Company Symbol 12/31* 3/31 6/30 %YTDAastrom Biosci ASTM 4.375 4.500 3.750 -14Adv Magnetics AVM 8.750 13.062 11.312 29Adv Poly Sys APOS 6.625 8.625 7.000 6Adv Tissue Sci ATIS 12.375 9.343 4.437 -64Affymetrix AFFX 31.125 34.812 24.062 -23Agouron AGPH 29.375 37.875 30.312 3Agritope AGTO 7.000 4.500 4.000 -43Alexion Pharma ALXN 12.500 12.375 10.000 -20Alkermes ALKS 19.875 24.875 17.875 -10Allelix AXB* 11.500 9.000 8.000 -30Alliance ALLP 7.250 7.562 4.187 -42Alpha Beta ABTI 2.593 2.125 2.437 -6AltaRex AXO* 3.000 2.260 1.050 -65Alteon ALTN 7.312 5.062 3.500 -52Alza AZA 31.812 44.812 43.250 36Am Bio Sci MABXA 1.906 1.750 1.156 -39Amarillo Biosci AMAR 5.500 3.250 2.750 -50AMBI Inc. AMBI 1.937 2.187 1.406 -27Amgen AMGN 54.125 60.875 65.375 21Amylin AMLN 5.437 2.750 3.781 -30Anergen ANRG 2.125 1.062 1.937 -9Anesta NSTA 16.375 18.625 14.437 -12Angiotech Pharma ANP* 10.000 16.500 14.750 48Aphton APHT 10.125 12.687 16.625 64Aquila Biopharma AQLA 4.187 7.125 4.187 0Aradigm ARDM 8.500 12.625 13.562 60Ariad Pharm ARIA 4.250 4.625 3.562 -16Aronex Pharma ARNX 4.250 3.562 3.937 -7ArQule ARQL 22.937 22.250 12.937 -44Atlantic Pharma ATLC 6.750 6.500 3.812 -44Atrix Labs ATRX 14.750 19.000 13.375 -9Aurora Bioscience ABSC 13.125 11.500 5.875 -55AutoImmune AIMM 3.312 2.312 2.562 -23Avax Technologies AVXT 3.687 4.250 2.437 -34AVI BioPharma AVII 6.812 7.125 6.250 -8Avigen AVGN 2.250 2.437 3.500 56Aviron AVIR 27.125 23.125 31.187 15Axogen AXG/U 39.750 57.000 63.000 58Axys Pharma AXPH 8.375 8.750 7.125 -15Bio-Tech Gen BTGC 10.750 8.500 7.093 -34Biochem Pharma BCHE 20.875 24.187 26.500 27BioCryst BCRX 7.000 7.500 7.812 12Biogen BGEN 36.375 48.187 49.000 35Bioject BJCT 1.281 1.500 1.812 41Biomatrix BIOX 30.000 29.875 41.000 37Biomira BIOMF 2.125 2.500 2.250 6Biomune Sys BIME 0.718 0.937 0.937 31Biora AB BIORY 20.750 25.000 26.500 28Bioreliance BREL 23.000 16.500 15.062 -35Biotime BTIM 19.000 14.250 6.250 -67BioTransplant BTRN 5.750 4.250 3.500 -39Boston Life BLSI 2.281 2.125 3.125 37British Biotech BBIOY 16.625 12.250 6.375 -62Cadus Pharma KDUS 6.375 8.312 7.750 22Calypte Biomed CALY 3.875 5.187 4.031 4Cambridge Neuro CNSI 1.968 2.312 0.593 -70Cantab Pharm (1) CNTBY 11.750 13.573 12.125 3Carrington CARN 4.312 4.437 4.812 12Cel-Sci HIV 6.625 4.625 4.937 -25Celgene CELG 8.437 10.875 10.625 26Cell Genesys CEGE 8.500 6.625 8.562 1Cell Therapeutics CTIC 17.000 4.125 2.687 -84Cellegy Pharma CLGY 8.375 7.125 5.562 -34CellPro CPRO 2.312 3.625 3.062 32Celtrix CTRX 1.812 2.812 2.062 14Centocor CNTO 33.250 44.625 36.250 9Cephalon CEPH 11.375 14.000 7.875 -31ChemTrak CMTR 0.750 0.718 0.187 -75Chiron CHIR 17.000 20.937 15.687 -8Cholestech CTEC 12.500 15.000 6.750 -46Chrysalis Intl CRLS 2.156 3.000 1.375 -36CIMA Labs CIMA 4.250 4.968 3.343 -21ClinTrials CCRO 7.875 7.125 4.875 -38CoCensys COCN 3.437 3.062 2.500 -27Collab. Clin. Res CCLR 5.062 4.250 4.125 -19CollaGenex CGPI 12.500 9.343 8.625 -31Columbia Labs COB 16.250 13.812 5.750 -65CombiChem (2) CCHM 8.000 - 6.937 -13Connetics Corp. CNCT 3.062 5.312 3.812 24Cor Thera CORR 22.500 12.375 13.875 -38Corixa CRXA 8.937 7.375 6.875 -23Cortech CRTQ 0.593 0.500 0.562 -5Cortecs Intl DLVRY 14.250 14.375 7.375 -48Cortex CORX 1.500 1.750 1.875 25Corvas CVAS 3.875 5.000 4.125 6Coulter Pharma CLTR 20.250 27.375 30.375 50Creative Bio CBMI 7.375 8.250 4.812 -35Crescendo Pharma CNDO 11.562 12.625 12.687 10Cubist Pharma CBST 5.812 4.500 4.750 -18Curagen Corp. CRGN 11.500 11.562 6.250 -46CV Therapeutics CVTX 9.375 9.500 8.625 -8Cyanotech CYAN 2.781 3.437 3.125 12Cygnus CYGN 19.875 16.500 10.437 -47Cypress Bio CYPB 1.437 2.625 2.968 107Cypros Pharma CYP 4.250 3.812 4.062 -4Cytel CYTL 1.500 1.781 1.375 -8Cytoclonal Pharma CYPH 6.875 10.250 7.000 2Cytogen CYTO 1.625 2.156 0.781 -52CytoTherapeut CTII 4.000 3.375 1.250 -69CytRx CYTR 2.937 3.375 2.125 -28Dekalb DKB 39.250 66.875 94.625 141DepoMed DPMD 4.250 12.375 10.250 141DepoTech DEPO 3.562 6.000 1.562 -56Diacrin DCRN 10.125 9.750 6.250 -38Diagnostic Prod DP 27.750 27.875 28.812 4Dianon Systems DIAN 9.375 9.750 9.250 -1Diatide DITI 9.125 10.750 8.750 -4Digene DIGE 8.625 8.875 9.750 13Discovery Labs DSCO 4.000 4.750 4.250 6DNAP Holding DNAP 4.859 4.000 4.187 -14Draxis Health DRAXF 3.062 2.906 2.562 -16Dura Pharm DURA 45.875 24.625 22.375 -51Dusa Pharma DUSA 11.500 15.500 6.812 -41DynaGen DYGN 1.400 0.562 0.437 -69Ecogen EECN 1.937 2.687 2.625 36Elan ELN 51.187 64.625 64.312 26Embrex EMBX 5.312 5.750 6.187 16Emisphere EMIS 18.625 17.875 12.062 -35Endorex ENDR 5.500 6.187 4.250 -23EntreMed ENMD 11.312 12.812 33.250 194Envirogen ENVG 1.500 1.250 1.250 -17Enzo Biochem ENZ 14.625 15.750 13.375 -9Enzon ENZN 5.500 6.875 6.375 16Epitope EPTO 5.000 6.875 6.500 30Epix Medical EPIX 13.000 13.187 10.250 -21Ergo Science ERGO 15.250 15.062 3.562 -77Ethical Hldgs ETHCY 3.125 3.000 0.375 -88Flamel Tech FLMLY 1.812 5.125 5.000 176GalaGen GGEN 1.875 1.625 3.062 63GelTex GELX 26.500 27.000 18.625 -30Gene Logic GLGC 8.000 7.625 7.000 -13Genelabs GNLB 2.812 4.000 3.000 7GeneMedicine GMED 5.062 2.875 3.125 -38Genentech GNE 60.625 70.437 67.875 12Genetronics GEB* 3.094 3.550 3.600 16Genome Thera GENE 6.312 8.625 4.500 -29Genset GENXY 19.750 29.000 29.375 49Gensia Sicor GNSA 5.812 5.000 4.000 -31Genta GNTA 0.781 0.968 1.343 72Genz Tiss Repair GENZL 6.875 8.625 6.562 -5Genzyme GENZ 27.750 32.000 25.562 -8Genzyme Trans GZTC 9.625 11.562 7.750 -19Geron GERN 8.250 12.375 9.375 14Gilead Sciences GILD 38.250 36.000 32.062 -16Gliatech GLIA 10.250 12.125 16.125 57Guilford Pharm GLFD 20.125 22.000 17.625 -12Hemacare HEMA 0.468 0.687 0.531 13Hemosol HML* 2.188 1.797 2.980 36Human Genome HGSI 39.750 39.812 35.687 -10Hycor Bio HYBD 1.562 1.750 2.000 28Hyseq HYSQ 9.625 12.500 10.812 12IBAH IBAH 3.750 5.343 5.937 58Icos ICOS 18.312 15.250 19.125 4ID Biomed IDB* 3.400 5.150 6.050 78IDEC Pharm IDPH 34.375 44.250 23.562 -31Idexx Labs IDXX 15.937 18.000 24.875 56Igen IGEN 13.250 42.375 40.875 208ILEX Oncology ILXO 7.375 10.125 9.875 34ImClone Sys IMCL 8.125 8.312 12.250 51Immucell ICCC 2.468 1.937 2.187 -11Immucor BLUD 8.625 9.625 8.687 1ImmuLogic IMUL 1.875 1.656 1.625 -13Immune Resp IMNR 11.125 9.812 15.000 35Immunex IMNX 54.000 67.375 66.250 23ImmunoGen IMGN 0.843 1.687 1.750 108Immunomed IMMU 3.625 5.062 4.437 22Incyte Pharm INCY 45.000 46.750 34.125 -24Inhale Ther Sys INHL 26.000 27.125 24.750 -5InKine Pharma INKP 1.375 1.343 1.281 -7Innovir INVR 0.375 0.718 0.343 -9InSite Vision (3) ISV 3.250 3.375 3.375 4Integra LifeScien (4) IART 8.875 8.875 7.000 -21Intercardia ITRC 17.875 20.375 10.000 -44Interferon Sci IFSC 8.687 7.125 1.156 -87Interneuron IPIC 9.500 10.437 3.625 -62Intl Murex MURXF 10.062 12.625 12.937 29Isis Pharm ISIP 12.312 15.250 13.687 11La Jolla Pharm LJPC 4.437 3.875 3.500 -21LeukoSite LKST 10.937 9.250 7.375 -33Lidak Pharm LDAKA 2.375 1.781 1.500 -37Life Tech LTEK 33.250 38.500 31.375 -6Lifecell LIFC 4.625 5.093 6.125 32Lifecore Bio LCBM 21.875 23.375 16.500 -25Ligand LGND 12.875 15.937 12.875 0Liposome Co LIPO 4.625 5.562 5.406 17LJL Biosystems LJLB 7.000 7.062 4.875 -30LXR Biotech LXR 2.375 3.812 1.937 -18Lynx Therapeutics LYNX 16.250 10.000 9.375 -42MacroChem MCHM 9.125 11.187 7.062 -23Magainin MAGN 8.062 5.562 5.312 -34Martek Bio MATK 8.250 15.187 14.562 77Matritech NMPS 4.875 5.125 2.062 -58Matrix MATX 3.437 4.625 4.375 27Maxim Pharma MMP 16.375 14.625 20.500 25Medarex MEDX 5.250 4.843 6.625 26Medical Science MSSI 5.625 4.000 4.500 -20MedImmune MEDI 42.875 55.125 62.375 45Megabios MBIO 14.250 9.250 7.625 -46Meridian Diag KITS 10.125 12.750 12.375 22Metra Biosys MTRA 3.625 2.250 2.000 -45Microcide Pharma MCDE 8.875 8.625 6.687 -25Micrologix Biotec MBI* 3.600 3.400 3.600 0Millennium MLNM 19.000 18.625 14.125 -26Molec Dynam MDYN 16.250 14.437 11.750 -28Molecular Bio MB 8.500 9.250 7.125 -16Molecular Devices MDCC 21.250 19.250 16.125 -24Mycogen MYCO 18.750 18.187 24.031 28Myriad Genetics MYGN 24.250 22.375 14.625 -40NABI NABI 3.406 3.062 3.031 -11Nanogen (5) NGEN 11.000 - 6.562 -40NaPro Biother NPRO 2.500 2.468 1.250 -50NeoPharm NEO 5.250 3.812 3.625 -31Neoprobe NEOP 6.000 4.562 2.750 -54NeoRx Corp. NERX 5.625 5.343 4.937 -12Neose Technol NTEC 15.250 13.625 16.000 5NeoTherapeutics NEOT 10.500 8.875 12.500 19Neurex NXCO 13.875 23.875 30.375 119Neurocrine Biosci NBIX 7.875 8.125 7.937 1Neurogen NRGN 13.500 15.375 17.750 31NeXstar Pharm NXTR 11.375 11.500 9.968 -12North Am Vacc NVX 24.937 17.500 15.500 -38Northfield Labs NFLD 9.125 10.000 14.750 62Novavax NOX 5.000 4.062 4.000 -20Noven NOVN 7.000 6.562 5.937 -15NPS Pharm NPSP 7.750 7.375 7.125 -8Oncor ONC 4.625 1.750 0.750 -84OncorMed ONM 7.000 5.062 3.437 -51Onyx Pharma ONXX 7.750 7.500 6.125 -21Ophidian Pharma (6) OPHD 4.422 - 3.250 -27OraVax ORVX 1.750 1.750 1.156 -34Organogenesis (7) ORG 21.500 27.000 19.625 -9Ortec Int'l ORTC 13.062 19.750 18.625 43OSI Pharma OSIP 6.750 6.125 5.625 -17Osteotech OSTE 27.250 25.875 17.750 -35Ostex Int'l OSTX 2.625 2.500 1.500 -43OXiGENE OXGN 17.500 14.875 12.187 -30Oxis Int'l OXIS 0.421 0.593 0.750 78Pacific Pharma PHA 0.937 0.562 0.437 -53Palatin Tech PLTN 5.875 6.125 4.937 -16Paracelsian PRLN 0.218 0.468 0.562 158Parexel Intl PRXL 37.000 31.250 36.375 -2PathoGenesis PGNS 37.125 33.500 29.000 -22Penederm DERM 10.000 12.937 20.000 100Pharma Prod Devlp PPDI 15.375 23.375 22.000 43Pharmacopeia PCOP 16.000 18.750 14.250 -11Pharmacyclics PCYC 25.625 29.125 23.750 -7Pharmos PARS 2.000 2.875 2.625 31Phoenix Intl PHX* 10.250 12.200 11.800 15Procept (8) PRCTC 10.000 9.375 4.125 -59ProCyte PRCY 0.937 1.500 0.812 -13Progenics Pharma PGNX 14.000 18.562 14.875 6Progenitor PGEN 2.375 2.062 1.625 -32Protein Design PDLI 40.000 39.250 24.093 -40Protein Poly PPTI 1.625 1.281 1.187 -27Qiagen QGENF 44.625 66.750 63.000 41QLT PhotoTher QLTIF 11.125 17.375 16.750 51Quidel QDEL 3.625 3.031 3.125 -14Quintiles QTRN 38.250 48.187 49.187 29Regeneron REGN 8.562 7.375 9.218 8Repligen RGEN 0.781 1.187 1.531 96Ribi Immuno RIBI 3.687 5.750 5.062 37RiboGene (9) RBO 7.000 - 6.937 -1Ribozyme Pharma RZYM 8.000 5.937 4.937 -38SangStat Med SANG 40.500 31.875 31.375 -23SciClone SCLN 3.437 3.968 3.750 9Scios SCIO 10.000 12.187 8.875 -11Sepracor SEPR 40.062 42.625 41.500 4Sequus Pharm SEQU 7.437 10.562 11.375 53Shaman SHMN 4.937 5.031 3.375 -32Sheffield SHM 1.375 0.750 2.125 55SIBIA Neurosci SIBI 6.500 5.250 5.125 -21Siga Pharma SGPH 4.625 4.250 3.875 -16Sonus Pharma SNUS 33.125 24.500 12.312 -63Sparta Pharm (10) SPTA 1.875 1.719 1.187 -37Stressgen Biotech SSB* 3.094 2.900 2.610 -16Sugen SUGN 13.125 13.625 16.250 24SunPharm SUNP 4.500 5.375 3.250 -28SuperGen SUPG 15.000 13.250 10.062 -33Synaptic Pharma SNAP 10.875 12.750 14.000 29Synbiotics SBIO 3.125 3.500 3.312 6Synsorb Biotech SYB* 7.700 10.300 7.150 -7T Cell Sci TCEL 2.437 2.937 2.500 3Targeted Genet TGEN 2.625 1.937 1.593 -39Techniclone Int'l TCLN 2.187 0.781 1.375 -37Teva Pharm TEVIY 47.312 42.750 35.187 -26Texas Biotech TXB 6.187 7.187 4.562 -26Theratech THRT 8.000 9.875 10.125 27Titan Pharma TTNPU 6.562 6.062 6.625 1Transcend Thera TSND 7.500 3.500 1.500 -80Transgene TRGNY 14.500 15.187 17.375 20Transkaryotic TKTX 35.125 32.375 25.750 -27Trega Biosciences TRGA 3.437 5.187 3.625 5Triangle Pharma VIRS 14.625 15.750 14.875 2Trimeris TRMS 13.000 7.500 7.375 -43Trinity Bio TRIBY 1.968 2.187 1.906 -3Tripos TRPS 14.625 13.000 14.000 -4Unigene UGNE 2.625 2.562 1.968 -25UroCor UCOR 6.187 7.218 7.125 15US Bioscience UBS 9.062 10.125 8.187 -10Vertex Pharm VRTX 33.000 31.937 22.500 -32Vical VICL 12.000 15.750 16.937 41VimRx VMRX 1.937 2.031 1.125 -42Vion Pharma VION 3.625 4.000 4.750 31Viragen VRGN 1.093 2.406 1.875 72ViroPharma VPHM 17.625 21.000 23.250 32Virus Research VRII 4.500 4.125 3.875 -14Visible Genetics VGINF 8.562 8.875 9.875 15Vyrex VYRX 6.125 6.437 4.250 -31Vysis VYSI 12.000 11.250 10.000 -17Xenova Group XNVAY 2.250 3.125 2.125 -6XOMA XOMA 5.562 4.687 4.812 -13Zonagen ZONA 18.187 22.000 21.937 21NOTES:1. Cantab Pharmaceuticals plc (NASDAQ:CNTBY; LSE:CTB) split its common stock 5 for 2, effective 5/26/98. The American Depositary Shares (ADSs) split as well. The historical prices have been adjusted accordingly.2. CombiChem Inc. (NASDAQ:CCHM) completed its IPO 5/8/98. The stock was priced at $8.00 per share.3. InSite Vision Inc. 's stock, which had been trading on NASDAQ under the symbol INSV, started trading instead on the American Stock Exchange under the symbol ISV, effective 6/10/98.4. Integra LifeSciences Corp. (NASDAQ:IART) reverse-split its stock 1 for 2, effective 5/26/98. The historical prices have been adjusted accordingly.5. Nanogen Inc. (NASDAQ:NGEN) completed its IPO 4/13/98. The stock was priced at $11.00 per share.6. Ophidian Pharmaceuticals Inc. (NASDAQ:OPHD) completed its IPO 5/7/98. The securities were priced at $6.10 per unit (with the unit share price equal to $4.422). The units split into shares and warrants (NASDAQ:OPHDW) on 6/12/98 and no longer trade.7. Organogenesis (AMEX:ORG) split its stock 5 for 4, effective 4/29/98. The historical prices have been adjusted accordingly.8. Procept Inc. (NASDAQ:PRCT) reverse-split its stock 1 for 10, effective 6/1/98. It is trading temporarily under the symbol PRCTC. The historical prices have been adjusted accordingly.9. RiboGene Inc. (AMEX:RBO) completed its IPO 5/28/98. The stock was priced at $7.00 per share.10. Sparta Pharmaceuticals Inc. (NASDAQ:SPTA) reverse-split its stock 1 for 5, effective 5/13/98. The historical prices have been adjusted accordingly.* The prices listed in the 12/31/97 column represent the 1997 closing prices or, for those stocks that started trading in 1998, the IPO prices. There are 312 stocks on this list; the average percent change year-to-date (YTD) is -2.74%.