Published June 3 (EPO); May 28 (WO); June 3 (GB)

AEA TechnologyGB 2 319 773

Antisense vector

Harwell, U.K.

Antisense vector for suppressing expression of a specific protein and its related phenotype.

Alabama, Univ. ofWO 98/22143

Vascular cell gene therapy

Birmingham, Ala.

Chimeric retrovirus-adenovirus system for localized intracellular delivery of genes in vascular cells.

Angeletti Molec. Biol. Res. Inst.WO 98/22128

CNTF for obesity

Pomezia, Italy

Methods for using ciliary neurotrophic factor (CNTF) receptors for treating obesity and associated diseases.

AstraWO 98/22135

Ulcer vaccines

Sodertalje, Sweden

Lipid aggregate containing a Helicobacter pylori antigen; for ulcer vaccines.

Beckman InstrumentsWO 98/22509

PSA-ACT complex antibodies

Fullerton, Calif.

Monoclonal antibodies that are specific for the PSA-ACT complex.

Boehringer IngelheimWO 98/22508

Tumor cell elimination

Ingelheim, Germany

Selective elimination of CD34-positive tumor cells using CD44-specific antibodies linked to a cytotoxic agent.

Boehringer MannheimWO 98/22136

Stable lyophilized antibodies

Mannheim, Germany

Stable lyophilized antibodies having sugars or amino sugars and surfactants as stabilizing agents.

Boehringer MannheimWO 98/22574

Cell isolation collagenase

Mannheim, Germany

Type I recombinant Clostridium histolyticum collagenase, encoding gene; for isolating cells and cell aggregates.

California, Univ. ofWO 98/22584

Enhancing immunoresponse

Oakland, Calif.

Gene for C1q receptor, encoded protein, antibodies; for enhancing host defense immunoresponse.

Cedars-Sinai Med. Ctr.WO 98/22587

Pituitary tumor-transforming genes

Los Angeles

Pituitary tumor-transforming genes, encoded proteins, antibodies, transgenics; for tumor therapeutics.

ChironEPO 845 537

Cytotoxic drug activation

Emeryville, Calif.

Recombinant replication-defective retroviruses; for expressing enzymes that activate cytotoxic pro-drugs.

ChironWO 98/22585 & 22586

Polyhomeotic tumor suppressor oncogene

Emeryville, Calif.

Human polyhomeotic 2 tumor suppressor oncogene on chromosome 1; for cancer diagnostics and therapeutics.

Cor TherapeuticsWO 98/22583

Modulating integrin actions

S. San Francisco

Beta-3 integrin binding protein, encoding gene; for modulating integrin-mediated signal transduction.

Duke Univ.WO 98/22502

Overexpressed cancer gene

Durham, N.C.

Gene product overexpressed in breast and ovarian cancer cells, encoding gene; for diagnostics and therapeutics.

Genetics Inst.WO 98/22501

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

GenzymeWO 98/22609

Airway epithelia targeting vectors

Framingham, Mass.

Targeting of airway epithelial cells with adenoviral vectors encoding appropriate proteins.

Hagiwara, Y., et al.WO 98/22590

Blue-green algae antibodies

Hyogo, Japan

Preparation of whole antibodies or single chain antibodies in blue-green algae.

Hayashibara SeibutsuEPO 845 530

Interferon-gamma inducing factors

Okayama, Japan

Variants of interferon-gamma inducing factors; for treating viral infections and immune system diseases.

HSC Res. Develop.WO 98/22140

Hybrid cell death proteins


Hybrid proteins having intracellular targeting and toxin domains, encoding genes; for producing cell death.

Human Genome SciencesWO 98/22575

Uropathogenic E. coli virulence genes

Rockville, Md.

Uropathogenic E. coli genes located in two regions that are associated with virulence.

Immuno-Designed MoleculesWO 98/22610

Destabilizing transfection complexes


Charge neutralizing polymeric complexes with DNA; for desta-bilization of cell membranes during transfection.

Incyte PharmaWO 98/22506

Human KDEL receptor

Palo Alto, Calif.

Human KDEL receptor, encoding gene sequences, antisense, antibodies, modulators, production methods.

Inst. Cytosignal Res.WO 98/22578

Cell signal inhibitors


Genes having reporter or apoptosis-inducing func-tions; for screening intracellular signal transmission inhibitors.

Inst. Cytosignal Res.WO 98/22581

Transcriptional repressor


Transcription repressor, encoding gene, identification of similar activity proteins; for therapeutics

Introgen TherapeuticsWO 98/22588

Increased adenoviral vector yields

Austin, Tex.

Low perfusion rate and suspension cell culture methods for in-creased yields of adenoviral vectors.

Iowa, Univ. ofWO 98/22144

Cystic fibrosis gene therapy

Iowa City, Iowa

Cationic molecules complexed with adenoviral vectors; for delivering CFTR genes to cystic fibrosis patients.

Itoh, K., et al.WO 98/22582

Cancer regression antigen

Saga, Japan

Human cancer regression antigen protein; for immunization against cancer and treating autoimmune diseases.

Japanese Natl. Inst. Infec. Dis.WO 98/22596

Gag protein preparation


Recombinant vaccinia virus vector; for preparing recombinant retroviral gag protein.

Kennedy Inst. Rheumatol.WO 98/22137

TNF/IL-12 antagonists


Tumor necrosis factor (TNF) and interleukin-12 (IL-12) antago-nists; for suppressing these proteins in immune diseases.

Kyowa HakkoWO 98/22616

VEGF Flt-1 receptor antibodies


Monoclonal antibodies to the vascular endothelial growth factor (VEGF) receptor Flt-1; for vascular diseases.

La Jolla Inst. Allergy Immunol.WO 98/22139

Galectin-4 and cancer

San Diego

Gene for human galectin-4 expressed in tumors, encoded protein, transgenics; for diagnosing and treating cancer.

LillyWO 98/22134

Streptococcus antibacterials


Streptococcus pneumoniae biosynthetic murB gene, vectors, production methods; for identifying inhibitors.

Ludwig Inst. Cancer Res.WO 98/22149

Colon cancer antigen antibodies

New York

Humanized antibodies and fragments to antigen A33; for the treatment of colon cancer.

Masucci, M.G.WO 98/22577

Increased half-life fusion proteins

Stockholm, Sweden

Fusion proteins having core and stabilizing subunits, encod-ing genes; for increased half-lives

McGill Univ.WO 98/22608

Transfected post-mitotic neurons


Post-mitotic neurons containing adenovirus vectors encoding proteins that modulate apoptosis and cell growth.

Michigan, Univ. ofWO 98/22492

Liver activins

Ann Arbor, Mich.

Activins/inhibins expressed in liver, encoding genes, ex-pression system, fusions, antibodies, transgenics.

Michigan, Univ. ofWO 98/22625

Isothermal amplification microdevices

Ann Arbor, Mich.

Microfabricated devices and methods for isothermal amplifi-cation of nucleic acids; for diagnostics.

Millenium BiotherapeuticsWO 98/22491

Secreted protein genes

Cambridge, Mass.

Method for finding genes for membrane-asso-ciated or secreted pro-teins using alkaline phos-phatase fusion pro-teins.

Minnesota, Univ. ofWO 98/22579

Breast cancer immunogen

Minneapolis, Minn.

Tumor immunogen induced by antisense oligos to an insulin-like growth factor type 1 gene; for treating breast cancer.

Mt. Sinai Sch. Med.WO 98/22145

Infant DNA vaccination

New York

DNA vaccination of infants; for effective cellular and humoral immune responses.

Nebraska, Univ. ofWO 98/22142

Cancer cell killing method

Lincoln, Neb.

Hydroxyl radical and an antisense oligo that down-regulates cellular oxidative repair pathways; for treating cancer.

Novo Nordisk BiotechWO 98/22598

Mutant surfactins

Davis, Calif.

Methods for producing mutant surfactin proteins from cul-tured Bacillus cells.

Oklahoma Med. Res. Fdn.WO 98/22597

Napsin aspartic protease

Oklahoma City, Okla.

Gene for the aspartic protease napsin cloned from a human liver library, encoded protein, antibodies.

Osaka Univ. Microbial Dis. Res.Fdn.EPO 845 270

Tetanus vaccine

Osaka, Japan

Functional antigen fragment of tetanus toxin, production methods; for making tetanus vaccine.

Pennsylvania, Univ. ofWO 98/22624

Immuno-RNA assay


Immunologically-based method for detection of the level of a specified protein using correla-tions to mRNA levels.

Rhone-Poulenc RorerWO 98/22606

Dyslipoproteinemia gene therapy

Antony, France

Adenoviral vectors encoding proteins involved in the re-verse transfer of cholesterol; for treating dyslipoproteinemia.

Rhone-Poulenc RorerWO 98/22607

Baculovirus vector production

Antony, France

Method for producing recombinant baculovirus vectors; for gene therapy.

Rockefeller Univ.WO 98/22623

Apoptosis prostate gland library

New York

cDNA libraries encoding proteins involved in prostate gland function and programmed cell death.

SeikagakuEPO 845 533

Keratan sulfate 6-sulfotransferase


Keratan sulfate 6-sulfotransferase, encoding gene; for transferring sulfate groups.

SmithKline BeechamEPO 845 531

Staphylococcus antibacterials


Staphylococcus SigB polypeptides and encoding gene sequenc-es, production methods; for treating infections.

SmithKline BeechamEPO 845 535

Streptococcus antibacterials


Streptococcus leader peptidase polypeptides, encoding gene sequences, production methods; for treating infections.

SmithKline BeechamWO 98/22133

Antibacterial screen


FabD polypeptides, encoding gene sequences, production methods; for screening antibacterial compounds.

Stichting Inst.WO 98/22503

Autoimmune antibody detection

Den Haag, Netherlands

Peptide derived from an antigen recognized by rheumatoid arthritis autoantibodies, antibodies to the peptide.

SugenWO 98/22507

Receptor tyrosine kinases

Redwood City, Calif.

Receptor tyrosine kinase genes, encoded proteins, antibod-ies; for screening modulators.

Sumitomo ElectricWO 98/22505

Epimorphin peptides

Osaka, Japan

Soluble N-terminal peptides derived from human epimorphin; for accelerating morphogenesis.

Sumitomo PharmaWO 98/22504


Osaka, Japan

Semaphorins, encoding genes, antisense antibodies; for diagnosing and treating nervous system diseases.

Takeda ChemicalEPO 845 529

G-protein coupled receptor

Osaka, Japan

Gene for a G-protein coupled receptor cloned from fetal brain, encoded protein; for screening for modulators.

TerumoEPO 845 540

Pulmonary adenocarcinoma antibodies


Monoclonal antibodies to a glycoprotein antigen from human pulmonary adenocarcinoma; for therapeutics.

Texas, Univ. ofWO 98/22605

Macrophage tumor targeting

Austin, Tex.

Transduction of macrophages with a GM-CSF gene; for target-ing tumors and vasculature with metalloelastases.

Virginia Mason Res. Ctr.WO 98/22621

Ataxia telangiectasia gene mutations


Methods of detecting mutations in the ataxia telangiectasia gene, identified mutations.

Wellesley Hosp. Fdn.WO 98/22497

Vasodilator tachykinin


Gene for preprotachykinin-C, encoded protein; for isolating Z tachykinin, a protein with vasodilator effects.

Wisconsin, Univ. ofWO 98/22622

Phenotype gene identification

Madison, Wis.

Cross-breeding of mutagenized and normal mice; for identify-ing phenotype controlling genes.

Wo, W.EPO 845 269

Calcitonin gene-related peptide

Salzburg, Austria

Liposomal human calcitonin gene-related peptide therapeutic composition for intravenous infusion or oral mucosal spray.

Yale Univ.WO 98/22589

Apoptosis inhibitor

New Haven, Conn.

Gene for the apoptosis inhbiting protein Survivin, encoded protein; for identifying apoptosis inhibitors.