Published July 29 (EPO); July 23 (WO)

Boehringer MannheimWO 98/31813

Antigen presenting inhibitor

Mannheim, Germany

Mouse cytomegalovirus gene, encoded protein; for inhibiting antigen presentation by MHC Class I molecules.

Boryung PharmaWO 98/31820

CTLA-Ig fusion protein

Seoul, S. Korea

CTLA-immunoglobulin (Ig) fusion protein, encoding gene sequences; for higher titer and decreased dosage.

Bourgogne, Univ. ofWO 98/31807

Mucous secretion virus vaccines

Dijon, France

Antibodies and peptides that recognize epitopes of viruses that invade via mucous secretions; for vaccines.

B.M.R.A.WO 98/31707

Neuropeptide Y receptor transgenics

Rotterdam, Netherlands

Transgenics with disrupted neuropeptide Y Y1 receptor genes, engineered genes and embryonic stem cells.

Brax GenomicsWO 98/31830

Mass spectrometry sequencing

Cambridge, U.K.

Hybridization probes with linked mass labels; for nucleic acid sequence determination by mass spectrometry.

Brax GenomicsWO 98/31831

Nucleic acid sequencing

Cambridge, U.K.

Nucleic acid sequencing in which the sequence is determined by the timing of release from templates.

California, Univ. ofWO 98/31324

Ovarian cancer chromosomal changes

Oakland, Calif.

Probes for the detection of chromosome 3 alterations that are associated with ovarian cancer.

California, Univ. ofWO 98/31388

Pathogen vaccines

Oakland, Calif.

Combinations of extracellular products of various pathogens; for vaccines.

CNRS (Natl. Ctr. Sci. Res.)WO 98/31808

Antibody gene transfer


Antibody gene transfer to mammalian cells; for systemic delivery of desired antibodies.

Chugai PharmaWO 98/31838

Differential gene expression


Isolation of genes via specific tags; for examining relative expression levels in tissue samples.

Cornell Univ.WO 98/31828

Herpes G protein coupled receptor

Ithaca, N.Y.

Reporter gene linked to constitutively active herpes G protein coupled receptor gene; for identifying modulators.

Curie, Univ. Pierre & MarieEPO 855 185

Gene therapy vector


Host vector system that produces infectious viral particles having a transgene; for gene therapy [in French].

CytelWO 98/31826

In vitro glycosylation modification

San Diego

Practical large-scale in vitro sialylation of glycoproteins; for modifying glycosylation patterns.

Duke Univ.WO 98/31396

Respiration uncoupling protein

Durham, N.C.

Respiration uncoupling protein, encoding gene sequences; for diagnosis and therapy of metabolic diseases.

Favre, D.WO 98/31827

In vitro translation

Villars-Tiercelin, Switzerland

Efficient production of biologically active polypeptides from an in vitro translation system.

Genencor Intl.WO 98/31821

Fungi production system

Rochester, N.Y.

Vectors and DNA sequences for fusion polypeptides; for secretion of recombinant proteins in filamentous fungi.

Genetic Engin. & Biotechnol. Ctr.WO 98/31814

Dengue virus vaccines

Havana, Cuba

Dengue virus proteins and derived synthetic peptides; for flavivirus vaccines.

Genetics Inst.WO 98/31802

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Genetics Inst.WO 98/31811

U4 hematopoietic receptor

Cambridge, Mass.

U4 hematopoietin receptor, fragments, encoding gene sequences, production methods.

Harvard Univ.WO 98/31839

Macromolecules on surfaces

Cambridge, Mass.

Immobilization of nucleic acids on self-assembled monolayers; for electrical determination of binding capabilities.

HoechstWO 98/31709

Laminin antibodies

Frankfurt, Germany

Antibodies that bind to the nidogen-binding domain of laminin, production method; for diagnostics and therapeutics.

Human Genome SciencesWO 98/31792

Hematopoietic signalling factor

Rockville, Md.

Hematopoietic signalling factor cytokine, encoding gene sequences, host cells, vectors, production method.

Human Genome SciencesWO 98/31798

Extracellular matrix polypeptide

Rockville, Md.

Human extracellular matrix polypeptide, encoding gene sequences, production method; for bone and vascular growth.

Human Genome SciencesWO 98/31799

Receptor polypeptides

Rockville, Md.

Receptor polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

Human Genome SciencesWO 98/31800

Human proteins

Rockville, Md.

Human proteins, encoding gene sequences, vectors, host cells, production methods; for diagnostics and therapeutics.

Human Genome SciencesWO 98/31801

Apoptosis inhibitor

Rockville, Md.

I-FLICE, an apoptosis inhibitor, encoding gene sequences, production methods; for identifying modulators.

Human Genome SciencesWO 98/31806

Fc-like receptor proteins

Rockville, Md.

Fc receptor-like proteins, encoding gene sequences, vectors, host cells, production methods; for identifying modulators.

Human Genome SciencesWO 98/31818

Matrilysin-like proteins

Rockville, Md.

Human TACE- and matrilysin-like proteins, encoding gene sequences, production methods; for identifying modulators.

HyseqWO 98/31836

Probe array assays

Sunnyvale, Calif.

Detection and quantification of nucleic acid sequences using probe arrays attached to substrates.

Incyte PharmaWO 98/31795

Human metallothionein

Palo Alto, Calif.

Human metallothionein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/31805

Zinc binding proteins

Palo Alto, Calif.

Human zinc binding proteins, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/31815

NADH dehydrogenase subunits

Palo Alto, Calif.

NADH dehydrogenase subunits, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/31833

Solid phase sequence separation

Palo Alto, Calif.

Enzymatic nucleic acid sequencing in which chain terminators are capturable on solid phase supports.

Incyte PharmaWO 98/31834

Fluorescent sequencing tags

Palo Alto, Calif.

Fluorescent labelled energy transfer primers; for multicomponent analysis in unified sequencing reactions.

Japan Sci. & Technol.EPO 855 442

CNS transcription regulator

Kawaguchi, Japan

Central nervous system (CNS) transcription regulator polypeptide, gene sequence it binds; for CNS formation study.

Japanese Ministry of AgricultureEPO 855 441

Stem cell purification

Inashiki, Japan

Antibodies to germinal stem cells linked to magnetic beads; for stem cell purification.

Maryland, Univ. ofWO 98/31835

Healthy genes

College Park, Md.

Genetic methods for identifying individuals for improving well-being and performance through exercise.

Mass. Gen. Hosp.WO 98/31700

Specific protein selection


Selection of specific proteins via the use of RNA-protein fusion complexes.

Max Planck Inst.WO 98/31791

IgA1 protease fragments

Munich, Germany

Immunoglobulin (Ig)-A1 protease fragment; for use as a carrier for polysaccharides in vaccines.

MaxygenWO 98/31837

Controlled cellular evolution

Santa Clara, Calif.

Iterative cycles of recombination and selection; for controlled evolution of cellular properties.

Miami, Univ. ofWO 98/31803

Mutant heat shock transcription factor


Mutant heat shock transcription factor; for altering cellular response to stress.

Microbial TechnicsWO 98/31786

Bacteria as vaccines

Cambridge, U.K.

Non-invasive, non-pathogenic, gram-positive microorganisms transfected with polysaccharide immunogen synthesis


Minnesota, Univ. ofWO 98/31816

Atriazine chlorohydrolase homologs


Atriazine chlorohydrolase homologs, encoding gene sequences; for degradation of triazine-containing compounds.

Molecular Biophotonics LabEPO 855 403

Targeted oligo therapeutic

Hamakita, Japan

Cyclic oligonucleotides with photocleavable group whose cleavage linearizes the oligo; for targeted therapy.

Montech Medical Develop.WO 98/31819

Yeast GAD expression

Melbourne, Australia

Expression of an antigenically active, recombinant hybrid glutamic acid decarboxylase (GAD) in yeast.

Netherlands Org. Technol. Develop.WO 98/31832

Cardiovascular disease allele

Delft, Netherlands

Gene polymorphism associated with increased risk of cardiovascular disease in smokers.

New York Univ.WO 98/31382

Malaria vaccine

New York

T cell epitopes that elicit responses to malarial parasites in patients of differing genetic backgrounds; for vaccines.

Pangaea PharmaWO 98/31398

Transfection microparticles

Cambridge, Mass.

Microparticles made of a polymeric material and nucleic acid; for cell transfection.

Rhone-Poulenc RorerWO 98/31395

Motor neuron gene therapy

Antony, France

Adenoviral vector-mediated gene transfer into muscle tissue; for gene therapy of medullary motor neurons.

RohmWO 98/31790

Fungal lysophospholipase

Darmstadt, Germany

Aspergillus lysophospholipase, cleaved fragments, fermentation production methods.

Rowett Res. Inst.WO 98/31793

Colostrum-derived growth factor

Aberdeen, U.K.

Partial protein and nucleic acid sequences of a pig colostrum-derived growth factor that regulates immune responses.

St. Justine Hosp.WO 98/31817

Human lysosomal sialidase


Human lysosomal sialidase, encoding gene sequences; for identifying gene mutations in sialidosis patients.

ScheringWO 98/31810


Kenilworth, N.J.

Chemokines and 7 transmembrane receptors, encoding gene sequences, antibodies, production and purification methods.

Scriptgen PharmaWO 98/31789

Mycobacterial RNA polymerase

Medford, Mass.

Mycobactrium tuberculosis RNA polymerase sigma subunit, encoding gene; for detecting inhibitors.

ShionogiWO 98/31809

Human CC chemokine SLC

Osaka, Japan

Human CC chemokine SLC, fragments, variants, encoding gene sequences, antibodies, modulators; for immunomodulation.

SmithKline BeechamEPO 855 404

IL-1 receptor antagonist beta


Interleukin (IL)-1 receptor antagonist beta, encoding gene sequences, production methods; for immunotherapy.

SmithKline BeechamEPO 855 443

Human 7-transmembrane receptor


Human 7-transmembrane receptor, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamEPO 855 444

Aspartic proteinase 2

Brentford, U.K.

Aspartic proteinase 2, encoding gene sequences, production methods; for prohormone processing and therapeutic design.

Texas A&M Univ.WO 98/31389

Staphylococcus infection therapy

College Stn., Texas

Antibodies that block binding of fibronectin binding protein to fibronectin, epitopes; for Staphylococcus infections.

Texas, Univ. ofWO 98/31701 & 31804

Endothelial PAS domain protein

Austin, Texas

Endothelial PAS domain protein, encoding gene sequences, primers, antibodies, production methods.

Toa GoseiWO 98/31794

VEGF inhibitor


Low molecular-weight vascular endothelial growth factor (VEGF) inhibitor, encoding gene sequences.

TosohEPO 855 447

Nucleic acid sequence assay

Shinnanyo, Japan

Fluorescence-based assay for specific RNA sequences involving an intermediate DNA synthesis step.

Virginia, Univ. ofWO 98/31376

Cancer gene therapy

Charlottesville, Va.

Adenoviral vector having a gene for thymidine kinase controlled by an osteocalcin promoter; for cancer therapy.

Wisconsin, Univ. ofWO 98/31397

Cellular diabetes treatment

Madison, Wis.

Hepatocytes transfected with a functioning proinsulin gene; for pancreatic beta cell replacement.

Wistar Inst.WO 98/31703

Mutated p53 domains


Mutated p53 oligomerization domains with changed three-dimensional structure, fusions, encoding gene sequences.

Yeda Res. & Develop.WO 98/31796

IFN receptor binding proteins

Rehovot, Israel

Interferon (IFN) receptor binding proteins, encoding gene sequences, antibodies; for modulating cellular IFN response.

ZymogeneticsWO 98/31797

Nuclear hormone receptor


Human tailless nuclear hormone receptor, encoding gene sequences; for finding ligands and making therapeutics.