Published July 8 (EPO); July 2 (WO)
Abbott LabsWO 98/28331
Variant acetylcholine receptor
Abbott Park, Ill.
Variant human alpha-7 nicotinic acetylcholine receptor, encoding gene sequences, vectors, production methods.
AmgenWO 98/28427
Obesity protein fusions
Thousand Oaks, Calif.
Genetic and chemical fusions of the N-terminal obese protein and Fc immunoglobulin regions; for treating obesity.
Bertling, W.WO 98/28415
Cloning vector system
Erlangen, Germany
Vector system containing a fusion sequence and restriction enzyme recognition sites; for cloning foreign proteins.
Boehringer IngelheimWO 98/28625
Hodgkin's disease therapy
Ingelheim, Germany
Measuring variant CD44 gene exon 10, antibodies to encoded exon fragment; for treating Hodgkin's disease.
Cobra TherapeuticsWO 98/28626
Cell transfection enhancement
Keele, U.K.
Method of screening for peptides bind to nucleic acids and enhance cell transfection.
Creative BiomoleculesWO 98/27995
Cardiac morphogens
Hopkinton, Mass.
Cardiac administration of morphogens of the TGF-beta family; for treating heart attacks.
Dade BehringWO 98/28443
Amplification method
Marburg, Germany
Method for polynucleotide amplification using modified oligos that are not extendable.
DiatechWO 98/28438
Point mutation detection
Brisbane, Australia
Process for detecting point mutations using primer bound to solid supports and mismatch mediated extension inhibition.
Emory Univ.WO 98/28325
Eukaryotic initiation factor 4E
Atlanta
Eukaryotic initiation factor 4E, encoding gene sequences, binding property mutants; for altering expression.
Gene-CellWO 98/28417
Non-adherent cell transfection
Houston
Microinjection needle with an adhesion molecule; for transfecting non-adherent cells for gene therapy.
GeneSystemsWO 98/28406
Non-adherent cell transfection
Houston
Microinjection needle with an adhesion molecule; for transfecting non-adherent cells for gene therapy.
GensetWO 98/28439
Specific sequence elimination
Paris
Eliminating specific gene sequences from libraries by selective binding and enzyme degradation of the sequences.
GeronWO 98/28442
Telomerase RNA component
Menlo Park, Calif.
Inhibition of the RNA component of telomerase by nucleotide binding; for diagnostics and therapeutics.
Human Genome SciencesWO 98/27932
Cerebellum specific protein
Rockville, Md.
Cerebellum and embryo specific protein, peptide fragments, encoding gene sequences, vectors, production methods.
Human Genome SciencesWO 98/28420
Parotid secretory protein
Rockville, Md.
Human parotid secretory protein, encoding gene sequences, production system; for screening modulators.
Human Genome SciencesWO 98/28421
Oncogene-induced secreted protein
Rockville, Md.
Human oncogene-induced secreted protein I, encoding gene sequences, production methods; for diagnosis and therapy.
Human Genome SciencesWO 98/28422
Apoptosis-related protein
Rockville, Md.
Human apoptosis-associated RAIDD protein, encoding gene sequences, production methods; for screening modulators.
ImmunexWO 98/28424 & 28426
NF-Kappa B ligands
Seattle
NF-Kappa B and its ligands, encoding gene sequences; for screening inhibitors and designing therapeutics.
Johns Hopkins Univ.WO 98/28445
Neutral sphingomyelinase
Baltimore
Genes for human neutral sphingomyelinase and fragments; for identifying modulators to treat related diseases.
LillyWO 98/28335 & 28414
Anti-obesity proteins
Indianapolis
Anti-obesity proteins; for patient administration and treatment of diabetes.
LillyWO 98/28413
Staphylococcus antibacterials
Indianapolis
Staphylococcus aureus monofunctional glycosyltransferase gene; for identifying inhibitors.
Magainin PharmaWO 98/27997
Inflammatory bowel disease
Plymouth Meeting, Penn.
Asthma-associated factor; for upregulating the Th2-mediated immune response involved in inflammatory bowel disease.
MerckWO 98/28003
Papillomavirus vaccines
Rahway, N.J.
Vaccine formulations containing recombinant early and late papillomavirus proteins combined with oxidized mannan.
Novo NordiskWO 98/28416
In vivo recombination
Bagsvaerd, Denmark
Forced artificial evolution by in vivo recombination between homologous sequences on two different DNA structures.
Novo NordiskWO 98/28429
Yeast production system
Bagsvaerd, Denmark
N-terminally proteins expressed in a yeast secretory expression system.
PepsynWO 98/28432
Transfection rate enhancement
Cambridge, U.K.
Stimulation of cells with growth factor regulating agents; for enhancing the rate of transfection.
Pharmacia & UpjohnWO 98/28412
Modified Factor Xa
Stockholm, Sweden
Modified coagulation Factor Xa with improved crystallization properties; for structural studies.
ProlifixWO 98/28334
Transcription factor antagonists
Abigdon, U.K.
Peptide antagonists derived from transcription factors; for activity inhibition and apoptosis induction.
PyroSequencingWO 98/28440
Pyrophosphate release sequencing
Uppsala, Sweden
Method of identifying a nucleotide base at a target position by detecting pyrophosphate release.
Queensland Dept. Hlth.WO 98/28004
Immunotherapy fusion protein
Brisbane, Austra-lia
Virus-like particle with hepatitis delta antigen fragment fusion immunotoxin enveloped by hepatitis B surface antigen.
ScheringWO 98/28425
IL-10 related cytokine
Kenilworth, N.J.
Mammalian cytokine related to interleukin (IL)-10, encoding gene sequences, antibodies; for therapeutics.
SmithKline BeechamWO 98/28005
Chlamydia vaccine
Rixensart, Belgium
Vaccines having the outer membrane protein from Chlamydia and a mucosal adjuvant; for preventing infertility.
SmithKline BeechamWO 98/28418
Tailless nuclear hormone receptors
Brentford, U.K.
Tailless nuclear hormone receptors, encoding gene sequences, production methods; for diagnostics and therapeutics.
Stanford Univ.WO 98/28419
Modulating vesicular release
Stanford, Calif.
Identification of binding antagonists of secretion-associated and syntaxin complexes; for modulating vesicular release.
Texas, Univ. ofWO 98/27994
Mitosis modulator
Austin, Tex.
Leucine heptad repeat protein, encoding gene; for modulating mitosis.
Texas, Univ. ofWO 98/28332
Dendritic cell expressed genes
Austin, Tex.
Genes expressed in long-term dendritic cell lines, encoded proteins, histidine fusion proteins, antibodies.
Texas, Univ. ofWO 98/28333
Moraxella antigens
Austin, Tex.
Moraxella catarrhaus antigens that form a high molecular weight complexes; for diagnostics and treatment.
Texas, Univ. ofWO 98/28423
Osteoclast inhibitory factors
Austin, Tex.
Osteoclast inhibitory factors; for inhibiting osteoclast formation and treating osteoporosis.
Vanderbilt Univ.WO 98/27819
Helicobacter ulcer vaccines
Nashville, Tenn.
Nucleic acid sequences from Helicobacter pylori, probes, mutant species; for making vaccines.
Wakunaga SeiyakuEPO 852 263
Mutated DNA analysis
Osaka, Japan
Solid phase method of binding nucleic acids to their complementary sequences; for analyzing mutant sequences.