Published October 23 & 30 (EPO); October 17 & 24 (WO)
Abbott Labs WO 96/33279
Antibodies by repertoire cloning
Abbott Park, Ill.
Repertoire cloning process for producing mammalian monoclonalantibodies, antibodies produced.
Acorda Therapeutics WO 96/32959
Enhanced neurite outgrowth
Neural cell adhesion molecules, fragments, encoding genes,transgenic mice; for enhancing neurite outgrowth.
Alabama, Univ. of WO 96/32494
Fusion protein with a viral inhibitory protein, encoding gene; forvirus inhibition.
Albert Ludwig Univ. WO 96/33272
Gene therapy vectors
Eukaryotic cell vectors with internal ribosome entry sequences; forcell transfection in gene therapy.
Amgen WO 96/32480
Thousand Oaks, Calif.
Antibodies to the protein expressed by the HER-2/neu oncogene; fordiagnosis.
Amgen Canada WO 96/32477
Lymphocyte interferon regulatory factor
Genes for lymphocyte interferon regulatory factor, encoded protein,production methods.
Asahi Breweries EPO 738 734
Gene for a dermatophagous allergen, encoded allergen, baculovirusproduction system; for vaccination.
Biocem WO 96/33277
Preduodenal lipases, encoding genes, expression in plants; forproduction.
Biocine WO 96/33274
Peptic ulcer vaccines
Helicobacter pylori genes, encoded proteins; for diagnosis of pepticulcers and vaccination.
Brussels Free Univ. EPO 739 981
Variable immunoglobulin fragments
Variable fragments of immunoglobulins that do not contain lightchains; for passive immunotherapy.
Burstein Labs WO 96/32841
Chimeric therapeutic molecule
San Juan Capistrano, Calif.
Hybrid molecule with a binding site and a therapeutic moietyenclosed in a delivery vehicle such as a liposome.
California, Univ. of WO 96/32956
p19 cell cycle inhibitor
Gene for the cell cycle inhibitor p19, encoded protein, antibodies,expression vector, host cells.
California, Univ. of WO 96/33271
BRCA1 mutations, primers, antibodies; for breast and ovarian cancerdiagnosis and therapy.
Cell Genesys WO 96/33266
Large genomic DNA deletions
Foster City, Calif.
Targeting construct for the generation of large genomic DNAdeletions, especially in MHC and immunoglobulin genes.
Chiron Viagene WO 96/33281 & 33282
Ex vivo cell transduction
High efficiency ex vivo transduction of hematopoietic stem cells byretroviral vectors; for somatic cell gene therapy.
Dalhousie Univ. WO 96/32087
Transgenic fish insulin
Transgenic fish containing the human insulin gene; for insulinproduction and islet cell harvesting.
Diaclone EPO 738 736
Monoclonal antibodies to gp130; for producing diagnostic reagentsand therapeutics [in French].
Genentech WO 96/32478
Increased half-life IgG
S. San Francisco
Polypeptides not containing the Fc region of immunoglobulin G(IgG); for increased half-life.
Genset WO 96/32473
Herpes dumbbell sense oligo
Dumbbell shaped sense oligonucleotide with a double-strandedmiddle section; for inhibiting herpes simplex virus.
Hoechst Japan WO 96/33215
MP52 bone protein
Gene for MP52 protein, encoded protein, its dimer, bacterialexpression system; for treating bone and cartilage diseases.
Human Genome Sciences WO 96/33276
Haemophilus influenzae Rd genome
Haemophilus influenzae Rd genome sequence, encoded proteins; fordiagnosis and therapy.
Hybridon WO 96/32474
Cooperative oligonucleotides that can undergo dimerization viacomplementary domains.
Incyte Pharma WO 96/33278
Eosinophilic C-C chemokine
Palo Alto, Calif.
C-C chemokine from eosinophils, encoding gene, antisense oligos,antibodies, expression vectors.
Incyte Pharma WO 96/32481
Phospholipase C homolog
Palo Alto, Calif.
Gene for a phospholipase C homolog, encoded protein, antisenseoligos, antibodies, expression system.
Incyte Pharma WO 96/32485
Cathepsin C homolog
Palo Alto, Calif.
Cathepsin C homolog, encoding gene, antibodies, antisense oligos,expression system; for testing monocyte activation.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 96/32489
Recombinant viral vector with a heterologous gene whose expressionis controlled by a glucose-inducible element.
Invitrogen EPO 738 779
Direct PCR cloning
San Diego, Calif.
Direct cloning of PCR amplified nucleic acids into vectors withoutpreparing primers.
Irish Agri. & Food Develop. Auth. WO 96/32482
Anti-microbial bacteriocin with nisin-like properties; for inhibitingnisin-producing bacterial strains.
Kanegafuchi WO 96/33217
Immunosuppressant cell adhesion molecule
Immunosuppressant cell adhesion molecule, its analogs; for makingtherapeutics.
LG Chemicals WO 96/32495
T cell activator antibodies
Seoul, S. Korea
Monoclonal antibodies to human 4-1BB accessory moleculeexpressed on activated T cells, encoding gene, hybridoma.
Mass. Gen. Hosp. EPO 739 980
Gene for CD19, encoded protein, expression vector, host cells,production method.
Mass. Gen. Hosp. WO 96/32503
Gene expression assay
Vector system for assaying gene expression using a reporter gene andtranscription factor interaction.
Massachusetts, Univ. Med. Ctr. WO 96/32932
Rotavirus DNA vaccine
Vaccine consisting of rotavirus DNA that encodes an antigen; forinduction of immune response upon host introduction.
Masucci, M.G. WO 96/32483
Proteins with engineered glycine-containing amino acid sequences;for immune system evasion.
Medclone WO 96/32493
Systemic lupus erythematosus DNA autoantigen, antibodies; fordiagnosis.
Medimmune WO 96/33269
Autocatalytic resistance deletion
Vector for transforming prokaryotes with gene sequences causingautocatalytic deletion of resistance genes.
Merck WO 96/33268
Gene for apopain, encoded protein, antibodies, antisense oligos; formodulating apoptosis.
Mt. Sinai Hosp. WO 96/32476
Neurite outgrowth protein
Protein that overcomes the inhibition of neurite outgrowth by centralnervous system myelin, encoding gene.
Netherlands TNO Org. WO 96/32486 & 32487
Lactic acid bacteria expression
Expression vectors for lactic acid bacteria; for efficient expression,secretion, and surface protein display.
Pharmacia WO 96/33216
Truncated insulin growth factor (IGF)-1, encoding gene, yeastexpression system.
San Tumor Res. EPO 739 984
Bivalent growth-inhibiting proteins
Bivalent polypeptides with at least two domains, one of whichinhibits the growth of tumor cells, encoding genes.
Spectragen WO 96/33205
DNA sequencing by extension
DNA sequencing by parallel oligonucleotide extensions; forelectrophoresis-free separation.
Speywood Lab WO 96/33273
Botulinum toxin for pain
Botulinum toxin derivatives; for modifying peripheral sensoryafferent functions and treating pain.
Texas, Univ. of WO 96/33275
Influenza hxuB/hxuC proteins
Haemophilus influenzae hxuB and hxuC proteins, encoding genes,antibodies; for diagnosis and vaccination.
Texas, Univ. of WO 96/33280
Adenoviral helper virus
Adenoviral helper virus system using the early coding region; forgene therapy.
TKB Assoc. WO 96/32140
Engineered veto cells
Pepper Pike, Ohio
Engineered veto cells that specifically inhibit growth, cytotoxicity, orinduce apoptosis in T cells.
Washington, Univ. of WO 96/32475
Altered DNA-binding proteins
Preparation of DNA-binding proteins with altered binding specificityby adding zinc finger motifs.
Yale Univ. WO 96/32479
Hookworm larvae antigens
New Haven, Ct.
Proteins released by hookworm larvae after infection, encodinggenes, antibodies; for vaccination.
(c) 1997 American Health Consultants. All rights reserved.