Published May 15 (EPO); May 7 (WO); May 15 (GB)

Abbott Labs WO 98/18945Breast tissue genesAbbott Park, Ill.Breast tissue genes, encoded proteins, antibodies; for diag-nosing and treating breast cancer.

Affymetrix WO 98/18967G6PD polymorphismsSanta Clara, Calif.Nucleic acid segments of the glucose-6 phosphate dehydroge-nase (G6PD) locus including polymorphic sites.

Barth, S. EPO 841 400 & 401Fusion toxins for cancerCologne, GermanyVector for bacterial expression of fusion toxins with anti-body or cytokine domains; for cancer therapy [in Ger-man].

California, Univ. of WO 98/18456Protease-activated receptor 3Oakland, Calif.Gene for protease-activated receptor 3, encoded protein, antibodies; for screening hemostasis modulators.

Calvo, F. WO 98/18960Malignant transformation assayParisDetection of malignant transformation of cells by measuring the appearance of a cancer-associated gene.

Canadian Natl. Res. Counc. WO 98/18927Yeast infection inhibitorsOttawa, Ont.Candida albicans proteins associated with virulence; for screening inhibitors of yeast infection.

Cell Genesys WO 98/18809Cancer cell cytolysisFoster City, Calif.Chimeric proteins with extracellular domains binding TAG-72 in a non-MHC restricted manner; for targeting cancer cells.

CNRS (Natl. Ctr. Sci. Res.) WO 98/18915Platinized fixing oligosParisIrreversible fixing of complementary RNAs by using platin-ized oligos; for RNA purification and blocking.

Chiron WO 98/18928E. coli vaccinesSiena, ItalyImmunogenic detoxified mutant subunit A of an E. coli heat labile toxin, encoded gene; for vaccines and adjuvants.

CSIRO (Comm. Sci. Ind. Res. Org.) WO 98/18918Triple helix proteinsCamp-bell, AustraliaStable expression of hydroxylated triple helix proteins in yeast; for production and purification.

Duke Univ. WO 98/18914Antiangiogenic agentDurham, N.C.Soluble Tie2 receptor, encoding gene; for use as an anti-angiogenic agent.

Eastern Virginia Med. Sch. WO 98/18913Bacterial expression of INGAPNorfolk, Va.Removal of the signal peptide sequence from INGAP; for successful bacterial expression.

Fred Hutchinson Cancer Res. Ctr. WO 98/19167Cell stress-regulated MHC genesSeattleCell stress-regulated human MHC class I genes; for diagnosis and treatment of graft rejection and other diseases.

GeneMedicine WO 98/18925Modified glucocorticoid receptorsThe Woodlands, TexasModified and hybrid glucocorticoid receptors, encoding genes; for therapeutics.

Genentech WO 98/18946Bacterial production systemS. San FranciscoBacterial production of recombinant proteins in association with DsbA or DsbC protein expression; for secretion.

Geron EPO 841 396Telomerase reverse transcriptaseMenlo Park, Calif.Gene for the catalytic subunit of human telomerase that encodes a reverse transcriptase; for therapeutics.

Human Genome Sciences WO 98/18824Human TNF receptorsRockville, Md.Human tumor necrosis factor (TNF) receptors, encoding genes; for identifying modulators.

Human Genome Sciences WO 98/18921Neutrokine-alphaRockville, Md.Neutrokine-alpha, a TNF family protein, encoding gene, soluble extracellular domain form; for immune system disorders.

Human Genome Sciences WO 98/18930 & 18931Streptococcus antigen vaccinesRockville, Md.Streptococcus pneumoniae antigens, encoding genes, sequences in computer-readable media; for diagnostics and vac-cines.

Incyte Pharma WO 98/18822Human LIM proteinsPalo Alto, Calif.Human LIM proteins, encoding genes, antisense, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 98/18911Human guanylate binding proteinsPalo Alto, Calif.Human guanylate binding proteins, encoding genes, antisense, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 98/18916Human P2X purinoreceptorPalo Alto, Calif.Human P2X purinoreceptor, encoding gene, antisense, antibod-ies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 98/18922Human phosphoproteinPalo Alto, Calif.Human phosphoprotein, encoding gene, antisense, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 98/18938Spermidine/spermine N1-acetyltransferasePalo Alto, Calif.Human spermidine/spermine N1-acetyltransferase, encoding gene, antibodies, antagonists,; for therapeutics.

Incyte Pharma WO 98/18942Rab proteinsPalo Alto, Calif.Human Rab and Rab-associated proteins, encoding genes, antibodies, antagonists; for therapeutics.

Italian Natl. Res. Counc. GB 2 319 082RT-PCR gene expression screenRomeDifferential screening of gene expression by random-primed reverse transcription (RT)-PCR.

Johns Hopkins Univ. WO 98/18811Antisense deliveryBaltimoreNucleic acid having an intact stem loop and an antisense portion; for allele-specific targeting in gene therapy.

Kishimoto, T. EPO 841 068Leukemia-inhibiting antisenseOsaka, JapanAntisense against Wilms' tumor gene; for growth inhibition of leukemia.

Krebs Res. Inst. WO 98/18919GABA(A) receptor subunitHeidelberg, GermanyGABA(A) receptor subunit epsilon-related protein, encoding gene, antibodies; for therapeutics.

Krebs Res. Inst. WO 98/18950Adeno-associated viral vectorsHeidelberg, GermanyAdeno-associated viral vectors with helper virus sequences; for forming virus particles.

Lescallet, J. WO 98/18966BRCA1 gene mutation detectionGreat Falls, Va.Corrected intron regions surrounding specific exons of the BRCA1 gene; for better amplification and mutation detection.

Merck GB 2 319 032Cyclooxygenase-2 inhibitorsRahway, N.J.Crystal structure of human cyclooxygenase-2; for designing inhibitors.

Merck WO 98/19158Growth hormone mimetic identificationRahway, N.J.Stably transformed cell line containing a reporter gene; for identification of growth hormone mimetics.

Mitsui Toatsu EPO 841 067Freeze-dried antibodiesTokyoFreeze-dried monoclonal antibody preparations containing carboxylic acids; for retention of biological activity.

NIH (Natl. Inst. Hlth.) WO 98/18963Manic-depressive markersBethesda, Md.Determination of susceptibility to manic-depressive illness using markers on chromosome 18.

Nebraska, Univ. of WO 98/18965Point mutation detectionLincoln, Neb.Point mutation detection using fluorescent dyes whose emis-sion changes dramatically when mismatches are present.

Novartis WO 98/18935Constitutive p70(56K) protein kinaseBasel, SwitzerlandProtein kinase related to p70(56K) with an acidic amino acid residue replacement; for conferring constitutive activity.

Novartis WO 98/18943Peptide oligomerizationBasel, SwitzerlandMethods for oligomerization of peptides having a domain capable of ligand binding.

Oxford Biomedica WO 98/18934Parkinson's disease therapyOxford, U.K.Vector containing operably-linked genes for tyrosine hydrox-ylase and DOPA decarboxylase; for Parkinson's gene therapy.

Pasteur Inst. WO 98/18959Genetic disease diagnosisParisSpecific DNA probes for diagnosing genetic diseases by determining probe size and inter-probe distances.

Proctor & Gamble WO 98/18906Mouse cardiac muscle cell lineCincinnati, OhioMouse cardiac muscle cell line derived from a transplantable cardiomyocyte lineage.

Rhone-Poulenc Rorer WO 98/18825p53 antibodiesAntony, FranceSingle chain antibodies against p53 protein, encoding genes; for inhibiting p53 action.

Sagami Chem, Res. Ctr. EPO 841 393Galectin-4-like proteinSagamihara, JapanGene for human galectin-4-like lactose-binding protein, encoded protein.

Searle WO 98/18923Flt-3 receptor agonistsChicagoGenes for Flt-3 receptor agonist proteins, encoded proteins, production methods; for therapeutics.

Searle WO 98/18924Stem cell factor receptor agonistsChicagoStem cell factor receptor agonist proteins, encoding genes, agonist production by circular permutation methods.

Searle WO 98/18926Erythropoietin receptor agonistsChicagoErythropoietin receptor agonists, encoding genes, agonist production by circular permutation methods.

Shanghai Cancer Inst. WO 98/18951Cancer gene therapyShanghai, ChinaReceptor-mediated gene transfer system for targeting tumors during gene therapy.

SmithKline Beecham EPO 841 394Staphylococcus antibacterialsPhiladelphiaStaphylococcus aureus genes and their encoded proteins; for screening antibacterials.

SmithKline Beecham EPO 841 399Human FIN-1 caspasePhiladelphiaGene for human FIN-1 caspase, encoded protein; for diagnos-tics and therapeutics to treat viral infection and cancer.

SmithKline Beecham WO 98/18819RSV antigen vaccineRixensart, BelgiumPurification of respiratory syncytial virus (RSV) protein antigens for use in vaccines.

SmithKline Beecham WO 98/18947Antibacterial screenPhiladelphiaPlasmid library of RNA targets; for identifying antibiotics that retard cell growth or cause cell death.

South Carolina, Med. Univ. of WO 98/18820Ricin fusion protein immunotoxinsCharleston, S.C.Ricin A toxin fusions; for immunotherapy of cancer and autoimmune disease.

SRL WO 98/18920Spinocerebellar ataxia geneTokyocDNA fragments of a gene associated with spinocerebellar ataxia type 2, encoded protein.

Stichting Inst. WO 98/18933Infectious RNA virus clonesLelystad, NetherlandsGeneration of infectious clones of RNA viruses; for diagnos-tics and therapeutics.

Washington, Univ. of WO 98/18324Viral infection therapySeattleRibonucleoside analogs for inducing RNA mutation during viral replication; for HIV and hepatitis C infec-tions.

Zeneca WO 98/18961Single-stranded DNA chipsLondonMethod for preparing an array of single-stranded DNA immobi-lized on a solid support.

— Compiled By Chester Bisbee