Published June 19 & 26 (EPO); June 13 & 20 (WO)
Abbott Labs HIV-2 synthetic EPO 717 109
Abbott Park, Ill. genes
Synthetic genes encoding HIV-2 envelope proteins and fragments,expression in E. coli; for detection.
Amgen Boulder TGF-a type WO 96/18735
Boulder, Colo. receptor
Gene for a TGF-a superfamily type II receptor that binds osteogenicprotein 1 (OP-1), encoded protein.
Angeletti Res. Inst. IL-6 agonists/ WO 96/18648
Pomezia, Italy antagonists
Identification of agonists and antagonists of human interleukin (IL)-6using a membrane glycoprotein.
Avigen AAV integration WO 96/18727
Alameda, Calif. vectors
Adeno-associated virus (AAV) vectors with sequences providing site-specific integration; for gene delivery.
Behringwerke Pseudomonas EPO 717 106
Marburg, Germany vaccine
Hybrid protein containing fusion of two Pseudomonas aeruginosaouter membrane proteins, antibodies; for therapy.
Bionebraska C-terminal amidated WO 96/17941
Lincoln, Neb. peptides
Production of recombinant peptides having a C-terminal -carboxamide, coding DNA, expression cassettes.
Bionebraska Carbonic WO 96/17942
Lincoln, Neb. anhydrase fusions
Production and purification of recombinant proteins fused tocarbonic anhydrase.
Boehringer Mannheim Collagen I EPO 718 309
Mannheim, Germany antibodies
N-terminal antigenic determinants of collagen I, antibodies againstcollagen I; for detection assay (in German).
Boehringer Mannheim DNA sequence EPO 718 408
Mannheim, Germany detection
Sensitive method for detecting specific nucleic acid sequences usingprimers and amplification (in German).
Boehringer Mannheim Degenerative WO 96/17865
Mannheim, Germany nerve genes
Genes expressed in degenerating and/or regenerating peripheralnerves; for neural disease diagnosis and therapy.
Boehringer Mannheim tPA protease WO 96/17928
Mannheim, Germany domain
Protease domain of human tissue type plasminogen activator (tPA);for reduced side effects during treatment.
Bristol-Myers Squibb Penicillin V EPO 718 402
Princeton, N.J. amidohydrolase
Gene for penicillin V amidohydrolase from Fusarium oxysporum,expression vectors, host cells; for production.
Bruschettini Herpes vaccines WO 96/17938
Glycoproteins from herpes simplex viruses, expression methods; forvaccine formulation.
California, Univ. of Phosphorylated WO 96/17866
Oakland, Calif. protein binding proteins
Protein domains that bind tyrosine phosphorylated proteins, encodinggenes; expression methods.
Chiron Hepatitis C EPO 718 400
Emeryville, Calif. translation control
Methods for controlling translation of hepatitis C virus proteins using5' untranslated region elements.
Chugai IL-6 receptor WO 96/18416
Inhibition of expression of human interleukin (IL)-6 receptor usingantisense oligos.
Ciba-Geigy CHO recombinant WO 96/18734
Basel, Switzerland secretory component
Recombinant secretory component from Chinese Hamster Ovary(CHO) cell lines.
Florida, Univ. of Periodontal disease WO 96/17936
Gainesville, Fla. treatment
DNA fragments coding for hemagglutinin/proteases fromPorphyromonas gingivalis, antibodies; for periodontal disease.
Fox Chase Cancer Ctr. Kinetochore WO 96/17867
Gene for a transiently-expressed kinetochore protein, encodedprotein; for cell growth detection.
French Myopathy Assoc. Muscular disease EPO 717 110
Gene for a calcium-dependent protease involved in muscular disease,encoded protein, mutated genes encoding protease.
Genetic Therapy Less immunogenic WO 96/18418
Gaithersburg, Md. adenoviral vectors
Adenoviral vectors modified to reduce host immune responses,producer cell lines.
Genzyme Cationic delivery WO 96/18372
Cambridge, Mass. amphiphiles
Cationic amphiphiles containing lipophilic groups and vectors forintracellular delivery of therapeutics.
Glaxo Modified RANTES WO 96/17935
Greenford, U.K. peptides
Modified RANTES peptides and fragments; for use as antagonists intherapy to reduce inflammation.
Harvard Univ. Single chain WO 96/18105
Cambridge, Mass. T cell receptor
Single chain T cell receptor that binds specifically to an MHC ligand.
Hayes et al. Liposome-mediated WO 96/18741
Houston CNS transfection
Methods for liposome-mediated transfer of genes to central nervoussystem (CNS) cells; for disease treatment.
Hitachi DNA preparation EPO 718 409
Preparation of DNA by digesting double-stranded DNA, attaching tooligomers, and amplifying the ligated material.
Hoffmann-La Roche Immunosuppressant WO 96/17874
Basel, Switzerland antibody fragments
Monovalent monoclonal antibody fragments; for down-regulatingHLA-DR expression on antigen presenting cells.
Human Genome Sciences Vascular growth WO 96/17931
Rockville, Md. factor
Gene for human vascular IBP-like growth factor, encoded protein,production methods; for wound healing.
Human Genome Sciences TIMP-4 WO 96/18725
Gene for human tissue inhibitor of metalloproteinases (TIMP)-4,encoded protein; for identifying antagonists.
Human Genome Sciences Prostatic growth WO 96/18730
Rockville, Md. factor
Gene for prostatic growth factor, encoded protein, antibodies; foridentifying antagonists and agonists.
Illinois, Univ. of Triplex forming WO 96/18732
Urbana, Ill. oligos
Oligos specifically designed for forming triplexes in single- ordouble-stranded DNA.
Immunex LERK-7 cytokine WO 96/17925
Gene for the cytokine, LERK-7, encoded protein, antibodies, hostcells transformed with the gene.
Immunex Herpes MHC-II WO 96/17939
Seattle binding proteins
Isolated proteins from herpes virus that bind to the class II majorhistocompatibility complex (MHC-II) antigen.
Incyte Pharma Adenoid-derived WO 96/17868
Palo Alto, Calif. chemokine
Chemokine derived from inflamed adenoids, encoding gene,antisense molecules, antibodies to the protein.
Innovir Labs Leukemia-associated WO 96/18733
New York RNA inactivation
Ribozymes and antisense oligos for cleavage or transcriptionblockage of leukemia-associated RNA.
Intl. Fdn. Thrombosis Res. Anti-thrombin WO 96/17622
Silver Spring, Md. binding antibodies
Monoclonal antibodies to glycoprotein Ib; for inhibiting thrombinbinding to platelets.
Johns Hopkins Univ. Hedgehog protein WO 96/17924
N- and C-terminal fragments of the hedgehog protein which arederived after specific cleavage.
Johns Hopkins Univ. JAK3 protein tyrosine WO 96/18639
Gene for JAK3 protein tyrosine kinase, encoded protein; forcontrolling cell growth and differentiation.
Karo Bio Anti-inflammatory WO 96/17927
Huddinge, Sweden reporter
Cell line with two reporter gene cassettes; for screening compoundsfor anti-inflammatory activity.
Kirin Beer Yeast production EPO 717 107
Candida utilis yeast strain designed for expression of heterologousproteins.
Krebs Res. Inst. Gene therapy WO 96/18737
Heidelberg, Germany viruses
Vectors/viruses with gene for binding region of poly (ADP ribose)-polymerase; for gene therapy.
Law, P.K. Myoblast therapy WO 96/18303
Memphis, Tenn. Myoblast therapy
Transformed and untransformed myoblast cells inserted into humans;for gene delivery and disease therapy.
Lynxvale Immune response WO 96/17625
Cambridge, U.K. enhancement
Coupling C3d molecules or ligands of CD21 or CD19 toimmunogens; for modulating the immune response.
Mass. Inst. Tech. Transplanted cell WO 96/18411
Cambridge, Mass. survival
Growth or angiogenic factors administered in combination with cellson polymeric matrices; for cell transplants.
Merck Transgenic WO 96/17926
Rahway, N.J. Alzheimer's model
Transgenic animals lacking the native amyloid precursor protein; foruse as an Alzheimer's model.
Michigan, Univ. of Cell transfection WO 96/17948
Ann Arbor, Mich. improvement
Improved cell transfection efficiency for viral vectors by depositingthe vector on a cell growth support.
Minnesota, Univ. of Neural autoimmune WO 96/18646
Minneapolis disease therapy
Heat shock peptides homologous to myelin components; for treatingneural autoimmune disease.
Mosca et al. Mice with human WO 96/17627
Ellicott City, Md. hematopoietic cells
Engraftment of human and primate pluripotent stem cells intoirradiated mice; for testing gene therapy protocols.
Nippon Shinyaku Antisense nucleic WO 96/18640
Kyoto, Japan acid homologue
An antisense nucleic acid homologue that has low toxicity; forsuppressing viral infections.
Novo Nordisk Less allergenic WO 96/17929
Bagsvaerd, Denmark polypeptide
Polypeptide with reduced allergenicity conjugated to a polymermolecule; for reducing allergic response.
Novo Nordisk Bacterial WO 96/17943
Bagsvaerd, Denmark extracellular proteins
Production of extracellular proteins in bacteria by transforming thebacteria with an extracellular protease.
Nycomed Pharma Factor VII fragments WO 96/18654
Factor VII fragment that contains residues 82-128, its variants; fortreating blood-clotting disorders.
Oriental Yeast Matrilysin EPO 718 403
Production of human matrilysin in transformed E. coli, purificationmethods.
Pasteur Inst. Neuronal EPO 717 105
Paris acetylcholine receptor
Genomic DNA fragments coding for the a2-subunit of the neuronalnicotinic acetylcholine receptor.
PPL Therapeutics Improved WO 96/17946
Roslin, U.K. transgene expression
Elimination of variegated expression of transgenes in transgenicsusing large portions of upstream gene sequences.
Ribozyme Pharma Immune WO 96/18736
Boulder, Colo. response ribozymes
Ribozymes cleaving RNA causing development/maintenance ofarthritic conditions/graft tolerance/immune response.
Rhone-Poulenc Rorer Motoneuron WO 96/18740
Antony, France gene therapy
Adenoviral vector-mediated gene transfer into medullarymotoneurons; for gene therapy.
Rhone-Poulenc Rorer Triple helix WO 96/18744
Antony, France formation
Hybridizing oligonucleotide bound to a solid support; for purifyingdouble-stranded DNA by triplex formation.
Salk Inst. CRF receptor WO 96/17934
La Jolla, Calif.
Gene for G-coupled corticotropin releasing factor (CRF) receptor,encoded protein.
Scriptgen Pharma Hepatitis B WO 96/17960
Medford, Mass. replication inhibition
High-throughput screening methods for identifying inhibitors ofhepatitis B virus replication mediated by the X protein.
SmithKline Beecham Somatostatin-like WO 96/18651
King of Prussia, Penn. receptor
Gene for a human somatostatin-like receptor, encoded protein; fordrug screening and development.
SmithKline Beecham Yeast infection WO 96/18745
King of Prussia, Penn. detection
Conserved nucleic acid sequences found in various yeasts; for strainidentification and infection detection.
Stringer, B.M.J. Chondrocyte WO 96/18728
Cyncoed, U.K. cell lines
Hypertrophic chondrocyte cell lines; for use in studying arthriticconditions and doing replacement surgery.
Sugen Probin tyrosine WO 96/18738
Redwood City, Calif. kinase
Gene for probin tyrosine kinase, encoded protein; fordiagnosis/treatment of defects in signal transduction pathways.
Takara Shuzo Site-directed EPO 718 404
Kyoto, Japan mutagenesis kit
Site-directed mutagenesis using a strand exchange reaction protein invitro and introducing mutated vector into cells.
Takeda Cell growth WO 96/17933
Osaka, Japan inhibiting factor
Gene for a cell growth inhibiting factor, encoded protein, expressionvector, host cells, assay system.
Targeted Genetics AAV vector WO 96/17947
Seattle packaging cells
Packaging cell lines developed for generating high titers ofrecombinant adeno-associated virus (AAV) vectors.
Tokyo Inst. Med. Sci. Non-A, non-B EPO 717 104
Antibodies to non-A, non-B hepatitis core structural protein,hybridoma; for preparing an assay kit.
U.S. Navy Hematopoietic WO 96/18726
Bethesda, Md. cell expansion
Compositions derived from supernatants of pig microvascularendothelial cells; for stimulating hematopoietic cells.
Wakunaga Non-specific WO 96/17932
Osaka, Japan hybridization inhibition
Inhibition of non-specific hybridization during primer extensionusing DNA complementary to the primer.
Washington, Univ. of Liver WO 96/18419
Retroviral and adenoviral vectors that induce hepatocyte growth andelimination of hepatitis infection.
Yeda Res. & Develop. Mycobacterial WO 96/17864
Rehovot, Israel autoimmune treatment
Purified protein and derivatives from Mycobacterium tuberculosis;for treating autoimmune diseases.
Yeda Res. & Develop. FAS/APO1 receptor f WO 96/18641
Rehovot, Israel unction modulators
Proteins capable of modulating the function of FAS/APO1 receptors,expression vectors, transformed cells.
_Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.