Stocks Which Gained Value: Greater Than 100 Percent

Company

Symbol

12/31/96

12/31/97

Change YTD

Lynx Therapeutics

LYNX

4

16.25

306

Osteotech

OSTE

7

27.25

289

Aviron

AVIR

7.5

27.125

262

Cytoclonal Pharma

CYPH

2.125

6.875

224

Immunex

IMNX

19.5

54

177

Igen

IGEN

5

13.25

165

NeoTherapeutics

NEOT

4.125

10.5

155

MedImmune

MEDI

17

42.875

152

ICN Pharma

ICN

19.625

49

150

Sepracor

SEPR

16.625

40.062

141

Icos

ICOS

7.625

18.312

140

Maxim Pharma

MMP

7

16.375

134

Cor Thera

CORR

9.875

22.5

128

Cholestech

CTEC

5.625

12.5

122

Biotime

BTIM

9.333

19

104

ViroPharma

VPHM

8.75

17.625

101

Stocks Which Gained Value: From 0 to 100 Percent

Company

Symbol

12/31/96

12/31/97

Change YTD

Zonagen

ZONA

9.375

18.187

94

Transkaryotic

TKTX

18.5

35.125

90

Biomatrix

BIOX

16

30

88

Enzon

ENZN

2.937

5.5

87

Epix Medical

EPIX

7

13

86

Cellegy Pharma

CLGY

4.5

8.375

86

Bioject

BJCT

0.687

1.281

86

InKine Pharma

INKP

0.75

1.375

83

PerSeptive Bio

PBIO

6.937

12.625

82

LeukoSite

LKST

6

10.937

82

Organogenesis

ORG

14.563

26.25

80

Progenics Pharma

PGNX

8

14

75

Incyte Pharm

INCY

25.75

45

75

Qiagen

QGENF

25.75

44.625

73

Inhale Ther Sys

INHL

15.125

26

72

PathoGenesis

PGNS

21.75

37.125

71

Cell Therapeutics

CTIC

10

17

70

Coulter Pharma

CLTR

12

20.25

69

Axogen

AXG/U

23.5

39.75

69

Scios

SCIO

6.14

10

63

Pharmacyclics

PCYC

16

25.625

60

Genzyme Trans

GZTC

6.125

9.625

57

Cel-Sci

HIV

4.25

6.625

56

Elan

ELN

33.25

51.187

54

Dekalb

DKB

25.5

39.25

54

CollaGenex

CGPI

8.125

12.5

54

Affymetrix

AFFX

20.187

31.125

54

SangStat Med

SANG

26.5

40.5

53

Gilead Sciences

GILD

25

38.25

53

Bioreliance

BREL

15

23

53

Molec Dynam

MDYN

10.75

16.25

51

T Cell Sci

TCEL

1.625

2.437

50

Lifecell

LIFC

3.125

4.625

48

ArQule

ARQL

15.75

22.937

46

OncorMed

ONM

4.812

7

45

Novavax

NOX

3.437

5

45

IDEC Pharm

IDPH

23.75

34.375

45

CV Therapeutics

CVTX

6.5

9.375

44

Alexion Pharma

ALXN

8.687

12.5

44

Parexel Intl

PRXL

25.813

37

43

Texas Biotech

TXB

4.375

6.187

41

MacroChem

MCHM

6.5

9.125

40

Draxis Health

DRAXF

2.187

3.062

40

DNAP Holding

DNAP

3.5

4.859

39

Alteon

ALTN

5.25

7.312

39

Intl Murex

MURXF

7.312

10.062

38

Molecular Devices

MDCC

15.562

21.25

37

Cygnus

CYGN

14.5

19.875

37

Atrix Labs

ATRX

10.75

14.75

37

Pharmos

PARS

1.468

2

36

NeoRx

NERX

4.125

5.625

36

Lidak Pharm

LDAKA

1.75

2.375

36

Immune Resp

IMNR

8.25

11.125

35

Life Tech

LTEK

25

33.25

33

Gliatech

GLIA

7.75

10.25

32

Molecular Bio

MB

6.5

8.5

31

Interferon Sci

IFSC

6.625

8.687

31

Aurora Bioscience

ABSC

10

13.125

31

Unigene

UGNE

2.031

2.625

29

Adv Tissue Sci

ATIS

9.562

12.375

29

Genzyme

GENZ

21.75

27.75

28

Diatide

DITI

7.125

9.125

28

Ortec Int'l

ORTC

10.375

13.062

26

Gensia Sicor

GNSA

4.625

5.812

26

Biora AB

BIORY

16.5

20.75

26

Tripos

TRPS

11.75

14.625

24

Genset

GENXY

16

19.75

23

Alza

AZA

25.875

31.812

23

SuperGen

SUPG

12.25

15

22

Lifecore Bio

LCBM

18

21.875

22

Megabios

MBIO

12

14.25

19

Vion Pharma

VION

3.062

3.625

18

Oncor

ONC

4

4.625

16

Ergo Science

ERGO

13.125

15.25

16

Amarillo Biosci

AMAR

4.75

5.5

16

Quintiles

QTRN

33.125

38.25

15

Genentech

GNE

53.625

60.625

13

Columbia Labs

COB

14.5

16.25

12

Sonus Pharma

SNUS

29.75

33.125

11

Protein Design

PDLI

36.5

40

10

Atlantic Pharma

ATLC

6.125

6.75

10

XOMA

XOMA

5.125

5.562

9

Millennium

MLNM

17.375

19

9

GelTex

GELX

24.25

26.5

9

Dianon Systems

DIAN

8.625

9.375

9

Trimeris

TRMS

12

13

8

Cypros Pharma

CYPR

3.937

4.25

8

Diagnostic Prod

DP

25.875

27.75

7

OSI Pharma

OSIP

6.375

6.75

6

LXR Biotech

LXR

2.25

2.375

6

AntiVirals

AVII

6.5

6.812

5

Immucell

ICCC

2.375

2.468

4

Sugen

SUGN

12.875

13.125

2

North Am Vacc

NVX

24.375

24.937

2

Crescendo Pharma

CNDO

11.5

11.562

1

Cantab Pharm

CNTBY

9.5

9.625

1

Micrologix Biotec

MBI*

3.6

3.6

0

Gene Logic

GLGC

8

8

0

Emisphere

EMIS

18.625

18.625

0

Amgen

AMGN

54.375

54.125

0

Stocks Which Lost Value

Company

Symbol

12/31/96

12/31/97

Change YTD

Diacrin

DCRN

10.25

10.125

-1

Visible Genetics

VGINF

8.75

8.562

-2

Synbiotics

SBIO

3.187

3.125

-2

Human Genome

HGSI

40.75

39.75

-2

Cortecs Intl

DLVRY

14.5

14.25

-2

Myriad Genetics

MYGN

25.25

24.25

-4

Integra LifeScien

IART

4.625

4.437

-4

Genz Tiss Repair

GENZL

7.125

6.875

-4

Dura Pharm

DURA

47.75

45.875

-4

Avax Technologies

AVXT

3.83

3.687

-4

Ribi Immuno

RIBI

3.875

3.687

-5

Cubist Pharma

CBST

6.125

5.812

-5

Teva Pharm

TEVIY

50.25

47.312

-6

Biogen

BGEN

38.75

36.375

-6

Centocor

CNTO

35.75

33.25

-7

Cell Genesys

CEGE

9.125

8.5

-7

Siga Pharma

SGPH

5

4.625

-8

Synaptic Pharma

SNAP

12

10.875

-9

Chiron

CHIR

18.625

17

-9

Celtrix

CTRX

2

1.812

-9

SunPharm

SUNP

5

4.5

-10

Microcide Pharma

MCDE

10

8.875

-11

GeneMedicine

GMED

5.687

5.062

-11

Immucor

BLUD

9.75

8.625

-12

BioTransplant

BTRN

6.5

5.75

-12

SIBIA Neurosci

SIBI

7.5

6.5

-13

Mycogen

MYCO

21.5

18.75

-13

Ligand

LGND

14.875

12.875

-13

Guilford Pharm

GLFD

23.25

20.125

-13

Agouron

AGPH

33.875

29.375

-13

Adv Poly Sys

APOS

7.625

6.625

-13

Aquila Biopharma

AQLA

4.875

4.187

-14

Northfield Labs

NFLD

10.75

9.125

-15

Neose Technol

NTEC

18

15.25

-15

CytRx

CYTR

3.437

2.937

-15

Anesta

NSTA

19.25

16.375

-15

Alkermes

ALKS

23.25

19.875

-15

Trinity Bio

TRIBY

2.343

1.968

-16

Shaman

SHMN

5.875

4.937

-16

Phoenix Intl

PHX*

12.25

10.25

-16

Magainin

MAGN

9.625

8.062

-16

Ariad Pharm

ARIA

5.062

4.25

-16

Pharmacopeia

PCOP

19.375

16

-17

Intercardia

ITRC

21.5

17.875

-17

ImClone Sys

IMCL

9.75

8.125

-17

Biochem Pharma

BCHE

25.125

20.875

-17

Vertex Pharm

VRTX

40.25

33

-18

Neurex

NXCO

17

13.875

-18

Embrex

EMBX

6.5

5.312

-18

Digene

DIGE

10.5

8.625

-18

Bio-Tech Gen

BTGC

13.125

10.75

-18

Quidel

QDEL

4.5

3.625

-19

Penederm

DERM

12.375

10

-19

Enzo Biochem

ENZ

18.125

14.625

-19

Neurocrine Biosci

NBIX

10

7.875

-21

Virus Research

VRII

5.75

4.5

-22

Meridian Diag

KITS

13

10.125

-22

Ecogen

EECN

2.5

1.937

-23

NeXstar Pharm

NXTR

15

11.375

-24

Metra Biosys

MTRA

4.75

3.625

-24

Celgene

CELG

11.125

8.437

-24

Transcend Thera

TSND

10

7.5

-25

Pacific Pharma

PHA

1.25

0.937

-25

Medarex

MEDX

7

5.25

-25

OXiGENE

OXGN

23.5

17.5

-26

La Jolla Pharm

LJPC

6

4.437

-26

Cypress Bio

CYPB

1.937

1.437

-26

Vical

VICL

16.5

12

-27

Ribozyme Pharma

RZYM

11

8

-27

Cadus Pharma

KDUS

8.75

6.375

-27

US Bioscience

UBS

12.625

9.062

-28

Creative Bio

CBMI

10.375

7.375

-29

Onyx Pharma

ONXX

11.125

7.75

-30

NPS Pharm

NPSP

11

7.75

-30

Neurogen

NRGN

19.25

13.5

-30

EntreMed

ENMD

16.25

11.312

-30

DepoMed

DPMD

6.1

4.25

-30

Xenova Group

XNVAY

3.25

2.25

-31

Hyseq

HYSQ

14

9.625

-31

Corvas

CVAS

5.625

3.875

-31

Corixa

CRXA

13

8.937

-31

CIMA Labs

CIMA

6.125

4.25

-31

Isis Pharm

ISIP

18

12.312

-32

Allelix

AXB*

16.8

11.5

-32

Discovery Labs

DSCO

6

4

-33

AMBI

AMBI

2.875

1.937

-33

Synsorb Biotech

SYB*

11.6

7.7

-34

Sequana Therap

SQNA

16.75

11

-34

Repligen

RGEN

1.187

0.781

-34

NeoPharm

NEO

8

5.25

-34

Immunomed

IMMU

5.5

3.625

-34

UroCor

UCOR

9.562

6.187

-35

Trega Biosciences

TRGA

5.25

3.437

-35

Triangle Pharma

VIRS

22.875

14.625

-36

Protein Poly

PPTI

2.562

1.625

-37

Geron

GERN

13.25

8.25

-38

Arris Pharm

ARRS

13.5

8.375

-38

Aastrom Biosci

ASTM

7

4.375

-38

Pharma Prod Devlp

PPDI

25.25

15.375

-39

ILEX Oncology

ILXO

12

7.375

-39

Theratech

THRT

13.25

8

-40

CoCensys

COCN

5.75

3.437

-40

ID Biomed

IDB*

5.75

3.4

-41

Genome Thera

GENE

10.75

6.312

-41

Targeted Genet

TGEN

4.5

2.625

-42

VimRx

VMRX

3.375

1.937

-43

Matritech

NMPS

8.5

4.875

-43

Anergen

ANRG

3.75

2.125

-43

Matrix

MATX

6.125

3.437

-44

IBAH

IBAH

6.75

3.75

-44

ChemTrak

CMTR

1.343

0.75

-44

Carrington

CARN

7.75

4.312

-44

Adv Magnetics

AVM

15.5

8.75

-44

QLT PhotoTher

QLTIF

20.125

11.125

-45

Cephalon

CEPH

20.5

11.375

-45

InSite Vision

INSV

6

3.25

-46

Ethical Hldgs

ETHCY

5.812

3.125

-46

Regeneron

REGN

16.125

8.562

-47

Alliance

ALLP

13.625

7.25

-47

Hycor Bio

HYBD

3

1.562

-48

Aphton

APHT

19.5

10.125

-48

AccuMed Intl

ACMI

2.5

1.312

-48

Titan Pharma

TTNPU

12.875

6.562

-49

Noven

NOVN

14

7

-50

Techniclone Int'l

TCLN

4.5

2.187

-51

Chrysalis Intl

CRLS

4.375

2.156

-51

Vyrex

VYRX

12.75

6.125

-52

Ostex Int'l

OSTX

5.5

2.625

-52

British Biotech

BBIOY

34.5

16.625

-52

AltaRex

AXO*

6.297

3

-52

Collab. Clin. Res

CCLR

10.75

5.062

-53

Calypte Biomed

CALY

8.25

3.875

-53

Am Bio Sci

MABXA

4.062

1.906

-53

Sequus Pharm

SEQU

16

7.437

-54

Genelabs

GNLB

6.125

2.812

-54

Biomira

BIOMF

4.75

2.125

-55

Avigen

AVGN

5

2.25

-55

Aronex Pharma

ARNX

9.375

4.25

-55

Progenitor

PGEN

5.375

2.375

-56

Idexx Labs

IDXX

36

15.937

-56

Envirogen

ENVG

3.375

1.5

-56

CytoTherapeut

CTII

9

4

-56

Cytel

CYTL

3.437

1.5

-56

SciClone

SCLN

8

3.437

-57

GalaGen

GGEN

4.375

1.875

-57

Epitope

EPTO

11.5

5

-57

Cyanotech

CYAN

6.437

2.781

-57

BioCryst

BCRX

16.375

7

-57

ProCyte

PRCY

2.25

0.937

-58

Amylin

AMLN

13

5.437

-58

Martek Bio

MATK

20

8.25

-59

Cortex

CORX

3.687

1.5

-59

Somatogen

SMTG

11

4.437

-60

Cortech

CRTQ

1.468

0.593

-60

Neoprobe

NEOP

15.375

6

-61

NABI

NABI

8.75

3.406

-61

Endorex

ENDR

14.063

5.5

-61

Sheffield

SHM

3.75

1.375

-63

Interneuron

IPIC

26

9.5

-63

Connetics

CNCT

8.25

3.062

-63

ImmunoGen

IMGN

2.375

0.843

-65

ClinTrials

CCRO

22.75

7.875

-65

Oxis Int'l

OXIS

1.25

0.421

-66

OraVax

ORVX

5.25

1.75

-67

Boston Life

BLSI

6.875

2.281

-67

Innovir

INVR

1.187

0.375

-68

Cytogen

CYTO

5.5

1.625

-70

Biocircuits

BIOC

2.906

0.875

-70

ImmuLogic

IMUL

6.375

1.875

-71

Sparta Pharm

SPTA

1.468

0.375

-74

Alpha Beta

ABTI

10.562

2.593

-75

Liposome

LIPO

19.125

4.625

-76

Flamel Tech

FLMLY

7.5

1.812

-76

Neurobio Tech

NTII

3.75

0.875

-77

NaPro Biother

NPRO

11

2.5

-77

DepoTech

DEPO

16.375

3.562

-78

AutoImmune

AIMM

15.375

3.312

-78

Viragen

VRGN

5.218

1.093

-79

Genta

GNTA

4.375

0.781

-82

CellPro

CPRO

12.5

2.312

-82

Cambridge Neuro

CNSI

11.875

1.968

-83

Hemacare

HEMA

3.125

0.468

-85

Procept

PRCT

7.438

1

-87

Paracelsian

PRLN

1.625

0.218

-87

DynaGen

DYGN

1.312

0.14

-89

Biomune Sys

BIME

14.688

0.718

-95


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