Published April 1 & 8 (EPO); March 26 & April 2 (WO); April 8 (GB)
American Cyanamid WO 98/13501
Mononegavirales virus vaccines
Recombinant RNA mononegavirales viruses with attenuating mutations in the 3' genomic promoter region; for vaccines.
Angeletti Molec. Biol. Inst. WO 98/12308
Soluble hepatitis protease fragments
Process for preparing and purifying soluble peptide fragments of the hepatitis C NS3 serine protease.
Angeletti Molec. Biol. Res. Inst. WO 98/13383
Adenoviral vectors encoding human interleukin (IL)-6 muteins with antagonist activity; for therapy.
Bailey, J.E., et al. WO 98/12913
Globin producing plants
Transgenic plants with inserted genes and enhanced growth characteristics; for producing globins.
Barcelona Free Univ. WO 98/12317
Metalocarboxypeptidase inhibitors, natural protein variants, and peptidomimetics; for use as antitumor agents.
Bavarian Nordic Res. Inst. WO 98/13500
Dengue virus vaccine
Recombinant MVA virus vectors expressing dengue virus antigens; for vaccines.
Biomec Technol. Transfer WO 98/12320
Gene expression control
Vector encoding a fusion of a stat protein and an activated nuclear receptor; for controlling gene expression.
British Biotech Pharma WO 98/13495
Human RANTES muteins
Muteins of human RANTES that aggregate less under physiological conditions and are less pro-inflammatory.
California, Univ. of WO 98/11779
Intestinal cell transfection
Oral administration of a gene for transfection of intestinal cells; for gastrointestinal delivery of therapeutics.
Calif. Inst. Technol. WO 98/13491
Genes for neurogenins, encoded proteins, antibodies; for therapeutics.
Case Western Res. Univ. WO 98/12316
Repeat sequence cloning
Method for stably cloning large repeating DNA sequences, especially alpha satellite DNA.
Cedars-Sinai Med. Ctr. WO 98/12323
Congenital heart disease protein
Gene for congenital heart disease protein, encoded protein, antibodies; for therapeutics.
Ctr. Blood Res. WO 98/12324
Monocyte chemotactic protein 5
Gene for monocyte chemotactic protein 5; for screening assays, diagnostics, and therapeutics.
Chiron EPO 832 980
Prodrug conversion vector
Recombinant viral vectors having a gene mediating prodrug conversion; for treating infections.
Chiron WO 98/12332
Treating intracellular pathogens
Treating intracellular infections using vaccines containing an antigen derived from the intracellular pathogen.
Chiron WO 98/12337
Gene function analysis
Random and targeted promoter integration; for analyzing gene function in cells and organisms.
Cold Sp. Harb. Labs WO 98/12339
Cold Sp. Harb., N.Y.
Replication-deficient retroviral vectors, packaging cell lines; for elucidating gene function.
Corixa EPO 834 567
Babesia microti antigens
Genes for Babesia microti antigens, encoded proteins, antibodies; for diagnosis and vaccine preparation.
Cornell Univ. WO 98/12341
Kaposi's herpesvirus propagation
Epstein-Barr virus-free lymphoma cell line having Kaposi's sarcoma-associated herpesvirus; for viral propagation.
Creative Biomolecules WO 98/13509
Bone morphogenesis gene
Gene expressed during mammalian tissue, particularly bone, morphogenesis; for identifying analogs for therapy.
Dana-Farber Cancer Inst. WO 98/13508
Gene therapy targeting cancers
Vectors with E2F transcription factor responsive promoters; for gene therapy that targets cancer cells.
Diagnocure WO 98/12227
Carcinoma antigen antibodies
Recombinant single chain antibodies directed against the gp54 carcinoma antigen; for diagnostics and therapeutics.
DNAVec Res. WO 98/12336
Artificial mammalian chromosome
Artificial chromosome with a centromere and DNA replication origin as well as telomeres added by host yeast cells.
Duke Univ. WO 98/12310
Apparatus and method for transfecting cells by electroporation.
Eisai EPO 834 740
Antibodies that can discriminate between osteocalcin and osteocalcin with glutamine as its 17th amino acid residue.
Favre, D. WO 98/12315
Cell-free translation extract
Efficient translation of mRNAs in a cytoplasmic extract from eukaryotic cells cultured in monolayers.
Fujita Hlth. Univ. EPO 834 562
Gene for a calpain inhibitor, encoded protein, production method.
Garvan Inst. Med. Res. WO 98/12303
Neuronal cell culture
Separation of neuronal and glial cells and methods for subsequent cell culture.
Genentech EPO 832 971
S. San Francisco
Derivatives of cell surface proteins homologous to the immunoglobulin superfamily; for treating HIV infection.
Genetics Inst. WO 98/12322
Bone morphogenic protein-16
Gene for bone morphogenic protein-16, encoded protein; for treating bone diseases and inducing cell growth.
Geron GB 2 317 891
Telomerase reverse transcriptase
Menlo Park, Calif.
Gene for the reverse transcriptase subunit of human telomerase, encoded protein, antibodies; for cancer and ageing.
Graham, F.L., et al. WO 98/13510
High capacity adenoviral vectors
Helper-dependent vector system; for producing high capacity adenoviral cloning vectors.
Harvard Univ. WO 98/12326
Genes for hedgehog-interacting proteins, encoded proteins; for modifying hedgehog-mediated induction.
Harvard Univ. WO 98/13494
Wilms' tumor binding proteins
Wilms' tumor WT1 binding proteins, assay for modulators; for controlling cell growth and differentiation.
Hoffmann-La Roche EPO 834 572
DAB transfection carriers
Alpha- and gamma-diaminobutyric acid (DAB) containing oligopeptides; for use as nucleic acid carriers in transfection.
Human Genome Sciences WO 98/12204
B cell translocation genes
Human B cell translocation genes, encoded proteins, vectors, host cell expression system.
Human Genome Sciences WO 98/12344
TNF receptor homologous genes
Genes for receptors having homology to type 2 tumor necrosis factor (TNF) receptor, encoded proteins, expression system.
Icos WO 98/13502
Protein binding disruption
Methods for identifying compounds that disrupt protein-protein interactions between known binding partners.
Idun Pharma WO 98/12328
Human Bad proteins
La Jolla, Calif.
Genes for human Bad proteins and functional fragments; for screening modifiers and affecting cell viability.
Incyte WO 98/12220
Human tumor proteins
Palo Alto, Calif.
Genes for human tumor proteins, antisense, encoded proteins, expression system; for treating cancer.
Incyte WO 98/12223
Palo Alto, Calif.
Genes for a human interferon-inducible protein, antisense, encoded protein, expression system.
Incyte WO 98/12325
GTP binding protein gamma-3
Palo Alto, Calif.
Gene for human GTP binding protein gamma-3, encoded protein, antibodies, expression system; for identifying modifiers.
Incyte WO 98/13484
Palo Alto, Calif.
Genes for human cathepsins, encoded proteins, antibodies, antisense, expression system; for diagnosis and therapy.
Kansas St. Univ. WO 98/12319
Broad spectrum therapeutic peptides from Staphylococcus; for antibacterials.
KM Biotech WO 98/13492
Genes for motoneurotrophic factors, encoded proteins, expression systems; for axonal regeneration.
Knappe, A., et al. WO 98/12330
Gene for a mammalian cytokine, encoded protein, antibodies; for diagnostics and therapeutics.
Leiden St. Univ. EPO 834 561 & WO 98/13490
Brain-specific calcium channel subunit and related migraine and neurological disorder genes on chromosome 19.
Ludwig Inst. Cancer Res. WO 98/13374
Tumor rejection antigen
Gene for a tumor rejection antigen, encoded protein; for cancer diagnostics and therapeutics.
Lxr Biotech WO 98/13493
Genes for the apoptosis-related SARP polypeptide, encoded protein, antibodies; for diagnostics and therapeutics.
Mass. Gen. Hosp. WO 98/12207
High synthetic gene expression
Synthetic gene with a less preferred amino acid codon replaced by a preferred codon; for high level expression.
Mass. Gen. Hosp. WO 98/12311
Baculovirus vector system
Baculovirus expression vector for transfecting recombinant genes into mammalian cells.
Max Planck Inst. WO 98/13489
Genes for tumor suppressors, encoded proteins, antibodies, antisense, production methods; for cancer treatment.
Maxygen WO 98/13485 & 13487
Gene therapy optimization
Santa Clara, Calif.
Optimization of expression vector performance by recursive sequence shuffling and selection; for gene therapy.
McGill Univ. WO 98/13507
Tumor-specific promoter Hex II, vectors incorporating the promoter; for targeted gene therapy.
Millennium Pharma WO 98/12302
Weight control genes
Genes for Tub interactor polypeptides of the weight control pathway, encoded proteins; for diagnosis and therapy.
MRC (Med. Res. Counc.) WO 98/12304
Hematopoietic stem cell culture
An in vitro cell culture system for the expansion of hematopoietic stem cells.
MRC (Med. Res. Counc.) WO 98/13496
Chaperone protein fragments
GroEL chaperone protein fragments, muteins, and modifications that retain activity.
NIH (Natl. Inst. Hlth.) WO 98/11914
Targeting antigens for vaccines
Targeting antigens to the MHC Class I processing pathway with an anthrax toxin fusion protein; for vaccines.
NIH (Natl. Inst. Hlth.) WO 98/13511
Retroviral vector packaging
Retroviral vectors with recombinant genes amplified by autocatalytic togavirus vectors in the cell cytoplasm.
Novartis WO 98/13499
Adenoviral packaging cells
Packaging cell lines for developing high capacity adenoviral vectors; for gene therapy.
Novo Nordisk WO 98/12300
Recombinant protein production
Expression system host cells having reduced levels of metalloprotease and alkaline protease; for producing proteins.
Ontogeny WO 98/12306
Hematopoietic stem cell generation
Viable stem cells obtained from an animal donor and transfected with a hematopoietic gene; for making stem cells.
Pharming EPO 832 981
Therapeutics secreted in milk
Vectors having enhancer sequences that can target transgenic gene expression to milk; for efficient secretion.
Reed, G.L. WO 98/12329 & 12334
Fibrinolysis enhancement using chimeric, humanized, and single chain antibodies to *-2-antiplasmin; for stroke.
Salk Inst. WO 98/12314
Quiescent cell transfection
La Jolla, Calif.
Retroviral vectors modified to be recognized by the nuclear import machinery of a non-dividing cell; for transfection.
Schering WO 98/13488
Cellular model systems used to determine amyloid precursor protein secretase activity; for Alzheimer's disease.
Shanghai Inst. Cell Biol. GB 2 317 890
Liver cancer antibodies
Radiolabelled mouse monoclonal antibody directed against primary liver carcinomas; for cancer therapy.
SmithKline Beecham EPO 832 973
Gene for a GTP-binding protein, encoded protein, production methods; for screening antibacterials.
SmithKline Beecham EPO 832 975
Gene for Staphylococcus aureus histidinol dehydrogenase, encoded protein; for screening antibacterials.
SmithKline Beecham EPO 832 977
Gene for sugar kinase, encoded protein, production methods; for screening antibacterials.
SmithKline Beecham EPO 832 978
Gene for 3-dehydroquinate synthase, encoded protein, production methods; for screening antibacterials.
SmithKline Beecham EPO 834 563
Human 7-transmembrane receptor
Gene for a human 7-transmembrane receptor, encoded protein, production methods; for treating infections.
SmithKline Beecham EPO 834 564
Mouse CC-CKR5 receptor
Gene for the mouse CC-CKR5 receptor, encoded protein, production methods; for knockouts modeling HIV infection.
SmithKline Beecham EPO 834 565
G-protein coupled receptor
Gene for human G-protein coupled receptor, encoded protein, production method; for treating infections.
SmithKline Beecham EPO 834 568
Saliva binding protein
Gene for a saliva binding protein, encoded protein; for screening antagonists, diagnosis, and therapy.
Spinal Cord Soc. WO 98/12305
Stable neuronal transfection
Fergus Falls, Minn.
Transfection of neurons with genes for proliferation cell nuclear factor, replication factor C, and a therapeutic.
Suntory WO 98/12313
Nitric oxide synthase inducers
Vector with inducible nitric oxide synthase control region linked to a reporter gene; for identifying inducers.
TDK EPO 834 560
Magnetic particle-bound proteins
Recombinantly produced proteins that bind to bacterial magnetic particles; for ease of purification.
Texas, Univ. of WO 98/11916
Defective virus for vaccines
Defective interfering virus particle with a naturally occurring core antigen internal deletion; for vaccines.
Texas, Univ. of WO 98/12327
BRCA1 gene binding proteins
Genes for proteins that bind the BRCA1 gene, encoded proteins; for cancer-related diagnostics and therapeutics.
Vanderbilt Univ. WO 98/12312
Viral antisense therapy
Antisense gene therapy for inhibition of RNA virus replication in the cell cytoplasm.
Vanderbilt Univ. WO 98/13473
Yeast production system
Yeast cell production system that has a modified signal peptidase complex; for recombinant protein expression.
Viromedica Pacific WO 98/12338
Gene therapy retroviral vectors
Seoul, S. Korea
Retroviral vectors for gene therapy with deleted gag and env genes; for high titer and increased gene expression.
Virus Res. Inst. WO 98/12205
Bacterial transcriptional regulators
Genes encoding mature transcriptional regulators from Enterococcus faecalis.
Washington Univ. WO 98/12309
Matrix metalloprotease inhibitors
St. Louis, Mo.
Interaction of matrix metalloprotease inhibitor TIMP-2 with gelatinase A as an assay for identifying other inhibitors.
Wisconsin, Univ. of WO 98/12318
Thrombin inhibitor made from parts of the fibrinogen gamma chain connected with a linker group.