Published Dec. 20 & 27 (EPO); Dec. 14 & 21 (WO); Dec. 20 (GB)

Advanced Technologies Modifying WO 95/34660

Staines, U.K. plant starch

Introduction of brittle-2 gene into plants causing increased ADPGPPase activity and subsequent starch synthesis.

Advanced Tissue Sci. Artificial WO 95/33821

La Jolla, Calif. cartilage

Growth and maturation of cartilage and other cells in a tissue-likestructure using TGF-a.

Ajinomoto Recombinant WO 95/34672

Tokyo L-glutamic acid

Gene for -ketoglutaric dehydrogenase, encoded protein, productionof L-glutamic acid in coryneform bacteria.

Akzo Nobel Reovirus EPO 687 728

Arnhem, Netherlands vaccine

Isolation of a relatively non-pathogenic strain of reovirus; for makingvaccines.

Alexion Pharma Xenograft WO 95/34202

New Haven, Conn. rejection reduction

Cellular expression of a protein having glycosyltransferase activity;for reducing xenograft rejection response.

Alitalo et al. FLT4 receptor WO 95/33772

Espoo, Finland kinase antibodies

Monoclonal antibodies to FLT4 receptor tyrosine kinase; fordetecting endothelial cell changes in the lymphatic system.

American Cyanamid Peptide binding WO 95/34646

Wayne, N.J. pair cells

Cell systems for measuring specific interaction of peptide bindingpairs using fusion proteins and reporter enzymes.

American Cyanamid Chitinase WO 95/34678

Wayne, N.J. inhibitors

Cells expressing yeast chitinase gene used to screen for chitinaseinhibitors; for identifying fungicides.

Amersham Intl. Magnetic bead WO 95/33827

Little Chalfont, U.K. precipitation

Recovery of desired materials from a mixture by precipitation usingassociated magnetic beads.

Banyu Pharma Glycosyltrans WO 95/34663

Tokyo ferase

Gene for glycosyltransferase, encoded protein; for low costglycosylation of indolopyrrolocarbazole derivatives.

Bayer Chinolon-resistant EPO 688 873

Leverkusen, Germany Staphylococcus

Fast DNA assay for the detection of chinolon-resistantStaphyloccocus aureus in clinical samples [in German].

Biosource Technol. Gene expression WO 95/34668

Vacaville, Calif. inhibition

Genetic constructs for the cytoplasmic expression of RNA inhibitoryto selected gene expression.

Boehringer Ingelheim CD44 variant WO 95/33771

Ingelheim, Germany antibody

Antibody against the epitope encoded by the exon v6 variant of theCD44 gene; for diagnosis and therapy.

Brigham & Women's Hosp. Maximized WO 95/33760

Boston sequential hybridization

Sequential nucleic acid hybridization steps with minimizedinterference from primers of previous steps.

Brigham & Women's Hosp. Hypertrophic WO 95/33856

Boston cardiomyopathy mutation

Detection method for sarcomeric thin filament protein mutation; fordiagnosing hypertrophic cardiomyopathy.

Brigham & Women's Hosp. Polycystic WO 95/34573

Boston kidney disease gene

Identification of the autosomal dominant polycystic kidney diseasegene; for identifying functional antagonists.

California, Univ. of Cancer WO 95/33820 & 33826

Oakland, Calif. transgenics

Transgenic mice with human papilloma virus oncogene expressed individing tissues; for progressive cancer models.

CNRS (Natl. Ctr. Sci. Res.) FIV peptide EPO 688 790

Paris fragment

Envelope peptide fragment from feline immunodeficiency virus(FIV); for diagnosis and therapy [in French].

Children's Hosp. AAV vector WO 95/34670

Columbus, Ohio gene delivery

Adeno-associated virus (AAV) vectors, stable host cells; fortherapeutic gene delivery.

Chiron Cytoplasmic WO 95/33835

Emeryville, Calif. immunogen expression

Gene transfection with a system allowing cytoplasmic expression; foreliciting immunogenic response.

Ciba Corning Diagnostics MN WO 95/34650

Medfield, Mass. oncogene

MN gene, a putative oncogene, encoded protein, antibodies,expression systems; for assay kits.

Ciba-Geigy Antipathogenic WO 95/33818

Basel, Switzerland substances

Genes for the production of antipathogenic substances, encodedproteins, expression vectors, and host cells.

Ciba-Geigy Bacillus WO 95/34656

Basel, Switzerland thuringiensis toxins

Bacillus thuringiensis toxin genes that encode toxins effective againstmoths/butterflies; for insertion into plants.

Ciba-Geigy Protoporphyrinogen WO 95/34659

Basel, Switzerland oxidase

Genes for protoporphyrinogen oxidase and mutations causingherbicide resistance; for making transgenic plants.

Columbia Univ. Phenotypic tumor WO 95/34680

New York suppressor assay

Identifying tumor suppressor genes by insertion of cDNAs intotransformed cells and assay of phenotype changes.

Connaught Labs Mutant pertussis EPO 688 868

Willowdale, Ont. vaccine

Mutant pertussis toxins that are not toxic, but retainimmunoreactivity; for toxin expression and vaccines.

Creative Biomolecules Tissue WO 95/33831

Hopkinton, Mass. morphogenic protein modulators

Tissue morphogenic protein gene control regions linked to a reportergene; for identifying modulators.

Dade Intl. Pilin fusion WO 95/34648

Deerfield, Ill. display method

Protein display method using a fusion between bacterial pilin and theprotein of interest.

Daikin RecA gene targeting EPO 687 738

Osaka, Japan

Cellular targeting of genes by using a nucleic acid probe bound toRecA protein and then assaying for the protein.

Danisco Guar legume WO 95/34667

Copenhagen, Denmark regeneration

Regeneration of guar legumes by introducing hormone inhibitorgenes; for making transgenic plants.

Delta Biotech Hsp150-minus WO 95/33833

Nottingham, U.K. yeasts

Yeast strains lacking hsp150 so that foreign proteins, especiallyalbumin, can be purified from the strain.

Diacrin Transplantable WO 95/33828

Charlestown, Mass. foreign cells

Cells modified to have reduced capacity to elicit antibody-mediatedhyperactute rejection; for transplantation.

DNX Biotherapeutics Transgenic WO 95/34572

Princeton, N.J. delta-hemoglobin

Transgenic animals that produce a more stable delta-like humanhemoglobin.

Du Pont Salmonella PCR WO 95/33854

Wilmington, Del. identification

Method for selection of diagnostic genetic marker fragments ofSalmonella; for PCR-based identification.

Fred Hutchinson AAV vector WO 95/33824

Cancer Res. Ctr. transduction


Increased efficiency of cellular transduction by using recombinantadeno-associated virus (AAV) vectors.

Gen. Engin. & Biotechnol. Ctr. HBV single WO 95/33832

Havana chain antibody

Recombinant single chain antibody fragment against hepatitis B virus(HBV) surface antigen and production in E. coli.

Gen-Probe MMLV reverse EPO 688 870

San Diego transcriptase

Plasmid for the expression of Moloney murine leukemia virus(MMLV) reverse transcriptase; for expression/purification.

Genencor Intl. Recombinant WO 95/34657 & Rochester, N.Y. indole/tryptophan 34658

E. coli genetically engineered to release regulatory pathways forproduction of substituted indoles and tryptophan.

Genentech Pantropic WO 95/33829

S. San Francisco neurotrophic factors

Genes for pantropic neurotrophic factors, encoded factors; forneuronal disorder treatment.

Genetics Inst. Osteoinductive EPO 688 869

Cambridge, Mass. products

Human and bovine osteoinductive factor products; for treatment ofbone and periodontal defects.

Genetics Inst. BMP-9 tissue WO 95/33830

Cambridge, Mass. repair

Purified bone morphogenic protein (BMP)-9 and productionprocesses; for tissue repair.

Genetics Inst. Protein-protein WO 95/34664

Cambridge, Mass. interaction display

Protein-protein interaction detection by display on cell surfaces usingthioredoxin/flagellin fusions.

Genvec Deficient adenoviral WO 95/34671

Rockville, Md. vectors

Multiply deficient adenoviral vectors and complementing cell lines;for gene therapy and vaccination.

Genzyme Fluorescent cell WO 95/34685

Cambridge, Mass. gene detection

Detection of DNA sequences in intact cells using fluorescentlylabelled nucleic acid probes.

Georgetown Univ. Genetically WO 95/34684

Washington tagged virus

Quantitation of virus load in a sample using a genetically tagged viralsequence.

Gist-Brocades Thermostable WO 95/34662

Delft, Netherlands xylanases

Thermostable xylanases isolated from anaerobic thermophilicbacteria; for use in pulp and paper manufacturing.

Gustave-Roussy Inst. EPIL/placentine WO 95/34653

Villejuif, France

Protein named EPIL/placentine and its analogs, coding sequences;for therapeutics.

Henry Ford Hlth. System Neuronatin WO 95/34640


Neuronatin, a neuronal-neonatal gene that is expressed in brain tissueduring rapid brain growth.

Holms, R.D. HIV autoimmune GB 2 290 293

London therapeutic

Gene for viral protein, encoded protein and anti-inflammatory astherapeutic; for treating autoimmune response in HIV.

Hybridon Schistosomiasis WO 95/33759

Worcester, Mass. oligo therapy

Antisense oligonucleotides that inhibit protein synthesis inschistosome worms; for therapy.

Ibex Technologies Bacterial WO 95/34635

Montreal heparinases

Genes for bacterial heparinases, encoded proteins, antibodies; forenzyme production.

Immunomedics Infected cell WO 95/33842

Morris Plains, N.J. vector targeting

Retroviral vectors lacking integration and replication sequences; fortargeting to already infected cells.

Inst. Biol. Genetics Res. Polyhydroxy WO 95/33838

Berlin alkanoate biopolymers

Microorganisms that simultaneously produce intracellularpolyhydroxy alkanoates and extracellular polysaccharides.

Inst. Biol. Genetics Res. 2-oxogluta- WO 95/34654

Berlin rate/malate translocator

Spinach plastid with 2-oxoglutarate/malate translocator; for makingtransgenic plants.

INSERM (Natl. Inst. Child spinal WO 95/33852

Hlth. & Med. Res.) muscular atrophies


Methods and probes for detecting markers bound to the chromosome5 locus of child spinal muscular atrophies.

Japan Energy Hirudin secretion EPO 687 731

Tokyo vector

Secretion vector for production of hirudin in transformedmicroorganisms.

Japan Tobacco Agrobacterial plant EPO 687 730

Tokyo transformation

Plant transformation by agrobacteria that contain vectors withsuitable genes and selectable markers.

Joslin Diabetes Ctr. Insulin signal WO 95/34201

Boston protein

Gene for pp60PIK, a downstream protein involved in the insulinsignalling pathway.

Kirin Beer Saccharide WO 95/34642

Tokyo manipulating enzymes

Genes for transferase and amylase, encoded proteins; formanipulating saccharides.

La Jolla Cancer Res. Fdn. FAS-associated WO 95/34661

La Jolla, Calif. proteins

Mammalian protein tyrosine phosphatases, FAS-associated proteins,genes for them; for controlling apoptosis.

Louisiana St. Univ. Bovine WO 95/34686

Baton Rouge, La. respiratory coronavirus

Human rectal tumor cell line used to propagate bovine respiratoryshipping fever coronavirus; for isolation/diagnosis.

Ludwig Inst. Cancer Res. HLA WO 95/33855

New York presented tumor antigen

Gene for a tumor antigen precursor whose processed form ispresented by an HLA molecule.

Ludwig Inst. Cancer Res. Retinol WO 95/34580

New York dehydrogenase

Gene for retinol dehydrogenase, a component associated with themembrane receptor for retinol binding protein.

Mass. Inst. Technol. Biopolymer EPO 688 865

Cambridge, Mass. production

Gene for acetoacetyl-CoA reductase; for cell transfection andbiosynthesis of polyhydroxybutyrate polymers.

MRC (Med. Res. Counc.) Site independent WO 95/33841

London transgene expression

Locus control subregions with chromatin opening domain; forintegration-site independent transgene expression.

MRC (Med. Res. Counc.) Polycystic WO 95/34649

London kidney disease

Polycystic kidney disease gene and its mutations, encoded proteinsand muteins; for diagnosis and therapy.

Meiji Milk Products Pig embryonic WO 95/34636

Tokyo stem cells

Pig embryonic stem cells reactive with antibodies to mouseembryonic carcinoma cells; for making transgenic pigs.

Microprobe Mycobacteria WO 95/34574

Bothell, Wash. detection probes

Oligonucleotide probes specific for ribosomal RNA precursors ofantibiotic-resistant mycobacteria; for detection.

Minnesota, Univ. of Transplant WO 95/34320

Minneapolis rejection inhibition

Inhibition of antigen-specific T cell responses with agents inhibitingcostimulatory signals; for transplant rejection.

Mitotix CDK4 binding WO 95/33819

Cambridge, Mass. proteins

Genes for proteins that bind human cyclin dependent kinase 4(CDK4), encoded proteins; for cell cycle control.

Nanogen Optical DNA WO 95/34890

San Diego storage

Optical memory storage of DNA content in samples by usingchromophoric methoxy compounds.

NIH (Natl. Inst. Hlth.) Pigment WO 95/33480

Bethesda, Md. epithelium-derived factor

Gene for neurotrophic factor named pigment epithelium-derivedfactor (PEDF), encoded protein; for therapy.

NIH (Natl. Inst. Hlth.) Therapeutic WO 95/34639

Bethesda, Md. retroviral particles

Retroviral vectors with envelope and therapeutic agent sequences; formaking recombinant retroviral particles.

NIH (Natl. Inst. Hlth.) Drug metabolism WO 95/34679

Bethesda, Md. gene mutations

Probes for drug metabolism genes; for making a kit to identifymutations in these genes.

NIH (Natl. Inst. Hlth.) Hemorrhagic WO 95/34682

Bethesda, Md. E. coli

Isolated nucleic acid sequences specific to hemorrhagic E. coli; fordiagnosis and kit development.

Neurocrine Biosciences CRF2 WO 95/34651

San Diego receptors

Gene for corticotropin releasing factor2 (CRF2) receptors, encodedreceptors, expression system.

New England Med. Ctr. Hosp. Helicobacter WO 95/33767

Boston nickel binding protein

Gene for nickel binding protein of Helicobacter pylori; for inhibitingurease assembly and bacterial pathogenicity.

New Zealand Conifer growth WO 95/33822

Forest Res. Inst. medium

Rotorua, New Zealand

Growth medium for conifer embryonic tissues and embryos that doesnot contain any plant hormones.

N. Carolina, Univ. of c-mer WO 95/33499

Chapel Hill. N.C. receptor gene

Gene for c-mer receptor, expression vectors, chimeric proteins andgenes, antibodies to c-mer receptor.

Novo Nordisk Pyrodictium WO 95/34644

Bagsvaerd, Denmark saccharide enzymes

Thermostable amylases, pullulanases, and xylanases fromPyrodictium.

Novo Nordisk Yeast leader WO 95/34666

Bagsvaerd, Denmark peptide sequences

Synthetic leader peptide sequences designed to allow polypeptidesecretion in yeast.

Novo Nordisk Biotech. Laccases WO 95/33836 & 33837

Davis, Calif.

Genes sequences that code for fungal laccases, encoded enzymes.

Oklahoma Med. Res. Fdn. Protein C WO 95/34652

Oklahoma City activation inhibition

Calcium binding-dependent recombinant antibody against theactivation region of protein C; for activation inhibition.

Oviedo Univ. Pneumolysine EPO 687 688

Oviedo, Spain antibodies

Antibodies to pneumolysine; for diagnosis of and therapy forpneumococci infection.

Panorama Res. Anti-apoptotic WO 95/34576

Mountain View, Calif. protease

Cytoplasmic protease from UV-induced lymphoma cells; forpreventing apoptotic intranuclear DNA fragmentation.

Pasteur Inst. HHV6/SIE EPO 688 874

Paris diagnosis

Nucleic acid fragments/diagnostic reagents derived from the genomeof HHV6/SIE; for infection diagnosis [in French].

Pharmacia Allergy WO 95/34578 & 34579

Stockholm, Sweden therapy

Genes for Phl p 1 epitope and atopy related antigens, encodedproteins, antibodies; for allergy therapy.

Plant Genetics Systems Anthocyanin WO 95/34634

Brussels, Belgium fertility restoration

Fertility restoration gene under the control of anthocyanin regulatorysequences; for sterility determination.

Protein Design Labs Humanized WO 95/34324

Mountain View, Calif. selectin antibodies

Humanized antibodies to P-selectin and E-selectin; for blockingfunctional interactions.

Purdue Univ. Prokaryotic WO 95/33843

W. Lafayette, Ind. aromatic amino acids

Prokaryotic cell transformants expressing enzymes that unblock thecommon pathway of aromatic amino acid synthesis.

Repligen Autoimmune WO 95/33770

Cambridge, Mass. therapy antibodies

Anti-CTLA4 antibodies that induce apoptosis in specific T cellpopulations; for purging autoimmune T cells.

Res. Ctr. Hlth & Welfare Quadroma WO 95/33844

Oberschleissheim, Germany bispecific antibodies

Production of heterologous bispecific antibodies with high purityusing quadromas.

Res. Corp. Technol. Longevity WO 95/33834

Tucson, Ariz. gene

Gene for longevity control in eukaryotic cells, sequences for differentfunctional domains; for senescence control.

Rhone-Poulenc Rorer Dyslipoproteinemia WO 95/33840

Antony, France treatment

Recombinant viruses encoding a lipase involved in lipoproteinmetabolism; for dyslipoproteinemia-related disease.

Rockefeller Univ. Staphylococcus WO 95/34655

New York infection prevention

Neutralization of the ability of Staphylococcus surface proteins tobind to catheters; for infection prevention.

SBL Vaccin Bacterial WO 95/33825

Stockholm, Sweden antigen isolation

Bacteria with temperature-sensitive plasmids encoding surfaceantigens; for antigen purification.

Scripps Res. Inst. Soluble WO 95/34641

La Jolla, Calif. chimeric integrins

Chimeric integrins and soluble structural mimics of the cytoplasmicdomains of transmembrane regions of integrins.

Searle Leukotriene-C4 WO 95/33839

Chicago synthase

Genes for leukotriene-C4 synthase, encoded protein, antisense oligos;for controlling leukotriene production.

Seibel, P. Compartment- WO 95/34665

Biedenkopf-Wallou, Germany specific targeting

Targeting of nucleic acids to cell compartments by specific proteins;for gene therapy.

Seikagaku Diagnostic WO 95/33758

Tokyo Mycoplasma antibody

Monoclonal antibodies to a glyceroglycophospholipid that is specificfor Mycoplasma fermentans; for detection.

Sloan-Kettering Inst. Ceramide-activated WO 95/34307

New York protein kinase

Purified membrane-bound ceramide-activated protein kinase; fortreating inflammatory disorders.

Solvay Microbial protease EPO 687 734

Brussels, Belgium secretion

Expression system for extracellular production of microbial proteasesin Aspergillus foetidus in French.

Somatix Therapy Broad-spectrum WO 95/34669

Alameda, Calif. vectors

Retroviral gene therapy vectors that express high levels of desiredprotein in a wide variety of transfected cells.

St. Luke's-Roosevelt Abdominal aortic WO 95/33476

Hosp, Ctr. aneurysm protein

New York

Purified protein associated with abdominal aortic aneurysms,antibodies against it; for treatment.

Stanford Univ. Antigen-pulsed WO 95/34638

Stanford, Calif. dendritic cells

Dendritic cell isolation from blood, exposure to lymphoma antigens,reinfusion for tumor-reactive immune response.

Stanford Univ. Estrogen receptor WO 95/34681

Stanford, Calif. regulator

Transcriptional regulator of the expression of the estrogen receptor(ERF-1); for cancer diagnosis and therapy.

Symbiotech Bacteriophage WO 95/34683

Woburn, Mass. protein fusions

Lambdoid bacteriophage with major tail protein fused to proteins ofinterest, fusion genes; for detection.

Systemix Hematopoietic WO 95/34676

Palo Alto, Calif. stem cell enrichment

Method of enriching myeloid or lymphoid progenitor cells that isbased on using cell specific markers.

_ Compiled By Chester A. Bisbee

Takara Thermostable EPO 687 732

Kyoto, Japan Pyrococcus a-galactosidase

Thermostable a-galactosidase from Pyrococcus furiosis, cloned gene,expression vector, host, production method.

Takara Thermostable WO 95/34645

Kyoto, Japan Pyrococcus protease

Thermostable protease from Pyrococcus furiosis, cloned gene,expression vector, transformed host, production method.

Teijin Modified cysteine EPO 687 685

Osaka, Japan peptide

Physiologically active peptide of defined sequence that contains amodified cysteine residue.

U.S. Navy T cell population WO 95/33823

Arlington, Va. selection

Preferential stimulation and growth of T cell populations byactivating surface molecules; for immunotherapy.

Urocor Urologic cancer WO 95/34637

Oklahoma City biomarkers

Methods for selectively inducing biomarker expression in urologiccancer; for diagnosis and therapy.

Vanderbilt Univ. Localizing gene WO 95/34647

Nashville, Tenn. delivery

Enhancing delivery of genes to nuclei and mitochondria by usingspecific localization complexes.

Wacker-Nagel, W. Conditional E. coli WO 95/34643

Oldenburg, Germany suicide

Temperature-induced nuclease gene transfected into E. coli strains;for conditional suicide.

(c) 1997 American Health Consultants. All rights reserved.