Published July 1 (EPO); June 25 (WO)
Plant production system
Vectors and production system for the expression and purification of recombinant proteins in plants.
BMLEPO 851 030
Helper T cell gene
Gene specifically expressed by Th2 subset of helper T cells, encoded protein, antibodies; for immunological diseases.
Chicago, Univ. ofWO 98/27229
Array hybridization DNA sequencing
Method of DNA sequencing by affinity fractionation and array hybridization.
Looped DNA replication
Hybridization of two nucleic acid strands such that a loop structure is formed and then replicated.
High titer retrovirus vectors
Method for preparing high titers of retroviral vectors using a recombination system.
Emory Univ.WO 98/27209
Polycationic oligomers complexed with nucleic acid; for improved transfection during gene therapy.
Gen-ProbeEPO 851 033
Oligos with promoters sequestered in stem-loop structures until target sequences appear; for amplification.
Genetic Engin. & Molec. Biol. Ctr.WO 98/27111
Substituted peptide derived from gonadotropin releasing hormone; for immunocastration.
Genetics Inst.WO 98/27205
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Hayashibara SeibutsuEPO 850 952
Interleukin (IL)-18 receptor proteins, monoclonal antibodies; for treating allergic diseases.
Gravin binding fragments
Protein binding fragments of gravin that bind protein kinase C, encoding gene sequences; for modulator identification.
Kosan BiosciencesWO 98/27203
Combinatorial polyketide production
Multiple vector system for combinatorially producing polyketides in yeast and bacteria.
Massachusetts, Univ. ofWO 98/27214
Transgenic cultured inner cell mass cells from cows and pigs; for making chimeras using embryonic stem cells.
Santa Clara, Calif.
Methods for recombination and selection of proteins; for polypeptide engineering.
McGill Univ.WO 98/27200
Replication origin consensus
Human and mammalian DNA replication origin consensus sequences; for use in vectors for gene therapy.
McGill Univ.WO 98/27227
Neurological disease pharmacogenetics
Pharmacogenetic methods to determine patient suitability for clinical trials and therapy for neurological diseases.
MRC (Med. Res. Counc.)WO 98/27213
Inflammation modulator assay
Recombinant lysophosphatidic acid acyltransferase, encoding gene; for identifying modulators of inflammation.
Mina Gerais, Fed. Univ. ofWO 98/27211
Belo Horizonte, Brazil
Interferon-beta-cis containing an amino acid substitution, encoding gene, production method; for antiviral therapy.
NestleEPO 851 028
Corneal epithelial cell line
Immortalized human epithelial cell line from corneas capable of expressing differentiated products [in French].
New Jersey, Univ. Med. & Dent.WO 98/27220
Bacterial production system
Concomitant inhibition of bacterial mRNA expression and prolonged expression of heterologous genes.
Pharmacia BiotechWO 98/27228
DNA sequencing method
Exposure of DNA sequences to deoxynucleotide mixtures during sequence elongation; for reducing compression artifacts.
Rhone-Poulenc RorerWO 98/27206
Basic helix-loop-helix protein
Basic helix-loop-helix protein, encoding gene sequences, expression vectors; for therapeutics.
T cell surface antigens
Genes encoding T cell surface antigens, encoded proteins, antibodies; for diagnosis and therapy.
Sembiosys GeneticsWO 98/27115
Oil body protein purification
Oil bodies and associated proteins fused to ligands; for purification of targets using density differences.
Targeted GeneticsWO 98/27204 & 27207
Replication-defective AAV vectors
Adeno-associated virus (AAV) split-packaging genes, recombinase cassettes, cells; for replication-defective vectors.
Terman, D.S.WO 98/26747
Superantigen T cell activation
Pebble Beach, Calif.
Combinations of superantigens and immunotherapeutic antigens; to activate or anergize selected T cell populations.
Diabetic islet stimulation
Insulin homolog polypeptide used to stimulate islet proliferation and beta-cell mass; for treating diabetics.