ShuzoEPO 857 783

Sulfotransferase

Kyoto, Japan

Sulfotransferase, encoding gene; for transferring sulfur groups in carbohydrate chains.

Texas, Univ. ofWO 98/33907

Chromosome 10 tumor suppressor

Austin, Texas

Tumor suppressor tyrosine phosphatase gene located on chromosome 10, mutations in gliomas and prostate cancer.

Yale Univ.WO 98/33925

Protein translation inhibitors

New Haven, Conn.

Amino acid amidotransferase, encoding gene; for identifying blocking agents for protein translation.

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