Published January 2 & 8 (EPO) December 27 & January 3 (WO)
Ariad Gene Therapeutics WO 96/41865
Vectors using rapamycin binding protein-based regulation of gene expression, for identifying agonists.
Australian Natl. Univ. WO 96/41878
Staphylococcus pathogenicity genes
Staphylococcus aureus genes suitable for determining strain pathogenicity, encoded proteins, antibodies; for therapy.
Baylor Coll. Med. EPO 752 477
Mutated steroid hormone receptors
Genes for mutated steroid hormone receptors, encoded muteins; for regulating expression in gene therapy.
Behringwerke EPO 751 147
Toxoplasma gondii antigen and its encoding gene, production methods; for use in assaying patient serum [in German].
Boehringer Mannheim EPO 752 474
N-glycolylneuraminic acid-free proteins
Gene for CMP-N-acetylneuraminic acid hydroxylase, encoded protein; for making N-glycolylneuraminic acid-free proteins.
Boehringer Mannheim WO 97/00241
Cationic and polycationic amphiphiles for making DNA and RNA aggregates; for transfection.
California, Univ. of WO 96/41873
Dry DNA formulations
Dry powder formulations of nucleic acids using cryoprotectants and lyophilization; for lung cell transfections.
Cor Therapeutics EPO 751 219
Platelet aggregation inhibitors
S. San Francisco
Snake venom platelet aggregation inhibitors of binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
French Atomic Energy Comm. EPO 752 475
Modified alkaline phosphatases
Modified bacterial alkaline phosphatases, encoding genes; for thermal stability in immunoassay reagents [in French].
French Inst. Sci. Res. WO 96/41884
Non-CD4 gp120 receptors
gp120 receptors that differ from the CD4 binding receptor; for detecting and preventing HIV infection.
Harvard Univ. WO 96/41883
Plasmin-resistant streptokinase, fusion proteins, and mutations with altered cleavage sites.
Idec Pharma EPO 752 248
B cell lymphoma antibody
San Diego, Calif.
Chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen; for B cell lymphoma.
Immunex WO 96/41624
TNF- converting enzyme
Gene for TNF- converting enzyme, encoded protein; for designing inhibitors as therapeutics.
Immuno WO 97/00322
Immunogenic component bonded or absorbed to an inactive flavivirus; for vaccine preparation.
Introgene WO 96/41875
p53 binding protein
Gene for a p53 binding protein related to Mdm2, encoded protein; for identification of similar proteins.
Introgene WO 97/00326
Adenoviral packaging systems
Packaging systems for human recombinant adenoviruses with mutations and large sizes to prevent recombination.
Krebs Res. Ctr. WO 96/41887
Gene for a DNase-active protein, encoded protein, antibodies, production process.
Madaus EPO 751 221
Gene for preprotein mistellektin, encoded protein; for diagnostics and therapeutics [in German].
Max Planck Inst. WO 96/41880
Helicobacter adherence gene
Helicobacter pylori adherence gene, encoded protein, antibodies; for therapy.
Microbiological Res. Auth. WO 96/41881
Botulinum toxin fragments
Type F botulinum toxin fragments that are not toxic, antibodies to them; for therapy.
Natl. Inst. Agron. Res. (INSERM) WO 96/41889
Yeast protein production
Upstream activator and recombinant promoter sequences functional in Yarrowia; for protein production in yeast.
Novo Nordisk WO 97/00316
Fungal trypsin production
Vector with a signal sequence for gene expression in filamentous fungi; for trypsin production.
Oregon Hlth. Sci. Univ. WO 97/00315
Protein kinase phosphatases
Mitogen-activated protein kinase phosphatase cDNAs and their expression products; for cell growth control.
Osteosa WO 97/00317 & 00318
Osteoclast stimulating factor
San Antonio, Tex.
Gene for osteoclast stimulating factor, encoded protein, antibodies, antagonists; for treating bone disease.
Pasteur Inst. EPO 752 473
Helicobacter flagellar protein
Helicobacter pylori flagellar protein gene, encoded protein, flagella-free strain production; for therapy [in French].
Pasteur Inst. WO 96/41877
Malarial pre-erythrocyte antigens
Malarial polypeptide antigens from the pre-erythrocyte stage; for designing therapeutics.
Progen WO 96/41810
DNA extraction apparatus
Apparatus for growing cells and extracting DNA from them using a hollow membrane filter.
Prolifix WO 97/00323
Adenovirus transactivation inhibition
Adenovirus E1A-associated protein that inhibits E1A transactivation, encoded gene.
Saskatchewan, Univ. of WO 96/41879
Streptococcus infection prevention
Streptococcus uberis CAMP factor gene, encoded protein, production methods; for infection treatment.
Schering WO 96/41885
Bacterial nitric oxide synthetase
Expression of soluble, active inducible nitric oxide synthetase in E. coli, dependant on calmodulin coexpression.
Sibia Neurosciences WO 96/41876
Nicotinic acetylcholine receptor
La Jolla, Calif.
Gene for human neuronal nicotinic acetylcholine receptor, encoded protein; for producing and ß subunits.
SmithKline Beecham WO 96/41886
Clavam antibiotic production
Plasmids with defective lysine amino transferase gene; for increased production of clavam antibiotics.
SmithKline Beecham WO 97/00319
Leptin mutants or variants linked to a human immunoglobulin domain; for prolonged clearance times in obesity treatment.
Stanford Univ. WO 97/00266
T cell transcription enhancers
Palo Alto, Calif.
Transcription enhancer sequences for late T cell expressed genes; for enhancing gene expression.
Takara Shuzo EPO 751 222
Gene for a protein with endoglycoceramidase activity, encoded protein and variants.
Takeda EPO 751 220
Human interleukin (IL)-2 gene and encoded non-glycosylated protein, purification methods.
Victoria, Univ. of WO 97/00067
Gene for Mycobacterium tuberculosis immunostimulatory proteins, encoded proteins; for making vaccines.
Yamanouchi Pharma WO 97/00320
MACIF mutein for rejection
Mutated human MACIF active protein, expression vector, production methods; for inhibiting hyperacute rejection.
Yeda Res. & Develop. WO 96/41523
Fibroblast growth factor
Fibroblast growth factor (FGF) 9, a high affinity ligand for FGF receptor 3; for transgenics and identifying agonists.