Published October 9 & 16 (EPO); October 3 & 10 (WO)
Abbott Labs EPO 736 601
Hepatitis GB virus
Abbott Park, Ill.
Hepatitis GB virus, immunogenic particles, antibodies to them; fordiagnosis and therapy.
Albert Einstein Coll. Med. WO 96/31242
Transplantable a-cells
New York
Recombinant, glucose-regulated, insulin producing a-cells controlledby tetracycline; for transplantation.
Amersham Intl. WO 96/30507
Differential expression vectors
Little Chalfont, U.K.
Vectors and DNA constructs for differential expression of proteins orfusions without transferring coding sequences.
Amgen WO 96/31599
NDF peptides
Thousand Oaks, Calif.
Peptides from the EGF-like domain of NDF/heregulins; forstimulating growth of colon epithelial and Schwann cells.
Amylin Pharma WO 96/31526
Obesity treatment proteins
San Diego, Calif.
Various forms and modifications of the ob gene product, encodinggenes, antibodies; for treating obesity.
Applied Genetics WO 96/30545
Primer extension mutation detection
San Diego, Calif.
Gene mutation detection by differential primer extension of mutantand wild-type target sequences.
Asahi Breweries WO 96/30539
Acarid allergen
Tokyo
Engineered acarid allergen and a process for producing it; for treatingthe allergic reactions.
Aviron WO 96/30387
Cytomegalovirus variants
Mountain View, Calif.
Toledo and Towne variants of cytomegalovirus, encoded proteins;for detecting and treating infections.
Bavarian Nordic Res. Inst. WO 96/30533
Pseudotype retroviral particles
Glostrup, Denmark
Retroviral vector system and packaging cell line for murine leukemiavirus (MLV); for pseudotype retroviral particles.
Baxter Intl. WO 96/30030
Immunization against tumors
Deerfield, Ill.
Fusions of tumor cells and dendritic-like cells; for cancerimmunotherapy.
Behringwerke EPO 737 747
Microbial antibody production
Marburg, Germany
Cytoplasmic expression of antibodies, antibody fragments, andfusions in E. coli [in German].
Behringwerke WO 96/30499
Rabies detection cell line
Marburg, Germany
Modified Vero-M cell line that can be used to grow rabies virus andto detect inhibitors of viral growth.
Beth Israel Hosp. WO 96/30535
Kidney gene therapy
Boston, Mass.
Gene transfer into the kidney by maintaining vector in contact withvasculature while avoiding ischemia.
Boehringer Mannheim EPO 736 543
Nuclear antigen antibodies
Mannheim, Germany
Production method for monoclonal antibodies to growth-associatedantigens of the cell nucleus [in German].
Boehringer Mannheim EPO 736 608 & 736 609
Specific amplification detection
Mannheim, Germany
Method for specific detection and amplification of DNA and RNAusing a proofreading DNA polymerase [in German].
Boehringer Mannheim WO 96/31606
tPA purification
Mannheim, Germany
Mutant of an Erythrina caffra inhibitor; for purification of tissueplasminogen activators (tPA).
California, Univ. of WO 96/31596
Estrogen activity assay
Oakland, Calif.
Vectors having estrogen inducible element linked to a reporter gene;for assaying estrogenic activity.
California, Univ. of WO 96/30505
BH55 hyaluronidase
Oakland, Calif.
BH55 hyaluronidase, encoding gene, antibodies, vectors, host cells;for production.
California, Univ. of WO 96/31604
HLA-G antibodies
Oakland, Calif.
Antibodies for the detection of HLA-G which is specificallyexpressed by invasive cytotrophoblasts.
Camerino Univ. WO 96/31601
EGF receptor immune response
Camerino, Italy
Polynucleotide immunogenic agents that induce an immune responseto members of the EGF receptor family.
Case Western Res. Univ. WO 96/30385
Restenosis treatment vectors
Cleveland, Ohio
Recombinant viral vectors with inserted recombinant protein genes;for treating post-angioplasty restenosis.
Case Western Res. Univ. WO 96/31605
TGF-a receptor mutations
Cleveland, Ohio
Cancer diagnosis and therapy based on mutations detected in TGF-areceptors.
Cell Genesys WO 96/31241
Modified cells for transplantation
Foster City, Calif.
Introduction of genes encoding virus-derived MHC down-regulatoryproteins; for making transplantable cells.
CNRS (Natl. Ctr. Sci. Res.) WO 96/30527
HIV env muteins
Paris
Muteins encoded by a mutated env gene from lentiviruses like HIV,peptide fragments, expression vectors.
Cytogen WO 96/31625
Functional domain identification
Princeton, N.J.
Recognition and isolation of therapeutically useful proteins via theirfunctional domains.
Genetic Therapy WO 96/30504
Targeted retroviral particles
Gaithersburg, Md.
Retroviral particles having a modified envelope polypeptide; for celltargeting.
Genzyme WO 96/30534
Safe adenoviral vectors
Cambridge, Mass.
Adenovirus vectors designed for safety in clinical applications; forgene therapy.
German Health Ministry EPO 736 600 & WO 96/31607
Retrovirus inhibiting lymphokine
Bonn, Germany
Immunodeficiency virus suppressing lymphokine; for inhibitingretroviral replication in blood.
Green Cross EPO 736 605
Protein production process
Osaka, Japan
Process for optimizing the growth of host cells and the production ofproteins from them.
Human Genome Sciences WO 96/30406
G-protein coupled receptors
Rockville, Md.
Genes for human G-protein coupled receptors, encoded proteins; foridentifying agonists and antagonists.
Human Genome Sciences WO 96/30524
DNA ligase III
Rockville, Md.
Gene for human DNA ligase III, encoded protein, expression system;for diagnosis and therapy.
Hybridon WO 96/31600
Gene expression modulation
Worcester, Mass.
Modulation of gene expression in an animal without depletingcomplement; for gene therapy.
Immuno WO 96/30521
Encephalitis virus sequence
Vienna, Austria
Complete nucleic acid sequence of the tick-borne encephalitis virus;for vaccine and therapeutic.
Immunogenetics Res. Fdn. WO 96/30511
MHC family genes
Perth, Australia
Polymorphic and multicopy members of the MHC gene family,derivatives, mutations, fragments.
Imp. Coll. Sci. Technol. Med. WO 96/30408
Prevention of miscarriage
London
Antibodies to a syncytiotrophoblast antigen that also binds to naturalkiller cells; for miscarriage prevention.
Inst. Phys. & Chem. Res. EPO 736 602
Sialyltransferase
Wako, Japan
Gene for a sialyltransferase, encoded protein; for producingextracellularly releasable product.
Isis Innovation WO 96/31602
Targeted retroviral particles
Oxford, U.K.
Retroviral vector particles containing murine leukemia virus andhaving a targeting protein on their surfaces.
Japan Tobacco WO 96/30510
Enhanced expression vector
Tokyo
DNA sequences that greatly enhance the expression of the foreigngene inserted into the vector.
Korean Green Cross WO 96/30513
Apoptosis regulating gene
Yongin, S. Korea
Bcl-2 related gene, its encoded protein, expression vector,transformed host; for cancer detection.
Ligand Pharma WO 96/30515
Transcriptional modifiers
San Diego, Calif.
Transcriptional regulatory element sequences linked to a promoterand a structural gene; for finding modifiers.
Eli Lilly WO 96/31122
Amyloid precursor protein protease
Indianapolis, Ind.
Gene for amyloid precursor protein protease, encoded protein,fragments of it.
Merck WO 96/30520
Papillomavirus L1 protein
Rahway, N.J.
Gene for human papillomavirus type 11 L1 protein and derivatives,encoded protein.
Michigan, Univ. of WO 96/31603
Apoptosis-associated protein
Ann Arbor, Mich.
Apoptosis-associated protein, fragments, antibodies, encoding gene;for diagnosis and therapy.
NIH (Natl. Inst. Hlth.) WO 96/30516
T lymphocyte receptors
Bethesda, Md.
Genes for T lymphocyte receptors that recognize tumor associatedantigens, T cells expressing the receptors.
New Jersey, Univ. Hlth. Sci. WO 96/30052
Neuronal connection stimulant
Piscataway, N.J.
Gene for limbic system-associated membrane protein, encodedprotein; for stimulating neuronal connections.
N. Carolina, Univ. of WO 96/31618
Gonorrhea vaccination
Chapel Hill, N.C.
Gene for an antigenic proteins from gonorrhea pathogens, encodedprotein; for vaccination.
Pasteur Inst. EPO 736 542
HIV infection prevention
Paris
Mycoplasma-derived proteins homologous to HIV glycoproteins,antibodies; for prevention of HIV infection [in French].
Pharming EPO 737 746
Transgenic protein production
Leiden, Netherlands
Production of recombinant proteins in transgenic bovine species andtheir secretion into milk.
Regeneron Pharma WO 96/31598
TIE-2 ligand
Tarrytown, N.Y.
Gene for the TIE-2 ligand, encoded protein, its receptor, antibodies,antagonists; for blocking neovascularization.
Res. Corp. Technol. WO 96/30384
Single-stranded circular oligos
Tucson, Ariz.
Single-stranded circular oligonucleotides; for binding to other single-stranded or double-stranded oligos.
Res. & Diag. Systems WO 96/30528
Transfected cell screen
Minneapolis, Minn.
Vector system with marker protein gene; for rapid and effectivescreening of transfected cell lines.
Rhone-Poulenc Rorer WO 96/30512
Conditional expression system
Antony, France
Expression system that creates and expresses bispecific chimericproteins with DNA and transactivator domains.
Sandoz WO 96/30532
Thrombosis gene therapy
Basel, Switzerland
Insertion of the gene encoding ATP diphosphohyrdolase intoendothelial cells; for treating thrombotic conditions.
Scripps Res. Inst. WO 96/30546
Factor V mutation
La Jolla, Calif.
Identification of a Factor V gene mutation that results in activatedprotein C resistance.
Shionogi WO 96/30522
HTLV transcription suppression
Osaka, Japan
Gene that suppresses transcription in human T cell lymphoma virus(HTLV)-1, expressed protein, vector.
Singapore, Natl. Univ. of WO 96/30531
Heavy metal-inducible vector
Singapore
Vector system with a heavy metal-inducible expression; forrecombinant protein production.
Sloan-Kettering Inst. WO 96/31534
p57 gene
New York
Gene for p57, encoded protein, vectors, antibodies, probes, andtransgenic animals containing the gene.
Stichting EPO 736 302
Gelatinase B
Leuven, Belgium
Gene for a metalloprotease, gelatinase B, encoded protein; formeasuring proteases and inhibitors.
Takeda EPO 736 599
Rat obese gene
Osaka, Japan
Rat obese gene, its product, antibodies to it, production methods.
Takeda WO 96/30506
Betacellulin antibodies
Osaka, Japan
Antibodies to human betacellulin that do not react with other growthfactors; for arterial sclerosis and cancer.
Tanox Biosystems WO 96/30400
Induction of HIV antibodies
Houston, Tex.
Immunogens and other peptides based on the binding site ofcomplement factors to HIV; for antibody induction.
Texas, Univ. of WO 96/30536
Targeted gene delivery
Austin, Tex.
Epidermal growth factor receptor binding protein complexed torecombinant protein and reporter genes; for delivery.
Texas, Univ. of WO 96/31613
Expression library immunization
Austin, Tex.
Expression library constructed from the fragmented genome of aselected pathogen; for immunization.
Transgene WO 96/31611
Yeast commercial production
Strasbourg, France
Nucleic acid fragments from yeast genomic DNA, expressionvectors, host strains; for commercial production.
Tularik WO 96/30404
Intracellular signalling proteins
S. San Francisco
Gene for intracellular signalling proteins that can induce apoptosis,encoded proteins; for growth inhibition.
Vical EPO 737 750
Nucleic acid delivery
San Diego, Calif.
Method of interstitial delivering of an isolated poly-nucleotide; fortherapeutic and antisense expression.
Washington Univ. WO 96/30519
Haemophilus adhesion proteins
St. Louis, Mo.
Genes for Haemophilus adhesion proteins, encoded proteins,antibodies; for diagnosis and therapy.
Washington, Univ. of WO 96/30514
HER-2/neu intracellular domain
Seattle, Wash.
Gene for the intracellular domain of the HER-2/neu oncogeneprotein; for treatment of cancer.
Wolf, H. WO 96/30523
Retroviral antigen presentation
Sternberg, Germany
Antigen presentation via DNA sequences encoding a protein capableof self-assembly into retrovirus-like particles.
Xenotech WO 96/30498
Recombined antibody genes
Foster City, Calif.
Modification of expressed antibodies using Cre-mediated site-specific homologous recombination.
Yale Univ. WO 96/30402
Large tumor suppressor protein
New Haven, Conn.
Gene for large tumor suppressor protein, encoded protein, fragments,analogs, antibodies; for diagnosis and therapy.
(c) 1997 American Health Consultants. All rights reserved.