Published November 20 & 27 (EPO);November 14 & 21 (WO); November 20(GB)
Abbott Labs WO 96/36722
Microbial production system
Abbott Park, Ill.
Microbial production of recombinantproteins as fusions with a carrierprokaryotic protein.
Alberta, Univ. of WO 96/36643
Calreticulin treating restenosis
Calreticulin and fragments; fortreating restenosis, plaque growth,and atherosclerosis.
Allelix Biopharma WO 96/36721
E. coli production system
Expression system for recombinantprotein production in E. coli hosts;for increased yield.
Amgen WO 96/36713
eck receptor ligands
Thousand Oaks, Calif.
Genes for eck receptor ligands,encoded ligands; for assaying bindingactivity and use in therapy.
Applied Res. Systems WO96/35782
IL-6 expression inhibition
Curacao, Netherlands Antilles
Transcription factor nucleotidebinding site that inhibits IL-6 geneexpression and activity.
Boehringer Ingelheim WO96/35784
Chromatin regulator genes
Chromatin regulator genes having a SETdomain; for diagnosis and therapy ofcancer.
Bristol-Myers Squibb WO96/36720
HER4 receptor regulator
Gene for EGF-like domain of heregulin,a regulator of the HER4 receptor,encoded heregulin; for receptoractivation.
California, Univ. of WO96/36355
Membrane lipoproteins of pathogenicstrains of Leptospira, encoding genes,antibodies; for diagnosingleptospirosis.
California, Univ. of WO96/36705
Virus resistance vectors
Viral vectors that stably transducecells and are amplified upon targetvirus infection of cells causingresistance.
Chiron WO 96/35783
Soluble IL-2 receptors
Coiled-coil mediated solution assemblyof stable heteromeric complexes of IL-2 receptor surface domains; forbinding.
Chiron WO 96/35787
Genes for proteins that caneffectively inhibit food intake and/orweight gain, encoded proteins,antibodies.
Eisai EPO 744 467
Multiple hepatitis C antigens
Multiple hepatitis C virus-associatedpeptides; for use as antigens in viraldetection kits.
Fox Chase Cancer Ctr. WO96/35777
Targeted gene integration
Chimeric enzymes with DNA binding andretroviral integrase moieties, encodedproteins; for gene integration.
French Atomic Energy Comm. EPO743 364
HIV transmission to fetus
Nucleic acid fragments and peptidesderived from HIV; for evaluationmaternal-fetal HIV transmission [inFrench].
Genetics Inst. WO 96/36710
Genes for bone morphogenic protein(BMP)-15-related proteins, encodedproteins, production; for tissuerepair.
Harvard Univ. WO 96/36730
Cell death protein
Protein with kinase and death domains,encoding gene, antibodies; forscreening apoptosis mediators.
Human Genome Sciences WO96/35703
Human inhibitor of apoptosis
Gene for human inhibitor of apoptosisgene 1, encoded protein; for detectingmutations and treating disease.
Human Genome Sciences WO96/35778
Gene for human uridine diphosphate(UDP) galactose-4-epimerase, encodedprotein; for treating galactosemia.
Human Genome Sciences WO96/36709
Gene for transforming growth factor(TGF)-aIII and mutations, encodedproteins; for diagnostic assays.
Imp. Cancer Res. Technol. GB2 300 859
Cytotoxic fusion proteins
Chimeric proteins with cell targetingand cytotoxic domains; for treatingcancer.
Introgene WO 96/35798
Gene therapy retroviral vectors
Retroviral vectors with an enhanceractive in undifferentiated cells andno superfluous retroviral sequences.
Johns Hopkins Univ. WO 96/35704
FGF homologous factor-2
Gene for fibroblast growth factor(FGF) homologous factor-2, encodedprotein, antibodies.
Johns Hopkins Univ. WO 96/35716
p16 DNA methylation
Methylation of p16 DNA and itsdecreased expression; for detectingtranscriptional block and presence oftumors.
Karo Bio WO 96/35785
Thyroid hormone receptor defect
Transgenic mammals having a defectivethyroid hormone receptor a gene andderived cells.
Eli Lilly EPO 743 321, 744 408, &WO 96/36644
Rhesus obesity gene
Rhesus gene for adipose tissue amountregulation, encoded protein, vectors,expression system.
Max Planck Inst. EPO 743 367
Gene expression analysis
Gene expression analysis in genefamilies by determining differentialexpression [in German].
Max Planck Inst. WO 96/35797
Hepatitis B vector
Hepatitis B vector with functionalgenes having partial deletions,production cells, expression methods.
Merck EPO 743 366
Recombinant bacteriophage expressingListeria genes; for listeriaidentification [in German].
Merck WO 96/36706
Large scale plasmid purification
Process for large scale isolation andpurification of all forms of plasmidDNA; for use as a therapeutic.
Michigan, Univ. of WO 96/36361
Single-stranded DNA antibodies
Ann Arbor, Mich.
Antibodies that bind single-strandedDNA but not double-stranded DNA; forscreening for DNA antibodies.
Minnesota, Univ. of WO 96/36360
Anti-CD19 cancer therapy
Single chain variable region fragmentsof anti-CD19 antibodies conjugated tocytotoxic agents; for cancer therapy.
NIH (Natl. Inst. Hlth.) WO96/35781
Phage display library of single chainrecombinant binding proteins; forinhibiting intracellular expression.
Progen Biotech WO 96/36708
Gene for an autoantigen that isassociated with a tendency forthrombosis, encoded protein,production methods.
Ramot Univ. WO 96/36695
Tel Aviv, Israel
Purified and isolated ataxia-telangiectasia gene, mutations thatcause this disease.
Rome, Univ. of WO 96/36706
Heat shock protein yeast homolog
Gene from the yeast Candida that ishomologous to the 70kd heat shockprotein gene, encoded protein; fortherapy.
St. Jude's Hosp. WO 96/35454
Stable virus packaging cells
Recombinant packaging and producercell lines; for making high titerretroviral vectors.
Salk Inst. EPO 743 520
Steroid receptor ligands
La Jolla, Calif.
Chimeric receptors with ligand bindingdomains of steroid receptor and yeastGAL4 protein; for identifying ligands.
Sanofi WO 96/35791
Insulin receptor substrate ribozyme
Coding sequence for a hammerheadribozyme against the insulin receptorsubstrate and fragments.
Scios WO 96/35788
APP protease inhibitor domain
Mountain View, Calif.
Analogs of the Kunitz proteaseinhibitor domain of amyloid precursorprotein (APP), encoding genes.
Strang Cancer Prev. Ctr. WO96/36711
Insulin gene expression regulators
Genes for homeoprotein regulators ofinsulin gene expression, encodedproteins, antibodies; for assays.
T Breeders WO 96/36696
Undifferentiated cell expansion
Cell culture of undifferentiated cellsand their isolation using specificsurface antigen binding molecules.
Takara Shuzo WO 96/36714
B cell tumor antibody fragment
Gene for a complementarity determiningregion of an immunoglobulin specificfor B cell tumors, encoded protein.
Thomas Jefferson Univ. WO96/36698
Apoptotic Ced-3 Ice cysteine protease
A member of the apoptotic Ced-3 Icecysteine protease gene family,encoding gene and fragments,antibodies.
Women's Res. Inst. WO 96/35789
Genes for multiple forms of interferontau, encoded proteins; for production.
(c) 1997 American Health Consultants. All rights reserved.