Published October 23 & 30 (EPO); October 17 & 24 (WO)

Abbott Labs WO 96/33279

Antibodies by repertoire cloning

Abbott Park, Ill.

Repertoire cloning process for producing mammalian monoclonalantibodies, antibodies produced.

Acorda Therapeutics WO 96/32959

Enhanced neurite outgrowth

New York

Neural cell adhesion molecules, fragments, encoding genes,transgenic mice; for enhancing neurite outgrowth.

Alabama, Univ. of WO 96/32494

Virus inhibition

Birmingham, Ala.

Fusion protein with a viral inhibitory protein, encoding gene; forvirus inhibition.

Albert Ludwig Univ. WO 96/33272

Gene therapy vectors

Freiburg, Germany

Eukaryotic cell vectors with internal ribosome entry sequences; forcell transfection in gene therapy.

Amgen WO 96/32480

HER-2/neu antibodies

Thousand Oaks, Calif.

Antibodies to the protein expressed by the HER-2/neu oncogene; fordiagnosis.

Amgen Canada WO 96/32477

Lymphocyte interferon regulatory factor

Mississauga, Ont.

Genes for lymphocyte interferon regulatory factor, encoded protein,production methods.

Asahi Breweries EPO 738 734

Dermatophagous allergen


Gene for a dermatophagous allergen, encoded allergen, baculovirusproduction system; for vaccination.

Biocem WO 96/33277

Preduodenal lipases

Aubiere, France

Preduodenal lipases, encoding genes, expression in plants; forproduction.

Biocine WO 96/33274

Peptic ulcer vaccines

Siena, Italy

Helicobacter pylori genes, encoded proteins; for diagnosis of pepticulcers and vaccination.

Brussels Free Univ. EPO 739 981

Variable immunoglobulin fragments

Brussels, Belgium

Variable fragments of immunoglobulins that do not contain lightchains; for passive immunotherapy.

Burstein Labs WO 96/32841

Chimeric therapeutic molecule

San Juan Capistrano, Calif.

Hybrid molecule with a binding site and a therapeutic moietyenclosed in a delivery vehicle such as a liposome.

California, Univ. of WO 96/32956

p19 cell cycle inhibitor

Oakland, Calif.

Gene for the cell cycle inhibitor p19, encoded protein, antibodies,expression vector, host cells.

California, Univ. of WO 96/33271

BRCA1 mutations

Oakland, Calif.

BRCA1 mutations, primers, antibodies; for breast and ovarian cancerdiagnosis and therapy.

Cell Genesys WO 96/33266

Large genomic DNA deletions

Foster City, Calif.

Targeting construct for the generation of large genomic DNAdeletions, especially in MHC and immunoglobulin genes.

Chiron Viagene WO 96/33281 & 33282

Ex vivo cell transduction

Emeryville, Calif.

High efficiency ex vivo transduction of hematopoietic stem cells byretroviral vectors; for somatic cell gene therapy.

Dalhousie Univ. WO 96/32087

Transgenic fish insulin

Halifax, N.S.

Transgenic fish containing the human insulin gene; for insulinproduction and islet cell harvesting.

Diaclone EPO 738 736

gp130 antibodies

Besancon, France

Monoclonal antibodies to gp130; for producing diagnostic reagentsand therapeutics [in French].

Genentech WO 96/32478

Increased half-life IgG

S. San Francisco

Polypeptides not containing the Fc region of immunoglobulin G(IgG); for increased half-life.

Genset WO 96/32473

Herpes dumbbell sense oligo


Dumbbell shaped sense oligonucleotide with a double-strandedmiddle section; for inhibiting herpes simplex virus.

Hoechst Japan WO 96/33215

MP52 bone protein


Gene for MP52 protein, encoded protein, its dimer, bacterialexpression system; for treating bone and cartilage diseases.

Human Genome Sciences WO 96/33276

Haemophilus influenzae Rd genome

Rockville, Md.

Haemophilus influenzae Rd genome sequence, encoded proteins; fordiagnosis and therapy.

Hybridon WO 96/32474

Cooperative oligos

Worcester, Mass.

Cooperative oligonucleotides that can undergo dimerization viacomplementary domains.

Incyte Pharma WO 96/33278

Eosinophilic C-C chemokine

Palo Alto, Calif.

C-C chemokine from eosinophils, encoding gene, antisense oligos,antibodies, expression vectors.

Incyte Pharma WO 96/32481

Phospholipase C homolog

Palo Alto, Calif.

Gene for a phospholipase C homolog, encoded protein, antisenseoligos, antibodies, expression system.

Incyte Pharma WO 96/32485

Cathepsin C homolog

Palo Alto, Calif.

Cathepsin C homolog, encoding gene, antibodies, antisense oligos,expression system; for testing monocyte activation.

INSERM (Natl. Inst. Hlth. Med. Res.) WO 96/32489

Glucose-inducible expression


Recombinant viral vector with a heterologous gene whose expressionis controlled by a glucose-inducible element.

Invitrogen EPO 738 779

Direct PCR cloning

San Diego, Calif.

Direct cloning of PCR amplified nucleic acids into vectors withoutpreparing primers.

Irish Agri. & Food Develop. Auth. WO 96/32482

Nisin-like bacteriocin

Dublin, Ireland

Anti-microbial bacteriocin with nisin-like properties; for inhibitingnisin-producing bacterial strains.

Kanegafuchi WO 96/33217

Immunosuppressant cell adhesion molecule

Osaka, Japan

Immunosuppressant cell adhesion molecule, its analogs; for makingtherapeutics.

LG Chemicals WO 96/32495

T cell activator antibodies

Seoul, S. Korea

Monoclonal antibodies to human 4-1BB accessory moleculeexpressed on activated T cells, encoding gene, hybridoma.

Mass. Gen. Hosp. EPO 739 980


Boston, Mass.

Gene for CD19, encoded protein, expression vector, host cells,production method.

Mass. Gen. Hosp. WO 96/32503

Gene expression assay

Boston, Mass.

Vector system for assaying gene expression using a reporter gene andtranscription factor interaction.

Massachusetts, Univ. Med. Ctr. WO 96/32932

Rotavirus DNA vaccine

Worcester, Mass.

Vaccine consisting of rotavirus DNA that encodes an antigen; forinduction of immune response upon host introduction.

Masucci, M.G. WO 96/32483

Immune-evading proteins

Stockholm, Sweden

Proteins with engineered glycine-containing amino acid sequences;for immune system evasion.

Medclone WO 96/32493

Lupus autoantibody

Irvine, Calif.

Systemic lupus erythematosus DNA autoantigen, antibodies; fordiagnosis.

Medimmune WO 96/33269

Autocatalytic resistance deletion

Gaithersburg, Md.

Vector for transforming prokaryotes with gene sequences causingautocatalytic deletion of resistance genes.

Merck WO 96/33268


Rahway, N.J.

Gene for apopain, encoded protein, antibodies, antisense oligos; formodulating apoptosis.

Mt. Sinai Hosp. WO 96/32476

Neurite outgrowth protein

Toronto, Ont.

Protein that overcomes the inhibition of neurite outgrowth by centralnervous system myelin, encoding gene.

Netherlands TNO Org. WO 96/32486 & 32487

Lactic acid bacteria expression

Delft, Netherlands

Expression vectors for lactic acid bacteria; for efficient expression,secretion, and surface protein display.

Pharmacia WO 96/33216

Truncated IGF-1

Stockholm, Sweden

Truncated insulin growth factor (IGF)-1, encoding gene, yeastexpression system.

San Tumor Res. EPO 739 984

Bivalent growth-inhibiting proteins

Freiburg, Germany

Bivalent polypeptides with at least two domains, one of whichinhibits the growth of tumor cells, encoding genes.

Spectragen WO 96/33205

DNA sequencing by extension

Hayward, Calif.

DNA sequencing by parallel oligonucleotide extensions; forelectrophoresis-free separation.

Speywood Lab WO 96/33273

Botulinum toxin for pain


Botulinum toxin derivatives; for modifying peripheral sensoryafferent functions and treating pain.

Texas, Univ. of WO 96/33275

Influenza hxuB/hxuC proteins

Austin, Tex.

Haemophilus influenzae hxuB and hxuC proteins, encoding genes,antibodies; for diagnosis and vaccination.

Texas, Univ. of WO 96/33280

Adenoviral helper virus

Austin, Tex.

Adenoviral helper virus system using the early coding region; forgene therapy.

TKB Assoc. WO 96/32140

Engineered veto cells

Pepper Pike, Ohio

Engineered veto cells that specifically inhibit growth, cytotoxicity, orinduce apoptosis in T cells.

Washington, Univ. of WO 96/32475

Altered DNA-binding proteins

Seattle, Wash.

Preparation of DNA-binding proteins with altered binding specificityby adding zinc finger motifs.

Yale Univ. WO 96/32479

Hookworm larvae antigens

New Haven, Ct.

Proteins released by hookworm larvae after infection, encodinggenes, antibodies; for vaccination.

(c) 1997 American Health Consultants. All rights reserved.