Published Aug. 14 & 21 (EPO); Aug. 8 & 15 (WO); Aug. 14 (GB)
Asahi Glass Yeast secretion WO 96/23890
Yeast expression system containing a secretory signal fused to aheterologous gene; for secretion.
Behringwerke Tumor EPO 727 435 & 727 436
Marburg, Germany antigen antibodies
Tumor-associated antigen monoclonal antibodies, CDR regions,humanized antibodies; for diagnosis and therapy (in German).
Behringwerke HIV-group EPO 727 483
Marburg, Germany retrovirus
HIV-group retrovirus, DNA sequences and encoded antigens,antibodies against them. (in German).
Ciba-Geigy Yeast WO 96/24678
Basel, Switzerland production method
Recombinant protein production method using Saccharomycescerevisiae as a host.
Berlex Labs Synthetic tyrosine WO 96/23883
Richmond, Calif. kinase ligands
Synthetic ligands binding receptor tyrosine kinases in which the mid-sequence domain is replaced by a peptide bridge.
Bertling, W. RNA viral WO 96/23889
Erlangen, Germany vector
Recombinant RNA viral vector that is not replication competent; forgene therapy.
Bio Merieux Listeria probes WO 96/24686
Marcy l'Etoile, France
Single-stranded oligonucleotide probes to ribosomal RNA 23S of thebacterial genus Listeria; for detection.
California, Univ. of Pancreas cell WO 96/24669
Oakland, Calif. transplants
Human pancreatic cell lines transformed with retroviral vectors; fortransplantation into diabetic patients.
Case Western Res. Univ. Osteogenic WO 96/24848
Cleveland cell antibodies
Monoclonal antibodies against human osteogenic cell surfaceantigens; for diagnosis and therapy.
Cell Genesys Chimeric WO 96/23814, 23881 &
Foster City, Calif. receptor signals 24671
Chimeric receptor molecules created for the delivery of co-stimulatory signals; for cancer and viral disease therapy.
Ctr. Blood Res. LIL-Stat WO 96/24692
Gene for LIL-Stat protein, encoded protein, assay for identifyingLIL-Stat inhibitors to treat inflammatory disease.
Gen-Probe Coccidioides WO 96/24691
San Diego immitis detection
Amplification primers and oligonucleotide probes to Coccidioidesimmitis; for detection.
Guy's & St. Thomas' Hosp. Bacterial WO 96/23886
London tooth adherence
Nucleic acid sequence encoding a polypeptide that inhibits theadherence of Streptococcus mutans to teeth.
Harvard Univ. Modified DNA EPO 727 496
Cambridge, Mass. polymerases
DNA polymerases with modified binding sites not distinguishingbetween dideoxy- and dexoynucleotides; for sequencing.
Human Genome Sciences Ubiquitin WO 96/23410
Rockville, Md. conjugating enzymes
Genes for ubiquitin conjugating enzymes 7, 8, and 9, encodedproteins; for use in preventing malignant cell growth.
Human Genome Sciences Chemokine WO 96/24668
Rockville, Md. a-11/a-1
Genes for Chemokine a-11 and a-1, encoded proteins; for diagnosisand treatment.
Hybridon HIV-1 inhibiting WO 96/23878
Worcester, Mass. oligos
Oligonucleotides that inhibit the transcription of HIV-1; for AIDStherapy.
Japanese Cancer Inst. Multiple EPO 727 486
Tokyo endocrine neoplasia
Chromosome 11 gene associated with multiple endocrine neoplasiatype 1, encoded transcription factor-like protein.
Johnson & Johnson DNA sample EPO 726 312
Clin. Diag. preparation
Nucleic acid sample preparation and storage using polyethyleneimineand surfactants.
Kabushiki Kaisha Mammalian EPO 726 313
Gene sequences for mammalian L-asparaginases, transformants forproducing this enzyme.
Kyowa Hakko Kogyo Ribonucleotide EPO 726 277
Tokyo reductase antibodies
Monoclonal antibodies against the R2 subunit of ribonucleotidereductase; for inhibiting enzyme activity.
Leukosite Mucosal vascular WO 96/24673
Cambridge, Mass. adressins
Mucosal vascular adressins, encoding genes; for identifyinginhibitors and modifying leukocyte recruitment.
Leuven Res. & Develop. Tumor growth EPO 727 487
Leuven, Belgium genes
Multiple tumor aberrant growth genes, encoded proteins; fordiagnosis and therapy.
Ligand Pharma Peroxisome WO 96/23884
San Diego growth receptors
Genes for peroxisome proliferator activated receptor subtypes,encoded proteins, antibodies to them.
Eli Lilly Human WO 96/23815 & 24670
Indianapolis obesity gene
Obesity gene, encoded protein and fragments, antibodies to them; forpurification, diagnosis, and assay.
Lion Peridontal disease EPO 726 314
Gene for Porphyromonas gingivalis fimbrillin protein, the antigen,antibodies; for treating peridontal disease.
Massachusetts, Univ. Target WO 96/23899
Med. Ctr. protein ligands
Method of isolating a random peptide-scaffold peptide fusion proteinthat binds a predetermined target protein.
McMaster Univ. High efficiency EPO 726 319
Hamilton, Ont. mRNA translation
High efficiency translation of mRNA using 5' and 3' sequences thatincrease the rate and time period of translation.
Medvet Science Strong stop WO 96/23876
Adelaide, Australia RNA
Expression system encoding strong stop RNA introduced intohematopoietic stem cells of AIDS patients; for therapy.
Merck Neuropeptide WO 96/23809
Rahway, N.J. Y receptor
Gene for neuropeptide Y receptor, encoded protein, antibodies to it;for identifying antagonists.
Mosaic Technol. Cell lysate WO 96/24688
Winter Hill, Mass. repair activity
DNA duplex oligomers subjected to lesions and then used to assayfor DNA repair activity in cell lysates.
Mt. Sinai Sch. Med. Inositol WO 96/24846
New York triphosphate receptor
Gene for human T cell inositol 1,4,5-triphosphate receptor/calciumrelease channel, encoded protein.
NIH (Natl. Inst. Hlth.) Tumor gene WO 96/24672
Bethesda, Md. int6
Tumor gene int6 and deduced amino acid sequence; for diagnosis,gene therapy, immunotherapy, and vaccines.
Nebraska, Univ. of Synthetic WO 96/23777
Lincoln, Neb. triplex forming compounds
Substituted quinoline or quinazoline-based monomers and polymers;for sequence-specific triplex binding to DNA.
New York Blood Ctr. Coffee WO 96/23869
New York bean a-galactosidase
Gene for coffee bean a-galactosidase, encoded protein, production;for removing B antigens from blood cells.
NEC Associative EPO 726 530
Tokyo memory DNA
DNA molecules used for forming an associative memory into whichinformation is written and from which it is read.
Pasteur Inst. Tuberculosis WO 96/23885
Mycobacterium tuberculosis protein, hybrid proteins; for vaccinesand detecting tuberculosis-specific antibodies.
Pennsylvania, Univ. of Saccular WO 96/23866
Gene for saccular collagen, encoded protein, antibodies to it; fortreatment by injection.
Rockefeller Univ. DEC WO 96/23882
New York receptor
Receptor from dendritic and epithelial cells (DEC), encoding gene;for identifying C-type lectin domain ligands.
St. Jude's Children's Cyclin-dependent WO 96/24603
Res. Hosp. kinase inhibitors
Genes for cyclin-dependent kinase inhibitors, encoded proteins; forcontrolling cell growth.
Saskatchewan, Univ. of GnRH-leukotoxin WO 96/24675
Saskatoon, Sask. chimeras
Gonadotrophin releasing hormone (GnRH)-leukotoxin chimeras,encoding genes; for increasing GnRH fragment immunogenicity.
Searle Thrombopoiesis WO 96/23888
Human ligands that induce thrombopoiesis during hematopoieticdifferentiation.
Sheffield, Univ. of Histamine H2 WO 96/23880
Western Bank, UK receptor variants
Nucleotide sequence for human histamine H2 receptor variants,amplification primers; for diagnosis.
Spanish Counc. Obtaining WO 96/24686
Scientific Invest. specific probes
Selection of specific probes from amplified DNA by solid phasehybridization to sample DNAs.
Tanabe, T. Prostacyclin EPO 727 490
Osaka, Japan synthase
Gene for prostacyclin synthase, encoded protein, expression vectors,host cells; for cardiovascular disease treatment.
Terrapin Technol. Glubodies WO 96/23879
S. San Francisco mimic antibodies
Naturally occurring protein domains that can be ligated to formglubodies which can mimic antibodies.
Texas, Univ. of Detecting WO 96/23895
Austin, Texas DNA damage
Method for detecting DNA damage, measuring DNA repair rates, andmonitoring DNA repair enzyme activity.
Thomas Jefferson Univ. Retroviral WO 96/24677
Philadelphia vector transduction
Improving transduction efficiency of retroviral vectors by usingdeoxyribonucleoside phosphates.
Univ. Coll. London Mutation WO 96/24687
London detection with heat
Detection of mutations and variations in double-stranded DNA byelectrophoresing the samples while heating them.
Upjohn N-acetylgalacto- EPO 726 318
Kalamazoo, Mich. saminyltransferase
Gene for N-acetylgalactosaminyltransferase, encoded protein; for usein polysaccharide synthesis on glycoproteins.
Whitehead Inst. Biomed. Res. Bioactive WO 96/24676
Cambridge, Mass. fusion proteins
Bioactive fusion proteins containing interleukins, productionmethods; for treating established tumors.
Wolf, H. Epstein-Barr EPO 726 315
Starnberg, Germany diagnosis
Epstein-Barr virus DNA sequences encoding a capsid antigen,expression vectors; for use in diagnosis.
Zeneca Tumor antigen GB 2 297 751
Antibodies against a tumor-related antigen, amino acid and DNAsequences, bacteriophage display of antigen mimic.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.