Published January 2 & 8 (EPO) December 27 & January 3 (WO)

Ariad Gene Therapeutics WO 96/41865

Rapamycin-based regulation

Cambridge, Mass.

Vectors using rapamycin binding protein-based regulation of gene expression, for identifying agonists.

Australian Natl. Univ. WO 96/41878

Staphylococcus pathogenicity genes

Acton, Australia

Staphylococcus aureus genes suitable for determining strain pathogenicity, encoded proteins, antibodies; for therapy.

Baylor Coll. Med. EPO 752 477

Mutated steroid hormone receptors

Houston, Tex.

Genes for mutated steroid hormone receptors, encoded muteins; for regulating expression in gene therapy.

Behringwerke EPO 751 147

Toxoplasmosis antigen

Marburg, Germany

Toxoplasma gondii antigen and its encoding gene, production methods; for use in assaying patient serum [in German].

Boehringer Mannheim EPO 752 474

N-glycolylneuraminic acid-free proteins

Mannheim, Germany

Gene for CMP-N-acetylneuraminic acid hydroxylase, encoded protein; for making N-glycolylneuraminic acid-free proteins.

Boehringer Mannheim WO 97/00241

Cationic transfection

Mannheim, Germany

Cationic and polycationic amphiphiles for making DNA and RNA aggregates; for transfection.

California, Univ. of WO 96/41873

Dry DNA formulations

Oakland, Calif.

Dry powder formulations of nucleic acids using cryoprotectants and lyophilization; for lung cell transfections.

Cor Therapeutics EPO 751 219

Platelet aggregation inhibitors

S. San Francisco

Snake venom platelet aggregation inhibitors of binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

French Atomic Energy Comm. EPO 752 475

Modified alkaline phosphatases


Modified bacterial alkaline phosphatases, encoding genes; for thermal stability in immunoassay reagents [in French].

French Inst. Sci. Res. WO 96/41884

Non-CD4 gp120 receptors


gp120 receptors that differ from the CD4 binding receptor; for detecting and preventing HIV infection.

Harvard Univ. WO 96/41883

Plasmin-resistant streptokinase

Cambridge, Mass.

Plasmin-resistant streptokinase, fusion proteins, and mutations with altered cleavage sites.

Idec Pharma EPO 752 248

B cell lymphoma antibody

San Diego, Calif.

Chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen; for B cell lymphoma.

Immunex WO 96/41624

TNF- converting enzyme

Seattle, Wash.

Gene for TNF- converting enzyme, encoded protein; for designing inhibitors as therapeutics.

Immuno WO 97/00322

Flavivirus vaccine

Vienna, Austria

Immunogenic component bonded or absorbed to an inactive flavivirus; for vaccine preparation.

Introgene WO 96/41875

p53 binding protein

Rijswijk, Netherlands

Gene for a p53 binding protein related to Mdm2, encoded protein; for identification of similar proteins.

Introgene WO 97/00326

Adenoviral packaging systems

Rijswijk, Netherlands

Packaging systems for human recombinant adenoviruses with mutations and large sizes to prevent recombination.

Krebs Res. Ctr. WO 96/41887

DNase-active protein

Heidelberg, Germany

Gene for a DNase-active protein, encoded protein, antibodies, production process.

Madaus EPO 751 221

Recombinant mistellektin

Koln, Germany

Gene for preprotein mistellektin, encoded protein; for diagnostics and therapeutics [in German].

Max Planck Inst. WO 96/41880

Helicobacter adherence gene

Munich, Germany

Helicobacter pylori adherence gene, encoded protein, antibodies; for therapy.

Microbiological Res. Auth. WO 96/41881

Botulinum toxin fragments

Salisbury, U.K.

Type F botulinum toxin fragments that are not toxic, antibodies to them; for therapy.

Natl. Inst. Agron. Res. (INSERM) WO 96/41889

Yeast protein production


Upstream activator and recombinant promoter sequences functional in Yarrowia; for protein production in yeast.

Novo Nordisk WO 97/00316

Fungal trypsin production

Bagsvaerd, Denmark

Vector with a signal sequence for gene expression in filamentous fungi; for trypsin production.

Oregon Hlth. Sci. Univ. WO 97/00315

Protein kinase phosphatases

Portland, Ore.

Mitogen-activated protein kinase phosphatase cDNAs and their expression products; for cell growth control.

Osteosa WO 97/00317 & 00318

Osteoclast stimulating factor

San Antonio, Tex.

Gene for osteoclast stimulating factor, encoded protein, antibodies, antagonists; for treating bone disease.

Pasteur Inst. EPO 752 473

Helicobacter flagellar protein


Helicobacter pylori flagellar protein gene, encoded protein, flagella-free strain production; for therapy [in French].

Pasteur Inst. WO 96/41877

Malarial pre-erythrocyte antigens


Malarial polypeptide antigens from the pre-erythrocyte stage; for designing therapeutics.

Progen WO 96/41810

DNA extraction apparatus

Darra, Australia

Apparatus for growing cells and extracting DNA from them using a hollow membrane filter.

Prolifix WO 97/00323

Adenovirus transactivation inhibition


Adenovirus E1A-associated protein that inhibits E1A transactivation, encoded gene.

Saskatchewan, Univ. of WO 96/41879

Streptococcus infection prevention

Saskatoon, Saskatchewan

Streptococcus uberis CAMP factor gene, encoded protein, production methods; for infection treatment.

Schering WO 96/41885

Bacterial nitric oxide synthetase

Kenilworth, N.J.

Expression of soluble, active inducible nitric oxide synthetase in E. coli, dependant on calmodulin coexpression.

Sibia Neurosciences WO 96/41876

Nicotinic acetylcholine receptor

La Jolla, Calif.

Gene for human neuronal nicotinic acetylcholine receptor, encoded protein; for producing and ß subunits.

SmithKline Beecham WO 96/41886

Clavam antibiotic production

Brentford, U.K.

Plasmids with defective lysine amino transferase gene; for increased production of clavam antibiotics.

SmithKline Beecham WO 97/00319

Chimeric leptins

Brentford, U.K.

Leptin mutants or variants linked to a human immunoglobulin domain; for prolonged clearance times in obesity treatment.

Stanford Univ. WO 97/00266

T cell transcription enhancers

Palo Alto, Calif.

Transcription enhancer sequences for late T cell expressed genes; for enhancing gene expression.

Takara Shuzo EPO 751 222


Kyoto, Japan

Gene for a protein with endoglycoceramidase activity, encoded protein and variants.

Takeda EPO 751 220

Non-glycosylated IL-2

Osaka, Japan

Human interleukin (IL)-2 gene and encoded non-glycosylated protein, purification methods.

Victoria, Univ. of WO 97/00067

Tuberculosis vaccines

Victoria, B.C.

Gene for Mycobacterium tuberculosis immunostimulatory proteins, encoded proteins; for making vaccines.

Yamanouchi Pharma WO 97/00320

MACIF mutein for rejection


Mutated human MACIF active protein, expression vector, production methods; for inhibiting hyperacute rejection.

Yeda Res. & Develop. WO 96/41523

Fibroblast growth factor

Rehovot, Israel

Fibroblast growth factor (FGF) 9, a high affinity ligand for FGF receptor 3; for transgenics and identifying agonists.