Published Aug. 14 & 21 (EPO); Aug. 8 & 15 (WO); Aug. 14 (GB)

Asahi Glass Yeast secretion WO 96/23890

Tokyo expression

Yeast expression system containing a secretory signal fused to aheterologous gene; for secretion.

Behringwerke Tumor EPO 727 435 & 727 436

Marburg, Germany antigen antibodies

Tumor-associated antigen monoclonal antibodies, CDR regions,humanized antibodies; for diagnosis and therapy (in German).

Behringwerke HIV-group EPO 727 483

Marburg, Germany retrovirus

HIV-group retrovirus, DNA sequences and encoded antigens,antibodies against them. (in German).

Ciba-Geigy Yeast WO 96/24678

Basel, Switzerland production method

Recombinant protein production method using Saccharomycescerevisiae as a host.

Berlex Labs Synthetic tyrosine WO 96/23883

Richmond, Calif. kinase ligands

Synthetic ligands binding receptor tyrosine kinases in which the mid-sequence domain is replaced by a peptide bridge.

Bertling, W. RNA viral WO 96/23889

Erlangen, Germany vector

Recombinant RNA viral vector that is not replication competent; forgene therapy.

Bio Merieux Listeria probes WO 96/24686

Marcy l'Etoile, France

Single-stranded oligonucleotide probes to ribosomal RNA 23S of thebacterial genus Listeria; for detection.

California, Univ. of Pancreas cell WO 96/24669

Oakland, Calif. transplants

Human pancreatic cell lines transformed with retroviral vectors; fortransplantation into diabetic patients.

Case Western Res. Univ. Osteogenic WO 96/24848

Cleveland cell antibodies

Monoclonal antibodies against human osteogenic cell surfaceantigens; for diagnosis and therapy.

Cell Genesys Chimeric WO 96/23814, 23881 &

Foster City, Calif. receptor signals 24671

Chimeric receptor molecules created for the delivery of co-stimulatory signals; for cancer and viral disease therapy.

Ctr. Blood Res. LIL-Stat WO 96/24692

Boston

Gene for LIL-Stat protein, encoded protein, assay for identifyingLIL-Stat inhibitors to treat inflammatory disease.

Gen-Probe Coccidioides WO 96/24691

San Diego immitis detection

Amplification primers and oligonucleotide probes to Coccidioidesimmitis; for detection.

Guy's & St. Thomas' Hosp. Bacterial WO 96/23886

London tooth adherence

Nucleic acid sequence encoding a polypeptide that inhibits theadherence of Streptococcus mutans to teeth.

Harvard Univ. Modified DNA EPO 727 496

Cambridge, Mass. polymerases

DNA polymerases with modified binding sites not distinguishingbetween dideoxy- and dexoynucleotides; for sequencing.

Human Genome Sciences Ubiquitin WO 96/23410

Rockville, Md. conjugating enzymes

Genes for ubiquitin conjugating enzymes 7, 8, and 9, encodedproteins; for use in preventing malignant cell growth.

Human Genome Sciences Chemokine WO 96/24668

Rockville, Md. a-11/a-1

Genes for Chemokine a-11 and a-1, encoded proteins; for diagnosisand treatment.

Hybridon HIV-1 inhibiting WO 96/23878

Worcester, Mass. oligos

Oligonucleotides that inhibit the transcription of HIV-1; for AIDStherapy.

Japanese Cancer Inst. Multiple EPO 727 486

Tokyo endocrine neoplasia

Chromosome 11 gene associated with multiple endocrine neoplasiatype 1, encoded transcription factor-like protein.

Johnson & Johnson DNA sample EPO 726 312

Clin. Diag. preparation

Rochester, N.Y.

Nucleic acid sample preparation and storage using polyethyleneimineand surfactants.

Kabushiki Kaisha Mammalian EPO 726 313

Hayashibara L-asparaginases

Okayama, Japan

Gene sequences for mammalian L-asparaginases, transformants forproducing this enzyme.

Kyowa Hakko Kogyo Ribonucleotide EPO 726 277

Tokyo reductase antibodies

Monoclonal antibodies against the R2 subunit of ribonucleotidereductase; for inhibiting enzyme activity.

Leukosite Mucosal vascular WO 96/24673

Cambridge, Mass. adressins

Mucosal vascular adressins, encoding genes; for identifyinginhibitors and modifying leukocyte recruitment.

Leuven Res. & Develop. Tumor growth EPO 727 487

Leuven, Belgium genes

Multiple tumor aberrant growth genes, encoded proteins; fordiagnosis and therapy.

Ligand Pharma Peroxisome WO 96/23884

San Diego growth receptors

Genes for peroxisome proliferator activated receptor subtypes,encoded proteins, antibodies to them.

Eli Lilly Human WO 96/23815 & 24670

Indianapolis obesity gene

Obesity gene, encoded protein and fragments, antibodies to them; forpurification, diagnosis, and assay.

Lion Peridontal disease EPO 726 314

Tokyo treatment

Gene for Porphyromonas gingivalis fimbrillin protein, the antigen,antibodies; for treating peridontal disease.

Massachusetts, Univ. Target WO 96/23899

Med. Ctr. protein ligands

Worcester, Mass.

Method of isolating a random peptide-scaffold peptide fusion proteinthat binds a predetermined target protein.

McMaster Univ. High efficiency EPO 726 319

Hamilton, Ont. mRNA translation

High efficiency translation of mRNA using 5' and 3' sequences thatincrease the rate and time period of translation.

Medvet Science Strong stop WO 96/23876

Adelaide, Australia RNA

Expression system encoding strong stop RNA introduced intohematopoietic stem cells of AIDS patients; for therapy.

Merck Neuropeptide WO 96/23809

Rahway, N.J. Y receptor

Gene for neuropeptide Y receptor, encoded protein, antibodies to it;for identifying antagonists.

Mosaic Technol. Cell lysate WO 96/24688

Winter Hill, Mass. repair activity

DNA duplex oligomers subjected to lesions and then used to assayfor DNA repair activity in cell lysates.

Mt. Sinai Sch. Med. Inositol WO 96/24846

New York triphosphate receptor

Gene for human T cell inositol 1,4,5-triphosphate receptor/calciumrelease channel, encoded protein.

NIH (Natl. Inst. Hlth.) Tumor gene WO 96/24672

Bethesda, Md. int6

Tumor gene int6 and deduced amino acid sequence; for diagnosis,gene therapy, immunotherapy, and vaccines.

Nebraska, Univ. of Synthetic WO 96/23777

Lincoln, Neb. triplex forming compounds

Substituted quinoline or quinazoline-based monomers and polymers;for sequence-specific triplex binding to DNA.

New York Blood Ctr. Coffee WO 96/23869

New York bean a-galactosidase

Gene for coffee bean a-galactosidase, encoded protein, production;for removing B antigens from blood cells.

NEC Associative EPO 726 530

Tokyo memory DNA

DNA molecules used for forming an associative memory into whichinformation is written and from which it is read.

Pasteur Inst. Tuberculosis WO 96/23885

Paris detection

Mycobacterium tuberculosis protein, hybrid proteins; for vaccinesand detecting tuberculosis-specific antibodies.

Pennsylvania, Univ. of Saccular WO 96/23866

Philadelphia collagen

Gene for saccular collagen, encoded protein, antibodies to it; fortreatment by injection.

Rockefeller Univ. DEC WO 96/23882

New York receptor

Receptor from dendritic and epithelial cells (DEC), encoding gene;for identifying C-type lectin domain ligands.

St. Jude's Children's Cyclin-dependent WO 96/24603

Res. Hosp. kinase inhibitors

Memphis, Tenn.

Genes for cyclin-dependent kinase inhibitors, encoded proteins; forcontrolling cell growth.

Saskatchewan, Univ. of GnRH-leukotoxin WO 96/24675

Saskatoon, Sask. chimeras

Gonadotrophin releasing hormone (GnRH)-leukotoxin chimeras,encoding genes; for increasing GnRH fragment immunogenicity.

Searle Thrombopoiesis WO 96/23888

Chicago induction

Human ligands that induce thrombopoiesis during hematopoieticdifferentiation.

Sheffield, Univ. of Histamine H2 WO 96/23880

Western Bank, UK receptor variants

Nucleotide sequence for human histamine H2 receptor variants,amplification primers; for diagnosis.

Spanish Counc. Obtaining WO 96/24686

Scientific Invest. specific probes

Madrid, Spain

Selection of specific probes from amplified DNA by solid phasehybridization to sample DNAs.

Tanabe, T. Prostacyclin EPO 727 490

Osaka, Japan synthase

Gene for prostacyclin synthase, encoded protein, expression vectors,host cells; for cardiovascular disease treatment.

Terrapin Technol. Glubodies WO 96/23879

S. San Francisco mimic antibodies

Naturally occurring protein domains that can be ligated to formglubodies which can mimic antibodies.

Texas, Univ. of Detecting WO 96/23895

Austin, Texas DNA damage

Method for detecting DNA damage, measuring DNA repair rates, andmonitoring DNA repair enzyme activity.

Thomas Jefferson Univ. Retroviral WO 96/24677

Philadelphia vector transduction

Improving transduction efficiency of retroviral vectors by usingdeoxyribonucleoside phosphates.

Univ. Coll. London Mutation WO 96/24687

London detection with heat

Detection of mutations and variations in double-stranded DNA byelectrophoresing the samples while heating them.

Upjohn N-acetylgalacto- EPO 726 318

Kalamazoo, Mich. saminyltransferase

Gene for N-acetylgalactosaminyltransferase, encoded protein; for usein polysaccharide synthesis on glycoproteins.

Whitehead Inst. Biomed. Res. Bioactive WO 96/24676

Cambridge, Mass. fusion proteins

Bioactive fusion proteins containing interleukins, productionmethods; for treating established tumors.

Wolf, H. Epstein-Barr EPO 726 315

Starnberg, Germany diagnosis

Epstein-Barr virus DNA sequences encoding a capsid antigen,expression vectors; for use in diagnosis.

Zeneca Tumor antigen GB 2 297 751

London antibodies

Antibodies against a tumor-related antigen, amino acid and DNAsequences, bacteriophage display of antigen mimic.

_ Compiled By Chester A. Bisbee

(c) 1997 American Health Consultants. All rights reserved.

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