Published May 27 (EPO); May 22 (WO); May 27 (GB)
Albert Einstein Coll. Med.WO 98/20898
Mycobacteria drug screen
Mycobacteria that are auxotrophic for diaminopimelate; for delivering vaccines and screening drugs.
Telomerase complex genes
Thousand Oaks, Calif.
Gene sequences encoding polypeptides of the telomerase complex; encoded peptides, preparation methods.
Angstrom PharmaWO 98/21230
Cancer inhibiting cyclic peptides
Cyclic peptides, joined with a linker, that bind urokinase-type plasminogen activator; for inhibiting cancer growth.
Barcelona, Free Univ. ofWO 98/20906
Diabetes gene therapy
Treatment of diabetes with a vector encoding a transcription factor controlled by a pancreatic-specific promoter.
Battelle Mem. Inst.WO 98/21348
EGF from plants
Production of human epithelial growth factor (EGF) in whole plants, non-edible portions, and plant cell cultures.
Boehringer IngelheimWO 98/21326
Cell growth inhibitors
Assay for elements of the anaphase promoting complex; for screening agents that inhibit rapidly growing cells.
Boehringer MannheimWO 98/21245
Neurotrophic factor antibodies
High affinity antibody against human BDNF; for inhibiting the survival of afferent ganglia neurons.
California, Univ. ofWO 98/21227
Sonic hedgehog cancer therapy
Mutant sonic hedgehog gene, encoded protein, antibodies; for drug screening and cancer treatment.
Cambridge Antibody Technol.EPO 844 306
Specific binding pair assays
Detection of specific binding pairs using surface membrane expression technology coupled with binding assays.
Cell growth control
Fusions of transcription factor E2F and retinoblastoma RB protein, encoding gene; for treating aberrant cell growth.
Cedars-Sinai Med. Ctr.WO 98/21333
Schwannomin-binding proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Fas ligand mutants
Mutant forms of Fas ligand, derivatives, and fusions, encoding genes; for treating autoimmune disease.
City of HopeWO 98/21233
Immunogenic cytomegalovirus peptides recognized by CD8+ class I MHC restricted cytotoxic T cells; for therapy.
Columbia Univ.WO 98/21352
Recombinant fusion nucleic acids
Generation of directed, recombinant fusion nucleic acids by PCR using appended 5' priming sequences that enhance fusion.
Cornell Univ.WO 98/21585
Activated ras ligand assay
Immobilized proteins treated with cell lysates containing activated ras protein; for finding binding partners.
Dana-Farber Cancer Inst.WO 98/21240
Human BY55 protein
Gene for the human BY55 protein, encoded protein, fragments; for recombinant expression.
Dana-Farber Cancer Inst.WO 98/21314
B cell activation
Methods for activation of B cells and subsequent expansion; for antigen presentation.
Ehrenberg, M.WO 98/21353
In vitro protein translation
Translation of solid phase bound mRNAs; for selective labelling and ease of purification using release factors.
Electrophoretics Intl.GB 2 319 607
Prion protein assay
Methods for detection and measurement of prion proteins in mononuclear cells.
Genetics Inst.WO 98/21332
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Genetics Inst.WO 98/21335
Gene for chordin, encoded protein, purification methods; for treating wounds and connective tissue defects.
Georgia St. Univ.WO 98/20901
Attenuated Rubella strains
Complete genome of Rubella virus RA27/3 strain, attenuating mutations, methods of developing attenuated strains.
Human Genome SciencesWO 98/21242
Gene for human calcitonin receptor, encoded protein, fragments; for modulator screens and diagnostics.
Inhibiting malarial drug resistance
Down-regulation of drug resistance gene expression in Plasmodium falciparum using specific antisense oligos.
Illinois, Univ. ofWO 98/21325
Multidrug resistance therapeutics
Immunological agents effective against the multidrug resistance transmembrane P-glycoprotein; for cancer therapy.
Incyte PharmaWO 98/21241
Palo Alto, Calif.
Human glutamate-binding protein, encoding gene sequences, modulators, antibodies; for diagnostics and therapeutics.
Incyte PharmaWO 98/21318
Palo Alto, Calif.
Gene for a human ubiquitin-conjugating enzyme, encoded protein, antibodies, modulators; for therapeutics.
Incyte PharmaWO 98/21329
Parotid secretory protein
Palo Alto, Calif.
Human parotid secretory protein, encoding gene sequences, antisense, antibodies, modulators.
Incyte PharmaWO 98/21331
Steroid binding proteins
Palo Alto, Calif.
Gene sequences encoding human steroid binding proteins, encoded proteins, antibodies, modulators.
Indiana Univ.WO 98/21330
Gene sequences encoding a human macrophage-derived C-C chemokine named Exodus, encoded protein, fragments, analogs.
KokenEPO 844 004
Gene delivery preparation
Gene preparations containing vectors and inserted genes combined with carriers.
Life TechnologiesWO 98/21355
Mutated reporter protein
Mutants of Aequorea victoria green fluorescent protein, encoding genes; for fluorescent and visible light assays.
Massachusetts, Univ. ofWO 98/21358
Huntington's disease therapeutics assay
Cells expressing mutated huntingtin proteins; for identifying agents that effect clathrin-mediated endocytosis.
Mass. Gen. Hosp.WO 98/21345
Hybrid gene therapy vectors
Gene therapy vectors having both herpes and adeno-associated virus elements; for making highly infectious virions.
Mayo Fdn.WO 98/21365
Prostate cancer diagnosis
Assay for prostate-specific glandular kallikrein hK2 polypeptide or its mRNA; for diagnosing prostate cancer.
Michigan St. Univ.WO 98/21344
Fusion immunogenic vaccines
E. Lansing, Mich.
Small peptide antigens fused into the B subunit of E. coli heat-labile enterotoxin; for immunogenic vaccines.
Millennium PharmaWO 98/21363
HNF diabetes treatment
Agonists of functional HNF bioactivity, mutant HNF, antibodies; for treating diabetes.
Minnesota, Univ. ofWO 98/21337
Streptococcus C3 binding protein
Human complement C3 binding protein from Streptococcus pneumoniae, purification; for therapeutics.
Hematopoietic stem cell antibodies
Antibodies against an antigen on hematopoietic mononuclear stem cells; for facilitating bone marrow transplants.
NIH (Natl. Inst. Hlth.)WO 98/21338
Insect baculovirus expression of viral particles containing hepatitis C and E1/E2 proteins; for antibody production.
New York Blood Ctr.WO 98/21224
Duffy blood group antigen
Gene for the Duffy blood group antigen, encoded protein, fragments, antibodies; for expression detection.
New York Blood Ctr.WO 98/21235
Malarial binding site
Malarial binding site peptide from the Duffy blood group antigen, encoding gene sequence; for malaria treatment.
New York Blood Ctr.WO 98/21316
Transgenic blood group antibodies
Methods for making monoclonal antibodies that are specific for polymorphic blood group antigens using transgenics.
Onyx PharmaWO 98/21342
Cell growth regulators
Gene sequences encoding cell growth regulatory proteins that phosphorylate cell cycle targets, encoded proteins.
Osiris TherapeuticsWO 98/20731
Mesenchymal stem cell isolation
Methods for isolating, purifying, and growing megakaryocyte-associated mesenchymal stem cells.
Pasteur MerieuxEPO 844 483
Cytotoxic activity assay
Method for detecting cellular cytotoxic activity using suspect and sensitive cells, gene isolation [in French].
Pasteur MerieuxWO 98/21225
Helicobacter polypeptides, encoding gene sequences; for vaccines to prevent infection and associated ulcers.
QBI EnterprisesWO 98/21321
Translationally regulated genes
Selective stimulation of mRNAs with a stress inducing element; for finding internal ribosome entry sites.
QBI EnterprisesWO 98/21366
Subtraction gene identification
Gene inactivation and determination of effect on cell phenotype; for subtraction analysis of affected gene.
Queen's Univ.WO 9821346
Plastid membrane transport protein
Plastid membrane transport protein, encoding gene constructs; for enhanced cellular translocation.
Rhone-Poulenc RorerWO 98/21327
APP endocytosis inhibitors
Peptides that interfere with the endocytosis of amyloid precursor protein (APP), encoding gene sequences.
Rhone-Poulenc RorerWO 98/21349
Liver cell-specific expression
Gene constructs, associated vectors, and hybrid promoters for liver cell-specific expression of proteins.
Sagami Chem. Res. Ctr.WO 98/21328
Human proteins having transmembrane domains, encoding genes, recombinant versions of these proteins.
SmithKline BeechamEPO 844 253
Tubby 2 polpeptides
Tubby 2 polypeptides and encoding gene sequences; for diagnosis and treatment of diabetes and obesity.
SmithKline BeechamEPO 844 305
hRAD54 polypeptides and encoding gene sequences; for diagnosis and treatment of syndromes prone to cancer conversion.
SmithKline BeechamEPO 844 307
Yeast caYAE1 polypeptides
caYAE1 polypeptides from Candida albicans yeast and encoding gene sequences; for infection diagnosis and treatment.
Soft GeneWO 98/21322
Safer gene therapy vectors
Gene therapy constructs having only the sequences necessary for expression; for safer gene vaccines.
Southern California, Univ. ofWO 98/20907
Bone marrow cell transfection
Isolation of TGF-beta-responsive cells from bone marrow; for transfection and therapeutic reintroduction.
Takeda ChemicalWO 98/21315
Presenilin variant cells
Transformed cells that secrete a presenilin 2 variant; for screening inhibitors for Alzheimer's therapeutics.
Texas, Univ. ofWO 98/21350
Viral vector production
Inducible viral vector synthetic promoter that works in helper cells but not in target cells; for production.
Texas, Univ. ofWO 98/21359
Glutathione S-transferase variants
Genomic clones/cDNAs for glutathione S-transferase variants, encoded proteins, antibodies; for diagnosing gliomas.
Tufts Univ.WO 98/20903
Hemolytic uremia antibodies
Humanized neutralizing antibodies specific for Shiga-like toxins; for treating hemolytic uremic syndrome.
Visible GeneticsWO 98/21361
Method and kit for direct isothermal sequencing of nucleic acids.