Published Feb. 14 & 21 (EPO & GB); Feb. 8 & 15 (WO)
Ajinomoto BCG immunogenic WO 96/04009
Fusion of the Mycobacterium bovis BCG a-antigen with a foreignantigen; for making an immunogenic vaccine.
Alabama, Univ. of Oxidative damage WO 96/04311
Birmingham, Ala. detection
Antibodies to nitrotyrosine; for detection of oxidative damage totissues.
American Cyanamid Cytomegalovirus WO 96/04383 &
Wayne, N.J. reduced MHC expression 04384
Identification of a human cytomegalovirus gene region involved indown-regulation of MHC class I gene expression.
Amgen Erythropoietin WO 96/03438
Thousand Oaks, Calif. receptor antibodies
Antibodies and fragments that activate the erythropoietin receptor,hybridomas; for erythropoiesis/treating anemia.
Anvret et al. Homologous WO 96/04397
Stockholm, Sweden recombination method
DNA-liposome preparation for gene transfection to replace mutantgenes by homologous recombination.
Baylor Coll. Med. Contraceptive WO 96/04310
Recombinant zona pellucida proteins with altered glycosylationpatterns, antibodies; for contraception.
Becton Dickinson Mycobacterial EPO 696 638
Franklin Lakes, N.J. lysis
One-step process for lysing mycobacteria; for DNA isolation andanalysis.
Boehringer Ingelheim Targeted WO 96/03517
Ingelheim, Germany transfection complex
Virus and viral vector preparation process for transfection usingpolycations and target cell ligands.
Boehringer Mannheim Interferon-inhibited EPO 696 639
Mannheim, Germany stem cells
Growth inhibition of hematopoietic stem cells using interferongamma; for protection during cytotoxic treatment.
Boehringer Mannheim Hepatitis C EPO 696 640
Mannheim, Germany antigen
Recombinant antigen from the NS3 region of hepatitis C; for animmunologic detection test (in German).
Cancer Res. Campaign Tech. Prodrug WO 96/03515
London cancer therapy
Cancer therapeutic comprising a vector capable of expressing anenzyme at the cell surface that can convert prodrugs.
Chiron Truncated hepatitis WO 96/04301
Emeryville, Calif. polypeptides
C-terminally truncated hepatitis C/E1/E2 polypeptides that removesmembrane-spanning region; for secretion.
Chiron Tissue WO 96/04377 & 040378
Emeryville, Calif. factor pathway inhibitor
Tissue factor pathway inhibitor, muteins, chimeric proteins, encodinggenes; for septic shock treatment.
Chiron Modified secreted WO 96/04382
Emeryville, Calif. viral proteins
Viral proteins modified to be secreted when expressed in productionhosts cells; for diagnostics and vaccines.
Ciba-Geigy Autoinhibitory WO 96/03501
Basel, Switzerland protein design
Determination of interactions between phosphatase/kinase andautoinhibitory polypeptides; for designing mimics.
Connaught Labs Hemagglutinin WO 96/03145
Swiftwater, Penn. conjugates
Conjugates of influenza hemagglutinin with a carrier; for making fluvaccines.
Connaught Labs Influenza WO 96/03506
Willowdale, Ont. Hin47 protein
Gene for analogues of influenza Hin47 protein, encoded protein withdecreased protease activity; for vaccines.
Demeter Biotech Ubiquitin- WO 96/03519 & 03522
Durham, N.C. lytic peptide fusions
Stabilized ubiquitin-lytic peptide fusion polypeptides, encodinggenes.
DGI Technologies Drug target WO 96/04557
Upper Montclair, N.J. antibodies
Antibodies to surface domain structure of pharmaceutical targets; fordesigning small molecule therapeutics.
Eisai Megakaryocyte WO 96/03434
Tokyo growth factor
Gene for megakaryocyte differentiation/proliferation factor, encodedprotein; for thrombocytopenia.
Gene Pharming Europe Collagen WO 96/03051
Leiden, Netherlands in milk
Collagen and procollagen transgenes; for creating transgenicmammals that secrete these proteins into their milk.
Genentech High-expressing WO 96/04391
S. San Francisco host cells
High-expressing host cell selection using a vector with marker andproduct gene controlled by same promoter.
Genetics Inst. Calcium-independent WO 96/03512
Cambridge, Mass. cytosolic phospholipase
Gene for calcium-independent cytosolic phospholipase A2/Benzyme, encoded protein; for screening anti-inflammatories.
German Res. Osteoclast- WO 96/04375
Ctr. Hlth. & Welfare modulating factors
Osteoclast-modulating factor production from osteoinductive virus-infected osteoblast cells.
Green Cross Urinary trypsin WO 96/03503
Osaka, Japan inhibitor
Process for production of urinary trypsin inhibitor and its domains inyeast, genes, proteins, and expression vector.
Harvard Univ. Receptor-ligand WO 96/03499
Cambridge, Mass. assay
Receptor-ligand assay using the receptors and their genes to identifyunknown ligands and their genes.
Hoechst Laminin antibodies EPO 696 597
Monoclonal antibodies against native laminin and the P1 domain (inGerman).
Human Genome Sciences Potassium WO 96/03415
Rockville, Md. channels
Genes for human potassium channels, encoded proteins; foridentifying agonists.
Innogenetics Phosphorylated WO 96/04309
Zwijnaarde, Netherlands tau antibodies
Monoclonal antibodies specific for phosphorylated tau protein; fordiagnosis of Alzheimer's disease.
Innogenetics Hepatitis C envelope WO 96/04385
Zwijnaarde, Netherlands proteins
Purified recombinant hepatitis C virus envelope proteins; for therapyand diagnosis.
INSERM (Natl. Inst. Non-linear WO 96/04374
Hlth. & Med. Res.) DNA/RNA oligo
Oligonucleotide that binds with non-linear DNA or RNA; forpreventing target sequence interaction.
Italian Natl. Res. Counc. Urokinase WO 96/03414
Rome, Italy receptor antisense oligos
Antisense oligos to human urokinase receptor; for treatment ofprimary and secondary cancers.
LTT Inst. Antiviral WO 96/03500
Kanagawa, Japan phosphorothioate oligos
Phosphorothioate oligos that have antiviral activity; for treatingherpes and HIV.
Lynxvale Herpes gene WO 96/04395
Cambridge, U.K. therapy vector
Herpes viral vector with inactivating mutations that reduceinfectivity; for gene therapy.
Magainin Pharma Biologically WO 96/04373
Plymouth Meeting, Penn. active fusions
E. coli hosts that express fusions between a carbohydrate bindingprotein and an amphiphilic peptide.
Mass. Gen. Hosp. HIV CD4 WO 96/03883
Cells expressing the membrane-bound portion of the CD4 receptor;for treating HIV.
Mass. Gen. Hosp. Ikaros gene WO 96/04372
Transfected cells and transgenic animals containing the Ikaros gene.
MRC Phosphoglucomutase GB 2 292 219
(Med. Res. Counc.) polymorphisms
Human phosphoglucomutase-1 gene and protein polymorphisms; formaking detection test kits.
MRC Mutant herpes WO 96/03997
(Med. Res. Counc.) cancer therapy
Mutant herpes simplex viruses with non-functional genes; for cancertreatment.
MRC Herpes vaccine WO 96/04394
(Med. Res. Counc.) vector
Herpes simplex genome viral vector which has substantially lost itstransducing properties; for therapy/vaccination.
Merck Modified bradykinin WO 96/03495
Rahway, N.J. receptor transgenics
Gene for modified bradykinin B2 receptor; for introduction into anon-human host animal.
Merck Herpes muscle- WO 96/03510
Rahway, N.J. specific vaccine
Genes encoding herpes simplex 2 proteins cloned into vectors thatwill express in muscle cells; for vaccination.
NIH (Natl. Inst. Hlth.) Hepatitis A WO 96/04376
Bethesda, Md. virus receptor
Gene for hepatitis A virus receptor, encoded protein, transgenicanimals with gene; for screening assay and vaccines.
NIH (Natl. Inst. Hlth.) Chromatin WO 96/04390
Bethesda, Md. insulator element
DNA sequence that acts as a chromatin insulator element protectingexpressed genes from cis-acting regulation.
New York Univ. Fibrin-binding WO 96/04304
New York molecules
Genes for fibrin-binding molecules, encoded proteins; fordiagnosis/treatment of fibrin deposition diseases.
Oregon Reg. Primate Ctr. Bombesin-like WO 96/03416
Beaverton, Ore. peptide receptors
Genes for receptors for bombesin-like peptides, encoded receptors,antibodies; for screening assay.
Queensland Res. Inst. T cell WO 96/03144
Herston, Australia polypeptide vaccines
Cytotoxic T lymphocyte epitopes and encoding polynucleotides; formaking polypeptide vaccines.
Ramot Univ. Mucin-derived WO 96/03502
Tel Aviv, Israel cancer therapy
Mucin-derived proteins; for use as diagnostic and treatment agentsfor cancer.
Regeneron Pharma Receptor WO 96/04389
Tarrytown, N.Y. kinase/cytokine chimeras
Chimeric receptors consisting of extracellular receptor tyrosinekinases domains and cytoplasmic cytokine domains.
Rhone-Poulenc Rorer Topoisomerase WO 96/03516
Antony, France IV
Gene for topoisomerase IV, encoded protein, expression vector; forscreening modulators.
Rockefeller Univ. Obesity GB 2 292 382
New York polypeptides
Genes for obesity polypeptides, encoded proteins, expression vectors;for treating obesity.
Roussel Uclaf Apoptosis-inducing WO 96/04387
Romainville, France protease genes
Genes for polypeptides with protease and apoptosis-inducing activitythat are related to IL-1a converting enzyme.
Rutgers Univ. Brain-specific WO 96/03043
New Brunswick, N.J. kinase
Gene for human brain-specific kinase, encoded protein, antibodies,expression vector; for neurodegeneration.
Salk Inst. Acetylcholine-gated WO 96/03504
La Jolla, Calif. ion channel
Gene for acetylcholine-gated ion channel subunit, encoded protein;for identifying modulators.
SmithKline Beecham Inhibiting WO 96/04380 & 04381
Brentford, U.K. bacterial adhesion
Polypeptides from Staphylococcus aureus; for the prevention ofbacterial adhesion to extracellular matrix.
SmithKline Beecham IL-4 fusion WO 96/04388
Brentford, U.K. antagonist
IL-4 mutant or variant fused to a human immunoglobulin constantdomain or its fragment; for IL-4 antagonism.
Systemix Brain NCAM WO 96/04396
Palo Alto, Calif.
Neural cell adhesion molecule (NCAM) expressed only in braintissue, encoding gene, splice variants and encoded proteins.
Texas, Univ. of Bone/prostate WO 96/04379
Austin, Tex. growth factor
Gene for bone and prostate-derived growth factor, encoded protein.
Warner-Lambert Viral resistance WO 96/04386
Morris Plains, N.J. gene transfection
Introduction of transdominant negative retroviral integrase gene intomammalian cells; for viral resistance.
Yissum Res. & Develop. Temperature- WO 96/03521
Jerusalem controlled expression
Expression vector with promoter that causes increased transcriptionat lowered temperatures.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.