Published June 17 (EPO); June 11 (WO)
Transgenic human antibodies
Transgenics having human variable immunoglobulin gene regions; for making B cells with high affinity antibodies.
Alabama, Univ. ofWO 98/24927
Pneumonia DNA vaccines
Streptococcus pneumoniae antigens, plasmids encoding them; for producing DNA vaccines.
T cell-specific chemokine
Thousand Oaks, Calif.
Chemokine specific for T cells, encoding gene, production methods.
Helicobacter pylori genes and encoded proteins; for ulcer diagnos-tics and vaccines.
Thyrotropin releasing hormone (TRH) receptor, encoding gene; for diagnostics and therapeutics.
Calpaines, production methods; for screening compounds to find inhibitors.
Biotie TherapiesWO 98/24921
Syndecan enhancer element
Syndecan enhancer element, binding proteins, transgenics; for targeting gene expression to wound sites.
Boston ProbesWO 98/24933
Preventing non-target sequence binding
Methods for suppressing DNA probe binding to non-target sequenc-es; for improved detection of mutations.
Brigham & Women's Hosp.WO 98/24886
Mast cell protease
Trypsin-like serine protease from mast cells that cleaves fibrinogen; for treating blood clot formation.
Brigham & Women's Hosp.WO 98/25142
Presinilin binding protein
ALARM protein or delta-catenin that is expressed in brain and binds to presinilin 1; for treating Alzheimer's.
Centenary Inst. Cancer Med.WO 98/24307
Transgenic production methods using embryonic stem cells implanted into blastocysts; for assessing gene function.
Thrombolytic agents linked to targeting molecules; for eliminating thrombi.
French Atomic Energy Comm.WO 98/24892
Vascular expression of genes
Vascular endothelium cadherin promoter, transgenics; for vascular tissue-specific expression of genes.
Stable expression system
The Woodlands, Texas
Actin gene-based vectors; for stable expression of recombi-nant insulin-like growth factor.
Genetics Inst.WO 98/24905
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genpharm Intl.WO 98/24884
Transgenic human antibodies
Palo Alto, Calif.
Transgenic animals producing human sequence antibodies that have substantial affinity for human antigens.
Human flavin-containing monooxygenase, encoding gene, vec-tors; for diagnostics and therapeutics.
Georgetown Univ.WO 98/24454
Human endogenous retrovirus-pleiotrophin (HERV-PTN) ribo-zymes; for inhibiting choriocarcinoma growth and invasion.
Cellular receptor inhibitors
Screening of libraries for compounds that interfere with ligand binding to cellular receptors.
Ft. Collins, Colo.
Parasitic nematode transglutaminase proteins, encoding genes, antibodies, modulators; for therapeutics.
Recombinant plague vaccine
Ft. Collins, Colo.
Recombinant plague bacteria genes in viral vectors; for vaccines.
HoechstEPO 848 061 & 848 063
Self-enhancing expression system
Self-enhancing, controllable expression system encoding a transcription factor and having hybrid promoters.
Hoffmann-La RocheWO 98/24896
Obese protein muteins
Muteins of the obese protein, encoding gene sequences, production methods.
Hoffmann-La RocheWO 98/24897
Junction adhesion protein
Tight junction adhesion protein, encoding gene sequences, antibodies, modifiers, transgenics.
Holzer, D.WO 98/24918
Gene trap vectors
Gene trap vectors with linked reporter genes; for identify-ing and isolating gene sequences.
Human Genome SciencesWO 98/24900
Pituitary adenylate cyclase activator
Human G-protein pituitary adenylate cyclase activating polypeptide-like receptor, encoding gene; for amnesia.
Human Genome SciencesWO 98/24908
Human chemokine beta-13, encoding gene sequences; for screening modulators and treating immune system disorders.
Incyte PharmaWO 98/24901
Lung growth factor variant
Palo Alto, Calif.
Lung growth factor variant, encoding gene sequences, anti-sense anti-bodies, modulators, production methods.
Stem cell genetic modification
Genetic modification of primate pluripotent repopulating stem cells using adeno-associated viral vectors.
Janssen PharmaWO 98/24810
Homolog for neurological disease
Vertebrate protein homolog of C. elegans UNC-53, encoding gene, vectors; for treating neurological diseases.
KM BiotechWO 98/24903
Erythroid differentiation factor
Erythroid differentiation and denucleation factors, encoding gene sequences; for treating hematologic diseases.
Krebs Res. Inst.WO 98/24894
PKD1 fragments, encoding gene sequences, antibodies, produc-tion methods.
Kyowa Hakko KogyoWO 98/24815 & 24899
IgA nephropathy gene
Protein isolated from leukocytes of patients with IgA ne-phropathy, encoding gene, oligos, antibodies.
Kyowa Hakko KogyoWO 98/24817
Eosinophil activating protein
Eosinophil activating protein, encoding gene, modulators, antibodies; for diagnosis and therapy.
Streptococcus biosynthetic inhibitors
Streptococcus pneumoniae stem peptide biosynthetic murl gene, encoded protein; for identifying inhibitors.
Magainin PharmaWO 98/24904
IL-9 receptor variants
Plymouth Meeting, Penn.
Interleukin (IL)-9 receptor variants, encoding gene sequenc-es; for treating atopic allergies and asthma.
MRC (Med. Res. Counc.)WO 98/24909
E. coli GroEL chaperone fragment coupled to a solid support; for refolding denatured cyclophilin A.
MRC (Med. Res. Counc.)WO 98/25145
Cervical lesion screen
Papillomavirus E4 protein antibodies; for screening precan-cerous cervical lesions.
MerckEPO 848 066
Methods for identifying hydrolytic enzymes using gene probes [in German].
Mutant ob receptors
Mutant ob receptors lacking one functional domain; for assays to identify ligands.
Minnesota, Univ. ofWO 98/24910 & 24911
Streptococcal toxin vaccines
Mutant streptococcal toxin A and C; for vaccines to protect against these toxins.
NIH (Natl. Inst. Hlth.)WO 98/24808
Peptide fragments of IgE having residues inducing end loop formation; for blocking receptors and hypersensitivity.
Netherlands Cancer Inst.WO 98/24915
Cell cycle progression control
Protein phosphatase 2A subunit polypeptide, encoding gene sequences; for preventing cell progression to G1 phase.
Neurocrine BiosciencesWO 98/24812
Cell death inhibitors
A6LA5A12 polypeptides and variants; for inhibiting stress-induced oxidative damage and cell death.
Nissin ShokuhinEPO 848 013
HIV gp120 antibodies
Monoclonal antibodies to HIV gp120 protein; for passive immunization.
North Carolina, Univ. ofWO 98/24931
DNA sequence binding assay
Chapel Hill, N.C.
Peptide-DNA binding and sequence specific DNA-binding pep-tides identified with combinatorial oligo librar-ies.
Pallisgaard, N.WO 98/24928
Detection of chromosomal abnormalities associated with conditions having characteristic nucleic acid sequences.
Pasteur Inst.WO 98/24898
Neuronal disease protein
KAL protein; for diagnosing and treating neuronal, retinal, and renal diseases.
Chain termination sequencing
Foster City, Calif.
Chain-termination type nucleic acid sequencing using 2'-de-oxyuridine-5'-triphosphate.
Pharmacia & UpjohnWO 98/24895
TNF receptor family member
Glucocorticoid-induced TNF receptor-related protein, encod-ing gene sequences, splice variants.
Y chromosome integrity probe
Y chromosome integrity nucleic acid probes for regions linked to normal fertility; for deletion detection.
Rhone-Poulenc RorerWO 98/24888
Lipoprotein lipase-like peptides
Lipoprotein lipase-like polypeptides, encoding gene sequenc-es, antibodies; for screening modulators.
Ribozyme PharmaWO 98/24913
IL-2 receptor ribozyme
Ribozyme that cleaves interleukin (IL)-2 receptor gamma chain RNA; for treating inflammatory diseases.
Sanitaria ScaligeraWO 98/24885
Immunoreactive Helicobacter pylori antigen, antibodies to it; for detection assays.
Mammalian monocyte cell genes, encoded proteins including antibodies; for diagnostics and therapeutics.
Scripps Res. Inst.WO 98/25144
Integrin activation inhibitors
La Jolla, Calif.
Cell lines transfected with a gene for a truncated integrin; for identifying integrin activation inhibitors.
Scriptgen PharmaWO 98/24891
Mycobacterium tuberculosis RNA polymerase alpha subunit, encod-ing gene sequences; for high-throughput inhibitor screens.
SmithKline BeechamEPO 848 060
Human 11cb splice variant
Polypeptides from the human 11cb splice variant, encoding gene, modulators; for treating infections.
SmithKline BeechamEPO 848 062
Alzheimer's aspartic protease
Aspartic protease, encoding gene, production methods; for treating Alzheimer's disease.
AAV vector liver delivery
Foster City, Calif.
Adeno-associated viral (AAV) vector-mediated delivery of genes to the liver.
South Carolina, Med. Univ. ofWO 98/24925
Tissue- and target RNA-specific ribozymes; for use as anti-microbial therapeutics.
Kinase linking protein
Redwood City, Calif.
FRS2 adaptor protein that links kinases to activating part-ners in cells, encoding gene sequences, modulator assays.
Sumitomo PharmaEPO 847 757
HGF gene, encoded protein; for topical administration to reduce side effects.
Swift, M.R., et al.WO 98/25125
Breast cancer disposition mutations
Germline mutations in the ataxia-telangiectasia gene associ-ated with a predisposition to breast cancer.
Prostate disease diagnosis
Oklahoma City, Okla.
Multivariate diagnostic model for prostate disease using serum assays of various significant mRNAs.
Vergara Piccalugo, A.EPO 848
Electromagnetic radiation cell control
Vina de Mar, Chile
Regulating tumor cell behavior by applying electromagnetic radiation similar to what is emitted by the cells.
VetigenEPO 848 059
Mammalian iodocyanopindolol binding non-adrenergic receptor, encoding gene, monoclonal antibodies.
Wake Forest Univ.WO 98/24923
HIV co-receptor inactivation
Inactivation and prevention of cell surface expression of co-receptors necessary for HIV binding to cells.