| Company | Symbol | Exchange | Share Price** | Share Price** | Percent | ||||
| 12/31/96 | 12/19/97 | Change (%) | |||||||
| Les Laboratories Aeterna Inc. | AEL | M | 10.75 | 7.30 | -32 | ||||
| Algene Biotechnologies Corp. | AGN.B | T | 2.70 | 1.25 | -54 | ||||
| Allelix Biopharmaceuticals Inc. | AXB | T | 16.80 | 10.35 | -38 | ||||
| Alta Genetics Inc. | AGI | T | 3.50 | 4.25 | +21 | ||||
| AltaRex Corp. | AXO | T | 6.30 | 3.00 | -52 | ||||
| Axcan Pharma Inc. | AXP | M | 13.10 | 12.80 | -2 | ||||
| BioChem Pharma Inc.* | BCH | M | 34.42* | 34.40 | 0 | ||||
| Biomira Inc. | BRA | T | 6.65 | 3.20 | -52 | ||||
| Bioniche Inc. | BNC | T | 0.92 | 0.60 | -35 | ||||
| Biovail Corp. Int'l. | BVF | T | 34.85 | 53.25 | +53 | ||||
| Briana Biotech Inc. | BIA | V | 0.34 | 0.59 | +74 | ||||
| Cangene Corp. | CNJ | T | 2.10 | 2.60 | +24 | ||||
| DiagnoCure Inc. | CUR | M | 3.70 | 2.25 | -39 | ||||
| Dimethaid Research Inc. | DIME | T | 2.90 | 3.20 | +10 | ||||
| Draxis Health Inc. | DAX | T | 3.20 | 4.50 | +41 | ||||
| Drug Royalty Corp. | DRI | T | 1.70 | 1.75 | +3 | ||||
| Empyrean Diagnostics Inc. | EMD | V | 0.40 | 1.15 | +188 | ||||
| Forbes Medi-Tech Inc. | FMI | V | 1.61 | 2.60 | +61 | ||||
| GenSci Regeneration Sciences Inc. | GNS | V | 1.70 | 1.77 | +4 | ||||
| HaemaCure Corp. | HAE | T | 4.30 | 3.50 | -19 | ||||
| Helix Biopharma Corp. | HBP | T | 1.65 | 0.36 | -78 | ||||
| Hemosol Inc. | HML | T | 3.75 | 1.95 | -48 | ||||
| Hyal Pharmaceutical Corp. | HPC | T | 4.90 | 0.65 | -87 | ||||
| IGT Pharma Inc. | IGT | V | 0.50 | 1.02 | +104 | ||||
| IBEX Technologies Inc. | IBT | T | 5.70 | 2.85 | -50 | ||||
| ID Biomedical Corp. | IDB | T | 5.75 | 3.25 | -43 | ||||
| Imutec Pharma Inc. | IUT | T | 1.53 | 0.91 | -41 | ||||
| Inex Pharmaceuticals Corp. | IEX | T | 11.75 | 3.50 | -70 | ||||
| Inflazyme Pharmaceuticals Ltd. | IZP | V | 2.66 | 1.63 | -39 | ||||
| Labopharm Inc. | DDS | M | 5.70 | 3.10 | -46 | ||||
| MDS Health Group | MHG.B | T | 23.60 | 33.30 | +41 | ||||
| Microbix Biosystems Inc. | MBX | T | 0.63 | 0.60 | -5 | ||||
| Micrologix Biotech Inc. | MBI | T | 3.60 | 3.85 | +7 | ||||
| Nortran Pharmaceuticals Ltd. | NRT | V | 0.84 | 0.91 | +8 | ||||
| Novopharm Biotech Inc. | NVO | T | 2.17 | 0.75 | -65 | ||||
| Nymox Corp. | NMX | M | 15.40 | 9.75 | -37 | ||||
| Phoenix Int'l. Life Sciences Inc. | PHX | M | 12.25 | 9.55 | -22 | ||||
| QLT PhotoTherapeutics Inc. | QLT | T | 27.75 | 16.55 | -40 | ||||
| Receptagen Ltd. | RCG | T | 1.20 | 0.10 | -92 | ||||
| Spectral Diagnostics Inc. | SDI | T | 8.80 | 6.75 | -23 | ||||
| StressGen Biotechnologies Corp. | SSB | T | 4.24 | 3.00 | -29 | ||||
| Synsorb Biotech Inc. | SYB | T | 11.60 | 7.35 | -37 | ||||
| Tm Biopharma Corp. | TMC | V | 0.28 | 0.65 | +132 | ||||
| Theratechnologies Inc. | THB | M | 1.75 | 1.50 | -14 | ||||
| Vasogen Inc. | VAS | M | 1.75 | 1.50 | -14 | ||||
| Xillix Technologies Corp. | XLX | T | 3.20 | 2.18 | -32 | ||||
| AVERAGE PERCENT CHANGE: 10% | |||||||||
| NOTES: | |||||||||
| * BioChem Pharma Inc. split its stock 2 for 1 in 4/97. The closing price on 12/31/96 listed in the chart is the post-split price and was used to calculate the percent change year-to-date. | |||||||||
| ** Share prices are quoted in Canadian dollars. The exchange rate on 12/22/97 was C$1.43/US$1. | |||||||||
| M = Montreal Stock Exchange; T = Toronto Stock Exchange; V = Vancouver Stock Exchange | |||||||||
