Published May 20 (EPO); May 14 (WO); May 20 (GB)

Abbott LabsWO 98/20143

Lung tissue genes

Abbott Park, Ill.

Genes that are transcribed in lung tissue; for diagnosis and treatment of lung cancer.

B.R.A.H.M.S. DiagnosticaWO 98/20343

Thyroid autoantibody detection

Berlin, Germany

Labelled, immobilized thyroid stimulating hormone receptor preparation; for detectingautoantibodies.

Boehringer IngelheimEPO 843 008

Anaphase promoting complex

Ingelheim, Germany

Methods for identifying subunits of the human anaphase promoting complex; forscreening inhibitors.

California, Univ. ofWO 98/19686

Vascular injury treatment

La Jolla, Calif.

Gene mutations in src, Ras, MEKK, and JNK; for transfection of vascular tissue toprevent mechanical injury response.

California, Univ. ofWO 98/20022

Soluble protein variants

Oakland, Calif.

Production of soluble variants of proteins that maintain the biological activity of theoriginal protein.

California, Univ. ofWO 98/20140

TNF receptor releasing enzyme

Oakland, Calif.

Tumor necrosis factor (TNF) receptor releasing enzyme; for modulating TNF levels atinflammation sites.

Children's Hosp.WO 98/20121

Obesity transgenics

Boston, Mass.

Transgenic mice expressing syndecan in hypothalamic regions important in weightcontrol; for screening obesity drugs.

ChironEPO 842 947

Hepatitis C asialoglycoproteins

Emeryville, Calif.

Expression of two hepatitis C virus envelope proteins with-out sialylation; forculturing the virus.

Cold Sp. Harb. LabsWO 98/20129

Leukemia-associated gene

Cold Sp. Harb., N.Y.

Constitutively expressed tyrosine phosphorylated protein associated with chronicmyelogenous leukemia, encoding gene.

Cornell Univ.WO 98/20164

Matrix mill DNA extraction

Ithaca, N.Y.

Matrix mill that uses continually alternating polarity coils to disrupt and process tissuesamples for study.

Curie Inst.WO 98/20123

Cystic fibrosis treatment

Paris

Vector for expressing normal CFTR protein and its epitopes; for treating cysticfibrosis.

CytelWO 98/20111

Bacterial expression system

San Diego, Calif.

Dual bacterial promoters operably linked to heterologous genes; for high proteinexpression in bacteria.

DiapharmGB 2 319 252

HIV therapeutics

St. Peter Port, U.K.

HIV polypeptides interacting with the fusin and CC-CKR-5 co-receptors; fordiagnostics and therapeutics.

Du PontWO 98/20160

Listeria diagnostic probes

Wilmington, Del.

Diagnostic gene sequences and primers for the identification of Listeria species.

Emory Univ.WO 98/19714

Hypertrophic cardiomyopathy model

Atlanta, Ga.

Transgenic mice deficient in adenine nucleotide translocator protein heart isoform; forhypertrophic cardiomyopathy.

GenentechWO 98/20036

HIV peptide antibodies

S. San Francisco

Cyclized peptides from HIV gp41 having con-strained a-helical regions; for antibodiesthat prevent viral membrane fusion.

GenespanWO 98/20146

Stable transient gene expression

Richmond, Wash.

Methods and agents for stabilizing transient gene expression in hepatocytes; foraltering glucose metabolism.

Genetics Inst.WO 98/20029

HNF3-delta proteins

Cambridge, Mass.

Purified HNF3-delta proteins, encoding genes; for regulating pancreatic celldifferentiation.

Genetics Inst.WO 98/20125 & 20130

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secretedprotein genes.

German Hlth. Welfare Inst.EPO 843 005

Colon carcinoma cell line

Oberschleissheim, Germany

Human colon carcinoma cell line with stable expression of HSP72 [in Ger-man].

Human Genome SciencesWO 98/20042

Blue-light photoreceptor

Rockville, Md.

Gene for human blue-light photoreceptor hCRY2, encoded protein, antibodies,production methods.

Human Genome SciencesWO 98/20110

Mucosal addressin CAM

Rockville, Md.

Human mucosal addressin cell adhesion molecule (CAM)-1, encoding gene; fordetecting cancer and inflammation.

Iatron LabsEPO 842 949

Fibrinogen digestion antibodies

Tokyo

Monoclonal antibodies that detect the D-monomer produced by digesting humanfibrinogen with granulocyte elastase.

Idec PharmaWO 98/19706

Organ rejection treatment

San Diego, Calif.

Antibodies that specifically block CD80 binding to CD28, thus inhibiting IL-2production; for treating rejection.

Imperial CollegeWO 98/20142

Notch interaction modulators

London

Modulators of interactions of Notch proteins and their ligands in T cell-associatedgraft rejection and autoimmunity.

Incyte PharmaWO 98/20040

Histamine H2 receptor

Palo Alto, Calif.

Histamine H2 receptor, encoding gene, antisense, antibodies, modulators; fordiagnostics and therapeutics.

Incyte PharmaWO 98/20117

Prostate-specific kallikrein

Palo Alto, Calif.

Prostate-specific kallikrein, encoding gene, antisense, antibodies, modulators; fordiagnostics and therapeutics.

Incyte PharmaWO 98/20128

Regulator of G-protein signalling

Palo Alto, Calif.

Human regulator of G-protein signalling, encoding gene, antibodies, modulators; fordiagnosis and therapeutics.

Incyte PharmaWO 98/20132

Tumor-associated Kazal inhibitor

Palo Alto, Calif.

Gene for human tumor-associated Kazal inhibitor, encoded protein, antisense,antibodies, modulators.

Incyte PharmaWO 98/20137

Human squalene epoxidase

Palo Alto, Calif.

Human squalene epoxidase, encoding gene, antisense, antibodies, modulators; fordiagnostics and therapeutics.

Infectio DiagnosticWO 98/20157

Pathogen DNA probes

Sainte-Foy, Que.

Universal DNA probes and amplification primers for rapid detection of commonbacterial and fungal pathogens.

Inst. Phys. Chem. Res.WO 98/20122

Full-length cDNA library

Saitama, Japan

Method of making a full-length cDNA library using efficiently labelled 5' Cap sites.

Iowa, Univ. ofWO 98/20131

Glaucoma-associated gene

Iowa City, Iowa

Glaucoma-associated gene and its encoded protein; for identifying modulating agents.

Jarvik, J.W.WO 98/20031

Tagged genes and proteins

La Jolla, Calif.

Genes with inserted exons; for tagging the encoded protein for recognition by anantibody.

Kyowa MedexEPO 843 019

Specific sequence determination

Tokyo

Carrier-bonded, labelled single-stranded DNA; for determining the level of specificDNA sequences.

Lexicon GeneticsWO 98/20030

Cell growth inhibition

The Woodlands, Texas

Disruption of the mammalian Rad51 protein; for blocking DNA repair pathways andinhibiting cell proliferation.

LillyEPO 843 006

PSA expression vectors

Indianapolis, Ind.

Recombinant expression vectors encoding prostate-specific antigen (PSA) andmodified forms; for diagnostics.

LillyEPO 843 012

Streptococcus antibacterials

Indianapolis, Ind.

Biosynthetic murG gene from Streptococcus pneumoniae; for inhibiting stem peptidebiosynthesis.

Ludwig Inst. Cancer Res.WO 98/20114

Receptor tyrosine kinase

New York

Receptor tyrosine kinase family, encoding genes; for diagnostics and therapeutics.

Mass. Gen. Hosp.WO 98/19691

IRS-1 dominant negative mutants

Boston, Mass.

Dominant negative mutants of mammalian IRS-1 proteins; for inhibiting tyrosylphosphorylation and treating cancer.

Michigan, Univ. ofWO 98/19711

Gene delivery condensing agents

Ann Arbor, Mich.

Aromatic amino acid-containing peptide condensing agents for receptor- andnonreceptor-mediated gene delivery.

Mochida PharmaEPO 842 948

Anti-Fas ligand antibodies

Tokyo

Anti-Fas ligand antibodies, hybridomas; for assaying Fas ligand and developingtherapeutics.

Mose Larsen, P., et al.WO 98/20124

Diabetes transgenics

Aarhus, Denmark

Transgenic animals expressing a diabetes-mediating protein; for drug screens.

NIH (Natl. Inst. Hlth.)WO 98/20135

Cell toxins

Bethesda, Md.

Protease-activatable Pseudomonas exotoxin A-like proproteins; for killing target cells.

Northwest BiotherapeuticsWO 98/19692

C4-2 tumor suppressor

Seattle, Wash.

Gene for the C4-2 tumor suppressor, encoded protein, anti-bodies; for diagnosis andtherapy.

Northwest BiotherapeuticsWO 98/20021

Brain tumor protein

Seattle, Wash.

Gene for D2-2 protein associated with brain tumors, encoded protein; for diagnosticsand therapeutics.

Nuevo Leon, Free Univ. ofWO 98/20035

Yeast human growth hormone

San Nicolas de los Garza, Nuevo Leon

Modified methylotrophic Pichia pastoris yeast inducible by methanol; for producinghuman growth hormone.

Oklahoma Med. Res. Fdn.WO 98/20041

Vascular injury treatment

Oklahoma City, Okla.

Endothelium-specific gene expression using the EPCR gene control elements; fortreating vascular injury.

Oklahoma Med. Res. Fdn.WO 98/20118

Modified Protein C

Oklahoma City, Okla.

Modified Protein C which is less sensitive to natural anti-body inhibitors and moreeffective in inhibiting clotting.

Onyx PharmaWO 98/20126

Phosphatidylinositol-3' kinase

Richmond, Calif.

Gene for phosphatidylinositol-3' kinase, encoded protein; for diagnosis and treatmentof cell growth disorders.

Onyx PharmaWO 98/20127

Guanine exchange factor

Richmond, Calif.

Guanine exchange factor, encoding gene, antibodies, ligands; for modulating cellsignalling pathways.

Pittsburgh, Univ. ofWO 98/19701

Genes promoting wound healing

Pittsburgh, Penn.

Transfecting graft tissue with the inducible nitric oxide synthetase gene; for promotingwound healing.

Ramot Univ.WO 98/20159

Bimolecular interaction library

Tel Aviv, Israel

Bimolecular interaction library made from mixtures of two phage display libraries withinteracting pairs.

Ramot Univ.WO 98/20169

Epitope mapping

Tel Aviv, Israel

Conformational epitopes mapped with overlapping peptides; for preparing antibodies.

St. Jude's Hosp.WO 98/19540

Selecting stem cells

Memphis, Tenn.

Hematopoietic stem cells transfected with mutant dihydro-folate reductase genes; forin vivo selection.

Scripps Res. Inst.WO 98/20119

Fatty-acid amide hydrolase

La Jolla, Calif.

Gene for fatty-acid amide hydrolase, encoded enzyme; for identifying inhibitors.

SequenomWO 98/20166

Mass spectrometry-based DNA diagnostics

San Diego, Calif.

Mass spectrometry-based processes for detecting specific DNA sequences inbiological samples.

ShionogiWO 98/19523

Lipogenous diabetes mouse model

Osaka, Japan

Mouse model for lipogenous type II diabetes and other obesity-related liver diseases.

SmithKline BeechamEPO 842 665

ICE-like apoptosis proteases

Philadelphia, Penn.

Human interleukin-beta converting enzyme (ICE)-like apoptosis proteases and theirantagonists and agonists.

SmithKline BeechamEPO 843 009

Myotrophin

Philadelphia, Penn.

Gene for human myotrophin, encoded protein, production methods; for diagnosticsand therapeutics.

SmithKline BeechamEPO 843 011

Staphylococcus antibacterials

Philadelphia, Penn.

Genes for Staphylococcus rsbU-1, encoded proteins; for developing antibacterialdiagnostics and therapeutics.

SmithKline BeechamEPO 843 014

Antibacterial screens

Brentford, U.K.

Tryptophanyl tRNA synthetase polypeptides and their encoding genes; forantibacterial screens.

SmithKline BeechamEPO 843 016

Staphylococcus antibacterials

Philadelphia, Penn.

Staphylococcus malonyl CoA:ACP transacylase, encoding gene; for antibacterialscreens.

SmithKline BeechamWO 98/19689

Streptococcus antibacterials

Philadelphia, Penn.

Streptococcus genes and their encoded proteins; for develop-ing inhibitors asantibacterials.

SmithKline BeechamWO 98/19704

Human RSV monoclonal antibodies

Philadelphia, Penn.

Human monoclonal antibodies to the fusin protein of respiratory syncytial virus(RSV); for treating infection.

SmithKline BeechamWO 98/20016

Herpes simplex genes

Philadelphia, Penn.

Genes from herpes simplex virus type-2, encoded proteins; for developing inhibitorsfor therapeutics.

SmithKline BeechamWO 98/20158

Obese protein modulators

Philadelphia, Penn.

Detection of modulators of the obese protein by using cells containing a reporter genelinked to a DNA response element.

SmithKline BeechamWO 98/20161

Essential growth gene assay

Philadelphia, Penn.

Identification of genes essential to the growth of an organ-ism by using a gridprepared from a genomic library.

Stanford Univ.WO 98/20032

Sprouty protein

Stanford, Calif.

Mammalian sprouty protein, encoding gene, gene therapy vector; for therapeutics.

Tanabe SeiyakuWO 98/20134

DNA gyrase inhibitor

Osaka, Japan

Gene for a protein that inhibits bacterial DNA gyrase activity, encoded protein; foridentifying modulators.

Texas, Univ. ofWO 98/20038

Sentrin

Austin, Texas

Gene for sentrin, encoded protein, production methods; for diagnostics and anti-apoptosis therapeutics.

Toyota JidoshaWO 98/20138

Mutated prenyl diphosphate synthase

Aichi, Japan

Prenyl diphosphate synthase with a mutation in the N-terminal region, encoding gene.

UnileverEPO 843 010

Carrot anti-freeze polypeptides

London

Carrot anti-freeze polypeptides; for protection of materials from the effects offreezing.

Whitehead Inst. Biomedical Res.WO 98/20165

Polymorphic site analysis

Cam-bridge, Mass.

Allelic-specific primers and probes as well as hybridizing flanking regions; forpolymorphic site analysis.

Wistar Inst.WO 98/20112

Wound healing transgenics

Philadelphia, Penn.

Transgenic mice lacking endogenous SPARC expression; for testing agents affectingwound healing and diabetes.

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