Published February 26 & March 5 (EPO); February 20 & 27 (WO)
Abbott Labs WO 97/07224 Hepatitis control elements Abbott Park, Ill. Control elements of the hepatitis A, B, or C virus; for controlling translation of viral proteins.
Alabama, Univ. of WO 97/07127 Suppressin Birmingham, Ala. Gene for suppressin protein, encoded protein, plasmids, host cells, production methods.
Avigen WO 97/06272 AAV vectors Alameda, Calif. Adeno-associated viral (AAV) vectors with a rearranged p5 promoter region, helper and producer cell lines.
Bio Merieux WO 97/06260 Multiple sclerosis-associated virus Marcy l'Etoile, France Viral material and nucleotide fragments associated with multiple sclerosis; for diagnosis and therapy.
Biopharm WO 97/06254 MP52 Arg for bone disease Heidelberg, Germany Human MP52 Arg protein; for treating bone and cartilage diseases.
Boehringer Mannheim WO 97/07220 Linker insertion mutagenesis Mannheim, Germany Linker insertion mutagenesis that modify protein structure, but not biologic activity.
Brussels Free Univ. WO 97/07208 Pronocioceptive proteins Brussels, Belgium Genes for proteins having pronocioceptive properties, encoded proteins; for making diagnostics and therapeutics.
California, Univ. of WO 97/07219 Cholesterol biosynthesis control Oakland, Calif. HMG-CoA reductase degradation protein gene family, encoded proteins; for controlling cholesterol biosynthesis
Canadian Health Ministry WO 97/07237 Burkholderia cepacia diagnosis Ottawa, Ont. Insertional sequence element characteristic of a virulent isolate of Burkholderia cepacia; for diagnosis.
Cell Genesys WO 97/07225 Refractory cell transfection Foster City, Calif. Retroviral packaging plasmids and vector transcripts from high expression plasmids; for transfecting refractory cells.
CSIRO (Comm. Sci. Ind. Res. Org.) WO 97/07132 Affinity purification tags Campbell, Australia Hexapeptides used as epitope tags attached to proteins and used for affinity purification.
Cornell Univ. WO 97/07233 Ectopic cell signalling receptors Ithaca, N.Y. Transfection of genes encoding cell signalling receptors that are not endogenous to the cell; for signal control.
Dana-Farber Cancer Inst. WO 97/06247 Cytokine-inducible deubiquinators Boston Deubiquinating enzymes inducible by cytokines, encoding genes; for cell growth regulation.
Duke Univ. WO 97/06257 HIV regulator genes Durham, N.C. Genes for HIV-1 Rev and HTLV-1 Rex post-transcriptional regulator proteins, encoded proteins.
Eberhard Karls Univ. WO 97/07204 Peanut agglutinin-binding glycoprotein antibodies Tubingen, Germany Antibodies to peanut agglutinin-binding glycoprotein on cell surfaces, hybridoma cells.
Emory Univ. WO 97/06249 Human immune system in mice Atlanta, Ga. Genetically immunodeficient mouse containing T cells of human origin in the peripheral blood.
Forssmann, W.-G. WO 97/06258 Guanylate cyclase activating peptide Hannover, Germany Guanylate cyclase activating peptide, encoding gene; for treating electrolyte transport and endocrine disorders.
Fuso Pharma WO 97/07133 & 07210 Conglutinin fusion Osaka, Japan Fusion protein with collagen residues and neck and sugar-binding regions of conglutinin; for use as an antiviral.
Genentech WO 97/07134 TNF receptor factor inhibitors S. San Francisco Inhibitors of TNF receptor associated factor-mediated signal transduction, encoding genes, production methods.
Genetics Inst. WO 97/07198 Secreted proteins Cambridge, Mass. Genes for secreted proteins, encoded proteins, production and purification methods.
Harvard Univ. WO 97/07213 Chromosome non-disjunction genes Cambridge, Mass. Gene transfection, determination of association with chromosome non-disjunction; for diagnosis and treatment.
Hisamitsu Pharma EPO 759 471 HIV gene therapy vector Tosu, Japan Recombinant HIV vector with foreign genes that inhibit HIV growth; for gene therapy.
Hoffmann-La Roche EPO 759 466 IL-12 receptor ß subunits Basel, Switzerland Genes for interleukin (IL)-12 receptor ß subunits, encoded protein, antibodies.
Hybridon WO 97/06252 Catalytic ribonuclease oligos Worcester, Mass. Synthetic oligonucleotides with enhanced ribonuclease activity; for making catalytic oligos.
Hybridon WO 97/06253 Reduced immunostimulatory oligos Worcester, Mass. Reduced immunostimulatory phosphorothioate oligonucleotides; for reducing immune response to oligo therapeutics.
Immunova WO 97/06263 Chlamydia trachomatis vaccine Ste.-Foy, Que. Hybrid protein of T helper and B cell stimulating epitopes from Chlamydia trachomatis outer membrane protein.
Imperial College WO 97/07209 EGF-like repeat assay London Receptors for use in screening compounds for EGF- or cadherin-like repeats.
Incyte Pharma WO 97/06262 Non-receptor tyrosine phosphatase Palo Alto, Calif. Non-receptor type human protein tyrosine phosphatase, encoding gene, oligos, antibodies.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 97/06256 Chromosome 6/11 cancer genes Paris Genes on chromosomes 6 and 11 that are overexpressed in leukemia and breast cancer; for diagnosis.
Introgene WO 97/07226 Polyphosphazene cationic carriers Rijswijk, Netherlands Organic polyphosphazenes as cationic carriers for nucleic acids; for transfection.
Krebs Res. Inst. WO 97/07227 DNA recombination agent Heidelberg, Germany Agent for recombination between large DNA fragments and cellular DNA; for accurate cellular DNA alteration.
Lek Tovarna WO 97/06251 Soluble TNF- receptor antibodies Ljubljana, Slovenia Monoclonal antibodies against soluble TNF- receptors and TNF-, hybridoma lines.
Massachusetts, Univ. Med. Ctr. WO 97/06823 Norwalk virus antibodies Worcester, Mass. Monoclonal antibodies for detecting Norwalk virus, particles, and virus-specific IgM by immunoassay.
Mass. Gen. Hosp. WO 97/06241 Transgenic pig organs Boston Transgenic pigs and pig cells that have genes encoding human HLA proteins.
MRC (Med. Res. Coun.) WO 97/06245 Brain-specific kinase London Gene for a threonine-tyrosine kinase expressed in brain; for investigating signal transduction in the brain.
Medvet Science WO 97/07215 Cytokine receptor agonists Adelaide, Australia Cytokine receptor family agonists; for preventing the activation of cytokine receptors.
Mitsubishi Chemical EPO 759 467 HGF activator protease inhibitor Tokyo Protein inhibitor of hepatocyte growth factor (HGF) activator protease activity, encoding gene, antibodies.
NIH (Natl. Inst. Hlth.) WO 97/07211 Diabetes autoantibodies Bethesda, Md. Methods for detecting autoantibodies in patients with insulin-dependent diabetes; for detection and treatment.
NIH (Natl. Inst. Hlth.) WO 97/07214 Adrenomedullin diabetes treatment Bethesda, Md. Use of adrenomedullin, a universal autocrine growth factor for cancer growth, and its antibodies to treat diabetes.
NIH (Natl. Inst. Hlth.) WO 97/07244 Subtractive amplified DNA isolation Bethesda, Md. Subtractive cDNA hybridization using biotinylated DNA and avidin-coated beads; for isolation of amplified DNA.
Nestle EPO 759 469 Bacteriocin Vevey, Switzerland Micrococcus bacteriocin, strain producing this substance, production method; for use as an antibacterial [in French].
Novo Nordisk WO 97/07205 & 07206 Polypeptide variant production Bagsvaerd, Denmark Polypeptide variants made by introducing an opened plasmid and homologous genes into recombinant host cells.
Oregon Hlth. Sci. Univ. WO 97/07212 Anti-opioid receptor peptide ligands Portland, Ore. Anti-opioid receptor protein and peptide ligands produced from it; for diagnosis and therapy.
Ottawa, Univ. of WO 97/06255 Apoptosis inhibitor genes Ottawa, Ont. Mammalian apoptosis inhibitor protein gene family; for inhibiting apoptosis and treating related diseases.
Pasteur Inst. WO 97/06271 Retroviral integration Paris Retroviral vectors with a Cre-lox recombinase; for viral element elimination and integration into the host genome.
Perkin-Elmer WO 97/06265 Cell selection system Foster City, Calif. Devices for isolating cells using binding pairs on the cell surfaces and solid support matrices.
Sandoz WO 97/07218 Fusion proteins for allergies Basel, Switzerland Fusion proteins with an antigen and a moiety interacting with CD32 receptor; for allergy therapy.
St. Jude's Children's Hosp. WO 97/07201 Mercaptopurine toxicity assay Memphis, Tenn. Mutant thiopurine S-methyltransferase genes, encoded proteins, antibodies; for mercaptopurine toxicity assay.
Sanko Junyaku WO 97/07207 Nucleic acid coprecipitate Tokyo Alcoholic nucleic acid extraction and purification using a coprecipitate that allows recovery of minute amounts of DNA.
Schweiz Serum Inst. WO 97/06270 Measles vaccines Bern, Switzerland Generation of non-segmented negative-strand RNA viruses from cDNAs; for measles vaccines.
Sumitomo Electric WO 97/06264 Bacterial peptide library Osaka, Japan Bacterial strains displaying fused proteins on their surfaces; for assaying activities.
Vertex Pharma WO 97/06249 Calcineurin binding pocket Cambridge, Mass. Calcineurin binding pocket for FK binding proteins, computer storage medium for three-dimensional representation.
von Melchner, H. et al. WO 97/07223 Self-deleting vectors Frankfurt, Germany Vectors encoding therapeutic proteins that delete viral-associated sequences upon transfection; for gene therapy.