Published May 22 & 29 (EPO); May 17 & 23 (WO);May 29 (GB)

Agennix Fungal lactoferrin WO 96/14413

Houston expression

Plasmids for production of lactoferrin and lactoferrin peptides in afungal expression system.

American Hlth. Fdn. Point mutation WO 96/15139

Valhalla, N.Y. detection

PCR-based method for detecting point mutations at a known site; fordiagnosis.

Amgen Hematopoietic WO 96/15230

Thousand Oaks, Calif. cell expansion

Stem cell factor and soluble interleukin-6 receptor used for ex vivoexpansion of multipotent hematopoietic cells.

Applied Res. Systems Human SCF WO 96/14410

Curacao, the Netherlands Antilles

Human SCF, a splice variant, a C-terminal peptide; for ensuringcorrect development of pre-implantation embryos.

Arch Develop. Pathological cell WO 96/15245

Chicago growth inhibition

Gene for a dominant-negative cell cycle regulatory protein insertedinto an expression vector; for growth inhibition.

Bar Ilan Univ. Protein-polyhydroxy WO 96/15236

Ramat Gan, Israel conjugates

Bioactive conjugates of immobilized proteins with polyhydroxypolymers such as cellulose.

Baxter Intl. T cell receptor WO 96/15153

Deerfield, Ill. antibodies

Human antibodies to T cell receptor peptides, production methods;for autoimmune disease therapy.

Biomay Mold fungus WO 96/14407

Linz, Austria allergens

Gene for Alternaria alternata mold fungus allergens, encodedallergens; for diagnosis and therapy.

Boehringer Mannheim Lipid-splitting WO 96/15234

Mannheim, Germany enzyme

Lipid-splitting enzyme from the cellular membrane fractions of bloodleukocytes and monocytes/macrophages.

California, Univ. of Glaucoma-associated WO 96/14411

Oakland, Calif. protein

A glucocorticoid-induced protein, TIGR, that is produced by cells ofthe trabecular meshwork; for glaucoma diagnosis.

California, Univ. of HIV maturation WO 96/14863

Oakland, Calif. inhibition

Vectors encoding defective HIV monomers that form inactiveprotease heterodimers; for viral maturation inhibition.

Cancer Res. Camp. Tech. Inducible WO 96/14420

London cell ablation

Transgenic animal with a gene for a nitoreductase that converts aprodrug into a cytotoxic one; for cell ablation.

Cedars-Sinai Med. Ctr. Chromosome WO 96/15144

Los Angeles gene 21 marker

Chromosome 21 gene for human EHOC-1 protein, encoded protein,antibodies, transgenic animals.

Cell Genesys Replication-deficient WO 96/14061

Foster City, Calif. adenoviral vectors

Replication-deficient adenoviral vectors with lethal early region genedeletions; for gene therapy.

Chang, L.-J. Hybrid LTR WO 96/14332

Gaithersburg, Md. retroviral vectors

Retroviral vectors with long terminal repeat (LTR) hybrids; for highlevel expression of products.

Colorado, Univ. of Yeast-based WO 96/14876

Boulder, Colo. delivery vehicles

Yeast-based delivery vehicles that have both yeast and heterologousportions; for immunomodulation.

Curie, Univ. of Pierre & Marie Cell WO 96/14395

Paris dissociation method

Dissociation method for adhesive eukaryotic cells using apolysaccharide polymer derivative.

Dako PNA/DNA WO 96/14341

Glostrup, Denmark complex antibodies

Antibodies against protein nucleic acid (PNA)/DNA complexes; forquantification of nucleic acids.

Diacrin Transplanting WO 96/14397,

Charlestown, Mass. pig neural cells 14398, & 14399

Pig cortical, mesencephalic, and striatal cells modified fortransplantation; for treating neurological defects.

Dundee, Univ. of PCNA binding WO 96/14334

Dundee, U.K. substances

Substances that bind to PCNA, including fragments and mimics; fortreating cancer and psoriasis.

Gen-Probe Mycoplasma EPO 713 920

San Diego pneumoniae probes

Oligonucleotide probes for Mycoplasma pneumoniae nucleic acids;for diagnosis.

Genentech Bacterial WO 96/14422

S. San Francisco disulfide bonds

Bacterial production of heterologous proteins with correct disulfidebonds using genes for disulfide bond generation.

Genentech Sensory/motoneuron WO 96/15244

S. San Francisco factor

Sensory and motor neuron-derived factor (SMDF), gene encodingthis protein; for affecting neural cell growth.

Grunenthal Thrombolytic EPO 712 934

Aachen, Germany protein

Protein with thrombolytic and anticoagulant activity; for productionof therapeutics (in German).

Hayashibara Seibutsu Interferon EPO 712 931

Okayama, Japan production induction

Polypeptide that induces gamma-interferon production, antibodies toit; for therapy.

Human Genome Sciences TNF-gamma WO 96/14328

Rockville, Md.

Gene for tumor necrosis factor (TNF)-gamma, encoded protein; forcell growth inhibition and inflammation treatment.

Human Genome Sciences DNA ligase III WO 96/14394

Rockville, Md.

Gene for human DNA ligase III polypeptide, encoded polypeptide;for diagnosis of mutant genes.

Human Genome Sciences Stanniocalcin-a WO 96/15147

Rockville, Md.

Gene for human stanniocalcin-a, encoded protein, productionmethod; for treating electrolyte disorders.

Human Genome Sciences Human MutT2 WO 96/15222

Rockville, Md.

Gene for a human protein (MutT2) that hydrolyzes and eliminatesoxidized guanine residues, encoded protein.

Hybridon Ribozyme WO 96/15240

Worcester, Mass. analogues

Ribozyme analogues that endonucleolytically cleave a sequence of 3'to 5' linked ribonucleotides.

Immuno Protein-free cell WO 96/15231

Vienna, Austria culture

Methods for producing viruses and heterologous proteins from viralvectors in protein-free cell culture.

Imperial Coll. Vaccination by WO 96/15237

London insects

Transgenic hematophagous insects that transmit a vaccine to the hostvia their salivary secretions.

Incell Electronic pulse WO 96/14836

Santa Clara, Calif. transfection

Transfection of cells using electronic pulse delivery; for makingtransgenic animals.

Inst. Psychiatry Transgenic GB 2 295 395

London Alzheimer's

Transgenic animals with a gene for a kinase that phosphorylates thetau protein; for Alzheimer's modeling.

Intl. Reagents Annexin-V WO 96/15152

Kobe, Japan antibodies

Anti-annexin-V monoclonal antibodies, hybridomas, productionprocess.

Japan Tobacco Transgenic viral WO 96/14734

Tokyo resistance

Transgenic animals with inhibited expression of S-adenosylhomocysteine hydrolase; for viral resistance.

Johns Hopkins Univ. HIC-1 tumor WO 96/14877

Baltimore suppressor

Gene for the tumor suppressor HIC-1, encoded protein; for diagnosisand therapy.

Julich Res. Ctr. Coryneform bacteria WO 96/15246

Julich, Germany expression system

DNA that regulates gene expression in coryneform bacteria; forexpression and production of heterologous proteins.

LG Chemical Arteriosclerosis WO 96/15141

Seoul, S. Korea therapeutic

Cholesteryl ester transfer protein inhibitor peptides; for use as anti-arteriosclerosis agents.

Mass. Gen. Hosp. Neural thread WO 96/15272

Boston protein

Gene for neural thread protein, encoded protein; for detection ofAlzheimer's and gene therapy.

Medeva Tetanus toxin GB 2 295 394

Amsterdam, fusions

the Netherlands

Vectors encoding the C fragment of tetanus toxin linked to aheterologous protein; for vaccines.

MRC (Med. Res. Coun.) Protein-assisted WO 96/14424

London transfection

Cell transfection method using proteins with high basic amino acidcontents.

Merck Modified neuropeptide WO 96/14331

Rahway, N.J. Y receptors

Neuropeptide Y receptors with modifications in the third intracellulardomain; for treating nervous system disease.

Merck Tuberculosis WO 96/15241

Rahway, N.J. vaccine

Genes encoding Mycobacterium tuberculosis proteins inserted intovectors for expression in muscle cells; for vaccines.

Merck Papillomavirus WO 96/15247

Rahway, N.J. proteins

Purified recombinant proteins of papillomaviruses and methods ofmaking and using them.

Molec. Immunol. Ctr. EGF receptor EPO 712 863

Havana antibodies

Humanized and chimeric monoclonal antibodies against epidermalgrowth factor (EGF) receptor; for diagnosis/therapy.

NIH (Natl. Inst. Hlth.) Chondrogenic WO 96/14335

Bethesda, Md. proteins

Cartilage-derived morphogenetic proteins and genes encoding someof them; for inducing chondrogenesis.

NIH (Natl. Inst. Hlth.) Mitogenic WO 96/15242

Bethesda, Md. activity inhibition

Genes that encode factors that inhibit the mitogenic activity ofmacrophage migration inhibitory factor.

Natl. Jewish Ctr. Non-pathological WO 96/14744

Immunol. Resp. Dis. mutated superantigens


Non-pathological mutated superantigens; for eliciting immuneresponse against other superantigens.

Neurospheres Dopaminergic WO 96/15224

Calgary, Alberta cell induction

Induction of dopaminergic cells in culture using FGF family proteins;for treating neurological disorders.

Neurospheres Neural stem WO 96/15226

Calgary, Alberta cell growth

Regulation of neural stem cell proliferation by the use of biologicalgrowth factors in vitro.

Novo Nordisk ISPK-1 gene WO 96/15233

Bagsvaerd, Denmark mutations

Gene for insulin-stimulated protein kinase (ISPK-1) and mutations ofthis gene.

Pasteur Inst. Campylobacter WO 96/15260

Paris fetus detection

Nucleotide sequences that specifically hybridize to Campylobacterfetus genomic DNA sequences; for detection.

Pennsylvania, Univ. of Bacterial cancer WO 96/14087

Philadelphia vaccines

Recombinant Listeria monocytogenes that express tumor specificantigens; for immunotherapy and cancer vaccines.

Pennsylvania, Univ. of Neurite-specific WO 96/14435

Philadelphia cDNAs

Determination and comparison of mRNA expression patterns inselected neurites; for identifying neurite-specific cDNAs.

Pennsylvania, Univ. of a3 integrin WO 96/15145

Philadelphia polypeptides

a3 integrin subunit specific polypeptides, cDNAs that encode thesepolypeptides, production methods.

Pierre Fabre Med. Hydrophobic WO 96/14409

Boulogne, France peptide analogues

Recombinant peptides with modifications in their non-transmembranehydrophobic region, encoding genes.

Pierre Fabre Med. Immunization WO 96/14415 & 14416

Boulogne, France adjuvant

Carrier protein fused to an antigen; for use as an immunostimulatoryadjuvant for immunization.

Pierre Fabre Med. RSV vaccine WO 96/14418

Boulogne, France

Respiratory syncytial virus (RSV) protein G expressed on bacterialmembranes; for vaccines.

Procter & Gamble BMP receptor WO 96/14412

Cincinnati kinase

Gene for a BMP receptor kinase protein, encoded protein, solublefragments, expression system.

Prolifix Transcription WO 96/15243

London factor E2F-4

Transcription factor E2F-4 that interacts with DP-1 and is regulatedby p107, gene encoding this factor.

Promega Tagged protein WO 96/15249

Madison, Wisc. purification

Production and purification of proteins for antibody production usingfusion proteins with non-charged tails.

Sandoz Hematopoietic WO 96/15227

Basel, Switzerland cell death

Induction of cell death in hematopoietic cells expressing CD43; forobtaining enriched cell populations.

Seo, J. T cell-deficient EPO 712 929

Seoul, S. Korea transgenics

Transgenic animal deficient in T cells made by targeting heat shockprotein expression to the thymus.

Seo, J. Transgenic EPO 712 930

Seoul, S. Korea diabetes

Transgenic animal with heat shock expression targeted to pancreatica cells; for making a diabetes model.

Stanford Univ. Immature T cell EPO 712 928

Palo Alto, Calif. peptides

Genes for T cell-specific peptides that are normally associated withimmature T cells; for production.

Stringer, B.M.J. Neural cell WO 96/14396

Cyncoed, U.K. lines

Production of a homogeneous neural cell line that can be induced toundergo apoptosis.

Stringer, B.M.J. Immortal human WO 96/14400

Cyncoed, U.K. cells

Undifferentiated human cells treated with an immortalizing agentwhose effects can be reversed as desired.

Stringer, B.M.J. Transgenic cell WO 96/14402

Cyncoed, U.K. selection

Transgenic animals with cells bearing selectable markers; forselectively depleting a particular cell/tissue type.

Stringer B.M.J. Specific cytotoxic WO 96/15238

Cyncoed, U.K. T cells

Targeted cytotoxic T cells with heterologous polypeptides conferringMHC Class I-restricted specificity.

Systemix Enriched WO 96/15228 & 15229

Palo Alto, Calif. hematopoietic stem cells

Methods of obtaining enriched populations of hematopoietic stemcells using a marker.

Trophix Pharma PNS sodium WO 96/14077

S. Plainfield, N.J. channels

Genes coding for peripheral nervous system (PNS)-specific sodiumchannel peptides; encoded peptides; for diagnosis.

Yissum Res. Develop. Microorgans WO 96/15225

Jerusalem, Israel

Microorgan culture methods; for maintaining cell growth and tissuestructure in vitro.

_ Compiled By Chester A. Bisbee

(c) 1997 American Health Consultants. All rights reserved.