Published November 20 & 27 (EPO);November 14 & 21 (WO); November 20(GB)

Abbott Labs WO 96/36722

Microbial production system

Abbott Park, Ill.

Microbial production of recombinantproteins as fusions with a carrierprokaryotic protein.

Alberta, Univ. of WO 96/36643

Calreticulin treating restenosis

Edmonton, Alberta

Calreticulin and fragments; fortreating restenosis, plaque growth,and atherosclerosis.

Allelix Biopharma WO 96/36721

E. coli production system

Missisauga, Ont.

Expression system for recombinantprotein production in E. coli hosts;for increased yield.

Amgen WO 96/36713

eck receptor ligands

Thousand Oaks, Calif.

Genes for eck receptor ligands,encoded ligands; for assaying bindingactivity and use in therapy.

Applied Res. Systems WO96/35782

IL-6 expression inhibition

Curacao, Netherlands Antilles

Transcription factor nucleotidebinding site that inhibits IL-6 geneexpression and activity.

Boehringer Ingelheim WO96/35784

Chromatin regulator genes

Ingelheim, Germany

Chromatin regulator genes having a SETdomain; for diagnosis and therapy ofcancer.

Bristol-Myers Squibb WO96/36720

HER4 receptor regulator

Princeton, N.J.

Gene for EGF-like domain of heregulin,a regulator of the HER4 receptor,encoded heregulin; for receptoractivation.

California, Univ. of WO96/36355

Leptospirosis detection

Oakland, Calif.

Membrane lipoproteins of pathogenicstrains of Leptospira, encoding genes,antibodies; for diagnosingleptospirosis.

California, Univ. of WO96/36705

Virus resistance vectors

Oakland, Calif.

Viral vectors that stably transducecells and are amplified upon targetvirus infection of cells causingresistance.

Chiron WO 96/35783

Soluble IL-2 receptors

Emeryville, Calif.

Coiled-coil mediated solution assemblyof stable heteromeric complexes of IL-2 receptor surface domains; forbinding.

Chiron WO 96/35787

Obesity genes

Emeryville, Calif.

Genes for proteins that caneffectively inhibit food intake and/orweight gain, encoded proteins,antibodies.

Eisai EPO 744 467

Multiple hepatitis C antigens

Kagoshima, Japan

Multiple hepatitis C virus-associatedpeptides; for use as antigens in viraldetection kits.

Fox Chase Cancer Ctr. WO96/35777

Targeted gene integration

Philadelphia, Penn.

Chimeric enzymes with DNA binding andretroviral integrase moieties, encodedproteins; for gene integration.

French Atomic Energy Comm. EPO743 364

HIV transmission to fetus


Nucleic acid fragments and peptidesderived from HIV; for evaluationmaternal-fetal HIV transmission [inFrench].

Genetics Inst. WO 96/36710

BMP-15-related proteins

Cambridge, Mass.

Genes for bone morphogenic protein(BMP)-15-related proteins, encodedproteins, production; for tissuerepair.

Harvard Univ. WO 96/36730

Cell death protein

Cambridge, Mass.

Protein with kinase and death domains,encoding gene, antibodies; forscreening apoptosis mediators.

Human Genome Sciences WO96/35703

Human inhibitor of apoptosis

Rockville, Md.

Gene for human inhibitor of apoptosisgene 1, encoded protein; for detectingmutations and treating disease.

Human Genome Sciences WO96/35778

UDP galactose-4-epimerase

Rockville, Md.

Gene for human uridine diphosphate(UDP) galactose-4-epimerase, encodedprotein; for treating galactosemia.

Human Genome Sciences WO96/36709


Rockville, Md.

Gene for transforming growth factor(TGF)-aIII and mutations, encodedproteins; for diagnostic assays.

Imp. Cancer Res. Technol. GB2 300 859

Cytotoxic fusion proteins


Chimeric proteins with cell targetingand cytotoxic domains; for treatingcancer.

Introgene WO 96/35798

Gene therapy retroviral vectors

Rijswijk, Netherlands

Retroviral vectors with an enhanceractive in undifferentiated cells andno superfluous retroviral sequences.

Johns Hopkins Univ. WO 96/35704

FGF homologous factor-2

Baltimore, Md.

Gene for fibroblast growth factor(FGF) homologous factor-2, encodedprotein, antibodies.

Johns Hopkins Univ. WO 96/35716

p16 DNA methylation

Baltimore, Md.

Methylation of p16 DNA and itsdecreased expression; for detectingtranscriptional block and presence oftumors.

Karo Bio WO 96/35785

Thyroid hormone receptor defect

Huddinge, Sweden

Transgenic mammals having a defectivethyroid hormone receptor a gene andderived cells.

Eli Lilly EPO 743 321, 744 408, &WO 96/36644

Rhesus obesity gene

Indianapolis, Ind.

Rhesus gene for adipose tissue amountregulation, encoded protein, vectors,expression system.

Max Planck Inst. EPO 743 367

Gene expression analysis

Munich, Germany

Gene expression analysis in genefamilies by determining differentialexpression [in German].

Max Planck Inst. WO 96/35797

Hepatitis B vector

Munich, Germany

Hepatitis B vector with functionalgenes having partial deletions,production cells, expression methods.

Merck EPO 743 366

Listeria determination


Recombinant bacteriophage expressingListeria genes; for listeriaidentification [in German].

Merck WO 96/36706

Large scale plasmid purification

Rahway, N.J.

Process for large scale isolation andpurification of all forms of plasmidDNA; for use as a therapeutic.

Michigan, Univ. of WO 96/36361

Single-stranded DNA antibodies

Ann Arbor, Mich.

Antibodies that bind single-strandedDNA but not double-stranded DNA; forscreening for DNA antibodies.

Minnesota, Univ. of WO 96/36360

Anti-CD19 cancer therapy

Minneapolis, Minn.

Single chain variable region fragmentsof anti-CD19 antibodies conjugated tocytotoxic agents; for cancer therapy.

NIH (Natl. Inst. Hlth.) WO96/35781

Expression inhibition

Bethesda, Md.

Phage display library of single chainrecombinant binding proteins; forinhibiting intracellular expression.

Progen Biotech WO 96/36708

Thrombosis autoantigen

Heidelberg, Germany

Gene for an autoantigen that isassociated with a tendency forthrombosis, encoded protein,production methods.

Ramot Univ. WO 96/36695

Ataxia-telangiectasia gene

Tel Aviv, Israel

Purified and isolated ataxia-telangiectasia gene, mutations thatcause this disease.

Rome, Univ. of WO 96/36706

Heat shock protein yeast homolog

Rome, Italy

Gene from the yeast Candida that ishomologous to the 70kd heat shockprotein gene, encoded protein; fortherapy.

St. Jude's Hosp. WO 96/35454

Stable virus packaging cells

Memphis, Tenn.

Recombinant packaging and producercell lines; for making high titerretroviral vectors.

Salk Inst. EPO 743 520

Steroid receptor ligands

La Jolla, Calif.

Chimeric receptors with ligand bindingdomains of steroid receptor and yeastGAL4 protein; for identifying ligands.

Sanofi WO 96/35791

Insulin receptor substrate ribozyme


Coding sequence for a hammerheadribozyme against the insulin receptorsubstrate and fragments.

Scios WO 96/35788

APP protease inhibitor domain

Mountain View, Calif.

Analogs of the Kunitz proteaseinhibitor domain of amyloid precursorprotein (APP), encoding genes.

Strang Cancer Prev. Ctr. WO96/36711

Insulin gene expression regulators

New York

Genes for homeoprotein regulators ofinsulin gene expression, encodedproteins, antibodies; for assays.

T Breeders WO 96/36696

Undifferentiated cell expansion

Worcester, Mass.

Cell culture of undifferentiated cellsand their isolation using specificsurface antigen binding molecules.

Takara Shuzo WO 96/36714

B cell tumor antibody fragment

Kyoto, Japan

Gene for a complementarity determiningregion of an immunoglobulin specificfor B cell tumors, encoded protein.

Thomas Jefferson Univ. WO96/36698

Apoptotic Ced-3 Ice cysteine protease

Philadelphia, Penn.

A member of the apoptotic Ced-3 Icecysteine protease gene family,encoding gene and fragments,antibodies.

Women's Res. Inst. WO 96/35789

Interferon tau

Wichita, Kan.

Genes for multiple forms of interferontau, encoded proteins; for production.

(c) 1997 American Health Consultants. All rights reserved.