Published January 15 & 22 (EPO & GB); December 19 & January 9 & 16 (WO)

Amicon GB 2 302 541 Polymerase initiating primers Beverly, Mass. Oligo primers of defined sequence that prime DNA polymerase initiating from double-stranded oligos.

Angeletti Molec. Biol. Res. Inst. WO 97/01634 Guanine-thymine binding protein Pomezia, Italy Gene for guanine-thymine binding protein, encoded protein; for mediation of mismatch repair.

Biotest EPO 754 755 EBV fusion proteins Dreieich, Germany Recombinant fusion proteins from Epstein-Barr virus (EBV); for making test kits to detect EBV antibodies [in German].

Boehringer Mannheim WO 97/00950 Immunoregulatory protein LST-1 Mannheim, Germany Gene for the immunoregulatory protein LST-1, encoded protein; for therapeutics.

Boston, City of Hosp. WO 97/01647 Identifying Pseudomonas cepacia Boston, Mass. Identifying DNA sequences of highly transmissible lineages of Pseudomonas cepacia, genes for pilin proteins.

Boston Univ. WO 97/00956 Adhesion molecules Boston, Mass. Genes for adhesion molecules, encoded proteins, antibodies; for treatment of cancer and heart attacks.

Chiron WO 97/00601 & 00893 IL-8 receptor antagonists Emeryville, Calif. Polypeptides that can modulate interleukin (IL)-8 receptor binding, encoding genes.

Cortecs Intl. WO 97/01638 Influenza vaccine Perth, Australia Gene for Haemophilus influenzae outer membrane protein, encoded protein; for vaccination.

Delta Biotech GB 2 302 329 Mutant yeast production strains Nottingham, U.K. Yeast production strains lacking functional heat shock protein genes; for easier foreign protein purification.

Guilford Pharma WO 96/40140 Neurotrophic immunophilin inhibitors Baltimore, Md. Neurotrophic pipecolic acid derivatives as inhibitors of FKBP-type immunophilins; for neuronal growth.

Guilford Pharma WO 96/40633 Neurotrophic immunophilin inhibitors Baltimore, Md. Neurotrophic N-glyoxyl-prolyl esters as inhibitors of FKPB-type immunophilins; for neuronal growth.

Harvard Univ. WO 97/00953 Vascular disease gene Cambridge, Mass. Aortic-preferentially-expressed-1 gene, control sequences, encoded protein; for vascular disease diagnosis/treatment.

Harvard Univ. WO 97/00957 Endothelial cell-specific promoter Cambridge, Mass. DNA sequences that act as an endothelial cell-specific promoter; for affecting endothelial cell growth.

Hoechst EPO 753 580 TIMP-3 promoter gene therapy Frankfurt, Germany Tissue inhibitor of metalloproteinase-3 (TIMP-3) promoter; for macrophage-specific gene therapy [in German].

Igen WO 97/01627 Ubiquitin fusion production Gaithersburg, Md. Process for getting high yields of recombinant protein with a ubiquitin peptide fusion expression system in E. coli.

Immunex WO 97/01633 Apoptosis-inducing cytokine Seattle, Wash. Apoptosis-inducing cytokine, encoding gene, antibodies, expression vector, host cells.

Immuno EPO 753 581 Recombinant cytoplasmic viruses Vienna, Austria Recombinant eukaryotic cytoplasmic viruses with selection and marker genes, production methods; for vaccines.

Imp. Cancer Res. Tech. WO 97/01571 Delta genes London Vertebrate Delta genes, encoded proteins, fragments, antibodies; for diagnosis and therapy.

Incyte Pharma WO 97/00952 EDG-2 receptor homolog Palo Alto, Calif. Gene for EDG-2 receptor homolog in human rheumatoid synovium, encoded protein, probes, antisense, antibodies.

Incyte Pharma WO 97/00955 RAB18 gene homolog Palo Alto, Calif. Gene for the human homolog of the mouse RAB18 gene, antisense, probes, encoded protein; for identifying agonists.

Innogenetics EPO 754 704 Hepatitis C epitopes Ghent, Belgium Synthetic peptide epitopes of hepatitis C virus; for detecting HCV antibodies and antigens.

Japan Tobacco EPO 753 248 SAHH-deficient transgenics Tokyo Transgenic organism with inhibited expression of S-adenosylhomocysteine hydrolase (SAHH) genes; for viral resistance.

Kirin Beer EPO 754 703 Peptide for mucin sugars Tokyo Specific peptide sequence that attaches a mucin sugar chain; for introducing sugar chains into a protein.

Kirin Beer WO 97/00959 Glycosylation inhibiting factor Tokyo Gene for an antigen non-specific glycosylation inhibiting factor, encoded protein; for immunosuppression.

Kyowa Hakko Kogyo EPO 753 577 Periodontal disease protein Tokyo Gene for surface protein of Pophyromonas gigivalis, encoded protein; for diagnosis/treatment of periodontal disease.

Leukosite WO 97/00960 Eotaxin cytokine Cambridge, Mass. Gene for a human chemotactic cytokine designated eotaxin, encoded protein; for treating immune diseases.

Ludwig Inst. Cancer Res. WO 97/01574 Mouse SMAGE-3 New York Autosomal gene for mouse tumor rejection antigen precursor (SMAGE)-3, encoded protein.

Madaus WO 97/01636 Mistletoe lectins Koln, Germany Genes for mistletoe lectins, encoded proteins, expression methods; for making immunotoxins.

Mass. Inst. Tech. WO 97/00949 Z-DNA binding protein Cambridge, Mass. Z-DNA binding protein that can also bind double-stranded RNA and has sequence similarities to adenosine deaminase.

Massachusetts, Univ. Med. Ctr. WO 97/01648 Human HIV protein Worcester, Mass. Human cellular protein that is essential for HIV Rev activity and HIV replication.

Micromet WO 97/00946 Epithelial tumors for vaccines Planegg, Germany Epithelial cell tumor cells with metastatic potential and introduced oncogene/immunostimulatory gene; for vaccines.

Neurex WO 97/01635 Bax-omega gene Menlo Park, Calif. Bax-omega gene, encoded protein; for inducing apoptosis and identifying binding compounds.

New England Biolabs WO 97/01642 Modified protein production Beverly, Mass. Modified proteins containing a controllable intervening protein sequence; for production and purification.

Ono Pharma EPO 753 527 & 528 PGE2/PGI2 receptors Osaka, Japan Genes for prostaglandin E2 (PGE2) and I2 (PGI2) receptors, encoded proteins, antibodies; for identifying agonists.

Orion-Yhtyma WO 97/01630 Human glandular kallikrein-1 Espoo, Finland Gene for human glandular kallikrein-1, encoded protein, baculovirus expression vector system.

Otsuka Pharma EPO 754 754 FK506 binding protein Tokyo Gene for an FK506 binding protein, encoded protein; for screening immunosuppressive and autoimmune disease agents.

Pittsburgh, Univ. of WO 97/00965 Lipidic vector for gene delivery Pittsburgh, Penn. Polycationic-vector complex associated with an anionic lipid and targeting proteins; for nucleic acid delivery.

Rhone-Poulenc Rorer WO 97/00947 Adenoviral therapeutics Antony, France Recombinant adenoviruses with a heterologous gene controlled by an inducible promoter, cell lines; for therapeutics.

St. Vincent's Hosp. WO 97/00958 TGF-ß like cytokine Darlinghurst, Australia Gene for a TGF-ß like cytokine, encoded protein, biologically active fragments, expression methods.

Sheffield, Univ. of WO 97/01639 Recombinant molecule selection Sheffield, U.K. Identification and isolation of recombinant molecules from cells that are only viable when containing this material.

SmithKline Beecham WO 97/01573 Early onset Alzheimer's genes King of Prussia, Penn. Genes associated with early onset Alzheimer's disease, encoded proteins.

SmithKline Beecham WO 97/01640 Hepatitis C vaccines Rixensart, Belgium Hepatitis C core or envelope proteins emulsified with an oil; for making vaccines.

Takara Shuzo EPO 753 579 Animal cell promoter sequence Kyoto, Japan DNA sequence with promoter activity; for directing expression of foreign proteins in animal cells.

Tanuma, S. EPO 754 751 DNases Tokyo Gene for DNases, encoded proteins; for controlling apoptosis and viral infection.

Texas, Univ. of WO 97/00954 C-CAM gene Austin, Tex. Gene for C-CAM, regulatory elements, encoded protein, adenoviral vector; for cancer cell growth inhibition.

Tularik WO 97/00690 IL-1 receptor-associated kinases S. San Francisco Interleukin (IL)-1 receptor-associated protein kinases, encoding genes, oligo probes; for pharmacologic screening.

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