Published January 2 & 8 (EPO) December 27 & January 3 (WO)

Ariad Gene Therapeutics WO 96/41865 Rapamycin-based regulation Cambridge, Mass. Vectors using rapamycin binding protein-based regulation of gene expression, for identifying agonists.

Australian Natl. Univ. WO 96/41878 Staphylococcus pathogenicity genes Acton, Australia Staphylococcus aureus genes suitable for determining strain pathogenicity, encoded proteins, antibodies; for therapy.

Baylor Coll. Med. EPO 752 477 Mutated steroid hormone receptors Houston, Tex. Genes for mutated steroid hormone receptors, encoded muteins; for regulating expression in gene therapy.

Behringwerke EPO 751 147 Toxoplasmosis antigen Marburg, Germany Toxoplasma gondii antigen and its encoding gene, production methods; for use in assaying patient serum [in German].

Boehringer Mannheim EPO 752 474 N-glycolylneuraminic acid-free proteins Mannheim, Germany Gene for CMP-N-acetylneuraminic acid hydroxylase, encoded protein; for making N-glycolylneuraminic acid-free proteins.

Boehringer Mannheim WO 97/00241 Cationic transfection Mannheim, Germany Cationic and polycationic amphiphiles for making DNA and RNA aggregates; for transfection.

California, Univ. of WO 96/41873 Dry DNA formulations Oakland, Calif. Dry powder formulations of nucleic acids using cryoprotectants and lyophilization; for lung cell transfections.

Cor Therapeutics EPO 751 219 Platelet aggregation inhibitors S. San Francisco Snake venom platelet aggregation inhibitors of binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

French Atomic Energy Comm. EPO 752 475 Modified alkaline phosphatases Paris Modified bacterial alkaline phosphatases, encoding genes; for thermal stability in immunoassay reagents [in French].

French Inst. Sci. Res. WO 96/41884 Non-CD4 gp120 receptors Paris gp120 receptors that differ from the CD4 binding receptor; for detecting and preventing HIV infection.

Harvard Univ. WO 96/41883 Plasmin-resistant streptokinase Cambridge, Mass. Plasmin-resistant streptokinase, fusion proteins, and mutations with altered cleavage sites.

Idec Pharma EPO 752 248 B cell lymphoma antibody San Diego, Calif. Chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen; for B cell lymphoma.

Immunex WO 96/41624 TNF- converting enzyme Seattle, Wash. Gene for TNF- converting enzyme, encoded protein; for designing inhibitors as therapeutics.

Immuno WO 97/00322 Flavivirus vaccine Vienna, Austria Immunogenic component bonded or absorbed to an inactive flavivirus; for vaccine preparation.

Introgene WO 96/41875 p53 binding protein Rijswijk, Netherlands Gene for a p53 binding protein related to Mdm2, encoded protein; for identification of similar proteins.

Introgene WO 97/00326 Adenoviral packaging systems Rijswijk, Netherlands Packaging systems for human recombinant adenoviruses with mutations and large sizes to prevent recombination.

Krebs Res. Ctr. WO 96/41887 DNase-active protein Heidelberg, Germany Gene for a DNase-active protein, encoded protein, antibodies, production process.

Madaus EPO 751 221 Recombinant mistellektin Koln, Germany Gene for preprotein mistellektin, encoded protein; for diagnostics and therapeutics [in German].

Max Planck Inst. WO 96/41880 Helicobacter adherence gene Munich, Germany Helicobacter pylori adherence gene, encoded protein, antibodies; for therapy.

Microbiological Res. Auth. WO 96/41881 Botulinum toxin fragments Salisbury, U.K. Type F botulinum toxin fragments that are not toxic, antibodies to them; for therapy.

Natl. Inst. Agron. Res. (INSERM) WO 96/41889 Yeast protein production Paris Upstream activator and recombinant promoter sequences functional in Yarrowia; for protein production in yeast.

Novo Nordisk WO 97/00316 Fungal trypsin production Bagsvaerd, Denmark Vector with a signal sequence for gene expression in filamentous fungi; for trypsin production.

Oregon Hlth. Sci. Univ. WO 97/00315 Protein kinase phosphatases Portland, Ore. Mitogen-activated protein kinase phosphatase cDNAs and their expression products; for cell growth control.

Osteosa WO 97/00317 & 00318 Osteoclast stimulating factor San Antonio, Tex. Gene for osteoclast stimulating factor, encoded protein, antibodies, antagonists; for treating bone disease.

Pasteur Inst. EPO 752 473 Helicobacter flagellar protein Paris Helicobacter pylori flagellar protein gene, encoded protein, flagella-free strain production; for therapy [in French].

Pasteur Inst. WO 96/41877 Malarial pre-erythrocyte antigens Paris Malarial polypeptide antigens from the pre-erythrocyte stage; for designing therapeutics.

Progen WO 96/41810 DNA extraction apparatus Darra, Australia Apparatus for growing cells and extracting DNA from them using a hollow membrane filter.

Prolifix WO 97/00323 Adenovirus transactivation inhibition London Adenovirus E1A-associated protein that inhibits E1A transactivation, encoded gene.

Saskatchewan, Univ. of WO 96/41879 Streptococcus infection prevention Saskatoon, Saskatchewan Streptococcus uberis CAMP factor gene, encoded protein, production methods; for infection treatment.

Schering WO 96/41885 Bacterial nitric oxide synthetase Kenilworth, N.J. Expression of soluble, active inducible nitric oxide synthetase in E. coli, dependant on calmodulin coexpression.

Sibia Neurosciences WO 96/41876 Nicotinic acetylcholine receptor La Jolla, Calif. Gene for human neuronal nicotinic acetylcholine receptor, encoded protein; for producing and ß subunits.

SmithKline Beecham WO 96/41886 Clavam antibiotic production Brentford, U.K. Plasmids with defective lysine amino transferase gene; for increased production of clavam antibiotics.

SmithKline Beecham WO 97/00319 Chimeric leptins Brentford, U.K. Leptin mutants or variants linked to a human immunoglobulin domain; for prolonged clearance times in obesity treatment.

Stanford Univ. WO 97/00266 T cell transcription enhancers Palo Alto, Calif. Transcription enhancer sequences for late T cell expressed genes; for enhancing gene expression.

Takara Shuzo EPO 751 222 Endoglycoceramidase Kyoto, Japan Gene for a protein with endoglycoceramidase activity, encoded protein and variants.

Takeda EPO 751 220 Non-glycosylated IL-2 Osaka, Japan Human interleukin (IL)-2 gene and encoded non-glycosylated protein, purification methods.

Victoria, Univ. of WO 97/00067 Tuberculosis vaccines Victoria, B.C. Gene for Mycobacterium tuberculosis immunostimulatory proteins, encoded proteins; for making vaccines.

Yamanouchi Pharma WO 97/00320 MACIF mutein for rejection Tokyo Mutated human MACIF active protein, expression vector, production methods; for inhibiting hyperacute rejection.

Yeda Res. & Develop. WO 96/41523 Fibroblast growth factor Rehovot, Israel Fibroblast growth factor (FGF) 9, a high affinity ligand for FGF receptor 3; for transgenics and identifying agonists.