Published July 22 (EPO); July 16 (WO)
Abbott LabsWO 98/30692
Abbott Park, Ill.
Human endosulfine gene, encoded protein, protein isoforms, production method, transformed host cells.
Alliance PharmaWO 98/30706
Chimeric immunomodulating agents having Fc receptor ligands and an immunosuppressive T cell receptor antagonist.
Beth Israel Deaconess Hosp.WO 98/30704
CSK homologous kinase, encoded protein; for detecting and treating cancer.
Boehringer MannheimEPO 854 196
DNA amplification method
Uncoupled, direct, exponential amplification and sequencing of DNA using a second thermostable polymerase.
Boehringer MannheimWO 98/30685 & 30686
Filtration DNA purification
Purification of nucleic acids using a cross-flow filtration centrifuge; for separating endotoxins from DNA.
ChironEPO 854 193
Retroviral packaging cells
Human retroviral packaging cell line; for the production of retroviral vector particles.
Genetics InstituteWO 98/30582, 30584, 30589, 30695, & 30696
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Hoffmann-La RocheEPO 854 197
Primers for PCR amplification of the HIV gag gene; for HIV detection.
Human Genome SciencesWO 98/30693 & 30694
Human TNF receptors
Human TNF receptors, encoding gene sequences, production methods; for identifying modulators.
Incyte PharmaWO 98/30690
Integral membrane protein
Palo Alto, Calif.
Human integral membrane protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/30691
Chloride channel protein
Palo Alto, Calif.
Human chloride channel protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Jayne, S., et al.WO 98/30701
Des Moines, Iowa
Synthetic marker genes designed for maximum expression; for improving transformation efficiency.
Jolly, D.J., et al.WO 98/30709
Prodrug gene therapy
Gene delivery vehicles having genes for selectable markers, non-immunogenic prodrugs, and an activator of the prodrug.
Kishimoto, T.WO 98/30688
JAK/STAT pathway protein
JAK/STAT pathway protein regulating STAT functions, encoding gene, antisense, antibodies; for cytokine regulation.
Krebs Res. Inst.WO 98/30687
SRCR domain protein
Protein containing an SRCR domain, encoding gene, antibodies, production method.
Life TechnologiesWO 98/30684
Bacterial production system
Linkage of recombinant genes to the thioredoxin gene; for production and purification of proteins in bacteria.
Ludwig Inst.EPO 854 185
Growth factor receptors
Growth factor receptors of the receptor protein tyrosine kinase family, encoding gene sequences; for ligand assays.
Mack, D.H.WO 98/30722
p53 mutation monitoring
Menlo Park, Calif.
Massive parallel monitoring of gene expression; for detecting p53 mutations and their functions.
Massachusetts, Univ. ofWO 98/30683
Nuclear transfer with differentiated fetal and adult donor cells; for producing transgenic cloned cells and animals.
Michigan, Univ. ofWO 98/30101
Ann Arbor, Mich.
Gene encoding Hrk, a member of the Bcl-2 signal transduction pathway, encoded protein; for inducing cell death.
Nexstar PharmaWO 98/30720
Bioconjugated RNA oligos
Methods for conjugating or derivatizing RNA oligonucleotides via transcription in the presence of 5'-modified guanosine.
Oriental YeastWO 98/30703
Modified alanine aminotransferase
Modified human alanine aminotransferase gene; for efficient production in E. coli.
Pasteur Inst.WO 98/30699
Mycobacterium tuberculosis P27 gene, encoded protein; for diagnosis and treatment of tuberculosis.
Scripps Res. Inst.WO 98/30238
Borna disease virus
La Jolla, Calif.
Human Borna disease virus genes, encoded proteins; for detection of genes, proteins, and antibodies in patients.
Scripps Res. Inst.WO 98/30677
La Jolla, Calif.
Transgenics with disrupted alpha-3 connexin gene; for studying age-related cataract formation.
ShimadzuEPO 854 195
Salivary DNA amplification
Nucleic acid amplification in salivary samples pretreated with heat and saccharide-degrading enzymes.
SmithKline BeechamEPO 854 186
Staphylococcus aureus gene for cell division, encoded protein, production method; for treating infection.
SmithKline BeechamEPO 854 187
Glucose 6-phosphate dehydrogenase
Glucose 6-phosphate dehydrogenase gene, encoded protein, production techniques; for making antibacterials.
SmithKline BeechamEPO 854 188
Streptococcus pneumoniae aroE polypeptides, encoding gene sequences, production methods; for antibacterials.
SmithKline BeechamEPO 854 191
Cardiac/brain tolloid-like protein
Human cardiac/brain tolloid-like protein, encoding gene sequences; for treating cardiac and neural diseases.
Steindler, D.A.WO 98/30678
Neural stem cells
Neural stem cells isolated using culture conditions that limit cell-cell contact; for transplantation.
Takeda ChemicalEPO 854 192
Mouse myeloma cell containing the human cathepsin gene, production method; for intervertebral hernia treatment.
Texas, Univ. ofWO 98/30577
Engineered IgA antibodies
Engineered Immunoglobulin A (IgA) antibodies, mini-antibodies; for mucosal transport and immune response induction.
Thomas Jefferson Univ.WO 98/30708
Integration promoting vector
Replication-deficient SV40 vector with heterologous genes flanked by integration sequences; for gene transfer.
Tsubota, K.WO 98/30697
IL-10 formation inhibition
Drugs inhibiting interleukin (IL)-10 formation, transgenics expressing IL-10 in exocrine glands; for gland disorders.
Univ. CollegeWO 98/30707
Herpes viral vector
Herpes simplex virus vector having promoter and latent-associated transcript P2 regions; for gene transfection.