Published June 17 (EPO); June 11 (WO)

AbgenixWO 98/24893

Transgenic human antibodies

Fremont, Calif.

Transgenics having human variable immunoglobulin gene regions; for making B cells with high affinity antibodies.

Alabama, Univ. ofWO 98/24927

Pneumonia DNA vaccines

Birmingham, Ala.

Streptococcus pneumoniae antigens, plasmids encoding them; for producing DNA vaccines.

AmgenWO 98/24907

T cell-specific chemokine

Thousand Oaks, Calif.

Chemokine specific for T cells, encoding gene, production methods.

AstraWO 98/24475

Ulcer vaccines

Sodertalje, Sweden

Helicobacter pylori genes and encoded proteins; for ulcer diagnos-tics and vaccines.

AstraWO 98/24818

TRH receptor

Sodertalje, Sweden

Thyrotropin releasing hormone (TRH) receptor, encoding gene; for diagnostics and therapeutics.

BASFWO 98/24916

Calpaines

Ludwigshafen, Germany

Calpaines, production methods; for screening compounds to find inhibitors.

Biotie TherapiesWO 98/24921

Syndecan enhancer element

Turku, Finland

Syndecan enhancer element, binding proteins, transgenics; for targeting gene expression to wound sites.

Boston ProbesWO 98/24933

Preventing non-target sequence binding

Bedford, Mass.

Methods for suppressing DNA probe binding to non-target sequenc-es; for improved detection of mutations.

Brigham & Women's Hosp.WO 98/24886

Mast cell protease

Boston, Mass.

Trypsin-like serine protease from mast cells that cleaves fibrinogen; for treating blood clot formation.

Brigham & Women's Hosp.WO 98/25142

Presinilin binding protein

Boston, Mass.

ALARM protein or delta-catenin that is expressed in brain and binds to presinilin 1; for treating Alzheimer's.

Centenary Inst. Cancer Med.WO 98/24307

Transgenic production

Camperdown, Australia

Transgenic production methods using embryonic stem cells implanted into blastocysts; for assessing gene function.

DiatideWO 98/24917

Targeted antithrombotics

Londonderry, N.H.

Thrombolytic agents linked to targeting molecules; for eliminating thrombi.

French Atomic Energy Comm.WO 98/24892

Vascular expression of genes

Paris

Vascular endothelium cadherin promoter, transgenics; for vascular tissue-specific expression of genes.

GeneMedicineWO 98/24922

Stable expression system

The Woodlands, Texas

Actin gene-based vectors; for stable expression of recombi-nant insulin-like growth factor.

Genetics Inst.WO 98/24905

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Genpharm Intl.WO 98/24884

Transgenic human antibodies

Palo Alto, Calif.

Transgenic animals producing human sequence antibodies that have substantial affinity for human antigens.

GensetWO 98/24914

Flavin-containing monooxygenase

Paris

Human flavin-containing monooxygenase, encoding gene, vec-tors; for diagnostics and therapeutics.

Georgetown Univ.WO 98/24454

HERV-PTN ribozymes

Washington, D.C.

Human endogenous retrovirus-pleiotrophin (HERV-PTN) ribo-zymes; for inhibiting choriocarcinoma growth and invasion.

GlaxoWO 98/25146

Cellular receptor inhibitors

Greenford, U.K.

Screening of libraries for compounds that interfere with ligand binding to cellular receptors.

HeskaWO 98/24887

Nematode transglutaminase

Ft. Collins, Colo.

Parasitic nematode transglutaminase proteins, encoding genes, antibodies, modulators; for therapeutics.

HeskaWO 98/24912

Recombinant plague vaccine

Ft. Collins, Colo.

Recombinant plague bacteria genes in viral vectors; for vaccines.

HoechstEPO 848 061 & 848 063

Self-enhancing expression system

Frankfurt, Germany

Self-enhancing, controllable expression system encoding a transcription factor and having hybrid promoters.

Hoffmann-La RocheWO 98/24896

Obese protein muteins

Basel, Switzerland

Muteins of the obese protein, encoding gene sequences, production methods.

Hoffmann-La RocheWO 98/24897

Junction adhesion protein

Basel, Switzerland

Tight junction adhesion protein, encoding gene sequences, antibodies, modifiers, transgenics.

Holzer, D.WO 98/24918

Gene trap vectors

Frankfurt, Germany

Gene trap vectors with linked reporter genes; for identify-ing and isolating gene sequences.

Human Genome SciencesWO 98/24900

Pituitary adenylate cyclase activator

Rockville, Md.

Human G-protein pituitary adenylate cyclase activating polypeptide-like receptor, encoding gene; for amnesia.

Human Genome SciencesWO 98/24908

Chemokine beta-13

Rockville, Md.

Human chemokine beta-13, encoding gene sequences; for screening modulators and treating immune system disorders.

Incyte PharmaWO 98/24901

Lung growth factor variant

Palo Alto, Calif.

Lung growth factor variant, encoding gene sequences, anti-sense anti-bodies, modulators, production methods.

IntrogeneWO 98/24924

Stem cell genetic modification

Leiden, Netherlands

Genetic modification of primate pluripotent repopulating stem cells using adeno-associated viral vectors.

Janssen PharmaWO 98/24810

Homolog for neurological disease

Beerse, Belgium

Vertebrate protein homolog of C. elegans UNC-53, encoding gene, vectors; for treating neurological diseases.

KM BiotechWO 98/24903

Erythroid differentiation factor

Montebello, Calif.

Erythroid differentiation and denucleation factors, encoding gene sequences; for treating hematologic diseases.

Krebs Res. Inst.WO 98/24894

PKD1 fragments

Heidelberg, Germany

PKD1 fragments, encoding gene sequences, antibodies, produc-tion methods.

Kyowa Hakko KogyoWO 98/24815 & 24899

IgA nephropathy gene

Tokyo

Protein isolated from leukocytes of patients with IgA ne-phropathy, encoding gene, oligos, antibodies.

Kyowa Hakko KogyoWO 98/24817

Eosinophil activating protein

Tokyo

Eosinophil activating protein, encoding gene, modulators, antibodies; for diagnosis and therapy.

LillyWO 98/24798

Streptococcus biosynthetic inhibitors

Indianapolis

Streptococcus pneumoniae stem peptide biosynthetic murl gene, encoded protein; for identifying inhibitors.

Magainin PharmaWO 98/24904

IL-9 receptor variants

Plymouth Meeting, Penn.

Interleukin (IL)-9 receptor variants, encoding gene sequenc-es; for treating atopic allergies and asthma.

MRC (Med. Res. Counc.)WO 98/24909

Chaperone-induced refolding

London

E. coli GroEL chaperone fragment coupled to a solid support; for refolding denatured cyclophilin A.

MRC (Med. Res. Counc.)WO 98/25145

Cervical lesion screen

London

Papillomavirus E4 protein antibodies; for screening precan-cerous cervical lesions.

MerckEPO 848 066

Hydrolytic enzymes

Darmstadt, Germany

Methods for identifying hydrolytic enzymes using gene probes [in German].

MerckWO 98/24881

Mutant ob receptors

Rahway, N.J.

Mutant ob receptors lacking one functional domain; for assays to identify ligands.

Minnesota, Univ. ofWO 98/24910 & 24911

Streptococcal toxin vaccines

Minneapolis

Mutant streptococcal toxin A and C; for vaccines to protect against these toxins.

NIH (Natl. Inst. Hlth.)WO 98/24808

Allergy inhibition

Bethesda, Md.

Peptide fragments of IgE having residues inducing end loop formation; for blocking receptors and hypersensitivity.

Netherlands Cancer Inst.WO 98/24915

Cell cycle progression control

Amsterdam

Protein phosphatase 2A subunit polypeptide, encoding gene sequences; for preventing cell progression to G1 phase.

Neurocrine BiosciencesWO 98/24812

Cell death inhibitors

San Diego

A6LA5A12 polypeptides and variants; for inhibiting stress-induced oxidative damage and cell death.

Nissin ShokuhinEPO 848 013

HIV gp120 antibodies

Osaka, Japan

Monoclonal antibodies to HIV gp120 protein; for passive immunization.

North Carolina, Univ. ofWO 98/24931

DNA sequence binding assay

Chapel Hill, N.C.

Peptide-DNA binding and sequence specific DNA-binding pep-tides identified with combinatorial oligo librar-ies.

Pallisgaard, N.WO 98/24928

Chromosomal abnormalities

Arhus, Denmark

Detection of chromosomal abnormalities associated with conditions having characteristic nucleic acid sequences.

Pasteur Inst.WO 98/24898

Neuronal disease protein

Paris

KAL protein; for diagnosing and treating neuronal, retinal, and renal diseases.

Perkin-ElmerWO 98/24930

Chain termination sequencing

Foster City, Calif.

Chain-termination type nucleic acid sequencing using 2'-de-oxyuridine-5'-triphosphate.

Pharmacia & UpjohnWO 98/24895

TNF receptor family member

Milan, Italy

Glucocorticoid-induced TNF receptor-related protein, encod-ing gene sequences, splice variants.

PromegaWO 98/24937

Y chromosome integrity probe

Madison, Wis.

Y chromosome integrity nucleic acid probes for regions linked to normal fertility; for deletion detection.

Rhone-Poulenc RorerWO 98/24888

Lipoprotein lipase-like peptides

Collegeville, Penn.

Lipoprotein lipase-like polypeptides, encoding gene sequenc-es, antibodies; for screening modulators.

Ribozyme PharmaWO 98/24913

IL-2 receptor ribozyme

Boulder, Colo.

Ribozyme that cleaves interleukin (IL)-2 receptor gamma chain RNA; for treating inflammatory diseases.

Sanitaria ScaligeraWO 98/24885

Helicobacter antigen

Avesa, Italy

Immunoreactive Helicobacter pylori antigen, antibodies to it; for detection assays.

ScheringWO 98/24906

Monocyte genes

Kenilworth, N.J.

Mammalian monocyte cell genes, encoded proteins including antibodies; for diagnostics and therapeutics.

Scripps Res. Inst.WO 98/25144

Integrin activation inhibitors

La Jolla, Calif.

Cell lines transfected with a gene for a truncated integrin; for identifying integrin activation inhibitors.

Scriptgen PharmaWO 98/24891

Tuberculosis therapeutics

Medford, Mass.

Mycobacterium tuberculosis RNA polymerase alpha subunit, encod-ing gene sequences; for high-throughput inhibitor screens.

SmithKline BeechamEPO 848 060

Human 11cb splice variant

Philadelphia

Polypeptides from the human 11cb splice variant, encoding gene, modulators; for treating infections.

SmithKline BeechamEPO 848 062

Alzheimer's aspartic protease

Philadelphia

Aspartic protease, encoding gene, production methods; for treating Alzheimer's disease.

SomatixWO 98/24479

AAV vector liver delivery

Foster City, Calif.

Adeno-associated viral (AAV) vector-mediated delivery of genes to the liver.

South Carolina, Med. Univ. ofWO 98/24925

Antimicrobial ribozymes

Charleston, S.C.

Tissue- and target RNA-specific ribozymes; for use as anti-microbial therapeutics.

SugenWO 98/24902

Kinase linking protein

Redwood City, Calif.

FRS2 adaptor protein that links kinases to activating part-ners in cells, encoding gene sequences, modulator assays.

Sumitomo PharmaEPO 847 757

HGF gene

Osaka, Japan

HGF gene, encoded protein; for topical administration to reduce side effects.

Swift, M.R., et al.WO 98/25125

Breast cancer disposition mutations

Scarsdale, N.Y.

Germline mutations in the ataxia-telangiectasia gene associ-ated with a predisposition to breast cancer.

UrocorWO 98/24935

Prostate disease diagnosis

Oklahoma City, Okla.

Multivariate diagnostic model for prostate disease using serum assays of various significant mRNAs.

Vergara Piccalugo, A.EPO 848

Electromagnetic radiation cell control

Vina de Mar, Chile

Regulating tumor cell behavior by applying electromagnetic radiation similar to what is emitted by the cells.

VetigenEPO 848 059

Non-adrenergic receptor

Paris

Mammalian iodocyanopindolol binding non-adrenergic receptor, encoding gene, monoclonal antibodies.

Wake Forest Univ.WO 98/24923

HIV co-receptor inactivation

Winston-Salem, N.C.

Inactivation and prevention of cell surface expression of co-receptors necessary for HIV binding to cells.

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