Published July 29 (EPO); July 23 (WO)
Boehringer MannheimWO 98/31813
Antigen presenting inhibitor
Mouse cytomegalovirus gene, encoded protein; for inhibiting antigen presentation by MHC Class I molecules.
Boryung PharmaWO 98/31820
CTLA-Ig fusion protein
Seoul, S. Korea
CTLA-immunoglobulin (Ig) fusion protein, encoding gene sequences; for higher titer and decreased dosage.
Bourgogne, Univ. ofWO 98/31807
Mucous secretion virus vaccines
Antibodies and peptides that recognize epitopes of viruses that invade via mucous secretions; for vaccines.
Neuropeptide Y receptor transgenics
Transgenics with disrupted neuropeptide Y Y1 receptor genes, engineered genes and embryonic stem cells.
Brax GenomicsWO 98/31830
Mass spectrometry sequencing
Hybridization probes with linked mass labels; for nucleic acid sequence determination by mass spectrometry.
Brax GenomicsWO 98/31831
Nucleic acid sequencing
Nucleic acid sequencing in which the sequence is determined by the timing of release from templates.
California, Univ. ofWO 98/31324
Ovarian cancer chromosomal changes
Probes for the detection of chromosome 3 alterations that are associated with ovarian cancer.
California, Univ. ofWO 98/31388
Combinations of extracellular products of various pathogens; for vaccines.
CNRS (Natl. Ctr. Sci. Res.)WO 98/31808
Antibody gene transfer
Antibody gene transfer to mammalian cells; for systemic delivery of desired antibodies.
Chugai PharmaWO 98/31838
Differential gene expression
Isolation of genes via specific tags; for examining relative expression levels in tissue samples.
Cornell Univ.WO 98/31828
Herpes G protein coupled receptor
Reporter gene linked to constitutively active herpes G protein coupled receptor gene; for identifying modulators.
Curie, Univ. Pierre & MarieEPO 855 185
Gene therapy vector
Host vector system that produces infectious viral particles having a transgene; for gene therapy [in French].
In vitro glycosylation modification
Practical large-scale in vitro sialylation of glycoproteins; for modifying glycosylation patterns.
Duke Univ.WO 98/31396
Respiration uncoupling protein
Respiration uncoupling protein, encoding gene sequences; for diagnosis and therapy of metabolic diseases.
Favre, D.WO 98/31827
In vitro translation
Efficient production of biologically active polypeptides from an in vitro translation system.
Genencor Intl.WO 98/31821
Fungi production system
Vectors and DNA sequences for fusion polypeptides; for secretion of recombinant proteins in filamentous fungi.
Genetic Engin. & Biotechnol. Ctr.WO 98/31814
Dengue virus vaccines
Dengue virus proteins and derived synthetic peptides; for flavivirus vaccines.
Genetics Inst.WO 98/31802
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genetics Inst.WO 98/31811
U4 hematopoietic receptor
U4 hematopoietin receptor, fragments, encoding gene sequences, production methods.
Harvard Univ.WO 98/31839
Macromolecules on surfaces
Immobilization of nucleic acids on self-assembled monolayers; for electrical determination of binding capabilities.
Antibodies that bind to the nidogen-binding domain of laminin, production method; for diagnostics and therapeutics.
Human Genome SciencesWO 98/31792
Hematopoietic signalling factor
Hematopoietic signalling factor cytokine, encoding gene sequences, host cells, vectors, production method.
Human Genome SciencesWO 98/31798
Extracellular matrix polypeptide
Human extracellular matrix polypeptide, encoding gene sequences, production method; for bone and vascular growth.
Human Genome SciencesWO 98/31799
Receptor polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
Human Genome SciencesWO 98/31800
Human proteins, encoding gene sequences, vectors, host cells, production methods; for diagnostics and therapeutics.
Human Genome SciencesWO 98/31801
I-FLICE, an apoptosis inhibitor, encoding gene sequences, production methods; for identifying modulators.
Human Genome SciencesWO 98/31806
Fc-like receptor proteins
Fc receptor-like proteins, encoding gene sequences, vectors, host cells, production methods; for identifying modulators.
Human Genome SciencesWO 98/31818
Human TACE- and matrilysin-like proteins, encoding gene sequences, production methods; for identifying modulators.
Probe array assays
Detection and quantification of nucleic acid sequences using probe arrays attached to substrates.
Incyte PharmaWO 98/31795
Palo Alto, Calif.
Human metallothionein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/31805
Zinc binding proteins
Palo Alto, Calif.
Human zinc binding proteins, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/31815
NADH dehydrogenase subunits
Palo Alto, Calif.
NADH dehydrogenase subunits, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/31833
Solid phase sequence separation
Palo Alto, Calif.
Enzymatic nucleic acid sequencing in which chain terminators are capturable on solid phase supports.
Incyte PharmaWO 98/31834
Fluorescent sequencing tags
Palo Alto, Calif.
Fluorescent labelled energy transfer primers; for multicomponent analysis in unified sequencing reactions.
Japan Sci. & Technol.EPO 855 442
CNS transcription regulator
Central nervous system (CNS) transcription regulator polypeptide, gene sequence it binds; for CNS formation study.
Japanese Ministry of AgricultureEPO 855 441
Stem cell purification
Antibodies to germinal stem cells linked to magnetic beads; for stem cell purification.
Maryland, Univ. ofWO 98/31835
College Park, Md.
Genetic methods for identifying individuals for improving well-being and performance through exercise.
Mass. Gen. Hosp.WO 98/31700
Specific protein selection
Selection of specific proteins via the use of RNA-protein fusion complexes.
Max Planck Inst.WO 98/31791
IgA1 protease fragments
Immunoglobulin (Ig)-A1 protease fragment; for use as a carrier for polysaccharides in vaccines.
Controlled cellular evolution
Santa Clara, Calif.
Iterative cycles of recombination and selection; for controlled evolution of cellular properties.
Miami, Univ. ofWO 98/31803
Mutant heat shock transcription factor
Mutant heat shock transcription factor; for altering cellular response to stress.
Microbial TechnicsWO 98/31786
Bacteria as vaccines
Non-invasive, non-pathogenic, gram-positive microorganisms transfected with polysaccharide immunogen synthesis
Minnesota, Univ. ofWO 98/31816
Atriazine chlorohydrolase homologs
Atriazine chlorohydrolase homologs, encoding gene sequences; for degradation of triazine-containing compounds.
Molecular Biophotonics LabEPO 855 403
Targeted oligo therapeutic
Cyclic oligonucleotides with photocleavable group whose cleavage linearizes the oligo; for targeted therapy.
Montech Medical Develop.WO 98/31819
Yeast GAD expression
Expression of an antigenically active, recombinant hybrid glutamic acid decarboxylase (GAD) in yeast.
Netherlands Org. Technol. Develop.WO 98/31832
Cardiovascular disease allele
Gene polymorphism associated with increased risk of cardiovascular disease in smokers.
New York Univ.WO 98/31382
T cell epitopes that elicit responses to malarial parasites in patients of differing genetic backgrounds; for vaccines.
Pangaea PharmaWO 98/31398
Microparticles made of a polymeric material and nucleic acid; for cell transfection.
Rhone-Poulenc RorerWO 98/31395
Motor neuron gene therapy
Adenoviral vector-mediated gene transfer into muscle tissue; for gene therapy of medullary motor neurons.
Aspergillus lysophospholipase, cleaved fragments, fermentation production methods.
Rowett Res. Inst.WO 98/31793
Colostrum-derived growth factor
Partial protein and nucleic acid sequences of a pig colostrum-derived growth factor that regulates immune responses.
St. Justine Hosp.WO 98/31817
Human lysosomal sialidase
Human lysosomal sialidase, encoding gene sequences; for identifying gene mutations in sialidosis patients.
Chemokines and 7 transmembrane receptors, encoding gene sequences, antibodies, production and purification methods.
Scriptgen PharmaWO 98/31789
Mycobacterial RNA polymerase
Mycobactrium tuberculosis RNA polymerase sigma subunit, encoding gene; for detecting inhibitors.
Human CC chemokine SLC
Human CC chemokine SLC, fragments, variants, encoding gene sequences, antibodies, modulators; for immunomodulation.
SmithKline BeechamEPO 855 404
IL-1 receptor antagonist beta
Interleukin (IL)-1 receptor antagonist beta, encoding gene sequences, production methods; for immunotherapy.
SmithKline BeechamEPO 855 443
Human 7-transmembrane receptor
Human 7-transmembrane receptor, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamEPO 855 444
Aspartic proteinase 2
Aspartic proteinase 2, encoding gene sequences, production methods; for prohormone processing and therapeutic design.
Texas A&M Univ.WO 98/31389
Staphylococcus infection therapy
College Stn., Texas
Antibodies that block binding of fibronectin binding protein to fibronectin, epitopes; for Staphylococcus infections.
Texas, Univ. ofWO 98/31701 & 31804
Endothelial PAS domain protein
Endothelial PAS domain protein, encoding gene sequences, primers, antibodies, production methods.
Toa GoseiWO 98/31794
Low molecular-weight vascular endothelial growth factor (VEGF) inhibitor, encoding gene sequences.
TosohEPO 855 447
Nucleic acid sequence assay
Fluorescence-based assay for specific RNA sequences involving an intermediate DNA synthesis step.
Virginia, Univ. ofWO 98/31376
Cancer gene therapy
Adenoviral vector having a gene for thymidine kinase controlled by an osteocalcin promoter; for cancer therapy.
Wisconsin, Univ. ofWO 98/31397
Cellular diabetes treatment
Hepatocytes transfected with a functioning proinsulin gene; for pancreatic beta cell replacement.
Wistar Inst.WO 98/31703
Mutated p53 domains
Mutated p53 oligomerization domains with changed three-dimensional structure, fusions, encoding gene sequences.
Yeda Res. & Develop.WO 98/31796
IFN receptor binding proteins
Interferon (IFN) receptor binding proteins, encoding gene sequences, antibodies; for modulating cellular IFN response.
Nuclear hormone receptor
Human tailless nuclear hormone receptor, encoding gene sequences; for finding ligands and making therapeutics.