Published February 4 & 11 (EPO); January 29 & February 5 (WO)

American Cyanamid WO 98/04703 Haemophilus vaccines Madison, N.J. An antigenic protein from Haemophilus influenzae, encoding gene; for vaccines.

Arch Develop. WO 98/04709 Apoptosis inhibiting protein Chicago Herpes simplex virus protein involved in activation of viral genes, encoded protein; for inhibiting apoptosis.

Astra Pharma WO 98/03548 Galanin receptor-2 Mississauga, Ontario Gene for galanin receptor-2, encoded protein; for diagnostics and therapeutics.

Bayer WO 98/03654 IL-4 muteins Pittsburgh Human interleukin (IL)-4 muteins, encoding gene, antibodies, expression system; for therapeutics.

Behring Diagnostics WO 98/03657 Viral IL-6 Marburg, Germany Viral interleukin (IL)-6 obtained by recombinant expression of human herpesvirus type-8 DNA; for therapy.

Biogen WO 98/04589 Gelsolin production Cambridge, Mass. Production of recombinant, oxidized gelsolin containing a disulfide bond in bacteria using refolding steps.

Biopharm WO 98/04688 Dopaminergic neuron survival promoters Heidelberg, Germany EGF-like and glia cell-derived neurotrophic factors, encoding genes; for promoting survival of dopaminergic neurons.

Bristol, Univ. of WO 98/03059 Galanin transgenic knock outs Bristol, U.K. Transgenic animals in which the galanin gene has been inactivated; for developing pain suppression therapeutics.

Cantab Pharma Res. WO 98/04706 Papillomavirus vaccines Cambridge, U.K. Fusions and aggregates of papillomavirus-derived antigens; for vaccines.

Ctr. Clin. & Basic Res. WO 98/04287 Bone loss prevention Ballerup, Denmark Peptide antagonists, antibodies, and antisense for membrane-type matrix metalloproteinases; for preventing bone loss.

Chiron Behring WO 98/04702 Ulcer therapeutics Marburg, Germany Helicobacter pylori membrane proteins or those firmly associated with membranes; for treating ulcers.

Choi, Y., et al. WO 98/04719 Immunosuppressive biovector Kyonggi-do, S. Korea Immunosuppressive biovector that inhibits the immune system of a transfected host.

Chugai WO 98/03663 TGF-b activated kinase Tokyo Human transforming growth factor (TGF)-b activated kinase, encoding gene.

Cold Sp. Harb. Labs WO 98/04712 Mutated protein tyrosine phosphatases Cold Sp. Harb., N.Y. Protein tyrosine phosphatases with a mutated aspartate residue, encoding gene; for catalytic attenuation.

Columbia Univ. WO 98/04576 Kaposi's herpes peptides New York Genes encoding Kaposi's sarcoma-associated herpesvirus peptides, isolated peptides, antibodies; for vaccines.

Day, R., et al. WO 98/04686 Prohormone convertase Sainte-Dorothee, Quebec Human prohormone convertase, encoding gene, antisense; for treating HIV and stopping cell growth.

Duke Univ. WO 98/03551 CD6 ligand Durham, N.C. CD6 ligand, fragments, antibodies to them; for inhibiting the interaction between the ligand and CD6.

Forsyth Dental Infirm. WO 98/03651 Osteoclast genes Boston Osteoclast-specific and -related gene sequences, methods of identifying related genes.

Fujisawa Pharma WO 98/03645 Membrane protein gene cloning Osaka, Japan Cloning method for membrane protein genes that does not use antibodies to or ligands of the protein.

Gardella, T.J., et al. WO 98/04591 Parathyroid hormone receptor agonists Cambridge, Mass. Mutated parathyroid hormone-related peptide analogs that act as parathyroid hormone receptor agonists and antagonists.

Genetics Inst. WO 98/04693-04696 Secreted protein genes Cambridge, Mass. Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

German Hlth. & Welfare Inst. WO 98/04592 Bispecific antibody production Oberscleissheim, Germany Simplified and cost-effective production of bispecific antibody fragments.

Gold, R., et al. WO 98/03647 Myelin for autoimmunity Wurzburg, Germany Use of recombinant myelin protein for treating T cell-mediated autoimmune disease of the peripheral nervous system.

Hagenmaier, H. WO 98/03676 Protein-protein interaction assay Tubingen, Germany Process for detecting effectors of intra- and intercellular protein-protein interactions, assay protein genes.

Hybridon WO 98/03646 Disease treatment oligos Worcester, Mass. Methods for administering oligos that down-regulate expression of genes involved in human diseases.

Incyte WO 98/03665 Human kallikrein Palo Alto, Calif. Gene for human kallikrein, antisense, encoded protein, antibodies, antagonists, expression system.

Incyte WO 98/04585 Human macrophage antigen Palo Alto, Calif. Gene for human macrophage antigen, encoded protein, antibodies, antagonists; for diagnostics and therapeutics.

Incyte WO 98/04691 Human proteolipid Palo Alto, Calif. Gene for a human proteolipid, encoded molecule, antibodies, antagonists; for diagnostics and therapeutics.

Incyte WO 98/04692 Neuronatin Palo Alto, Calif. Gene for a human neuronatin, encoded protein, antibodies, antagonists; for diagnostics and therapeutics.

Incyte WO 98/04714 mRNA editing enzyme Palo Alto, Calif. Human mRNA editing enzyme, encoding gene, antisense, inhibitors; for diagnostics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 98/03653 Transplant rejection treatment Paris Genes for antibodies to graft-vs.-host reaction antibodies, encoding genes; for treating transplant rejection.

Japan Tobacco EPO 823 477 Phospholipase D antisense Tokyo Antisense to the phospholipase D gene; for modifying the phospholipid composition of cells and organisms.

Johns Hopkins Univ. WO 98/04284 Kaposi's herpes genes Baltimore Genes from Kaposi's sarcoma-associated herpesvirus type 8, encoded proteins.

Lilly EPO 822 257 & WO 98/04721 Streptococcus therapeutics Indianapolis Genes encoding enzymes for stem peptide biosynthesis in Streptococcus pneumoniae; for making anti-infectives.

Lilly WO 98/03642 ICE-related protease Indianapolis Interleukin-1b converting enzyme (ICE)-related protease gene, encoded protein; for apoptosis inhibitor screen.

Manitoba, Univ. of WO 98/04274 Mosquito allergen immunotherapy Winnipeg, Manitoba Recombinant mosquito salivary allergen, encoding gene, antibodies; for skin testing and immunotherapy.

Maryland, Univ. of WO 98/03206 Mouse butyrophilin gene College Park, Md. Mouse butyrophilin gene; for expressing recombinant proteins in the milk of transgenic animals.

Mass. Gen. Hosp. WO 98/03549 Melatonin 1a receptor promoter Boston Promoter sequences from the melatonin 1a receptor; for screening transcriptional activators.

MRC (Med. Res. Counc.) WO 98/04707 & 04708 Herpesvirus vaccines London Herpesvirus antiviral agents and peptidomimetics that inhibit DNA replication; for vaccines.

MRC (Med. Res. Counc.) WO 98/04726 Herpes nerve infections London Herpesvirus strains lacking specific functional genes; for treating nervous system infections.

Merlin Diagnostics WO 98/03871 Microsporidia infection assay Bornheim, Germany Microsporidia antigens, antibodies to them, and encoding genes; for infection detection.

Michigan St. Univ. WO 98/04736 Urea assay E. Lansing, Mich. Mutant urease from Klebsiella aerogenes having low substrate affinity; for measuring urea in body fluids.

Millennium WO 98/04590 Conservins Cambridge, Mass. Conservins, members of the TGF-b superfamily, encoding genes; for diagnostics and therapeutics.

Minnesota, Univ. of WO 98/03656 Salmonella infection detection Minneapolis Truncated, recombinant SEF14 fimbria antigen from Salmonella enteritidis; for infection diagnosis.

Mt. Sinai Sch. Med. WO 98/04683 & 04697 Tumor suppressor gene New York Class II tumor suppressor gene down-regulated at the mRNA level by oncogenes in transformed cells.

New York Univ. WO 98/04587 Tubulin folding mediators New York Protein cofactors that mediate a- and b-tubulin folding, encoding genes; for identifying folding inhibitors.

NIH (Natl. Inst. Hlth.) WO 98/03652 Histone acetylating protein Bethesda, Md. p300/CBP-associated protein that acetylates histones, encoding gene; for transcription modulator screen.

NIH (Natl. Inst. Hlth.) WO 98/03669 RNase cell transformation vectors Bethesda, Md. Cell transformation vectors encoding RNases, transfected cells; for inhibiting viruses and cancer growth.

NIH (Natl. Inst. Hlth.) WO 98/04717 Cell growth inhibition Bethesda, Md. Double-stranded RNA-dependent protein kinase-derived peptide antagonists, encoding gene; for inhibiting cell growth.

Nika Universal WO 98/04731 Protein drug activation method Moscow Methods for producing active protein precursors linked to a processing protease; for therapeutics.

Novartis WO 98/03644 Alzheimers transgenics Basel, Switzerland Transgenics having both amyloid- and tau-related features of Alzheimers as well as appropriate behavioral changes.

Novartis WO 98/04718 Fusion peptides for allergies Basel, Switzerland Fusion polypeptides with immunoglobulin E binding and human serum albumin domains; for allergic diseases.

Ortho Pharma WO 98/04285 CMV antigen presentation genes Raritan, N.J. Human cytomegalovirus (CMV) genes encoding proteins essential for MHC class-1 mediated antigen presentation.

Pangenetics WO 98/03670 T cell tolerance induction Amsterdam, Netherlands Antibody or trispecific diabody that binds to CD40, 80, and/or 86; for inducing T cell tolerance.

Pasteur Inst. WO 98/04698 CXCR4 receptor ligand chemokine Paris LESTR/fusin/CXCR4 receptor ligand chemokine, derivatives; for treating or preventing HIV viral infections.

Pasteur Inst. WO 98/04711 Mycobacterial diagnostic Paris Desaturase antigen of Mycobacterium tuberculosis, encoding gene; for diagnostics.

Peptide Therapeutics WO 98/03543 & 03544 HSV diagnostics antigens Cambridge, U.K. Epitopes from phage display libraries expressing Herpes simplex virus (HSV)-2 glycoprotein G; for diagnostics.

Pharmacia & Upjohn WO 98/03649 Cyclin E Kalamazoo, Mich. Constructs and complexes of human cyclin E; for influencing cell cycle events.

Rockefeller Univ. WO 98/03197 HTLV antigens and vaccines New York Protein antigens derived from human T cell leukemia virus (HTLV); for vaccines and other therapeutics.

SBL Vaccine WO 98/04588 Lymphocyte stimulating factor Stockholm, Sweden Lymphocyte stimulating factor from sleeping sickness trypanosomes, encoding gene, antibodies; for vaccination.

Searle WO 98/04286 Herpesvirus vaccine Chicago Assembly-deficient herpesvirus that is not virulent but can generate a protective immune response.

Sloan-Kettering Inst. WO 98/04720 DNA vaccines New York DNA vaccines having sequences encoding antigens and cell sorting signals; for activating the immune system.

SmithKline Beecham EPO 823 478 Human cartilage gene Philadelphia Human cartilage gp 39-like gene, encoded protein, antagonists; for diagnostics and therapeutics.

SmithKline Beecham WO 98/03534 CGRP receptor component factor King of Prussia, Pa. Human calcitonin gene-related peptide (CGRP) receptor component factor, encoding gene, production method; for therapy.

SmithKline Beecham WO 98/03539 G-protein coupled receptor King of Prussia, Pa. Gene for a G-protein coupled receptor, encoded protein, antagonists; for diagnosis and therapy.

SmithKline Beecham WO 98/03643 Alzheimers transgenics Munich, Germany Human amyloid precursor peptide gene mutations; for Alzheimers transgenics that develop amyloid plaques.

Takeda WO 98/03648 Fas ligand-like protein Osaka, Japan Gene for a Fas ligand-like protein, encoded protein, antibodies; for treating apoptosis-related diseases.

Therion Biologics WO 98/04727 & 04728 Pox virus tumor vaccines Cambridge, Mass. Recombinant pox viruses that express cell-encoded, tumor-associated antigens; for invoking immune responses.

Tokyo Metro Inst. Med. Sci. WO 98/03060 Hepatitis C animal model Tokyo Animals having hepatitis C virus cDNAs introduced into them; for developing diagnostics and therapeutics.

Transgene WO 98/04705 Papillomavirus infection therapy Strasbourg, France Late and early region papillomavirus proteins combined with an immunostimulator; for cancer therapy.

Urocor WO 98/04689 Prostate cancer diagnostic probes Oklahoma City Genetic probes for the presence of prostate cancer-specific RNA species; for diagnostics.

Washington Univ. WO 98/03650 Ninjurin proteins St. Louis Ninjurin proteins, cellular adhesion proteins expressed in a variety of tissue types, encoding gene.

Wellcome Fdn. EPO 822 255 Antibodies from CHO cells Greenford, U.K. Antibodies produced in CHO cells using heavy and light chain vectors and having glycosylation patterns of these cells.

Whitehead Inst. WO 98/04704 Class II transcription inhibitor Cambridge, Mass. Eukaryotic global negative regulator of class II transcription, encoding gene; for transcription repression.

Winger, E.E. WO 98/04738 Target sequence identification Alameda, Calif. Real-time homogeneous nucleotide assay with sequential measurement of fragments characterizing target sequences.

Wisconsin, Univ. of WO 98/03545 Chemoprotective gene regulators Madison, Wis. Set of seven nuclear proteins that bind to the antioxidant response element of the genes of chemoprotective enzymes.

Wisconsin, Univ. of WO 98/04734 Protein folding catalysts Madison, Wis. Small molecular weight dithiols used as substitutes for protein folding catalysts.

Yamanouchi Pharma WO 98/04580 Optimizing therapeutic peptides Tokyo Synthesis and assay of randomly generated peptides; for producing proteins with enhanced biological activity.

— Compiled by Chester A. Bisbee