Published April 29 & May 6 (EPO); April 23 & 30 (WO); May 6 (GB)

Adv. Res. Technol. Inst.WO 98/17684

DNA repair fusion proteins

Bloomington, Ind.

Genes for DNA repair fusion proteins, encoded protein; for transgenics and chemotherapeutic screens.

Adv. Tissue Sci.WO 98/17791

Pre-chondrocyte cell banks

La Jolla, Calif.

Isolation of pre-chondrocytes from the umbilical cord; for cell expansion and freezing for cell banks.

AmgenWO 98/16642

Keratinocyte growth factor variants

Thousand Oaks, Calif.

Genes for keratinocyte growth factor-2 variants, encoded proteins; for stimulating epithelial cell growth.

AmgenWO 98/17798

Placental-derived growth factors

Thousand Oaks, Calif.

Genes for placental-derived growth factors, encoded pro-teins; for growth of prostate and epi-thelial cells.

BittechWO 98/16660

Cell cycle regulator screen

Westlake Village, Calif.

Methods for screening cell cycle regulatory proteins using reporter genes linked to cyclin/CDK gene control regions.

Boehringer MannheimWO 98/16637

Fanconi anemia gene

Mannheim, Germany

Gene associated with Fanconi anemia, encoded protein, anti-bodies; for diagnosis and therapy.

Boehringer MannheimWO 98/17691

Hemagglutinin antibodies

Mannheim, Germany

Monoclonal antibodies against a specific nonapeptide epitope from influenza hemagglutinin; for diagnostics.

British Biotech. Res. Counc.WO 98/16634

Increased transgene expression

Swindon, U.K.

Specific regulatory sequences linked to highly expressed genes; for increased expression in transgenics.

California, Univ. ofWO 98/16628

Prostate cancer model

Oakland, Calif.

Immune deficient mice having a human prostate metastatic cancer xenograft; for studying prostate cancer.

California, Univ. ofWO 98/16655

Human plasma hyaluronidase

Oakland, Calif.

Gene for human plasma hyaluronidase, encoded protein, im-munoaffinity puri-fication; for treating cancer.

CanjiWO 98/17801

Interferon-a expression

San Diego, Calif.

Vectors for the delivery and tissue-specific expression of interferon-a.

Cedars-Sinai Med. Ctr.WO 98/17795

Down Syndrome-CAMs

Los Angeles, Calif.

Genes for Down Syndrome-cell adhesion molecules (CAMs), encoded proteins, antibodies; for finding modulators.

Chemoserotherapeutic Res. Inst.WO 98/16647

Hepatitis C immunotherapy

Kumamoto, Japan

Peptide that binds chimpanzee neutralizing antibodies for hepatitis C virus, encoding gene; for immunotherapy.

Children's Hosp.WO 98/17688

Osteometrin

Boston, Mass.

Osteometrin, a phosphoprotein expressed in bone and dentin tissue; for osteoporosis and bone cancer diagnosis.

ChromaxomeWO 98/17811

Combinatorial gene expression libraries

San Diego, Calif.

Combinatorial gene expression libraries having genes from a variety or organisms; for generating metabolic pathways.

CorixaWO 98/16645 & 16646

Tuberculosis therapy

Seattle, Wash.

Genes for Mycobacterium tubercu-losis protein antigen frag-ments, encoded proteins, antibodies; for immuno-therapy.

Dartmouth CollegeWO 98/16659

Apoptosis-related deoxyribonuclease

Hanover, N.H.

Gene for deoxyribonuclease II, encoded protein, antibodies; for identifying modulators of apoptosis.

Duke Univ.WO 98/17683

Protein phosphatase inhibitor

Durham, N.C.

Gene for human protein phosphatase inhibitor-1, encoded protein; for screening non-insulin dependent diabetes.

Florida, Univ. ofWO 98/16554

Rickettsial disease vaccines

Gainesville, Fla.

Nucleic acid vaccines containing genes that protect against rickettsial diseases; for diagnosis and therapy.

GeneMedicineWO 98/17689 & 17814

Multiple gene delivery vectors

The Woodlands, Texas

Lipid-based delivery systems for delivery and expression of multiple genes, particularly using the interleukin-12 gene.

GenentechWO 98/17797

ErbB2 apoptosis-inducing antibodies

S. San Francisco, Calif.

Antibodies to ErbB2 that bind to an epitope in domain 1; for inducing cell death.

Genetics Inst.WO 98/17687

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Georgia, Univ. ofWO 98/16649

Pasteurella neuraminidase

Athens, Ga.

Gene for Pasteurella multocida neuraminidase, encoded pro-tein, antibodies; for diagno-sis.

HSC Res. & Develop.WO 98/17793

Mammalian Fringe proteins

Toronto, Ont.

Genes for mammalian Fringe proteins, encoded proteins that interact with the Notch receptor signalling pathway.

Human Genome SciencesWO 98/16643

Brain tPA serpin

Rockville, Md.

Gene for brain-associated inhibitor of tissue type plasmino-gen activator (tPA), encoded protein; for modifi-er screens.

Hunan Med. Univ.EPO 838 526

Gene therapy minichromosomes

Changsha, China

Human satellite minichromosomes that are stably maintained extrachromosomally and replicated; for gene therapy.

Hyal PharmaWO 98/17320

Hyaluronan targeted genes

Mississauga, Ont.

Linkage of hyaluronan to nucleic acids to be used for gene therapy.

ImmusolWO 98/17308

HIV inhibiting ribozymes

San Diego, Calif.

Ribozymes that cleave fusin and CKR5 co-receptor RNA; for inhibiting HIV infection.

Incyte PharmaWO 98/16640

Human Reg I-gamma

Palo Alto, Calif.

Gene for human Reg I-gamma, encoded protein, antibodies, antisense, production methods.

Incyte PharmaWO 98/17794

Eosinophil-derived basic protein

Palo Alto, Calif.

Gene for human eosinophil-derived basic protein, encoded protein, antibodies, modulators, antisense.

InnovationWO 98/17812

Transcriptional activation

Oxford, U.K.

Regulation of gene locus expression by transcript-dependent transcriptional activation of normally unexpressed genes.

Japan TobaccoWO 98/16654

Multimeric protein production

Tokyo

Production of multimeric proteins by fusing cells engineered to express separate components of the protein.

Krebs Res. Inst.WO 98/17824

DNA strand break assay

Heidelberg, Germany

Automated system that measures DNA strand breaks in cell lysate samples using fluorescence detection methods.

LillyWO 98/16542

Penicillin binding protein

Indianapolis, Ind.

Gene for penicillin binding protein from Streptococcus pneumoniae, encoded protein; for identifying inhibitors.

Mass. Gen. Hosp.WO 98/16557

G-protein receptor drug screen

Boston

Chimeric polypeptides derived from Ga subunits of various G-protein linked receptors; for screening therapeutics.

Max Planck Inst.WO 98/16552

Helicobacter vaccines

Munich, Germany

Recombinant live vaccine for Helicobacter pylori; for pro-tective immunity against ulcers.

McGill Univ.WO 98/17823

Clock gene therapeutics

Montreal, Que.

Homologs of the C. elegans nematode clk-1 clock gene; for diagnosing cancer and slowing physiological rates.

McLean Hosp.WO 98/16627

Alzheimer's transgenics

Belmont, Mass.

Transgenics with amyloid precursor protein-C100 poly-peptide fused with the flag amino acid sequence; for Alzheimer's.

Michigan, Univ. ofWO 98/17783

Adenoviral vectors

Ann Arbor, Mich.

Adenoviral vectors with the E2b genome region or the entire viral coding region deleted; for transfecting large genomes.

MitokorWO 98/17826

Diabetes-associated mitochondrial gene mutations

San Diego, Calif.

Mitochondrial gene mutations associated with diabetes, cell model systems; for identifying therapeutics.

Mitsubishi ChemicalWO 98/16636

Engineered phenotypes

Tokyo

Fusion of gene control regions with coding sequences ex-pressing a protein causing a specific phenotype.

NIH (Natl. Inst. Hlth.)WO 98/16641

Tissue growth-inducing protein

Bethesda, Md.

Gene for Frzb protein that is involved in bone, muscle, and nerve tissue formation, encoded protein, production methods.

NIH (Natl. Inst. Hlth.)WO 98/17796

CD97 angiogenesis inhibition

Bethesda, Md.

Gene for the T cell surface antigen CD97 a subunit, encoded protein; for inhibiting inflammation and angiogenesis.

NIH (Natl. Inst. Hlth.)WO 98/17805

Meningitis therapeutics

Bethesda, Md.

Genes from invasion-deficient Neisseria meningitidis, encod-ed proteins, anti-bodies, antisense; for meningitis thera-py.

Netherlands Hlth. Res. Inst.EPO 839 912

RNA virus vaccines

Lelystad, Netherlands

Modified RNA viruses and vaccines that can infect host cells not otherwise susceptible to infection.

Osaka Univ.EPO 839 911

Attenuated chickenpox vaccine

Osaka, Japan

Identification of attenuated chickenpox virus strains using restriction enzyme analysis; for making vaccines.

Osaka Univ.WO 98/17785

Rotavirus vaccines

Osaka, Japan

Isolation and purification of rotavirus antigens from cul-tured cells; for diagnostics and vaccines.

Oxford BiomedicaWO 98/17815, 17816 & 17817

Retroviruses for non-dividing cells

Oxford, U.K.

Lentivirus retroviral production systems for producing viral particles to infect non-dividing cells, for HIV therapy.

Pasteur Inst.WO 98/16553

Bordetella vaccine

Lille, France

Bordetella strain expressing a hybrid filamentous hemagglu-tinin toxin; for vaccines.

Pasteur Inst.WO 98/17804

Ulcer vaccines

Paris

Gene for Helicobacter pylori the gamma-glutamyltransferase antigen, encoded protein; for ulcer vaccines.

Paul Sabatier Univ.WO 98/17818

Artificial membranes

Toulouse, France

Linear artificial membrane structures made from polycationic lipid polymers; for making films and particles.

Pennsylvania, Univ. ofWO 98/17323

Targeted vaccines

Philadelphia, Penn.

Vectors with gene sequences for an immunogenic target linked to an intracellular targeting molecule; for vaccines.

Pennsylvania, Univ. ofWO 98/17799

DNA vaccines

Philadelphia, Penn.

Live attenuated and DNA vaccines encoding cytokines and foreign antigens; for immunotherapy.

Rhone-Poulenc RorerWO 98/17686

GAX transcriptional regulators

Antony, France

Chimeras containing GAX protein domains; for identifying binding partners and repressing gene transcription.

Rockefeller Univ.WO 98/16638

Increased affinity ligands

New York

Ligands having peptide sequences that bind to two different domains of a target molecule; for increased affinity.

Roslin Inst.GB 2 318 792

Oocytes for cloning

Roslin, U.K.

Reconstituting animal embryos by using unactivated oocytes and donor nuclei; for making transgenics.

SearleWO 98/17810

Chimeric hematopoietic receptors

Chicago, Ill.

Multifunctional chimeric hematopoietic receptors, encoding genes; for identifying modulators.

ShionogiWO 98/17800

Human CC chemokine LARC

Kumamoto, Japan

Gene for the human CC chemokine LARC, encoded protein, antibodies, vectors; for immunotherapy.

SmithKline BeechamEPO 838 523 & 838 524

Staphylococcus antibacterials

Philadelphia, Penn.

Genes for RsbW-1 and RsbV-1 polypeptides, encoded peptides, antago-nists; for treating Staphylococcus infections.

SmithKline BeechamEPO 838 525

Staphylococcus antibacterials

Philadelphia, Penn.

Genes for greA polypeptides, encoded peptides, antago-nists, production method; for treating Staphylococcus infections.

SmithKline BeechamEPO 839 908

Human ELF3 gene

Philadelphia, Penn.

Gene for human ELF3, encoded protein, production method; for treating various cancers.

SmithKline BeechamEPO 839 910

Staphylococcus antibacterials

Philadelphia, Penn.

Gene for Spo-rel, a Staphylococcus relA/spot homolog, encod-ed protein, antagonists; for diagnosis and therapy.

SomatogenWO 98/17809

Reduced protoporphyrin hemoglobin

Boulder, Colo.

Reduction of protoporphyrin IX in recombinant hemoglobin solutions by overexpressing the hemH gene.

South Florida, Univ. ofWO 98/17782

Alzheimer's transgenics

Tampa, Fla.

Alzheimer's transgenic model system containing genes for amyloid precursor protein and presenilins.

SugenWO 98/16639

Signal transduction diseases

Redwood City, Calif.

Gene for RDGB proteins, encoded proteins; for diagnosis and treatment of signal transduction pathway diseas-es.

Sunol Molec. SystemsWO 98/17792

Computer designed antibodies

Miami, Fla.

Computer-based methods for designing antibodies with en-hanced affinity for binding proteins such as prothrombin.

Swiss Cancer Res. Inst.EPO 839 915

Mucosal vaccine delivery

Lausanne, Switzer-land

Secretory immunoglobulin A antibody linked to an antigen, encoding gene; for inducing mucosal immunity.

Takara ShuzoWO 98/17808

Leukemia-associated protein kinase

Kyoto, Japan

Receptor type protein kinase gene with a membrane region tandem duplication, encoding gene; for leukemia diagno-sis.

Targeted GeneticsWO 98/17806

E1A minigene tumor suppressors

Seattle, Wash.

Functional domains of E1A proteins, encoding minigenes; for suppressing transformation.

Texas A&M Univ.WO 98/16630

Germ cells for transgenics

College Stn., Texas

Methods for isolating and culturing primordial germ cells; for making non-rodent transgenics.

Utah, Univ. ofWO 98/16653

Plasmid isolation

Salt Lake City, Utah

Rapid isolation of intact plasmid DNA from bacterial ly-sates.

Washington Univ.WO 98/17682

Cell death muteins

St. Louis, Mo.

Serine-substituted muteins of Bcl-xl/Bcl-2 associated cell death regulators, encoding genes; for decreased apoptosis.

Yale Univ.WO 98/17827

Eukaryotic Rad52 proteins

New Haven, Conn.

Genes for eukaryotic Rad52 proteins, gene complexes, encoded proteins.

ZenecaGB 2 318 791

mRNA abundance assay

London

Single-stranded DNA probes immobilized to a solid support; for measuring the abundance of mRNAs and DNAs.

ZymogeneticsWO 98/16635

Insulin homolog genes

Seattle, Wash.

Genes for insulin homologs located on chromosome 12, encoded proteins, antibodies.

ZymogeneticsWO 98/16644

Fibroblast growth factor homologs

Seattle, Wash.

Gene for z fibroblast growth factor (zFGF)-5, encoded pro-tein, antibodies; for treating cardiac conditions.

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