Published July 31 & Aug. 7 (EPO); July 25 & Aug. 1 (WO); July 31(GB)
Alabama, Univ. of Fas gene WO 96/22370
Birmingham, Ala. control regions
5'-flanking control regions of the fas gene, transgenic mice with thesecontrol regions; for studying T cell senescence.
Allergan Psoriasis gene WO 96/23080
Waco, Tex. sequence
Gene sequence induced by an anti-psoriatic synthetic retinoid; forstudying psoriasis.
Amgen FGF analogues WO 96/22369
Thousand Oaks, Calif.
Analogues of proteins of the fibroblast growth factor (FGF) familythat show enhanced stability and activity.
Amgen EPH-like WO 96/23000
Thousand Oaks, Calif. receptor ligands
Polypeptides that bind to EPH-like receptors, encoding genes; formodulating cell growth and differentiation.
Armitage, I.M. Antigenic WO 96/22377
Activation of T cells by modified, antigenic immunoglobulins; forimmune system stimulation.
Bayer Prostate-specific EPO 715 139
Pittsburgh antigen kits
Recombinant prostate-specific antigen and immunologically cross-reactive fragments; for commercial kits.
Baylor Coll. Med. Cell growth WO 96/22688
Gene sequences for genetic determinants that control cell growthcapacity; for cancer and viral infection treatment.
Bio Merieux Toxoplasma EPO 724 016
Marcy l'Etoile, France gondii detection
Peptide specifically reacting with antibodies against Toxoplasmagondii P30 protein; for viral detection (in French).
Bioinvent Intl. Colorectal WO 96/22310
Lund, Sweden cancer antibodies
Monoclonal antibodies against various cancer cells, especially thosefrom colorectal cancer; for diagnosis.
Bioinvent Intl. Phage coat WO 96/22393
Lund, Sweden protein selection
Method of detecting and selecting bacteriophages expressing specificproteins on their coats.
Bioprogress Mammary gland EPO 725 141
Method of introducing genetic material into mammary gland ducts;for genetic transformation of mammary gland cells.
Biotechnology General Carboxypeptidase WO 96/23064
Iselin, N.J. B purification
Expression, refolding, and purification of enzymatically activerecombinant carboxypeptidase B.
Boehringer Mannheim Hodgkin's WO 96/22384
Mannheim, Germany cells antibodies
Antibodies to CD30 antigen that releases the antigen from Hodgkin'sdisease cells; for treatment.
Bristol-Myers Squibb gp39 WO 96/23071
New York antibodies
Monoclonal antibodies and binding fragments against human gp39;for inhibiting B cell activation.
British Secretary of Defense Mutant WO 96/22376
Farnborough, U.K. luciferases
Luciferases modified to have greater heat stability, genes encodingthese mutants; for luminescence assays.
Cell Genesys Fused cell WO 96/22380
Foster City, Calif. screening
Improved screen of fused cells for desired gene presence by taggingthe expressed protein of interest with a marker.
Clontech Labs Amplification WO 96/23079
Palo Alto, Calif. suppressing adaptors
Ligation adaptors for suppressing DNA fragment amplificationduring PCR cycles.
Columbia Univ. RNA intron WO 96/22689
New York catalysts
RNA catalysts with conserved group II intron catalytic regions; fortherapy development.
Cor Therapeutics C140 cell WO 96/23225
S. San Francisco surface receptor
Gene for the C140 cell surface receptor, encoded protein, antibodies;for identifying agonists and antagonists.
Cornell Univ. Recombinase- WO 96/22364
Ithaca, N.Y. mediated recombination
Genes for recombinases, variants, encoded proteins; for assistinghomologous recombination in cells.
Dedhar et al. Hormonal WO 96/23001
Richmond Hill, Ont. responsiveness modulators
Proteins that modulate hormonal responsiveness by binding to theDNA-binding domains of receptor gene sequences.
Fox Chase Cancer Ctr. Stress-responsive WO 96/22367
Philadelphia polymerase subunit
Gene for stress-responsive subunit of human RNA polymerase II,encoded protein, antibodies; for designing therapeutics.
Gene Shears Anti-retroviral WO 96/22368
Neutral Bay, Australia ribozymes
Ribozymes targeted to retroviral packaging sequence expressionconstructs, recombinant vectors containing them.
Genetic Therapy Brain gene WO 96/22112
Gaithersburg, Md. therapy
Transfection of endothelial cells by intravascular administration; fortherapeutic delivery to the brain.
Glaxo RANTES WO 96/23068
Greenford, U.K. chemokine binder
Chemokine receptor that binds to RANTES; for screeningantagonists and treating allergies and graft rejection.
Hirano, T. Pre-B cell EPO 725 135
Osaka, Japan growth
Gene for protein supporting pre-B cell growth and adhesion, encodedprotein; for arthritis and myeloma diagnosis.
Hoffmann-La Roche IL-1 receptor WO 96/23067
Basel, Switzerland accessory protein
Gene for interleukin (IL)-1 receptor accessory protein, encodedprotein, antibodies; for preventing inflammation.
Human Genome Sciences Prostate- WO 96/22360
Rockville, Md. specific reductase
Gene for human prostate-specific reductase, encoded protein,antibodies; for prostate cancer diagnosis and treatment.
Hybridon Oligos inhibiting WO 96/23065
Worcester, Mass. neovascularization
Oligos specific for vascular endothelial cell growth factor; forinhibiting neovascularization.
Incyte Pharma Fetal spleen WO 96/22374
Palo Alto, Calif. chemokine
Gene for a chemokine expressed in fetal spleen, encoded protein,antibodies.
Kentucky, Univ. of Antibody WO 96/22373
Lexington, Ky. melanoma treatment
Anti-idiotype antibody against ganglioside GD2 antibodies; fordetection and treatment of melanoma.
Keygene Sequence repeat WO 96/22388
Process for selective amplification of simple sequence repeatrestriction fragments; for forensic analysis.
Kirin Beer Modified EPO 725 137
Tokyo carotenoid production
Gene for a keto group introducing enzyme, encoded protein; formaking ketocarotenoids.
Kirin Beer Thrombopoietin WO 96/22309
Monoclonal antibodies against human thrombopoietins (TPOs); fordetection and purification of TPOs.
Kyowa Virus detection EPO 725 081
Monoclonal antibody against specific human Mx protein Mxepitopes; for viral infection diagnosis.
Leukosite C-C chemokine WO 96/22371
Cambridge, Mass. receptor 3
Gene for C-C chemokine receptor 3, encoded protein, antibodies; fordiagnosis and therapy of immune disorders.
Ligand Pharma Retinoid X WO 96/23070
San Diego receptor gamma
Gene for human retinoid X receptor gamma, encoded protein; forscreening ligands that bind the receptor.
Massachusetts, Nonsense-mediated WO 96/22301
Univ. Med. Ctr. mRNA decay
Gene for a protein in the nonsense-mediated mRNA decay pathway,encoded protein, fragments; for pathway inhibition.
Merck Frosst Prostaglandin WO 96/23066
Kirkland, Ont. receptor
Gene for a prostaglandin receptor, encoded protein, expression cellhost; for identifying modulators.
Nexia Biotech Mammary WO 96/22379
Ste. Anne de gland transfection
Infusion of solution containing transfecting DNA into the ruminantmammary gland; for direct gene transfer.
NeXstar Pharma Spectroscopic WO 96/22383
Boulder, Colo. DNA detection
Methods of detecting spectroscopically labeled nucleic acids andreceptors to determine presence of biological targets.
N. Carolina, Univ. of DNA ligation WO 96/22365
Chapel Hill, N.C. enzymes
Genes for enzymes that cleave and ligate DNA, encoded enzymes;for use in vivo and in vitro.
Novo Nordisk Multicopy genes WO 96/23073
Bagsvaerd, Denmark in bacteria
Gram positive bacteria with multiple copies of a DNA sequence andsubsequent deletion of a marker gene.
Pasteur Inst. Deafness-associated EPO 725 136
Gene for USHER-1B, a myosin variant involved in deafnesssyndromes, encoded protein; for diagnosis
Pharmacia Biotech Thermococcus WO 96/22389
Milwaukee, Wis. barossii polymerase
Purified DNA polymerase from Thermococcus barossii; for increasedheat stability.
Pittsburgh, Univ. of Connective WO 96/22793
Pittsburgh tissue gene transfer
Gene transfer into connective tissue cells; for disease treatment anddeveloping animal models.
Rhone-Poulenc Rorer Adenovirus WO 96/22378
Antony, France production cells
Cells for the production of modified adenoviruses to be used for genetherapy.
Salk Inst. Xenopus vitamin WO 96/22390
La Jolla, Calif. D-like receptor
Gene for a vitamin D-like receptor from Xenopus, encoded protein.
Sanofi Periplasmic protein EPO 725 140
Extraction of periplasmic proteins expressed in microorganisms usingarginine; for purification (in French).
Scripps Res. Inst. Chemical WO 96/22391
La Jolla, Calif. bonding detection
Reaction cassette for highly sensitive detection of chemical bondformation and creation.
Sheffield, Univ. of H2 receptor GB 2 297 328
Balm Green, U.K. region
Nucleotide sequences encoding the human H2 receptor region,primers for amplification; for diagnosis.
Snow Brand Milk Products Osteoblast EPO 725 080
Sapporo, Japan growth factor
Gene for a protein with osteoblast proliferating activity derived fromfibroblasts, encoded protein; for therapy.
Texas, Univ. of Hematopoietic WO 96/22693
Austin, Tex. stem cells
Undifferentiated pluripotent hematopoietic stem cells and methods ofproduction; for cancer diagnosis and therapy.
Vessel Res. Lab Angioplasty WO 96/23069
Tokyo reconstriction therapy
Gene for smooth muscle myosin heavy-chain isoform protein, theprotein; for treating post-angioplasty reconstriction.
Wakunaga Complementary WO 96/23077
Osaka, Japan DNA chain replacement
Nucleic acid amplification and discrimination by replacement ofcomplementary chains by competitive hybridization.
Wisconsin, Univ. of Primate WO 96/22362
Madison, Wis. embryonic stem cells
Purified primate embryonic stem cells, method of preparation; for usein transfection and transgenic production.
Zymogenetics Appetite WO 96/22308
Seattle suppression factors
N-terminally modified ob protein, its purification from yeast; foridentification of appetite suppression factors.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.