Published June 3 (EPO); May 28 (WO); June 3 (GB)
AEA TechnologyGB 2 319 773
Antisense vector for suppressing expression of a specific protein and its related phenotype.
Alabama, Univ. ofWO 98/22143
Vascular cell gene therapy
Chimeric retrovirus-adenovirus system for localized intracellular delivery of genes in vascular cells.
Angeletti Molec. Biol. Res. Inst.WO 98/22128
CNTF for obesity
Methods for using ciliary neurotrophic factor (CNTF) receptors for treating obesity and associated diseases.
Lipid aggregate containing a Helicobacter pylori antigen; for ulcer vaccines.
Beckman InstrumentsWO 98/22509
PSA-ACT complex antibodies
Monoclonal antibodies that are specific for the PSA-ACT complex.
Boehringer IngelheimWO 98/22508
Tumor cell elimination
Selective elimination of CD34-positive tumor cells using CD44-specific antibodies linked to a cytotoxic agent.
Boehringer MannheimWO 98/22136
Stable lyophilized antibodies
Stable lyophilized antibodies having sugars or amino sugars and surfactants as stabilizing agents.
Boehringer MannheimWO 98/22574
Cell isolation collagenase
Type I recombinant Clostridium histolyticum collagenase, encoding gene; for isolating cells and cell aggregates.
California, Univ. ofWO 98/22584
Gene for C1q receptor, encoded protein, antibodies; for enhancing host defense immunoresponse.
Cedars-Sinai Med. Ctr.WO 98/22587
Pituitary tumor-transforming genes
Pituitary tumor-transforming genes, encoded proteins, antibodies, transgenics; for tumor therapeutics.
ChironEPO 845 537
Cytotoxic drug activation
Recombinant replication-defective retroviruses; for expressing enzymes that activate cytotoxic pro-drugs.
ChironWO 98/22585 & 22586
Polyhomeotic tumor suppressor oncogene
Human polyhomeotic 2 tumor suppressor oncogene on chromosome 1; for cancer diagnostics and therapeutics.
Cor TherapeuticsWO 98/22583
Modulating integrin actions
S. San Francisco
Beta-3 integrin binding protein, encoding gene; for modulating integrin-mediated signal transduction.
Duke Univ.WO 98/22502
Overexpressed cancer gene
Gene product overexpressed in breast and ovarian cancer cells, encoding gene; for diagnostics and therapeutics.
Genetics Inst.WO 98/22501
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Airway epithelia targeting vectors
Targeting of airway epithelial cells with adenoviral vectors encoding appropriate proteins.
Hagiwara, Y., et al.WO 98/22590
Blue-green algae antibodies
Preparation of whole antibodies or single chain antibodies in blue-green algae.
Hayashibara SeibutsuEPO 845 530
Interferon-gamma inducing factors
Variants of interferon-gamma inducing factors; for treating viral infections and immune system diseases.
HSC Res. Develop.WO 98/22140
Hybrid cell death proteins
Hybrid proteins having intracellular targeting and toxin domains, encoding genes; for producing cell death.
Human Genome SciencesWO 98/22575
Uropathogenic E. coli virulence genes
Uropathogenic E. coli genes located in two regions that are associated with virulence.
Immuno-Designed MoleculesWO 98/22610
Destabilizing transfection complexes
Charge neutralizing polymeric complexes with DNA; for desta-bilization of cell membranes during transfection.
Incyte PharmaWO 98/22506
Human KDEL receptor
Palo Alto, Calif.
Human KDEL receptor, encoding gene sequences, antisense, antibodies, modulators, production methods.
Inst. Cytosignal Res.WO 98/22578
Cell signal inhibitors
Genes having reporter or apoptosis-inducing func-tions; for screening intracellular signal transmission inhibitors.
Inst. Cytosignal Res.WO 98/22581
Transcription repressor, encoding gene, identification of similar activity proteins; for therapeutics
Introgen TherapeuticsWO 98/22588
Increased adenoviral vector yields
Low perfusion rate and suspension cell culture methods for in-creased yields of adenoviral vectors.
Iowa, Univ. ofWO 98/22144
Cystic fibrosis gene therapy
Iowa City, Iowa
Cationic molecules complexed with adenoviral vectors; for delivering CFTR genes to cystic fibrosis patients.
Itoh, K., et al.WO 98/22582
Cancer regression antigen
Human cancer regression antigen protein; for immunization against cancer and treating autoimmune diseases.
Japanese Natl. Inst. Infec. Dis.WO 98/22596
Gag protein preparation
Recombinant vaccinia virus vector; for preparing recombinant retroviral gag protein.
Kennedy Inst. Rheumatol.WO 98/22137
Tumor necrosis factor (TNF) and interleukin-12 (IL-12) antago-nists; for suppressing these proteins in immune diseases.
Kyowa HakkoWO 98/22616
VEGF Flt-1 receptor antibodies
Monoclonal antibodies to the vascular endothelial growth factor (VEGF) receptor Flt-1; for vascular diseases.
La Jolla Inst. Allergy Immunol.WO 98/22139
Galectin-4 and cancer
Gene for human galectin-4 expressed in tumors, encoded protein, transgenics; for diagnosing and treating cancer.
Streptococcus pneumoniae biosynthetic murB gene, vectors, production methods; for identifying inhibitors.
Ludwig Inst. Cancer Res.WO 98/22149
Colon cancer antigen antibodies
Humanized antibodies and fragments to antigen A33; for the treatment of colon cancer.
Masucci, M.G.WO 98/22577
Increased half-life fusion proteins
Fusion proteins having core and stabilizing subunits, encod-ing genes; for increased half-lives
McGill Univ.WO 98/22608
Transfected post-mitotic neurons
Post-mitotic neurons containing adenovirus vectors encoding proteins that modulate apoptosis and cell growth.
Michigan, Univ. ofWO 98/22492
Ann Arbor, Mich.
Activins/inhibins expressed in liver, encoding genes, ex-pression system, fusions, antibodies, transgenics.
Michigan, Univ. ofWO 98/22625
Isothermal amplification microdevices
Ann Arbor, Mich.
Microfabricated devices and methods for isothermal amplifi-cation of nucleic acids; for diagnostics.
Millenium BiotherapeuticsWO 98/22491
Secreted protein genes
Method for finding genes for membrane-asso-ciated or secreted pro-teins using alkaline phos-phatase fusion pro-teins.
Minnesota, Univ. ofWO 98/22579
Breast cancer immunogen
Tumor immunogen induced by antisense oligos to an insulin-like growth factor type 1 gene; for treating breast cancer.
Mt. Sinai Sch. Med.WO 98/22145
Infant DNA vaccination
DNA vaccination of infants; for effective cellular and humoral immune responses.
Nebraska, Univ. ofWO 98/22142
Cancer cell killing method
Hydroxyl radical and an antisense oligo that down-regulates cellular oxidative repair pathways; for treating cancer.
Novo Nordisk BiotechWO 98/22598
Methods for producing mutant surfactin proteins from cul-tured Bacillus cells.
Oklahoma Med. Res. Fdn.WO 98/22597
Napsin aspartic protease
Oklahoma City, Okla.
Gene for the aspartic protease napsin cloned from a human liver library, encoded protein, antibodies.
Osaka Univ. Microbial Dis. Res.Fdn.EPO 845 270
Functional antigen fragment of tetanus toxin, production methods; for making tetanus vaccine.
Pennsylvania, Univ. ofWO 98/22624
Immunologically-based method for detection of the level of a specified protein using correla-tions to mRNA levels.
Rhone-Poulenc RorerWO 98/22606
Dyslipoproteinemia gene therapy
Adenoviral vectors encoding proteins involved in the re-verse transfer of cholesterol; for treating dyslipoproteinemia.
Rhone-Poulenc RorerWO 98/22607
Baculovirus vector production
Method for producing recombinant baculovirus vectors; for gene therapy.
Rockefeller Univ.WO 98/22623
Apoptosis prostate gland library
cDNA libraries encoding proteins involved in prostate gland function and programmed cell death.
SeikagakuEPO 845 533
Keratan sulfate 6-sulfotransferase
Keratan sulfate 6-sulfotransferase, encoding gene; for transferring sulfate groups.
SmithKline BeechamEPO 845 531
Staphylococcus SigB polypeptides and encoding gene sequenc-es, production methods; for treating infections.
SmithKline BeechamEPO 845 535
Streptococcus leader peptidase polypeptides, encoding gene sequences, production methods; for treating infections.
SmithKline BeechamWO 98/22133
FabD polypeptides, encoding gene sequences, production methods; for screening antibacterial compounds.
Stichting Inst.WO 98/22503
Autoimmune antibody detection
Den Haag, Netherlands
Peptide derived from an antigen recognized by rheumatoid arthritis autoantibodies, antibodies to the peptide.
Receptor tyrosine kinases
Redwood City, Calif.
Receptor tyrosine kinase genes, encoded proteins, antibod-ies; for screening modulators.
Sumitomo ElectricWO 98/22505
Soluble N-terminal peptides derived from human epimorphin; for accelerating morphogenesis.
Sumitomo PharmaWO 98/22504
Semaphorins, encoding genes, antisense antibodies; for diagnosing and treating nervous system diseases.
Takeda ChemicalEPO 845 529
G-protein coupled receptor
Gene for a G-protein coupled receptor cloned from fetal brain, encoded protein; for screening for modulators.
TerumoEPO 845 540
Pulmonary adenocarcinoma antibodies
Monoclonal antibodies to a glycoprotein antigen from human pulmonary adenocarcinoma; for therapeutics.
Texas, Univ. ofWO 98/22605
Macrophage tumor targeting
Transduction of macrophages with a GM-CSF gene; for target-ing tumors and vasculature with metalloelastases.
Virginia Mason Res. Ctr.WO 98/22621
Ataxia telangiectasia gene mutations
Methods of detecting mutations in the ataxia telangiectasia gene, identified mutations.
Wellesley Hosp. Fdn.WO 98/22497
Gene for preprotachykinin-C, encoded protein; for isolating Z tachykinin, a protein with vasodilator effects.
Wisconsin, Univ. ofWO 98/22622
Phenotype gene identification
Cross-breeding of mutagenized and normal mice; for identify-ing phenotype controlling genes.
Wo, W.EPO 845 269
Calcitonin gene-related peptide
Liposomal human calcitonin gene-related peptide therapeutic composition for intravenous infusion or oral mucosal spray.
Yale Univ.WO 98/22589
New Haven, Conn.
Gene for the apoptosis inhbiting protein Survivin, encoded protein; for identifying apoptosis inhibitors.