Published Oct. 8 & 15 (EPO); Oct. 2 & 9 (WO)

Amrad WO 97/35887 B cell induction factors Kew, Australia Growth factors or catalytic antibody precursors that bind to B cell surfaces; for inducing B cell mitogenesis.

Amrad WO 97/35971 bcl-w gene Kew, Australia bcl-w gene of the bcl-2 gene family, encoded protein; for controlling cellular apoptosis.

Asahi WO 97/37018 Shear stress protein Osaka, Japan Gene for a protein that is expressed in vascular endothelial cells under shear stress, encoded protein, inhibitors.

Astra WO 97/37044 Ulcer vaccines Sodertalje, Sweden Pure preparations of Helicobacter pylori polypeptides, encoding genes; for ulcer diagnostics and vaccines.

Bavarian Nordic Res. Inst. WO 97/35994 Cytochrome P450 vector Glostrup, Denmark Replication defective retroviral vector with a P450 gene controlled by target-specific or X-ray inducible promoters.

Blood Ctr. Res. Fdn. WO 97/37225 Phospholipid transport protein Milwaukee Protein that mediates calcium-dependent transbilayer movement of phospholipids, encoding gene, inhibitor.

Boehringer Mannheim EPO 799 890 Streptavidin mutants Mannheim, Germany Recombinant streptavidin mutants with an inactive core; for assays using biotinylated molecules [in German].

Boston Univ. WO 97/35998 Melanin synthesis control Boston Administration of a modulator of protein kinase activation of tyrosinase; for controlling melanin synthesis.

British Biotech Pharma WO 97/35985 Biosensors for receptor ligands Oxford, U.K. Preparation of cells expressing a mutant G-protein coupled receptor on their surfaces; for assaying ligands.

California, Univ. of WO 97/35478 Selective cell activation Oakland, Calif. Selective cell activation using an artificial ligand with decreased affinity for a G protein-coupled receptor.

California, Univ. of WO 97/35993 PSA gene regulatory elements Oakland, Calif. Positive regulatory elements for the prostate specific antigen (PSA) gene; for tissue-specific expression.

California, Univ. of WO 97/36481 HIV packaging cell line Oakland, Calif. Packaging cell line that forms mature, but not infective, HIV particles; for HIV gene therapy.

Cancer Res. Camp. Technol. WO 97/35975 E2F-like transcription factor London Gene for an E2F-like transcription factor, encoded protein, fragments, oligos; for repressing cell growth.

CNRS (Natl. Ctr. Sci. Res.) EPO 799 889 Potassium channels Paris Genes for mammalian potassium channels, encoded proteins; for drug screening [in French].

Chiron WO 97/35969 Urokinase receptor ligands Emeryville, Calif. Peptide ligands of the urokinase receptor that inhibit integrin and vitronectin binding, encoding genes.

Cold Spr. Harb. Lab WO 97/35967 Altered teleomerase transgenics Cold Spr. Harb., N.Y. Transgenic animals with altered teleomerase expression; for identifying compounds affecting teleomerase expression.

CSIRO (Comm. Sci. & Ind. Res. Org.) WO 97/37013 Targeted ribozymes Campbell, Australia Asymmetric hammerhead ribozymes that can be covalently linked to a delivery agent; for targeting RNA sequences.

Curie, Univ. Pierre & Marie EPO 799 893 Defective viral particles Paris Defective viral particles that can be obtained in vivo or in vitro; for vaccinating infected individuals [in French].

Cytel WO 97/35959 Galactosyltransferase production San Diego Gene expression system inserted into NSO cells; for producing galactosyltransferase.

Dainippon Pharma WO 97/35963 B-2 adrenergic receptor Osaka, Japan Gene for a B-2 adrenergic receptor subtype, encoded protein, production method; for screening agonists and antagonists.

Dana-Farber Cancer Inst. WO 97/35979 TRIO proteins Boston Gene for TRIO proteins, encoded proteins, antibodies; for diagnostic and therapeutic assays.

Dana-Farber Cancer Inst. WO 97/36928 Mitochondrial apoptosis screen Boston Monoclonal antibodies against a mitochondrial membrane protein expressed during apoptosis; for cell sorting.

French Atomic Energy Comm. WO 97/35972 Recombinant protein secretion Paris Recombinant genes encoding proteins with hydrophobic domains; for allowing secretion in heterologous cells.

Genentech WO 97/35885 ErbB3 antibodies S. San Francisco ErbB3 antibodies; for reducing heregulin-induced ErbB2 activation of cells.

Genentech WO 97/37020 Apoptosis peptides S. San Francisco Apoptosis peptides, encoding genes, chimeric molecules, antibodies.

German Res. Ctr. Hlth. & Welfare WO 97/37015 Erythroleukemia differentiation protein Oberschleissheim, Germany Protein having differentiation-inducing activity in Friend's erythroleukemia cell lines.

Harvard Univ. WO 97/35961 Transcription factor degradation Cambridge, Mass. Protein catalyzing the covalent attachment of ubiquitin to transcription factor E2A, encoding gene; for degrading E2A.

Harvard Univ. WO 97/35990 Histone deacetylases Cambridge, Mass. Genes for histone deacetylases, encoded proteins; for controlling chromatin structure.

Harvard Univ. WO 97/37027 Ubiquitinated cyclins Cambridge, Mass. Ubiquitin carrier polypeptides involved in ubiquitination of cyclins, encoding genes, antibodies, inhibitors.

Human Genome Sciences WO 97/35976 Epidermal differentiation factor Rockville, Md. Gene for epidermal differentiation factor, encoded protein, production methods; for treating skin diseases.

Human Genome Sciences WO 97/36915 & 37021 Cystatin F Rockville, Md. Genes for human cystatin F, encoded protein, expression systems; for identifying agonists and antagonists.

Human Genome Sciences WO 97/37022 NKAF II Rockville, Md. Gene for human natural killer cell activating factor (NKAF) II, encoded protein, agonists, antagonists.

Icos WO 97/35982 Macrophage-derived C-C chemokine Bothell, Wash. Gene for a macrophage-derived C-C chemokine, encoded protein, analogs, antibodies; for diagnosis and therapy.

Immunex WO 97/36919 LERK-8 cytokine Seattle Gene for the LERK-8 cytokine, encoded protein, antibodies, transformed cells.

Immunogen WO 97/37010 Apoptosis control protein Cambridge, Mass. Active survival domains of insulin-like growth factor-1 receptor, fragments; for controlling apoptosis.

Incyte WO 97/35989 Cyclic acid phosphodiesterases Palo Alto, Calif. Genes for cyclic nucleotide phosphodiesterases, encoded proteins, antisense; for identifying antagonists.

Isis Innovation WO 97/35962 Anti-neuronal degradation antibodies Oxford, U.K. Antibodies to a soluble peptide derived from acetylcholinesterase; for treating neuronal degradation.

Japanese Inst. Hlth. Sci. WO 97/37017 & 37019 Cytostatic factor Tokyo Gene for a cytostatic protein, encoded protein, vectors, production methods; for cancer therapy.

Johns Hopkins Univ. WO 97/35991 T cell activation complexes Baltimore Recombinant divalent versions of peptide/MHC complexes; for T cell binding and activation.

Korean Inst. Sci. Technol. WO 97/37025 Surface anchoring proteins Seoul, Korea Vectors for expressing surface anchoring proteins; for binding foreign proteins to cell surfaces.

Kyowa Hakko EPO 799 835 FGF-8 antibodies Tokyo Monoclonal antibodies against fibroblast growth factor (FGF)-8; for treating hormone-dependent cancer.

Ludwig Inst. Cancer Res. WO 97/35610 Tumor rejection antigen antibodies New York Monoclonal antibodies that bind the tumor rejection antigen precursor Melan-A, hybridomas, immunogenic compositions.

Massachusetts, Univ. of WO 97/37009 Making transgenic cows Amherst, Mass. Cultured inner cell mass cells from pigs and cows; for producing transgenic animals.

Maxygen WO 97/35957 DNA uptake enhancement Santa Clara, Calif. Transferring or evolving genes associated with DNA uptake; for enhanced DNA uptake.

Maxygen WO 97/35966 Metabolic engineering Santa Clara, Calif. Evolution of metabolic pathways and enhancement of bioprocessing using recursive sequence recombination.

NIH (Natl. Inst. Hlth.) WO 97/35978 Von Hippel-Lindau disease gene Bethesda, Md. Partial intron sequence of the Von Hippel-Lindau gene; methods for detecting carriers and treating the disease.

Nippon Steel WO 97/37030 Oncogene binding proteins Tokyo Plasmid with oncogene promoters and reporter genes; for identifying cancer-related DNA binding proteins.

Nippon Suisan WO 97/35970 Vibrio parahaemolyticus assay Tokyo Oligos for detecting Vibrio parahaemolyticus; for use in a PCR-based assay on non-purified specimens.

Nippon Zeon WO 97/36924 Antimycoplasma vaccines Tokyo Viral vector encoding a fusion of a mycoplasma antigen and a herpesvirus membrane protein; for antimycoplasma vaccines.

Ohio Univ. WO 97/36477 Heart failure transgenics Athens, Ohio Overexpression of selected heart muscle genes in transgenics; for modeling heart failure.

Osaka Univ. Microbial Dis. Res. Fdn. WO 97/35612 Tetanus vaccine Osaka, Japan Functional fragment antigen of tetanus toxin with immunogenicity equal to the whole molecule; for vaccines.

Otago, Univ. of WO 97/37031 Parapoxvirus vectors Dunedin, New Zealand Parapoxvirus vectors with foreign genes encoding an antigen; for inducing immune responses.

Pacific Northwest Cancer Fdn. WO 97/35616 PSA extracellular domain antibodies Seattle Monoclonal antibodies specific for the extracellular domain of prostate specific antigen (PSA); for immunoassays.

Pasteur Inst. WO 97/33974 Vascular disease therapy Paris Regulatory sequences of the SM22 gene, vectors; for treating coronary disease, particularly restenosis.

Pharmacia & Upjohn WO 97/36929 20 KDa hGH assay Stockholm, Sweden Monoclonal antibodies to the 20 kilodalton (kDa) version of human growth hormone (hGH); for quantification assays.

Protein Design Labs WO 97/37029 PDGF-B antibodies Mountain View, Calif. Humanized monoclonal antibodies to platelet-derived growth factor (PDGF)-B, derivatives; for treating restenosis.

Sankyo EPO 799 891 Anti-Fas antibodies Tokyo Anti-Fas recombinant antibodies with reduced immunogenicity, encoding genes; for autoimmune disease treatments.

Setratech WO 97/37011 Mismatched meiotic recombination Paris In vivo meiotic recombination of partially homologous DNA sequences in cells with defective mismatch repair systems.

SmithKline Beecham EPO 801 132 Staphylococcal antibacterials Brentford, U.K. Genes for Staphylococcal FtsH polypeptides, encoded proteins, production methods; for antibacterial screens.

SmithKline Beecham WO 97/37026 Biosynthesis modulation Philadelphia Polynucleotides and encoded polypeptides, transformed recombinant host cells; for modulating biosynthetic activity.

Spanish Sci. Invest. Counc. WO 97/36930 Cancer therapy antibodies Madrid, Spain Monoclonal antibodies to a tumor-associated antigen located in the cellular cytoskeleton; for cancer therapy.

Sugen WO 97/35872 Contactin associated protein Redwood City, Calif. Contactin associated protein, protein domains, encoding genes; for mediating neurite growth and differentiation.

Sugen WO 97/36918 Insulin-dependent diabetes diagnosis Redwood City, Calif. Genes for MOT12 polypeptides, encoded proteins, antibodies; for diagnosing and treating insulin-dependent diabetes.

Takeda EPO 799 892 Calpain Osaka, Japan Gene for calpain, encoded protein, its fragments, antibodies; for identifying ligands and treating hemorrhage.

TDK WO 97/35964 Proteins bound to magnetic particles Tokyo Fine magnetic particles isolated from bacteria; for binding desired proteins and manipulating the coated particles.

Therion Biologics WO 97/35997 Myelin immunotherapy Cambridge, Mass. Recombinant pox virus with a gene encoding myelin protein; for immunotherapy.

Transgene WO 97/35995 Antitumor cell populations Strasbourg, France Transfected cells expressing immunostimulatory and cytostatic genes; for treating cancer.

Transgene WO 97/35996 Viral packaging cell line Strasbourg, France Packaging cell line derived from human 293 cells that expresses a functional viral envelope protein.

Trinity College WO 97/37014 Genetic suppression and replacement Dublin, Ireland Expression suppression by ligands binding to genes and replacement with gene sequence analogs.

Vical WO 97/35992 Tetracycline-controlled expression vectors San Diego Tetracycline-controlled eukaryotic expression vector systems with positive feedback control; for use in gene therapy.

Wakunaga Siekyaku EPO 799 888 Non-specific hybridization inhibition Osaka, Japan Inhibition of non-specific hybridization during primer extension by using another complementary strand.

Yamanouchi Pharma EPO 799 836 Phospholipase antibodies Tokyo Monoclonal antibodies that inhibit type II phospholipase A2 activity; for treating cardiac and cerebral infarctions.

Yeda Res. & Develop. WO 97/37016 TNF receptor binding proteins Rehovot, Israel Gene for a protein that binds tumor necrosis factor (TNF) receptor-associated factor, fragments, production methods.

No Comments