Published Oct. 22 & 29 (EPO); Oct. 16 & 23 (WO)

Amgen WO 97/38101 Stem cell factor analogues Thousand Oaks, Calif. Stem cell factor analogues, encoding genes, vectors, host cells, production methods.

Applied Res. Systems WO 97/38103 & 38104 IL-6 mutein Curacao, Netherlands Antilles Interleukin (IL)-6 mutein, encoding gene; for use as a potent IL-6 antagonist in treating autoimmune disease.

Aronex Pharma WO 97/39120 VEGF antisense The Woodlands, Texas Antisense inhibitors of vascular endothelial cell growth factor (VEGF) expression; for macrophage treatment.

Bayer WO 97/37998 Neuropeptide Y receptor Y5 Pittsburgh Gene for neuropeptide Y receptor Y5, encoded protein, vectors, production methods; for treating obesity.

Biotechnol. Res. Ctr. EPO 803 573 Cytokine/antigen gene vector Braunschweig, Germany Polycistronic expression vector construct having cytokine and antigen genes; for vaccines.

Boehringer Mannheim WO 97/38108 Soluble hepatitis G antigens Mannheim, Germany Production of recombinant soluble hepatitis G virus antigens in eukaryotic host cells; for use in diagnostics assays.

California Pacific Med. Ctr. WO 97/38085 Cancer gene amplification San Francisco, Calif. Surface membrane display of products of genes amplified in cancer cells; for developing therapeutics.

Chiron Viagene WO 97/38087 Alphavirus-based vectors Emeryville, Calif. Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis.

Curie, Univ. of Pierre & Marie WO 97/38118 Defective viral vaccine particles Paris Expression vector with structural gene elements of viral particles; for making vaccines with defective particles.

Cytel WO 97/37682 & 37682 Carbohydrate synthesis gene San Diego Gene for GDP-fucose pyrophosphorylase, encoded protein; for carbohydrate synthesis.

Exponential Biotherapies WO 97/39118 Bacteriophage antibacterials New York Bacteriophage that are genotypically modified to delay inactivation by the host defense system; for antibacterials.

Florida, Univ. of WO 97/39127 Hybrid fusion interferons Gainesville, Fla. Hybrid fusion interferons, encoding genes; for antiviral and anti-cell growth applications without cytotoxicity.

Genetics Institute WO 97/38084 & 39102 & 39123 Secretory expression system Cambridge, Mass. Genes and vectors for expression of recombinant proteins by secretion from host cells.

German Health Ministry WO 97/38105 Interleukin-16 Bonn, Germany Gene for interleukin-16, encoded protein, recombinant host cells, production methods.

Human Genome Sciences WO 97/38002 Extracellular EGF-like protein Rockville, Md. Genes for extracellular epidermal growth factor (EGF)-like protein, encoded protein; for wound healing.

Human Genome Sciences WO 97/38003 Hematopoietic-specific protein Rockville, Md. Gene for human hematopoietic-specific protein, encoded protein; for identification of agonists.

Hybridon WO 97/38097 Cooperative oligos Cambridge, Mass. Synthetic, cooperative oligos that bind different single-stranded DNAs and also have dimerization domains.

Icos WO 97/39124 Integrin modulators Bothell, Wash. Genes for cytoplasmic modulators of integrin regulation and signalling, agonists; for controlling inflammation.

Immusol WO 97/38723 Targeted viral vectors San Diego Recombinant viral vectors targeted to cells by using targeting agents and blocking wild-type vector binding.

Incyte Pharma WO 97/38100 Cachexia-associated protein Palo Alto, Calif. Gene for human cachexia-associated protein, encoded protein, antisense, antibodies; for treating obesity.

Incyte Pharma WO 97/39126 RANTES homologue Palo Alto, Calif. Prostate-derived gene for a human RANTES homologue, encoded protein; for treating immune deficiency diseases.

Johns Hopkins Univ. WO 97/39105 Human MAD genes Baltimore Human chromosome 18 genes related to MAD genes of Drosophila; for diagnosing and treating cancers.

Johns Hopkins Univ. WO 97/39133 Neuronal cell growth factor Baltimore Gene for a neuronal cell growth factor, encoded protein; for promotion of dendritic outgrowth and neuronal migration.

Kieta Holdings WO 97/38110 Ulcer treatments Saint-Prex, Switzerland Isolation of metabolic enzymes from Helicobacter pylori; for making inhibitors and antisense to treat ulcers.

K.U. Leuven Res. & Develop. WO 97/38083 MAG gene family member Leuven, Belgium New member of the multitumor aberrant growth (MAG) gene family located on the short arm of chromosome 3.

Liverpool, Univ. of WO 97/39117 Conditional immortalized cells Liverpool, U.K. Transgenics and derived cell lines with oncogenes controlled by cell-specific promoters; for conditional immortalization.

Manitoba, Univ. of WO 97/38098 Hyaluronan receptor Winnipeg, Manitoba Gene for human hyaluronan receptor, cDNA, encoded protein; for cancer diagnosis.

Maryland, Univ. of WO 97/37685 Shigella vaccines Baltimore Shigella variants with mutations in the Gua operon; for making vaccines.

Mayo Fdn. WO 97/38086 Interleukin-5 transgenics Rochester, Minn. Transgenic mice having the human interleukin-5 gene incorporated into their cells.

Mercator Genetics WO 97/38137 Hereditary hemochromatosis gene Menlo Park, Calif. Hereditary hemochromatosis gene, mutant genes, encoded proteins; for screening, diagnosis and therapeutics.

Miami, Univ. of WO 97/39132 Stabilized troponin preparations Miami Stabilized preparations of human troponins, fusions and fragments; for assaying troponin levels.

Michigan, Univ. of WO 97/38729 In vivo gene transfer Ann Arbor, Mich. Matrix-associated gene transfection into repair cells at wound sites; for in vivo gene transfer.

Mochida Pharma WO 97/38099 TRAF5 signalling protein Tokyo Gene for TRAF5, a signalling protein containing zinc fingers and coiled coils, encoded protein; for antagonist screen.

Molec. Biol. Resources WO 97/39113 Bacillus PCR polymerase Milwaukee Biologically active fragment of a thermostable, full-length DNA polymerase I of Bacillus stearothermophilus; for PCR.

Muro Pharma WO 97/39122 Mast cell degranulation inhibitor Tewksbury, Mass. Gene for mast cell 78 kDalton phosphoprotein, encoded protein; for inhibiting mast cell degranulation.

NIH (Natl. Inst. Hlth.) WO 97/38112 Recombinant Onc protein Bethesda, Md. Mutant of a recombinant Onc protein having a cyclized amino terminus; for use as an anticancer or antiviral agent.

NIH (Natl. Inst. Hlth.) WO 97/38119 Targeting retroviral vectors Bethesda, Md. Retroviral vectors with modified envelope proteins; for targeting of the vector.

Nebraska, Univ. of WO 97/37999 Synthetic triple helixes Lincoln, Neb. Substituted quinoline polymers binding double-stranded DNA, assembling into triple helixes with sequence specificity.

New York Univ. Med. Ctr. WO 97/37684 CNS gene therapy New York Implantation of transfected cells that produce tumoricidal factors into the brain; for CNS gene therapy.

New Mexico, Univ. of WO 97/39010 Papillomavirus probes Albuquerque, N.M. DNA probes for both homologous and newly discovered variant regions of human papillomaviruses.

N. Carolina St. Univ. WO 97/39130 Keratinase produced in Bacillus Raleigh, N.C. Method for expressing and secreting recombinant keratinase from Bacillus subtilis; for enzyme production.

Novartis WO 97/38114 Puromycin-sensitive aminopeptidases Basel, Switzerland Genes for puromycin-sensitive aminopeptidases, encoded proteins, antibodies, production methods; for diagnostics.

Osiris Therapeutics WO 97/39104 Cryopreserved mesenchymal stem cells Baltimore Cryopreserved preparations of homogeneous viable human mesenchymal stem cells, subculturing; for cell restoration.

Otsuka Pharma EPO 803 570 Mutant insulin receptor Tokyo Gene for a mutant insulin receptor, encoded protein, probes; for diagnosing insulin-dependent diabetes.

Progen Biotech WO 97/38082 Hypertonia gene Heidelberg, Germany Gene for hypertonia, located on chromosome 12 between defined genomic markers.

Res. Corp. Technol. EPO 803 574 Retroviral expression vectors Tucson, Ariz. Expression vectors that produce fusion proteins that are secreted in budding viral particles.

St. Vincent Inst. Med. Res. WO 97/38109 Immunorejection of tumors Fitzroy, Australia Transfection of tumor cells with a gene for glycosyltransferase; for inducing immune responses against tumors.

Salk Inst. WO 97/38117 Ecdysone receptor genes La Jolla, Calif. Genes for ecdysone receptors, encoded proteins, vectors, transgenics; for hormone-modulated gene expression.

Schering WO 97/39121 & 39125 Glycosylation end product ligands Berlin Agents specifically interacting with advanced glycosylation end products and receptors; for diagnosis and therapy.

Scripps Res. Inst. WO 97/39021 Targeting therapeutics La Jolla, Calif. Drugs having targeting and therapeutic domains; for targeting therapeutic agents.

Seikagaku WO 97/38113 Hyaluronate synthetase Tokyo Gene for human hyaluronate synthetase, encoded protein, analogues and encoding genes.

Sequana Therapeutics WO 97/38004 Neurosensory defect gene family La Jolla, Calif. Gene family associated with neurosensory defects; for use in diagnosis and therapy.

Sloan-Kettering Inst. WO 97/38091 Growth control transgenics New York Transgenics lacking the cyclin-dependent kinase inhibitor function of p27Kipi; for controlling cell growth.

SmithKline Beecham WO 97/38714-38722 & 39011-39017 Streptococcus antibacterials Philadelphia Streptococcus pneumoniae tRNA synthetase genes, encoded proteins, production methods; for antibacterial screens.

S. Florida, Univ. of WO 97/38133 Alzheimer's disease diagnosis Tampa, Fla. Variant genes for presenilin-2, encoded proteins; for diagnosing Alzheimer's disease.

Southern California, Univ. of WO 97/39150 Fluorophore-labeled DNA Los Angeles DNA synthesis methods using mutant bacteriophage T4 DNA polymerase; for incorporating fluorophores.

Stanford Univ. WO 97/39131 Soluble hormone receptors Stanford, Calif. Chimeric proteins with N-terminal glycoprotein hormone receptor and membrane anchor domains; for soluble receptors.

Talko Pharma EPO 802 258 Artificial genes Osaka, Japan DNA synthesis without templates; for making artificial genes and chromosomes.

Texas, Univ. of WO 97/39135 Enhanced transgene expression Austin, Texas Transfection of tumor cells after treatment with a DNA-damaging agent; for enhanced expression of transgenes.

Therexsys WO 97/39128 HIV infection therapeutic Keele, U.K. Gene for two operatively linked binding sites for the HIV rev protein; for HIV infection treatment.

Ueno, N. EPO 803 571 TGF-ß pathway protein Sapporo, Japan Gene for TAB1 protein, which activates the TAK1 factor in the TGF-ß signalling pathway, encoded protein.

Unilever WO 97/38102 Antigen-binding proteins London Multivalent and multispecific antigen-binding protein made from various antibody domains; for therapeutics.

Vanderbilt Univ. WO 97/39119 Infection and cancer prevention Nashville Mammalian genes involved in viral infection and tumor suppression; for preventing viral infection and cancer.

Wabco WO 97/39129 Non-A, non-E hepatitis virus Meppel, Netherlands Non-A, non-E hepatitis virus, isolated genes, proteins, antibodies; for diagnostics and therapeutics.