Published July 22 (EPO); July 16 (WO)

Abbott LabsWO 98/30692

Human endosulfine

Abbott Park, Ill.

Human endosulfine gene, encoded protein, protein isoforms, production method, transformed host cells.

Alliance PharmaWO 98/30706

Chimeric immunomodulators

San Diego

Chimeric immunomodulating agents having Fc receptor ligands and an immunosuppressive T cell receptor antagonist.

Beth Israel Deaconess Hosp.WO 98/30704

Cancer-related kinase

Boston

CSK homologous kinase, encoded protein; for detecting and treating cancer.

Boehringer MannheimEPO 854 196

DNA amplification method

Mannheim, Germany

Uncoupled, direct, exponential amplification and sequencing of DNA using a second thermostable polymerase.

Boehringer MannheimWO 98/30685 & 30686

Filtration DNA purification

Mannheim, Germany

Purification of nucleic acids using a cross-flow filtration centrifuge; for separating endotoxins from DNA.

ChironEPO 854 193

Retroviral packaging cells

Emeryville, Calif.

Human retroviral packaging cell line; for the production of retroviral vector particles.

Genetics InstituteWO 98/30582, 30584, 30589, 30695, & 30696

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Hoffmann-La RocheEPO 854 197

HIV detection

Basel, Switzerland

Primers for PCR amplification of the HIV gag gene; for HIV detection.

Human Genome SciencesWO 98/30693 & 30694

Human TNF receptors

Rockville, Md.

Human TNF receptors, encoding gene sequences, production methods; for identifying modulators.

Incyte PharmaWO 98/30690

Integral membrane protein

Palo Alto, Calif.

Human integral membrane protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/30691

Chloride channel protein

Palo Alto, Calif.

Human chloride channel protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Jayne, S., et al.WO 98/30701

Improved transformation

Des Moines, Iowa

Synthetic marker genes designed for maximum expression; for improving transformation efficiency.

Jolly, D.J., et al.WO 98/30709

Prodrug gene therapy

Leucadia, Calif.

Gene delivery vehicles having genes for selectable markers, non-immunogenic prodrugs, and an activator of the prodrug.

Kishimoto, T.WO 98/30688

JAK/STAT pathway protein

Osaka, Japan

JAK/STAT pathway protein regulating STAT functions, encoding gene, antisense, antibodies; for cytokine regulation.

Krebs Res. Inst.WO 98/30687

SRCR domain protein

Heidelberg, Germany

Protein containing an SRCR domain, encoding gene, antibodies, production method.

Life TechnologiesWO 98/30684

Bacterial production system

Rockville, Md.

Linkage of recombinant genes to the thioredoxin gene; for production and purification of proteins in bacteria.

Ludwig Inst.EPO 854 185

Growth factor receptors

New York

Growth factor receptors of the receptor protein tyrosine kinase family, encoding gene sequences; for ligand assays.

Mack, D.H.WO 98/30722

p53 mutation monitoring

Menlo Park, Calif.

Massive parallel monitoring of gene expression; for detecting p53 mutations and their functions.

Massachusetts, Univ. ofWO 98/30683

Transgenic clones

Amherst, Mass.

Nuclear transfer with differentiated fetal and adult donor cells; for producing transgenic cloned cells and animals.

Michigan, Univ. ofWO 98/30101

Apoptosis induction

Ann Arbor, Mich.

Gene encoding Hrk, a member of the Bcl-2 signal transduction pathway, encoded protein; for inducing cell death.

Nexstar PharmaWO 98/30720

Bioconjugated RNA oligos

Boulder, Colo.

Methods for conjugating or derivatizing RNA oligonucleotides via transcription in the presence of 5'-modified guanosine.

Oriental YeastWO 98/30703

Modified alanine aminotransferase

Tokyo

Modified human alanine aminotransferase gene; for efficient production in E. coli.

Pasteur Inst.WO 98/30699

Tuberculosis treatment

Paris

Mycobacterium tuberculosis P27 gene, encoded protein; for diagnosis and treatment of tuberculosis.

Scripps Res. Inst.WO 98/30238

Borna disease virus

La Jolla, Calif.

Human Borna disease virus genes, encoded proteins; for detection of genes, proteins, and antibodies in patients.

Scripps Res. Inst.WO 98/30677

Cataract transgenics

La Jolla, Calif.

Transgenics with disrupted alpha-3 connexin gene; for studying age-related cataract formation.

ShimadzuEPO 854 195

Salivary DNA amplification

Kyoto, Japan

Nucleic acid amplification in salivary samples pretreated with heat and saccharide-degrading enzymes.

SmithKline BeechamEPO 854 186

Staphylococcus antibacterials

Philadelphia

Staphylococcus aureus gene for cell division, encoded protein, production method; for treating infection.

SmithKline BeechamEPO 854 187

Glucose 6-phosphate dehydrogenase

Philadelphia

Glucose 6-phosphate dehydrogenase gene, encoded protein, production techniques; for making antibacterials.

SmithKline BeechamEPO 854 188

Streptococcus antibacterials

Philadelphia

Streptococcus pneumoniae aroE polypeptides, encoding gene sequences, production methods; for antibacterials.

SmithKline BeechamEPO 854 191

Cardiac/brain tolloid-like protein

Philadelphia

Human cardiac/brain tolloid-like protein, encoding gene sequences; for treating cardiac and neural diseases.

Steindler, D.A.WO 98/30678

Neural stem cells

Memphis, Tenn.

Neural stem cells isolated using culture conditions that limit cell-cell contact; for transplantation.

Takeda ChemicalEPO 854 192

Human cathepsin

Osaka, Japan

Mouse myeloma cell containing the human cathepsin gene, production method; for intervertebral hernia treatment.

Texas, Univ. ofWO 98/30577

Engineered IgA antibodies

Austin, Texas

Engineered Immunoglobulin A (IgA) antibodies, mini-antibodies; for mucosal transport and immune response induction.

Thomas Jefferson Univ.WO 98/30708

Integration promoting vector

Philadelphia

Replication-deficient SV40 vector with heterologous genes flanked by integration sequences; for gene transfer.

Tsubota, K.WO 98/30697

IL-10 formation inhibition

Chiba, Japan

Drugs inhibiting interleukin (IL)-10 formation, transgenics expressing IL-10 in exocrine glands; for gland disorders.

Univ. CollegeWO 98/30707

Herpes viral vector

London

Herpes simplex virus vector having promoter and latent-associated transcript P2 regions; for gene transfection.

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