Published January 21 & 28 (EPO); January 15 & 22 (WO)

Akzo Nobel WO 98/02538 Melanoma vaccines Arnhem, Netherlands Melanoma-associated peptide analogues recognized by tumor infiltrating lymphocytes; for vaccines.

Amgen WO 98/01555 Soluble TNF type I/II receptors Thousand Oaks, Calif. Truncated, soluble tumor necrosis factor (TNF) type I and II receptors, encoding genes, production methods.

Asahi EPO 819 763 Acarid allergen Tokyo Gene for the main acarid allergen, encoded allergen, mutated allergen; for treating allergic diseases.

Asahi WO 98/02458 Differentiation inhibiting protein Osaka, Japan Gene for a human serrate-2 polypeptide, encoded protein, antibodies; for inhibiting differentiation.

Barcelona Free Univ. EPO 820 773 Glucokinase diabetes treatment Bellaterra, Spain Gene for glucokinase; for expressing a therapeutically effective amount of the enzyme in a diabetic patient.

Beth Israel Deaconess Med. Ctr. WO 98/01556 Hematopoietic-specific LAPTMS Boston Hematopoietic-specific, lysosomal-associated multispanning membrane protein (LAPTMS) that interacts with ubiquitin.

Beth Israel Deaconess Med. Ctr. WO 98/01580 Hereditary atopy diagnosis Boston Gene for HTm4 protein, encoded protein, expression system; for detecting hereditary atopy.

Branton, P.E., et al. WO 98/01563 Apoptotic adenovirus E4 proteins St. Lambert, Quebec Adenovirus E4 proteins and their analogues, encoding proteins; for inducing cell death.

California, Univ. of WO 98/01542 Human telomerase gene Oakland, Calif. Human telomerase gene, probes, encoded protein, functional derivatives, antibodies; for diagnosis and therapy.

California, Univ. of WO 98/02539 Disease-associated chromosome 20 region Oakland, Calif. Gene sequences from a disease-associated, amplified region of chromosome 20; for diagnosis and therapy.

Cambridge Antibody Technol. WO 98/01757 Biotinylated CEA ligands Royston, U.K. Method of biotinylating antibodies and ligands that bind carcinoembryonic antigen (CEA), for label enhancement.

CNRS (Natl. Ctr. Sci. Res.) WO 98/01579 Protein interaction assay Paris Vectors with indicator genes having mutated or normal control regions; for detecting protein-protein interactions.

CNRS (Natl. Ctr. Sci. Res.) WO 98/02534 Opiate receptor transgenics Paris Transgenic animals with modified opiate receptor gene expression in neuronal tissues; for testing therapeutics.

Children's Hosp. Med. Ctr. WO 98/02577 Gene and product detection Boston Methods of simultaneously detecting and visualizing a transfected gene and its product in a cell.

Chugai WO 98/02543 VEGF-like proteins Niihari, Japan Genes for vascular endothelial cell growth factor (VEGF)-like proteins, encoded proteins; for treating cancer.

Connaught Labs WO 98/01559 Mycobacterial vaccines N. York, Ontario Genes for mycobacterial proteins associated with cell binding and entry, encoded proteins; for vaccines.

Curie, Univ. Pierre & Marie WO 98/02529 Productive viral packaging lines Paris Highly productive packaging cell lines that make defective viruses needing complementation functions.

DNA Vec Res. WO 98/01027 Embryo gene electroporation Tsukuba, Japan In vivo electroporation of genes with a reporter function into undifferentiated cells in early animal embryos.

Fred Hutchinson Cancer Res. Ctr. WO 98/01755 Cytoskeletal dynamics proteins Seattle Genes for proteins involved in cytoskeletal dynamic events, encoded proteins; for therapeutic evaluation.

Genentech WO 98/01564 HIV breakthrough strain vaccines S. San Francisco HIV envelope protein genes from breakthrough isolates from vaccine trials, encoded proteins, antibodies; for vaccines.

Genentech WO 98/02540 Chimeric heteromultimer adhesins S. San Francisco Chimeric heteromultimer adhesins that are extracellular ErbB domains and antagonists of neuregulin; for cancer therapy.

Genentech WO 98/02541 Gamma-heregulin S. San Francisco Gene for gamma-heregulin, antisense, encoded protein, antibodies; for growth control in tumors.

Genetics Inst. WO 98/01469, 01552-01554 Secreted protein genes Cambridge, Mass. Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

German Hlth. & Welfare Inst. EPO 821 060 Tumor therapy E-cadherin antibodies Oberschleissheim, Germany Monoclonal antibodies against mutations of E-cadherin, for tumor diagnosis and therapy [in German].

Hayashibara Seibutsu EPO 819 757 & 821 005 IFN-gamma inducing peptide Okayama, Japan Interleukin-1b converting enzyme that activates an interferon (IFN)-gamma inducing polypeptide, production method.

Hisamitsu Pharma EPO 819 701 AAV purification Tosu, Japan Monoclonal antibodies against adeno-associated virus (AAV) CAP protein; for gene therapy vector purification.

Immunex WO 98/01538 Antigen-pulsed dendritic cells Seattle Antigen-expressing, activated dendritic cells; for stimulating immune responses against various antigens.

Incyte WO 98/01566 Ubiquitin-conjugating enzyme Palo Alto, Calif. Gene for a human ubiquitin-conjugating enzyme, probes, antisense, encoded protein, antagonists, antibodies.

Incyte WO 98/02456 Human C-type lectin Palo Alto, Calif. Gene for a human C-type lectin, encoded protein, antisense, expression system; for diagnostic assays.

Incyte WO 98/02459 Monocyte chemotactic proprotein Palo Alto, Calif. Human monocyte chemotactic proprotein, encoding genes, antibodies, antagonists; for diagnostic assays.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 98/02455 Nuclear transcriptional mediator Paris Gene for a nuclear receptor transcriptional mediator, encoding gene, antibodies; for identifying antagonists.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 98/02547 Meningitis therapeutics Paris Genes for Neisseria meningitidis antigens, encoded proteins, antibodies; treating meningitis.

Intellivax WO 98/01558 Mucosal immunity induction Baltimore Peptide antigens, hydrophobic materials, and immunopotentiating membrane carriers; for inducing mucosal immunity.

Janssen Pharma WO 98/02544 IL-12 gene regulatory sequences Boerse, Belgium Interleukin (IL)-12 gene regulatory sequences, vectors, expression system; for identifying IL-12 modulators.

Julien, J.-P., et al. WO 98/02036 Neurodegeneration transgenics Montreal Transgenic animal model having inactivated neuronal intermediate filament genes; for studying neurodegeneration.

Manchester, Univ. of WO 98/01560 Modified protein G antibodies Manchester, U.K. Modified protein G and fragments that selectively bind antibodies when compared to unmodified forms.

Manitoba, Univ. of WO 98/02546 Chlamydia DNA immunization Winnipeg, Manitoba Nucleic acid immunization to Chlamydia using the gene for the major outer membrane protein.

Massachusetts, Univ. of WO 98/02576 Individual gene transcription Boston In situ hybridization methods that can effectively distinguish a gene and its transcribed RNA.

Max Delbruck Ctr. Molec. Med. WO 98/01539 Cellular tumor vaccine Berlin Conditional immortalization process using retroviruses for tumor cells isolated from patients; for vaccines.

Max Planck Inst. WO 98/01551 Tyrosine kinase-associated protein-1 gene Munich, Germany Tyrosine kinase-associated protein-1 gene, encoded enzyme, antibodies; for diagnosis and therapy.

MRC (Med. Res. Counc.) WO 98/02559 Protein production mutants London Selection of cell mutants resistant to toxicity from recombinant protein over-expression; for protein production.

Mixson, A.J. EPO 819 758 Cationic transfection complexes Rockville, Md. Cationic vehicles for transfection; for treating endothelial cells with anti-angiogenic peptides or tumor suppressors.

Morphosys WO 98/02462 Modified immunoglobulin domains Martinsreid, Germany Modified immunoglobulin superfamily domains, encoding genes; for improving solubility, yield, and handling.

Mt. Sinai Hosp. WO 98/01548 Receptor tyrosine kinase modulation Toronto Complex of oligomerized Elk-related receptor tyrosine kinase and a transmembrane ligand; for modulating its activity.

Mt. Sinai Sch. Med. WO 98/01562 Mismatched DNA binding proteins New York Thermostable protein that enhances binding of a thermostable mismatch binding protein to bulge loops in mismatched DNA.

Mt. Sinai Sch. Med. WO 98/02525 Pituitary differentiation factor New York Pituitary differentiation factor, encoding gene; for treating breast and prostatic cancer.

NIH (Natl. Inst. Hlth.) WO 98/01574 Cloning in yeast Bethesda, Md. Methods of producing yeast artificial chromosomes; for gene cloning and recombination.

NIH (Natl. Inst. Hlth.) WO 98/02530 Attenuated RSV vaccines Bethesda, Md. Attenuated respiratory syncytial virus (RSV) with temperature-sensitive and cold-adapted mutations; for vaccines.

NIH (Natl. Inst. Hlth.) WO 98/02548 Infectious papillomvirus pseudoparticles Bethesda, Md. Infectious papillomvirus pseudoviral particles; for gene therapy.

New Jersey, Univ. of Med. & Dent. WO 98/02542 IL-10 receptor subunit Newark, N.J. Interleukin (IL)-10 receptor subunit mediating intracellular signalling, encoding gene; for controlling cell function.

New Jersey, Univ. Med. & Dent. WO 98/02558 Cytokine response assays Newark, N.J. Chimeric receptors with a cytokine intracellular domain that interacts with Jak-Stat proteins; for response assays.

Novo Nordisk WO 98/01473 Insulin from yeast Bagsvaerd, Denmark Production of insulin and insulin analogue precursors and insulin-like peptides in protease-deficient yeast cells.

Promega WO 98/02537 Site-specific mutagenesis Madison, Wis. Site-specific mutagenesis and mutant selection using antibiotic resistance markers with altered substrate specificity.

Recombinant Biocatalysis WO 98/01581 Random gene generation La Jolla, Calif. Generation of random polynucleotides by blocking synthesis or amplification of specific sequences; for DNA shuffling.

Robarts Res. Inst. WO 98/02564 Herpes/Epstein Barr vectors London, Ontario Hybrid herpes/Epstein Barr virus vectors that can be encapsulated in an infectious particle; for gene therapy.

Rochester, Univ. of WO 98/01468 Growth-induced chondrocyte proteins Rochester, N.Y. Chondrocyte proteins expressed in areas of bone growth, encoding gene, antibodies; for treating arthritis.

Salerno, J.C. WO 98/02555 Nitric oxide synthase regulators Troy, N.Y. Regulatory peptides for constitutive nitric oxide synthases, encoding genes, peptidomimetics, antibodies.

Schering WO 98/01557 Chemokines Kenilworth, N.J. Chemokines, receptors, antibodies to them, encoding genes; for diagnosis.

Schering WO 98/02557 TNF-a convertases Kenilworth, N.J. Mammalian tumor necrosis factor (TNF)-a convertases, encoding genes, vectors, production methods.

Seikagaku Kogyo EPO 821 066 Glycosaminoglycan sulfotransferase Tokyo Human glycosaminoglycan sulfotransferase, encoding gene; for transferring sulfates to chondroitins and keratin sulfates.

Senapathy, P. WO 98/02575 Contiguous genome sequencing Wheaton, Ill. Contiguous PCR-based genome sequencing method for use with very long DNA segments.

Sidney Kimmel Cancer Ctr. WO 98/01123 Cancer cell apoptosis San Diego Apoptosis induction in cancer cells by treatment with inhibitors of DNA repair in combination with p53 gene therapy.

SmithKline Beecham EPO 821 061 CGRP receptor component factor Philadelphia Human calcitonin gene-related peptide (CGRP) receptor component factor, encoding gene, production method; for therapy.

SmithKline Beecham WO 98/01475 Insulin receptor isoform King of Prussia, Pa. Gene for growth factor receptor-binding insulin receptor isoform, encoded protein, production method.

Sumitomo Electric EPO 819 766 Leishmanial protozoa probes Osaka, Japan Polynucleotide probes for detecting various leishmanial protozoa in specimens; for diagnosis and therapy.

Takara Shuzo WO 98/02535 PCR site-directed mutagenesis Kyoto, Japan Site-directed mutagenesis using PCR amplification of vectors with genes inserted into target sequences.

Texas, Univ. of WO 98/01460 BRCA1 protein antibodies Austin, Texas Use of BRCA1 protein antibodies to localize the protein in vivo and in vitro; for breast cancer diagnosis.

Texas, Univ. of WO 98/01547 Chronic myelogenous leukemia antisense Austin, Texas Liposomal Grb2 and Crk1 gene, whose products interact with the tumorigenic protein bcr-abl, antisense preparations.

Toronto, Univ. of WO 98/01549 Presenilin gene mutations Toronto, Ontario Mutations of presenilin genes, encoded proteins; for identifying binding ligands and making transgenic models.

Tularik WO 98/01541 TRAF2-associated protein kinase S. San Francisco Tumor necrosis factor receptor-associated factor 2 (TRAF2)-associated protein kinase, encoding gene; for diagnostics.

Tularik WO 98/01543 Human telomerase gene S. San Francisco Human telomerase gene, probes, encoded protein, functional derivatives, antibodies; for diagnosis and therapy.

Utah, Univ. of WO 98/01740 Williams syndrome genes Salt Lake City Williams syndrome-associated elastin and LIM-kinase genes on chromosome 7; for diagnosis.

Utrecht Univ. WO 98/01550 Gastrointestinal nematode antigens Utrecht, Netherlands Genes encoding gastrointestinal nematode antigens, encoded proteins; for vaccine development.

Vanderbilt Univ. WO 98/01573 HIV gp41 infection enhancing domains Nashville Mutated antibody-dependent infection enhancing domains of HIV gp41; for modulating anti-HIV immune responses.

Wakunaga Pharma WO 98/02574 Gene mutation detection Osaka, Japan Solid-phase, amplification methods for determining gene mutations and polymorphisms.

Washington Univ. WO 98/01756 Mitosis-associated kinase St. Louis Human kinase involved in activation of mitosis-associated proteins, encoding gene; for controlling cell growth.

Wisconsin, Univ. of WO 98/02561 Yeast virus production Madison, Wis. Methods for synthesizing nucleic acid-containing, encapsulated, infectious viral particles in yeast.

Zymogenetics WO 98/02565 Yeast production strains Seattle Transformation of Pichia methanolica by recombinant vectors using electroporation; for commercial production.

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