Published May 27 (EPO); May 22 (WO); May 27 (GB)
Albert Einstein Coll. Med.WO 98/20898
Mycobacteria drug screen
New York
Mycobacteria that are auxotrophic for diaminopimelate; for delivering vaccines and screening drugs.
AmgenWO 98/21343
Telomerase complex genes
Thousand Oaks, Calif.
Gene sequences encoding polypeptides of the telomerase complex; encoded peptides, preparation methods.
Angstrom PharmaWO 98/21230
Cancer inhibiting cyclic peptides
San Diego
Cyclic peptides, joined with a linker, that bind urokinase-type plasminogen activator; for inhibiting cancer growth.
Barcelona, Free Univ. ofWO 98/20906
Diabetes gene therapy
Bellaterra, Spain
Treatment of diabetes with a vector encoding a transcription factor controlled by a pancreatic-specific promoter.
Battelle Mem. Inst.WO 98/21348
EGF from plants
Richland, Wash.
Production of human epithelial growth factor (EGF) in whole plants, non-edible portions, and plant cell cultures.
Boehringer IngelheimWO 98/21326
Cell growth inhibitors
Ingelheim, Germany
Assay for elements of the anaphase promoting complex; for screening agents that inhibit rapidly growing cells.
Boehringer MannheimWO 98/21245
Neurotrophic factor antibodies
Mannheim, Germany
High affinity antibody against human BDNF; for inhibiting the survival of afferent ganglia neurons.
California, Univ. ofWO 98/21227
Sonic hedgehog cancer therapy
Oakland, Calif.
Mutant sonic hedgehog gene, encoded protein, antibodies; for drug screening and cancer treatment.
Cambridge Antibody Technol.EPO 844 306
Specific binding pair assays
Royston, U.K.
Detection of specific binding pairs using surface membrane expression technology coupled with binding assays.
CanjiWO 98/21228
Cell growth control
San Diego
Fusions of transcription factor E2F and retinoblastoma RB protein, encoding gene; for treating aberrant cell growth.
Cedars-Sinai Med. Ctr.WO 98/21333
Schwannomin-binding proteins
Los Angeles
Schwannomin-binding proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
ChironWO 98/21232
Fas ligand mutants
Emeryville, Calif.
Mutant forms of Fas ligand, derivatives, and fusions, encoding genes; for treating autoimmune disease.
City of HopeWO 98/21233
Cytomegalovirus immunotherapy
Duarte, Calif.
Immunogenic cytomegalovirus peptides recognized by CD8+ class I MHC restricted cytotoxic T cells; for therapy.
Columbia Univ.WO 98/21352
Recombinant fusion nucleic acids
New York
Generation of directed, recombinant fusion nucleic acids by PCR using appended 5' priming sequences that enhance fusion.
Cornell Univ.WO 98/21585
Activated ras ligand assay
Ithaca, N.Y.
Immobilized proteins treated with cell lysates containing activated ras protein; for finding binding partners.
Dana-Farber Cancer Inst.WO 98/21240
Human BY55 protein
Boston
Gene for the human BY55 protein, encoded protein, fragments; for recombinant expression.
Dana-Farber Cancer Inst.WO 98/21314
B cell activation
Boston
Methods for activation of B cells and subsequent expansion; for antigen presentation.
Ehrenberg, M.WO 98/21353
In vitro protein translation
Uppsala, Sweden
Translation of solid phase bound mRNAs; for selective labelling and ease of purification using release factors.
Electrophoretics Intl.GB 2 319 607
Prion protein assay
Surrey, U.K.
Methods for detection and measurement of prion proteins in mononuclear cells.
Genetics Inst.WO 98/21332
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genetics Inst.WO 98/21335
Chordin
Cambridge, Mass.
Gene for chordin, encoded protein, purification methods; for treating wounds and connective tissue defects.
Georgia St. Univ.WO 98/20901
Attenuated Rubella strains
Atlanta, Ga.
Complete genome of Rubella virus RA27/3 strain, attenuating mutations, methods of developing attenuated strains.
Human Genome SciencesWO 98/21242
Calcitonin receptor
Rockville, Md.
Gene for human calcitonin receptor, encoded protein, fragments; for modulator screens and diagnostics.
HybridonWO 98/21323
Inhibiting malarial drug resistance
Cambridge, Mass.
Down-regulation of drug resistance gene expression in Plasmodium falciparum using specific antisense oligos.
Illinois, Univ. ofWO 98/21325
Multidrug resistance therapeutics
Urbana, Ill.
Immunological agents effective against the multidrug resistance transmembrane P-glycoprotein; for cancer therapy.
Incyte PharmaWO 98/21241
Glutamate-binding protein
Palo Alto, Calif.
Human glutamate-binding protein, encoding gene sequences, modulators, antibodies; for diagnostics and therapeutics.
Incyte PharmaWO 98/21318
Ubiquitin-conjugating enzyme
Palo Alto, Calif.
Gene for a human ubiquitin-conjugating enzyme, encoded protein, antibodies, modulators; for therapeutics.
Incyte PharmaWO 98/21329
Parotid secretory protein
Palo Alto, Calif.
Human parotid secretory protein, encoding gene sequences, antisense, antibodies, modulators.
Incyte PharmaWO 98/21331
Steroid binding proteins
Palo Alto, Calif.
Gene sequences encoding human steroid binding proteins, encoded proteins, antibodies, modulators.
Indiana Univ.WO 98/21330
Exodus chemokine
Bloomington, Ind.
Gene sequences encoding a human macrophage-derived C-C chemokine named Exodus, encoded protein, fragments, analogs.
KokenEPO 844 004
Gene delivery preparation
Tokyo
Gene preparations containing vectors and inserted genes combined with carriers.
Life TechnologiesWO 98/21355
Mutated reporter protein
Rockville, Md.
Mutants of Aequorea victoria green fluorescent protein, encoding genes; for fluorescent and visible light assays.
Massachusetts, Univ. ofWO 98/21358
Huntington's disease therapeutics assay
Boston
Cells expressing mutated huntingtin proteins; for identifying agents that effect clathrin-mediated endocytosis.
Mass. Gen. Hosp.WO 98/21345
Hybrid gene therapy vectors
Boston
Gene therapy vectors having both herpes and adeno-associated virus elements; for making highly infectious virions.
Mayo Fdn.WO 98/21365
Prostate cancer diagnosis
Rochester, Minn.
Assay for prostate-specific glandular kallikrein hK2 polypeptide or its mRNA; for diagnosing prostate cancer.
Michigan St. Univ.WO 98/21344
Fusion immunogenic vaccines
E. Lansing, Mich.
Small peptide antigens fused into the B subunit of E. coli heat-labile enterotoxin; for immunogenic vaccines.
Millennium PharmaWO 98/21363
HNF diabetes treatment
Cambridge, Mass.
Agonists of functional HNF bioactivity, mutant HNF, antibodies; for treating diabetes.
Minnesota, Univ. ofWO 98/21337
Streptococcus C3 binding protein
Minneapolis
Human complement C3 binding protein from Streptococcus pneumoniae, purification; for therapeutics.
MorphogenesisWO 98/21334
Hematopoietic stem cell antibodies
Alachua, Fla.
Antibodies against an antigen on hematopoietic mononuclear stem cells; for facilitating bone marrow transplants.
NIH (Natl. Inst. Hlth.)WO 98/21338
Virus-like particles
Bethesda, Md.
Insect baculovirus expression of viral particles containing hepatitis C and E1/E2 proteins; for antibody production.
New York Blood Ctr.WO 98/21224
Duffy blood group antigen
New York
Gene for the Duffy blood group antigen, encoded protein, fragments, antibodies; for expression detection.
New York Blood Ctr.WO 98/21235
Malarial binding site
New York
Malarial binding site peptide from the Duffy blood group antigen, encoding gene sequence; for malaria treatment.
New York Blood Ctr.WO 98/21316
Transgenic blood group antibodies
New York
Methods for making monoclonal antibodies that are specific for polymorphic blood group antigens using transgenics.
Onyx PharmaWO 98/21342
Cell growth regulators
Richmond, Calif.
Gene sequences encoding cell growth regulatory proteins that phosphorylate cell cycle targets, encoded proteins.
Osiris TherapeuticsWO 98/20731
Mesenchymal stem cell isolation
Baltimore, Md.
Methods for isolating, purifying, and growing megakaryocyte-associated mesenchymal stem cells.
Pasteur MerieuxEPO 844 483
Cytotoxic activity assay
Lyon, France
Method for detecting cellular cytotoxic activity using suspect and sensitive cells, gene isolation [in French].
Pasteur MerieuxWO 98/21225
Ulcer vaccine
Lyon, France
Helicobacter polypeptides, encoding gene sequences; for vaccines to prevent infection and associated ulcers.
QBI EnterprisesWO 98/21321
Translationally regulated genes
Nes-Ziona, Israel
Selective stimulation of mRNAs with a stress inducing element; for finding internal ribosome entry sites.
QBI EnterprisesWO 98/21366
Subtraction gene identification
Nes-Ziona, Israel
Gene inactivation and determination of effect on cell phenotype; for subtraction analysis of affected gene.
Queen's Univ.WO 9821346
Plastid membrane transport protein
Kingston, Ont.
Plastid membrane transport protein, encoding gene constructs; for enhanced cellular translocation.
Rhone-Poulenc RorerWO 98/21327
APP endocytosis inhibitors
Antony, France
Peptides that interfere with the endocytosis of amyloid precursor protein (APP), encoding gene sequences.
Rhone-Poulenc RorerWO 98/21349
Liver cell-specific expression
Antony, France
Gene constructs, associated vectors, and hybrid promoters for liver cell-specific expression of proteins.
Sagami Chem. Res. Ctr.WO 98/21328
Transmembrane proteins
Sagamihara, Japan
Human proteins having transmembrane domains, encoding genes, recombinant versions of these proteins.
SmithKline BeechamEPO 844 253
Tubby 2 polpeptides
Brentford, U.K.
Tubby 2 polypeptides and encoding gene sequences; for diagnosis and treatment of diabetes and obesity.
SmithKline BeechamEPO 844 305
hRAD54 polypeptides
Philadelphia
hRAD54 polypeptides and encoding gene sequences; for diagnosis and treatment of syndromes prone to cancer conversion.
SmithKline BeechamEPO 844 307
Yeast caYAE1 polypeptides
Philadelphia
caYAE1 polypeptides from Candida albicans yeast and encoding gene sequences; for infection diagnosis and treatment.
Soft GeneWO 98/21322
Safer gene therapy vectors
Berlin, Germany
Gene therapy constructs having only the sequences necessary for expression; for safer gene vaccines.
Southern California, Univ. ofWO 98/20907
Bone marrow cell transfection
Los Angeles
Isolation of TGF-beta-responsive cells from bone marrow; for transfection and therapeutic reintroduction.
Takeda ChemicalWO 98/21315
Presenilin variant cells
Osaka, Japan
Transformed cells that secrete a presenilin 2 variant; for screening inhibitors for Alzheimer's therapeutics.
Texas, Univ. ofWO 98/21350
Viral vector production
Austin, Texas
Inducible viral vector synthetic promoter that works in helper cells but not in target cells; for production.
Texas, Univ. ofWO 98/21359
Glutathione S-transferase variants
Austin, Texas
Genomic clones/cDNAs for glutathione S-transferase variants, encoded proteins, antibodies; for diagnosing gliomas.
Tufts Univ.WO 98/20903
Hemolytic uremia antibodies
Medford, Mass.
Humanized neutralizing antibodies specific for Shiga-like toxins; for treating hemolytic uremic syndrome.
Visible GeneticsWO 98/21361
Isothermal sequencing
Toronto, Ont.
Method and kit for direct isothermal sequencing of nucleic acids.