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Company Symbol Exchange Share Price** Share Price** Percent
12/31/96 12/19/97 Change (%)
Les Laboratories Aeterna Inc. AEL M 10.75 7.30 -32
Algene Biotechnologies Corp. AGN.B T 2.70 1.25 -54
Allelix Biopharmaceuticals Inc. AXB T 16.80 10.35 -38
Alta Genetics Inc. AGI T 3.50 4.25 +21
AltaRex Corp. AXO T 6.30 3.00 -52
Axcan Pharma Inc. AXP M 13.10 12.80 -2
BioChem Pharma Inc.* BCH M 34.42* 34.40 0
Biomira Inc. BRA T 6.65 3.20 -52
Bioniche Inc. BNC T 0.92 0.60 -35
Biovail Corp. Int'l. BVF T 34.85 53.25 +53
Briana Biotech Inc. BIA V 0.34 0.59 +74
Cangene Corp. CNJ T 2.10 2.60 +24
DiagnoCure Inc. CUR M 3.70 2.25 -39
Dimethaid Research Inc. DIME T 2.90 3.20 +10
Draxis Health Inc. DAX T 3.20 4.50 +41
Drug Royalty Corp. DRI T 1.70 1.75 +3
Empyrean Diagnostics Inc. EMD V 0.40 1.15 +188
Forbes Medi-Tech Inc. FMI V 1.61 2.60 +61
GenSci Regeneration Sciences Inc. GNS V 1.70 1.77 +4
HaemaCure Corp. HAE T 4.30 3.50 -19
Helix Biopharma Corp. HBP T 1.65 0.36 -78
Hemosol Inc. HML T 3.75 1.95 -48
Hyal Pharmaceutical Corp. HPC T 4.90 0.65 -87
IGT Pharma Inc. IGT V 0.50 1.02 +104
IBEX Technologies Inc. IBT T 5.70 2.85 -50
ID Biomedical Corp. IDB T 5.75 3.25 -43
Imutec Pharma Inc. IUT T 1.53 0.91 -41
Inex Pharmaceuticals Corp. IEX T 11.75 3.50 -70
Inflazyme Pharmaceuticals Ltd. IZP V 2.66 1.63 -39
Labopharm Inc. DDS M 5.70 3.10 -46
MDS Health Group MHG.B T 23.60 33.30 +41
Microbix Biosystems Inc. MBX T 0.63 0.60 -5
Micrologix Biotech Inc. MBI T 3.60 3.85 +7
Nortran Pharmaceuticals Ltd. NRT V 0.84 0.91 +8
Novopharm Biotech Inc. NVO T 2.17 0.75 -65
Nymox Corp. NMX M 15.40 9.75 -37
Phoenix Int'l. Life Sciences Inc. PHX M 12.25 9.55 -22
QLT PhotoTherapeutics Inc. QLT T 27.75 16.55 -40
Receptagen Ltd. RCG T 1.20 0.10 -92
Spectral Diagnostics Inc. SDI T 8.80 6.75 -23
StressGen Biotechnologies Corp. SSB T 4.24 3.00 -29
Synsorb Biotech Inc. SYB T 11.60 7.35 -37
Tm Biopharma Corp. TMC V 0.28 0.65 +132
Theratechnologies Inc. THB M 1.75 1.50 -14
Vasogen Inc. VAS M 1.75 1.50 -14
Xillix Technologies Corp. XLX T 3.20 2.18 -32
AVERAGE PERCENT CHANGE: 10%
NOTES:
* BioChem Pharma Inc. split its stock 2 for 1 in 4/97. The closing price on 12/31/96 listed in the chart is the post-split price and was used to calculate the percent change year-to-date.
** Share prices are quoted in Canadian dollars. The exchange rate on 12/22/97 was C$1.43/US$1.
M = Montreal Stock Exchange; T = Toronto Stock Exchange; V = Vancouver Stock Exchange

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