Published July 1 (EPO); June 25 (WO)

BiocemWO 98/27202

Plant production system

Aubiere, France

Vectors and production system for the expression and purification of recombinant proteins in plants.

BMLEPO 851 030

Helper T cell gene

Tokyo

Gene specifically expressed by Th2 subset of helper T cells, encoded protein, antibodies; for immunological diseases.

Chicago, Univ. ofWO 98/27229

Array hybridization DNA sequencing

Chicago

Method of DNA sequencing by affinity fractionation and array hybridization.

CytocellWO 98/27225

Looped DNA replication

Banbury, U.K.

Hybridization of two nucleic acid strands such that a loop structure is formed and then replicated.

EisaiWO 98/27217

High titer retrovirus vectors

Tokyo

Method for preparing high titers of retroviral vectors using a recombination system.

Emory Univ.WO 98/27209

Polycation-mediated transfection

Atlanta, Ga.

Polycationic oligomers complexed with nucleic acid; for improved transfection during gene therapy.

Gen-ProbeEPO 851 033

Target-triggered amplification

San Diego

Oligos with promoters sequestered in stem-loop structures until target sequences appear; for amplification.

Genetic Engin. & Molec. Biol. Ctr.WO 98/27111

Immunocastration

Havana, Cuba

Substituted peptide derived from gonadotropin releasing hormone; for immunocastration.

Genetics Inst.WO 98/27205

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Hayashibara SeibutsuEPO 850 952

IL-18 receptors

Okayama, Japan

Interleukin (IL)-18 receptor proteins, monoclonal antibodies; for treating allergic diseases.

IcosWO 98/27116

Gravin binding fragments

Bothell, Wash.

Protein binding fragments of gravin that bind protein kinase C, encoding gene sequences; for modulator identification.

Kosan BiosciencesWO 98/27203

Combinatorial polyketide production

Burlingame, Calif.

Multiple vector system for combinatorially producing polyketides in yeast and bacteria.

Massachusetts, Univ. ofWO 98/27214

Transgenic cows

Amherst, Mass.

Transgenic cultured inner cell mass cells from cows and pigs; for making chimeras using embryonic stem cells.

MaxygenWO 98/27230

Protein evolution

Santa Clara, Calif.

Methods for recombination and selection of proteins; for polypeptide engineering.

McGill Univ.WO 98/27200

Replication origin consensus

Montreal

Human and mammalian DNA replication origin consensus sequences; for use in vectors for gene therapy.

McGill Univ.WO 98/27227

Neurological disease pharmacogenetics

Montreal

Pharmacogenetic methods to determine patient suitability for clinical trials and therapy for neurological diseases.

MRC (Med. Res. Counc.)WO 98/27213

Inflammation modulator assay

London

Recombinant lysophosphatidic acid acyltransferase, encoding gene; for identifying modulators of inflammation.

Mina Gerais, Fed. Univ. ofWO 98/27211

Modified interferon-beta

Belo Horizonte, Brazil

Interferon-beta-cis containing an amino acid substitution, encoding gene, production method; for antiviral therapy.

NestleEPO 851 028

Corneal epithelial cell line

Vevey, Switzerland

Immortalized human epithelial cell line from corneas capable of expressing differentiated products [in French].

New Jersey, Univ. Med. & Dent.WO 98/27220

Bacterial production system

Piscataway, N.J.

Concomitant inhibition of bacterial mRNA expression and prolonged expression of heterologous genes.

Pharmacia BiotechWO 98/27228

DNA sequencing method

Milwaukee

Exposure of DNA sequences to deoxynucleotide mixtures during sequence elongation; for reducing compression artifacts.

Rhone-Poulenc RorerWO 98/27206

Basic helix-loop-helix protein

Antony, France

Basic helix-loop-helix protein, encoding gene sequences, expression vectors; for therapeutics.

ScheringWO 98/27114

T cell surface antigens

Kenilworth, N.J.

Genes encoding T cell surface antigens, encoded proteins, antibodies; for diagnosis and therapy.

Sembiosys GeneticsWO 98/27115

Oil body protein purification

Calgary, Alberta

Oil bodies and associated proteins fused to ligands; for purification of targets using density differences.

Targeted GeneticsWO 98/27204 & 27207

Replication-defective AAV vectors

Seattle, Wash.

Adeno-associated virus (AAV) split-packaging genes, recombinase cassettes, cells; for replication-defective vectors.

Terman, D.S.WO 98/26747

Superantigen T cell activation

Pebble Beach, Calif.

Combinations of superantigens and immunotherapeutic antigens; to activate or anergize selected T cell populations.

ZymogeneticsWO 98/27210

Diabetic islet stimulation

Seattle, Wash.

Insulin homolog polypeptide used to stimulate islet proliferation and beta-cell mass; for treating diabetics.

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