Published April 29 & May 6 (EPO); April 23 & 30 (WO); May 6 (GB)
Adv. Res. Technol. Inst.WO 98/17684
DNA repair fusion proteins
Genes for DNA repair fusion proteins, encoded protein; for transgenics and chemotherapeutic screens.
Adv. Tissue Sci.WO 98/17791
Pre-chondrocyte cell banks
La Jolla, Calif.
Isolation of pre-chondrocytes from the umbilical cord; for cell expansion and freezing for cell banks.
Keratinocyte growth factor variants
Thousand Oaks, Calif.
Genes for keratinocyte growth factor-2 variants, encoded proteins; for stimulating epithelial cell growth.
Placental-derived growth factors
Thousand Oaks, Calif.
Genes for placental-derived growth factors, encoded pro-teins; for growth of prostate and epi-thelial cells.
Cell cycle regulator screen
Westlake Village, Calif.
Methods for screening cell cycle regulatory proteins using reporter genes linked to cyclin/CDK gene control regions.
Boehringer MannheimWO 98/16637
Fanconi anemia gene
Gene associated with Fanconi anemia, encoded protein, anti-bodies; for diagnosis and therapy.
Boehringer MannheimWO 98/17691
Monoclonal antibodies against a specific nonapeptide epitope from influenza hemagglutinin; for diagnostics.
British Biotech. Res. Counc.WO 98/16634
Increased transgene expression
Specific regulatory sequences linked to highly expressed genes; for increased expression in transgenics.
California, Univ. ofWO 98/16628
Prostate cancer model
Immune deficient mice having a human prostate metastatic cancer xenograft; for studying prostate cancer.
California, Univ. ofWO 98/16655
Human plasma hyaluronidase
Gene for human plasma hyaluronidase, encoded protein, im-munoaffinity puri-fication; for treating cancer.
San Diego, Calif.
Vectors for the delivery and tissue-specific expression of interferon-a.
Cedars-Sinai Med. Ctr.WO 98/17795
Los Angeles, Calif.
Genes for Down Syndrome-cell adhesion molecules (CAMs), encoded proteins, antibodies; for finding modulators.
Chemoserotherapeutic Res. Inst.WO 98/16647
Hepatitis C immunotherapy
Peptide that binds chimpanzee neutralizing antibodies for hepatitis C virus, encoding gene; for immunotherapy.
Children's Hosp.WO 98/17688
Osteometrin, a phosphoprotein expressed in bone and dentin tissue; for osteoporosis and bone cancer diagnosis.
Combinatorial gene expression libraries
San Diego, Calif.
Combinatorial gene expression libraries having genes from a variety or organisms; for generating metabolic pathways.
CorixaWO 98/16645 & 16646
Genes for Mycobacterium tubercu-losis protein antigen frag-ments, encoded proteins, antibodies; for immuno-therapy.
Dartmouth CollegeWO 98/16659
Gene for deoxyribonuclease II, encoded protein, antibodies; for identifying modulators of apoptosis.
Duke Univ.WO 98/17683
Protein phosphatase inhibitor
Gene for human protein phosphatase inhibitor-1, encoded protein; for screening non-insulin dependent diabetes.
Florida, Univ. ofWO 98/16554
Rickettsial disease vaccines
Nucleic acid vaccines containing genes that protect against rickettsial diseases; for diagnosis and therapy.
GeneMedicineWO 98/17689 & 17814
Multiple gene delivery vectors
The Woodlands, Texas
Lipid-based delivery systems for delivery and expression of multiple genes, particularly using the interleukin-12 gene.
ErbB2 apoptosis-inducing antibodies
S. San Francisco, Calif.
Antibodies to ErbB2 that bind to an epitope in domain 1; for inducing cell death.
Genetics Inst.WO 98/17687
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Georgia, Univ. ofWO 98/16649
Gene for Pasteurella multocida neuraminidase, encoded pro-tein, antibodies; for diagno-sis.
HSC Res. & Develop.WO 98/17793
Mammalian Fringe proteins
Genes for mammalian Fringe proteins, encoded proteins that interact with the Notch receptor signalling pathway.
Human Genome SciencesWO 98/16643
Brain tPA serpin
Gene for brain-associated inhibitor of tissue type plasmino-gen activator (tPA), encoded protein; for modifi-er screens.
Hunan Med. Univ.EPO 838 526
Gene therapy minichromosomes
Human satellite minichromosomes that are stably maintained extrachromosomally and replicated; for gene therapy.
Hyal PharmaWO 98/17320
Hyaluronan targeted genes
Linkage of hyaluronan to nucleic acids to be used for gene therapy.
HIV inhibiting ribozymes
San Diego, Calif.
Ribozymes that cleave fusin and CKR5 co-receptor RNA; for inhibiting HIV infection.
Incyte PharmaWO 98/16640
Human Reg I-gamma
Palo Alto, Calif.
Gene for human Reg I-gamma, encoded protein, antibodies, antisense, production methods.
Incyte PharmaWO 98/17794
Eosinophil-derived basic protein
Palo Alto, Calif.
Gene for human eosinophil-derived basic protein, encoded protein, antibodies, modulators, antisense.
Regulation of gene locus expression by transcript-dependent transcriptional activation of normally unexpressed genes.
Japan TobaccoWO 98/16654
Multimeric protein production
Production of multimeric proteins by fusing cells engineered to express separate components of the protein.
Krebs Res. Inst.WO 98/17824
DNA strand break assay
Automated system that measures DNA strand breaks in cell lysate samples using fluorescence detection methods.
Penicillin binding protein
Gene for penicillin binding protein from Streptococcus pneumoniae, encoded protein; for identifying inhibitors.
Mass. Gen. Hosp.WO 98/16557
G-protein receptor drug screen
Chimeric polypeptides derived from Ga subunits of various G-protein linked receptors; for screening therapeutics.
Max Planck Inst.WO 98/16552
Recombinant live vaccine for Helicobacter pylori; for pro-tective immunity against ulcers.
McGill Univ.WO 98/17823
Clock gene therapeutics
Homologs of the C. elegans nematode clk-1 clock gene; for diagnosing cancer and slowing physiological rates.
McLean Hosp.WO 98/16627
Transgenics with amyloid precursor protein-C100 poly-peptide fused with the flag amino acid sequence; for Alzheimer's.
Michigan, Univ. ofWO 98/17783
Ann Arbor, Mich.
Adenoviral vectors with the E2b genome region or the entire viral coding region deleted; for transfecting large genomes.
Diabetes-associated mitochondrial gene mutations
San Diego, Calif.
Mitochondrial gene mutations associated with diabetes, cell model systems; for identifying therapeutics.
Mitsubishi ChemicalWO 98/16636
Fusion of gene control regions with coding sequences ex-pressing a protein causing a specific phenotype.
NIH (Natl. Inst. Hlth.)WO 98/16641
Tissue growth-inducing protein
Gene for Frzb protein that is involved in bone, muscle, and nerve tissue formation, encoded protein, production methods.
NIH (Natl. Inst. Hlth.)WO 98/17796
CD97 angiogenesis inhibition
Gene for the T cell surface antigen CD97 a subunit, encoded protein; for inhibiting inflammation and angiogenesis.
NIH (Natl. Inst. Hlth.)WO 98/17805
Genes from invasion-deficient Neisseria meningitidis, encod-ed proteins, anti-bodies, antisense; for meningitis thera-py.
Netherlands Hlth. Res. Inst.EPO 839 912
RNA virus vaccines
Modified RNA viruses and vaccines that can infect host cells not otherwise susceptible to infection.
Osaka Univ.EPO 839 911
Attenuated chickenpox vaccine
Identification of attenuated chickenpox virus strains using restriction enzyme analysis; for making vaccines.
Osaka Univ.WO 98/17785
Isolation and purification of rotavirus antigens from cul-tured cells; for diagnostics and vaccines.
Oxford BiomedicaWO 98/17815, 17816 & 17817
Retroviruses for non-dividing cells
Lentivirus retroviral production systems for producing viral particles to infect non-dividing cells, for HIV therapy.
Pasteur Inst.WO 98/16553
Bordetella strain expressing a hybrid filamentous hemagglu-tinin toxin; for vaccines.
Pasteur Inst.WO 98/17804
Gene for Helicobacter pylori the gamma-glutamyltransferase antigen, encoded protein; for ulcer vaccines.
Paul Sabatier Univ.WO 98/17818
Linear artificial membrane structures made from polycationic lipid polymers; for making films and particles.
Pennsylvania, Univ. ofWO 98/17323
Vectors with gene sequences for an immunogenic target linked to an intracellular targeting molecule; for vaccines.
Pennsylvania, Univ. ofWO 98/17799
Live attenuated and DNA vaccines encoding cytokines and foreign antigens; for immunotherapy.
Rhone-Poulenc RorerWO 98/17686
GAX transcriptional regulators
Chimeras containing GAX protein domains; for identifying binding partners and repressing gene transcription.
Rockefeller Univ.WO 98/16638
Increased affinity ligands
Ligands having peptide sequences that bind to two different domains of a target molecule; for increased affinity.
Roslin Inst.GB 2 318 792
Oocytes for cloning
Reconstituting animal embryos by using unactivated oocytes and donor nuclei; for making transgenics.
Chimeric hematopoietic receptors
Multifunctional chimeric hematopoietic receptors, encoding genes; for identifying modulators.
Human CC chemokine LARC
Gene for the human CC chemokine LARC, encoded protein, antibodies, vectors; for immunotherapy.
SmithKline BeechamEPO 838 523 & 838 524
Genes for RsbW-1 and RsbV-1 polypeptides, encoded peptides, antago-nists; for treating Staphylococcus infections.
SmithKline BeechamEPO 838 525
Genes for greA polypeptides, encoded peptides, antago-nists, production method; for treating Staphylococcus infections.
SmithKline BeechamEPO 839 908
Human ELF3 gene
Gene for human ELF3, encoded protein, production method; for treating various cancers.
SmithKline BeechamEPO 839 910
Gene for Spo-rel, a Staphylococcus relA/spot homolog, encod-ed protein, antagonists; for diagnosis and therapy.
Reduced protoporphyrin hemoglobin
Reduction of protoporphyrin IX in recombinant hemoglobin solutions by overexpressing the hemH gene.
South Florida, Univ. ofWO 98/17782
Alzheimer's transgenic model system containing genes for amyloid precursor protein and presenilins.
Signal transduction diseases
Redwood City, Calif.
Gene for RDGB proteins, encoded proteins; for diagnosis and treatment of signal transduction pathway diseas-es.
Sunol Molec. SystemsWO 98/17792
Computer designed antibodies
Computer-based methods for designing antibodies with en-hanced affinity for binding proteins such as prothrombin.
Swiss Cancer Res. Inst.EPO 839 915
Mucosal vaccine delivery
Secretory immunoglobulin A antibody linked to an antigen, encoding gene; for inducing mucosal immunity.
Takara ShuzoWO 98/17808
Leukemia-associated protein kinase
Receptor type protein kinase gene with a membrane region tandem duplication, encoding gene; for leukemia diagno-sis.
Targeted GeneticsWO 98/17806
E1A minigene tumor suppressors
Functional domains of E1A proteins, encoding minigenes; for suppressing transformation.
Texas A&M Univ.WO 98/16630
Germ cells for transgenics
College Stn., Texas
Methods for isolating and culturing primordial germ cells; for making non-rodent transgenics.
Utah, Univ. ofWO 98/16653
Salt Lake City, Utah
Rapid isolation of intact plasmid DNA from bacterial ly-sates.
Washington Univ.WO 98/17682
Cell death muteins
St. Louis, Mo.
Serine-substituted muteins of Bcl-xl/Bcl-2 associated cell death regulators, encoding genes; for decreased apoptosis.
Yale Univ.WO 98/17827
Eukaryotic Rad52 proteins
New Haven, Conn.
Genes for eukaryotic Rad52 proteins, gene complexes, encoded proteins.
ZenecaGB 2 318 791
mRNA abundance assay
Single-stranded DNA probes immobilized to a solid support; for measuring the abundance of mRNAs and DNAs.
Insulin homolog genes
Genes for insulin homologs located on chromosome 12, encoded proteins, antibodies.
Fibroblast growth factor homologs
Gene for z fibroblast growth factor (zFGF)-5, encoded pro-tein, antibodies; for treating cardiac conditions.