Published September 24 & October 1 (EPO); September 18 & 25 (WO)

Adv. Res. & Technol. Inst. WO 97/34501 Folate receptor-directed metalloproteases Bloomington, Ind. Gene for folate receptor-directed metalloproteases, encoded protein, antibodies; for expression monitoring.

Akzo Nobel EPO 798 378 Estrogen receptors Arnhem, Netherlands Gene for estrogen receptors, encoded proteins, chimeric receptors.

Australian Natl. Univ. WO 97/33614 Bacterial autoimmunity treatment Acton, Australia Antigens from Coxiella; for treating autoimmune disease and pancreatic islet cell rejection.

British Columbia, Univ. of WO 97/34000 Caulobacter production system Vancouver, British Columbia Caulobacter production system using fusions gene encoding S-layer protein C-terminus and the recombinant protein.

California, Univ. of WO 97/33473 Cancer apoptosis inhibition Oakland, Calif. Inhibition of cancer cell apoptosis resistance by modifying the expression of bcl-2.

California, Univ. of WO 97/34002 Rheumatoid arthritis vaccine Oakland, Calif. Rheumatoid arthritis vaccine compositions that use atherogenic peptides.

California, Univ. of WO 97/34638 Antisense introns Oakland, Calif. Vectors, cassettes, and host cells producing stable introns with antisense sequences; for gene inhibition therapy.

California Inst. Technol. WO 97/34483 Transfection efficiency control Pasadena, Calif. Control of transfection efficiency by modifying cell proteoglycans and plasma glycosaminoglycans.

Cytel WO 97/34621 HLA-A2.1 antigen binding ligands San Diego Immunogenic peptides that bind glycoproteins encoded by the HLA-A2.1 allele; for immune response.

DNAVec Res. WO 97/34007 Blood cell expression vector Ibaraki, Japan Expression vector that uses a Tec tyrosine kinase promoter; for expressing genes in blood and liver cells.

Fodstad WO 97/33611 Blood cancer immunotoxins Oslo, Norway Selective killing of malignant cells in blood cell preparations by using immunotoxins.

Genentech WO 97/33616 IgE allergy treatment S. San Francisco Methods of treating allergic diseases by using anti-immunoglobulin E (IgE) antibodies and other IgE antagonists.

Genentech WO 97/35019 Stem cell growth S. San Francisco Gene for non-receptor protein tyrosine phosphatase of hematopoietic stem cells, encoded protein; for stem cell growth.

Harvard Univ. WO 97/33901 Smooth muscle LIM protein Cambridge, Mass. Gene for smooth muscle cell LIM protein, encoded protein; for diagnosing vascular injury and inhibiting cell growth.

Harvard Univ. WO 97/34641 Stat6-deficient transgenics Cambridge, Mass. Transgenic animals with modified Stat6 signaling pathway genes; for evaluating function modulators.

Human Genome Sciences WO 97/33902 TNF variants Rockville, Md. Genes for human tumor necrosis factor variants, encoded proteins, agonists, antagonists.

Human Genome Sciences WO 97/33904 Death domain-containing receptors Rockville, Md. Gene for death domain-containing receptors of the TNF family, encoded proteins, production methods; for screens.

Human Genome Sciences WO 97/35010 Human chemokine a-2 Rockville, Md. Gene for human chemokine a-2, encoded protein, antagonist screening; for treating cancer and autoimmune disease.

Idun Pharma WO 97/35020 Mch4/Mch5 apoptotic proteases La Jolla, Calif. Genes for the apoptotic proteases Mch4 and Mch5, encoded proteins, functional fragments.

Immune Response WO 97/33994 Intron-less gene expression Carlsbad, Calif. Increased expression of intron-less genes by cotransfecting with viral post-transcriptional regulatory sequences.

Immune Response WO 97/33998 Targeted interferon delivery Carlsbad, Calif. Complex containing an interferon gene with nucleic acid and cell surface binding agents; for targeted delivery.

Immunomedics WO 97/34632 B cell antibodies Morris Plains, N.J. Glycosylated humanized antibodies and antibody fragments against B cells.

Incyte WO 97/35006 Cell death protein Palo Alto, Calif. Gene for human cell death-associated protein from rheumatoid synovium, antisense, encoded protein, antibodies.

Innovir Labs WO 97/33991 Short external guide sequences New York Short external guide sequences that hybridize to RNase P RNA; for cleavage.

Isis Innovation WO 97/35005 Cystic fibrosis gene therapy Oxford, U.K. CFTR gene regulatory element that enhances the activity of CFTR promoter; for cystic fibrosis gene therapy.

Johns Hopkins Univ. WO 97/35003 Selective gene expression Baltimore Selective expression of desired genes transfected into cells that are expressing endogenous oncoproteins.

Johns Hopkins Univ. WO 97/35007 FGF homologous factor-3 Baltimore Gene for fibroblast growth factor (FGF) homologous factor-3, encoded protein, antibodies.

Krebs Res. Inst. WO 97/35015 Tyrosine phosphatase-related protein Heidelberg, Germany Gene for a tyrosine phosphatase-related protein, encoded protein, antibodies.

Lyakh, S.P., et al. WO 97/34010 & 34011 Antitumor preparation Moscow Antitumor melanin-containing preparation derived from the Antarctic black yeast Nadsoniella nigra.

Mass. Gen. Hosp. WO 97/33979 Hepatitis C animal model Boston Transgenic model of hepatitis C infection using animals whose hepatocytes express hepatitis C proteins.

Mass. Gen. Hosp. WO 97/33980 Wound healing animal model Boston Transgenic animals with disrupted nitric oxidase synthase gene; for studying wound healing and hypertension.

Max Planck Inst. WO 97/35022 Bacterial production system Munich, Germany Stable fusion proteins for use in export systems for recombinant proteins in bacterial cells.

MRC (Med. Res. Counc.) WO 97/35004 Cell stimulation London Chimeric polypeptide with CD28 intracellular signaling, transmembrane, and extracellular antigen binding domains.

Mitsui Toatsu EPO 798 380 Bacterial production method Tokyo E. coli production method for secretion of recombinant protein into the periplasmic space by modifying Sec expression.

Munin WO 97/33995 Extracellular signalling molecules Chicago Gene for extracellular signalling molecules, encoded proteins; for modulating angiogenesis and carcinogenesis.

NIH (Natl. Inst. Hlth.) WO 97/35008 Chimeric protein cancer vaccine Bethesda, Md. Chimeric protein with hepatitis B virus core antigen and tumor antigen regions; for cancer vaccines.

NIH (Natl. Inst. Hlth.) WO 97/35021 Prostate cancer treatment Bethesda, Md. Prostate-specific antigen peptide with more than one epitope combined with HLA molecules; for treating prostate cancer.

New York Univ. WO 97/35018 Growth control phosphatase New York Gene for growth factor-inducible serine/threonine phosphatase FIN13, encoded protein; for controlling growth.

Otsuka Pharma EPO 796 913 GDP dissociation protein Tokyo Genes for GDP dissociation stimulating protein and other related proteins, encoded proteins.

Proscript WO 97/35014 I-kappa-Ba phosphorylating kinase Cambridge, Mass. Gene for a kinase capable of site-specific phosphorylation of I-kappa-Ba, encoded protein; for gene therapy.

Rhone-Poulenc Rorer WO 97/34009 Cancer gene therapy Antony, France Recombinant adenoviral vectors containing genes for tumor-specific antigens; for tumor gene therapy.

Rhone-Poulenc Rorer WO 97/35002 Plasmid purification Antony, France Method for purifying pharmaceutical-grade plasmid DNA using hydroxyapatite columns.

Rhone-Poulenc Rorer WO 97/35024 Cancer gene therapy constructs Antony, France Vectors for the intracellular expression of enzyme combinations that destroy growing cells; for cancer gene therapy.

Schering WO 97/34144 Receptor-related compound screen Berlin Method for screening receptor-related compounds using a plasmid encoding low-molecular-weight hen urokinase.

Seikagaku EPO 798 376 Keratan sulfate hydrolase Tokyo Keratan sulfate hydrolase from Bacillus circulans; for tissue remodeling.

Senju Pharma EPO 798 375 Lens epithelial cell line Osaka, Japan Temperature-sensitive human lens epithelial cell line immortalized by exogenous genes; for transplants.

Shionogi WO 97/33977 Arthritis-fighting T cells Osaka, Japan Human T cell clone that recognizes antigens expressed by synovial cells of rheumatoid arthritis patients.

Sloan-Kettering Inst. WO 97/34634 Anti-ganglioside antibodies New York Recombinant antibodies with variable regions of light and heavy chains of anti-GD2 ganglioside antibodies.

SmithKline Beecham WO 97/33903 Human MutY King of Prussia, Pa. Gene for human MutY, encoded protein, production methods; for mutation detection and cancer diagnosis.

SmithKline Beecham WO 97/35037 Tissue remodeling antibodies Philadelphia Monoclonal antibodies against tissue remodeling proteins; for detecting altered expression of these proteins.

S. Alabama Med. Sci. Fdn. WO 97/33610 Schistosoma DNA vaccine Mobile, Ala. Gene for Schistosoma mansoni glutathione S-transferase; for vaccination against parasitic infection.

S. Alabama Med. Sci. Fdn. WO 97/34915 Nuclear-targeted plasmid Mobile, Ala. Plasmid and targeting molecule; for delivering DNA to the cell nucleus.

S. California, Univ. of WO 97/33615 HIV immunoprotection Los Angeles Sheep arthritis-encephalitis virus immunogens; for in vivo or in vitro immunoprotection against HIV.

Sovarec WO 97/33999 Trypanosome histone antigens Epalinges, Switzerland Isolated or recombinantly produced histones from trypanosomes; for use as antigens in immunotherapy.

Stanford Univ. WO 97/34625 Cystatin B mutants Stanford, Calif. Genes and genomic DNA encoding human cystatin B, mutations of the gene.

Takara Shuzo WO 97/34006 Restriction enzyme plasmid Kyoto, Japan Plasmid that allows a restriction enzyme gene to be isolated in the absence of a modification enzyme gene.

Texas, Univ. of WO 97/34631 More stable Ig domains Austin, Texas Recombinant vectors encoding immunoglobulin (Ig)-like domains and fragments having increased half-lives.

Texas, Univ. of WO 97/35012 Chemotherapy enhancement Austin, Texas EA1 antigen inhibition of the neu oncogene tyrosine kinase product effects on cancer chemotherapy resistance.

Toa Med. Electronics EPO 798 388 Gene mutation detection Kobe, Japan Gene detection using gene fragments linked to antigens or antibodies; for detecting mutations.

Toyota Chuo EPO 798 387 Nucleic acid detection Aichi, Japan Nucleic acid detection using immobilized DNA and a hapten-linked probe followed by anti-hapten antibody treatment.

Utah, Univ. of WO 97/34913 Rheumatoid arthritis diagnosis Salt Lake City Gene for superantigen Mycoplasma arthriditis T cell mitogen, mutated genes; for diagnosing rheumatoid arthritis.

Xenotech WO 97/34912 Directed recombination Fremont, Calif. Switch regions from immunoglobulin genes used for directing recombination in associated target sequences in vectors.

Xoma WO 97/35009 BPI-assisted bacterial production Berkeley, Calif. Method for recombinant protein production in bacteria using bacteriocidal/permeability-increasing protein (BPI).

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