Published Dec. 20 & 27 (EPO); Dec. 14 & 21 (WO); Dec. 20 (GB)
Advanced Technologies Modifying WO 95/34660
Staines, U.K. plant starch
Introduction of brittle-2 gene into plants causing increased ADPGPPase activity and subsequent starch synthesis.
Advanced Tissue Sci. Artificial WO 95/33821
La Jolla, Calif. cartilage
Growth and maturation of cartilage and other cells in a tissue-likestructure using TGF-a.
Ajinomoto Recombinant WO 95/34672
Tokyo L-glutamic acid
Gene for -ketoglutaric dehydrogenase, encoded protein, productionof L-glutamic acid in coryneform bacteria.
Akzo Nobel Reovirus EPO 687 728
Arnhem, Netherlands vaccine
Isolation of a relatively non-pathogenic strain of reovirus; for makingvaccines.
Alexion Pharma Xenograft WO 95/34202
New Haven, Conn. rejection reduction
Cellular expression of a protein having glycosyltransferase activity;for reducing xenograft rejection response.
Alitalo et al. FLT4 receptor WO 95/33772
Espoo, Finland kinase antibodies
Monoclonal antibodies to FLT4 receptor tyrosine kinase; fordetecting endothelial cell changes in the lymphatic system.
American Cyanamid Peptide binding WO 95/34646
Wayne, N.J. pair cells
Cell systems for measuring specific interaction of peptide bindingpairs using fusion proteins and reporter enzymes.
American Cyanamid Chitinase WO 95/34678
Wayne, N.J. inhibitors
Cells expressing yeast chitinase gene used to screen for chitinaseinhibitors; for identifying fungicides.
Amersham Intl. Magnetic bead WO 95/33827
Little Chalfont, U.K. precipitation
Recovery of desired materials from a mixture by precipitation usingassociated magnetic beads.
Banyu Pharma Glycosyltrans WO 95/34663
Gene for glycosyltransferase, encoded protein; for low costglycosylation of indolopyrrolocarbazole derivatives.
Bayer Chinolon-resistant EPO 688 873
Leverkusen, Germany Staphylococcus
Fast DNA assay for the detection of chinolon-resistantStaphyloccocus aureus in clinical samples [in German].
Biosource Technol. Gene expression WO 95/34668
Vacaville, Calif. inhibition
Genetic constructs for the cytoplasmic expression of RNA inhibitoryto selected gene expression.
Boehringer Ingelheim CD44 variant WO 95/33771
Ingelheim, Germany antibody
Antibody against the epitope encoded by the exon v6 variant of theCD44 gene; for diagnosis and therapy.
Brigham & Women's Hosp. Maximized WO 95/33760
Boston sequential hybridization
Sequential nucleic acid hybridization steps with minimizedinterference from primers of previous steps.
Brigham & Women's Hosp. Hypertrophic WO 95/33856
Boston cardiomyopathy mutation
Detection method for sarcomeric thin filament protein mutation; fordiagnosing hypertrophic cardiomyopathy.
Brigham & Women's Hosp. Polycystic WO 95/34573
Boston kidney disease gene
Identification of the autosomal dominant polycystic kidney diseasegene; for identifying functional antagonists.
California, Univ. of Cancer WO 95/33820 & 33826
Oakland, Calif. transgenics
Transgenic mice with human papilloma virus oncogene expressed individing tissues; for progressive cancer models.
CNRS (Natl. Ctr. Sci. Res.) FIV peptide EPO 688 790
Envelope peptide fragment from feline immunodeficiency virus(FIV); for diagnosis and therapy [in French].
Children's Hosp. AAV vector WO 95/34670
Columbus, Ohio gene delivery
Adeno-associated virus (AAV) vectors, stable host cells; fortherapeutic gene delivery.
Chiron Cytoplasmic WO 95/33835
Emeryville, Calif. immunogen expression
Gene transfection with a system allowing cytoplasmic expression; foreliciting immunogenic response.
Ciba Corning Diagnostics MN WO 95/34650
Medfield, Mass. oncogene
MN gene, a putative oncogene, encoded protein, antibodies,expression systems; for assay kits.
Ciba-Geigy Antipathogenic WO 95/33818
Basel, Switzerland substances
Genes for the production of antipathogenic substances, encodedproteins, expression vectors, and host cells.
Ciba-Geigy Bacillus WO 95/34656
Basel, Switzerland thuringiensis toxins
Bacillus thuringiensis toxin genes that encode toxins effective againstmoths/butterflies; for insertion into plants.
Ciba-Geigy Protoporphyrinogen WO 95/34659
Basel, Switzerland oxidase
Genes for protoporphyrinogen oxidase and mutations causingherbicide resistance; for making transgenic plants.
Columbia Univ. Phenotypic tumor WO 95/34680
New York suppressor assay
Identifying tumor suppressor genes by insertion of cDNAs intotransformed cells and assay of phenotype changes.
Connaught Labs Mutant pertussis EPO 688 868
Willowdale, Ont. vaccine
Mutant pertussis toxins that are not toxic, but retainimmunoreactivity; for toxin expression and vaccines.
Creative Biomolecules Tissue WO 95/33831
Hopkinton, Mass. morphogenic protein modulators
Tissue morphogenic protein gene control regions linked to a reportergene; for identifying modulators.
Dade Intl. Pilin fusion WO 95/34648
Deerfield, Ill. display method
Protein display method using a fusion between bacterial pilin and theprotein of interest.
Daikin RecA gene targeting EPO 687 738
Cellular targeting of genes by using a nucleic acid probe bound toRecA protein and then assaying for the protein.
Danisco Guar legume WO 95/34667
Copenhagen, Denmark regeneration
Regeneration of guar legumes by introducing hormone inhibitorgenes; for making transgenic plants.
Delta Biotech Hsp150-minus WO 95/33833
Nottingham, U.K. yeasts
Yeast strains lacking hsp150 so that foreign proteins, especiallyalbumin, can be purified from the strain.
Diacrin Transplantable WO 95/33828
Charlestown, Mass. foreign cells
Cells modified to have reduced capacity to elicit antibody-mediatedhyperactute rejection; for transplantation.
DNX Biotherapeutics Transgenic WO 95/34572
Princeton, N.J. delta-hemoglobin
Transgenic animals that produce a more stable delta-like humanhemoglobin.
Du Pont Salmonella PCR WO 95/33854
Wilmington, Del. identification
Method for selection of diagnostic genetic marker fragments ofSalmonella; for PCR-based identification.
Fred Hutchinson AAV vector WO 95/33824
Cancer Res. Ctr. transduction
Increased efficiency of cellular transduction by using recombinantadeno-associated virus (AAV) vectors.
Gen. Engin. & Biotechnol. Ctr. HBV single WO 95/33832
Havana chain antibody
Recombinant single chain antibody fragment against hepatitis B virus(HBV) surface antigen and production in E. coli.
Gen-Probe MMLV reverse EPO 688 870
San Diego transcriptase
Plasmid for the expression of Moloney murine leukemia virus(MMLV) reverse transcriptase; for expression/purification.
Genencor Intl. Recombinant WO 95/34657 & Rochester, N.Y. indole/tryptophan 34658
E. coli genetically engineered to release regulatory pathways forproduction of substituted indoles and tryptophan.
Genentech Pantropic WO 95/33829
S. San Francisco neurotrophic factors
Genes for pantropic neurotrophic factors, encoded factors; forneuronal disorder treatment.
Genetics Inst. Osteoinductive EPO 688 869
Cambridge, Mass. products
Human and bovine osteoinductive factor products; for treatment ofbone and periodontal defects.
Genetics Inst. BMP-9 tissue WO 95/33830
Cambridge, Mass. repair
Purified bone morphogenic protein (BMP)-9 and productionprocesses; for tissue repair.
Genetics Inst. Protein-protein WO 95/34664
Cambridge, Mass. interaction display
Protein-protein interaction detection by display on cell surfaces usingthioredoxin/flagellin fusions.
Genvec Deficient adenoviral WO 95/34671
Rockville, Md. vectors
Multiply deficient adenoviral vectors and complementing cell lines;for gene therapy and vaccination.
Genzyme Fluorescent cell WO 95/34685
Cambridge, Mass. gene detection
Detection of DNA sequences in intact cells using fluorescentlylabelled nucleic acid probes.
Georgetown Univ. Genetically WO 95/34684
Washington tagged virus
Quantitation of virus load in a sample using a genetically tagged viralsequence.
Gist-Brocades Thermostable WO 95/34662
Delft, Netherlands xylanases
Thermostable xylanases isolated from anaerobic thermophilicbacteria; for use in pulp and paper manufacturing.
Gustave-Roussy Inst. EPIL/placentine WO 95/34653
Protein named EPIL/placentine and its analogs, coding sequences;for therapeutics.
Henry Ford Hlth. System Neuronatin WO 95/34640
Neuronatin, a neuronal-neonatal gene that is expressed in brain tissueduring rapid brain growth.
Holms, R.D. HIV autoimmune GB 2 290 293
Gene for viral protein, encoded protein and anti-inflammatory astherapeutic; for treating autoimmune response in HIV.
Hybridon Schistosomiasis WO 95/33759
Worcester, Mass. oligo therapy
Antisense oligonucleotides that inhibit protein synthesis inschistosome worms; for therapy.
Ibex Technologies Bacterial WO 95/34635
Genes for bacterial heparinases, encoded proteins, antibodies; forenzyme production.
Immunomedics Infected cell WO 95/33842
Morris Plains, N.J. vector targeting
Retroviral vectors lacking integration and replication sequences; fortargeting to already infected cells.
Inst. Biol. Genetics Res. Polyhydroxy WO 95/33838
Berlin alkanoate biopolymers
Microorganisms that simultaneously produce intracellularpolyhydroxy alkanoates and extracellular polysaccharides.
Inst. Biol. Genetics Res. 2-oxogluta- WO 95/34654
Berlin rate/malate translocator
Spinach plastid with 2-oxoglutarate/malate translocator; for makingtransgenic plants.
INSERM (Natl. Inst. Child spinal WO 95/33852
Hlth. & Med. Res.) muscular atrophies
Methods and probes for detecting markers bound to the chromosome5 locus of child spinal muscular atrophies.
Japan Energy Hirudin secretion EPO 687 731
Secretion vector for production of hirudin in transformedmicroorganisms.
Japan Tobacco Agrobacterial plant EPO 687 730
Plant transformation by agrobacteria that contain vectors withsuitable genes and selectable markers.
Joslin Diabetes Ctr. Insulin signal WO 95/34201
Gene for pp60PIK, a downstream protein involved in the insulinsignalling pathway.
Kirin Beer Saccharide WO 95/34642
Tokyo manipulating enzymes
Genes for transferase and amylase, encoded proteins; formanipulating saccharides.
La Jolla Cancer Res. Fdn. FAS-associated WO 95/34661
La Jolla, Calif. proteins
Mammalian protein tyrosine phosphatases, FAS-associated proteins,genes for them; for controlling apoptosis.
Louisiana St. Univ. Bovine WO 95/34686
Baton Rouge, La. respiratory coronavirus
Human rectal tumor cell line used to propagate bovine respiratoryshipping fever coronavirus; for isolation/diagnosis.
Ludwig Inst. Cancer Res. HLA WO 95/33855
New York presented tumor antigen
Gene for a tumor antigen precursor whose processed form ispresented by an HLA molecule.
Ludwig Inst. Cancer Res. Retinol WO 95/34580
New York dehydrogenase
Gene for retinol dehydrogenase, a component associated with themembrane receptor for retinol binding protein.
Mass. Inst. Technol. Biopolymer EPO 688 865
Cambridge, Mass. production
Gene for acetoacetyl-CoA reductase; for cell transfection andbiosynthesis of polyhydroxybutyrate polymers.
MRC (Med. Res. Counc.) Site independent WO 95/33841
London transgene expression
Locus control subregions with chromatin opening domain; forintegration-site independent transgene expression.
MRC (Med. Res. Counc.) Polycystic WO 95/34649
London kidney disease
Polycystic kidney disease gene and its mutations, encoded proteinsand muteins; for diagnosis and therapy.
Meiji Milk Products Pig embryonic WO 95/34636
Tokyo stem cells
Pig embryonic stem cells reactive with antibodies to mouseembryonic carcinoma cells; for making transgenic pigs.
Microprobe Mycobacteria WO 95/34574
Bothell, Wash. detection probes
Oligonucleotide probes specific for ribosomal RNA precursors ofantibiotic-resistant mycobacteria; for detection.
Minnesota, Univ. of Transplant WO 95/34320
Minneapolis rejection inhibition
Inhibition of antigen-specific T cell responses with agents inhibitingcostimulatory signals; for transplant rejection.
Mitotix CDK4 binding WO 95/33819
Cambridge, Mass. proteins
Genes for proteins that bind human cyclin dependent kinase 4(CDK4), encoded proteins; for cell cycle control.
Nanogen Optical DNA WO 95/34890
San Diego storage
Optical memory storage of DNA content in samples by usingchromophoric methoxy compounds.
NIH (Natl. Inst. Hlth.) Pigment WO 95/33480
Bethesda, Md. epithelium-derived factor
Gene for neurotrophic factor named pigment epithelium-derivedfactor (PEDF), encoded protein; for therapy.
NIH (Natl. Inst. Hlth.) Therapeutic WO 95/34639
Bethesda, Md. retroviral particles
Retroviral vectors with envelope and therapeutic agent sequences; formaking recombinant retroviral particles.
NIH (Natl. Inst. Hlth.) Drug metabolism WO 95/34679
Bethesda, Md. gene mutations
Probes for drug metabolism genes; for making a kit to identifymutations in these genes.
NIH (Natl. Inst. Hlth.) Hemorrhagic WO 95/34682
Bethesda, Md. E. coli
Isolated nucleic acid sequences specific to hemorrhagic E. coli; fordiagnosis and kit development.
Neurocrine Biosciences CRF2 WO 95/34651
San Diego receptors
Gene for corticotropin releasing factor2 (CRF2) receptors, encodedreceptors, expression system.
New England Med. Ctr. Hosp. Helicobacter WO 95/33767
Boston nickel binding protein
Gene for nickel binding protein of Helicobacter pylori; for inhibitingurease assembly and bacterial pathogenicity.
New Zealand Conifer growth WO 95/33822
Forest Res. Inst. medium
Rotorua, New Zealand
Growth medium for conifer embryonic tissues and embryos that doesnot contain any plant hormones.
N. Carolina, Univ. of c-mer WO 95/33499
Chapel Hill. N.C. receptor gene
Gene for c-mer receptor, expression vectors, chimeric proteins andgenes, antibodies to c-mer receptor.
Novo Nordisk Pyrodictium WO 95/34644
Bagsvaerd, Denmark saccharide enzymes
Thermostable amylases, pullulanases, and xylanases fromPyrodictium.
Novo Nordisk Yeast leader WO 95/34666
Bagsvaerd, Denmark peptide sequences
Synthetic leader peptide sequences designed to allow polypeptidesecretion in yeast.
Novo Nordisk Biotech. Laccases WO 95/33836 & 33837
Genes sequences that code for fungal laccases, encoded enzymes.
Oklahoma Med. Res. Fdn. Protein C WO 95/34652
Oklahoma City activation inhibition
Calcium binding-dependent recombinant antibody against theactivation region of protein C; for activation inhibition.
Oviedo Univ. Pneumolysine EPO 687 688
Oviedo, Spain antibodies
Antibodies to pneumolysine; for diagnosis of and therapy forpneumococci infection.
Panorama Res. Anti-apoptotic WO 95/34576
Mountain View, Calif. protease
Cytoplasmic protease from UV-induced lymphoma cells; forpreventing apoptotic intranuclear DNA fragmentation.
Pasteur Inst. HHV6/SIE EPO 688 874
Nucleic acid fragments/diagnostic reagents derived from the genomeof HHV6/SIE; for infection diagnosis [in French].
Pharmacia Allergy WO 95/34578 & 34579
Stockholm, Sweden therapy
Genes for Phl p 1 epitope and atopy related antigens, encodedproteins, antibodies; for allergy therapy.
Plant Genetics Systems Anthocyanin WO 95/34634
Brussels, Belgium fertility restoration
Fertility restoration gene under the control of anthocyanin regulatorysequences; for sterility determination.
Protein Design Labs Humanized WO 95/34324
Mountain View, Calif. selectin antibodies
Humanized antibodies to P-selectin and E-selectin; for blockingfunctional interactions.
Purdue Univ. Prokaryotic WO 95/33843
W. Lafayette, Ind. aromatic amino acids
Prokaryotic cell transformants expressing enzymes that unblock thecommon pathway of aromatic amino acid synthesis.
Repligen Autoimmune WO 95/33770
Cambridge, Mass. therapy antibodies
Anti-CTLA4 antibodies that induce apoptosis in specific T cellpopulations; for purging autoimmune T cells.
Res. Ctr. Hlth & Welfare Quadroma WO 95/33844
Oberschleissheim, Germany bispecific antibodies
Production of heterologous bispecific antibodies with high purityusing quadromas.
Res. Corp. Technol. Longevity WO 95/33834
Tucson, Ariz. gene
Gene for longevity control in eukaryotic cells, sequences for differentfunctional domains; for senescence control.
Rhone-Poulenc Rorer Dyslipoproteinemia WO 95/33840
Antony, France treatment
Recombinant viruses encoding a lipase involved in lipoproteinmetabolism; for dyslipoproteinemia-related disease.
Rockefeller Univ. Staphylococcus WO 95/34655
New York infection prevention
Neutralization of the ability of Staphylococcus surface proteins tobind to catheters; for infection prevention.
SBL Vaccin Bacterial WO 95/33825
Stockholm, Sweden antigen isolation
Bacteria with temperature-sensitive plasmids encoding surfaceantigens; for antigen purification.
Scripps Res. Inst. Soluble WO 95/34641
La Jolla, Calif. chimeric integrins
Chimeric integrins and soluble structural mimics of the cytoplasmicdomains of transmembrane regions of integrins.
Searle Leukotriene-C4 WO 95/33839
Genes for leukotriene-C4 synthase, encoded protein, antisense oligos;for controlling leukotriene production.
Seibel, P. Compartment- WO 95/34665
Biedenkopf-Wallou, Germany specific targeting
Targeting of nucleic acids to cell compartments by specific proteins;for gene therapy.
Seikagaku Diagnostic WO 95/33758
Tokyo Mycoplasma antibody
Monoclonal antibodies to a glyceroglycophospholipid that is specificfor Mycoplasma fermentans; for detection.
Sloan-Kettering Inst. Ceramide-activated WO 95/34307
New York protein kinase
Purified membrane-bound ceramide-activated protein kinase; fortreating inflammatory disorders.
Solvay Microbial protease EPO 687 734
Brussels, Belgium secretion
Expression system for extracellular production of microbial proteasesin Aspergillus foetidus in French.
Somatix Therapy Broad-spectrum WO 95/34669
Alameda, Calif. vectors
Retroviral gene therapy vectors that express high levels of desiredprotein in a wide variety of transfected cells.
St. Luke's-Roosevelt Abdominal aortic WO 95/33476
Hosp, Ctr. aneurysm protein
Purified protein associated with abdominal aortic aneurysms,antibodies against it; for treatment.
Stanford Univ. Antigen-pulsed WO 95/34638
Stanford, Calif. dendritic cells
Dendritic cell isolation from blood, exposure to lymphoma antigens,reinfusion for tumor-reactive immune response.
Stanford Univ. Estrogen receptor WO 95/34681
Stanford, Calif. regulator
Transcriptional regulator of the expression of the estrogen receptor(ERF-1); for cancer diagnosis and therapy.
Symbiotech Bacteriophage WO 95/34683
Woburn, Mass. protein fusions
Lambdoid bacteriophage with major tail protein fused to proteins ofinterest, fusion genes; for detection.
Systemix Hematopoietic WO 95/34676
Palo Alto, Calif. stem cell enrichment
Method of enriching myeloid or lymphoid progenitor cells that isbased on using cell specific markers.
_ Compiled By Chester A. Bisbee
Takara Thermostable EPO 687 732
Kyoto, Japan Pyrococcus a-galactosidase
Thermostable a-galactosidase from Pyrococcus furiosis, cloned gene,expression vector, host, production method.
Takara Thermostable WO 95/34645
Kyoto, Japan Pyrococcus protease
Thermostable protease from Pyrococcus furiosis, cloned gene,expression vector, transformed host, production method.
Teijin Modified cysteine EPO 687 685
Osaka, Japan peptide
Physiologically active peptide of defined sequence that contains amodified cysteine residue.
U.S. Navy T cell population WO 95/33823
Arlington, Va. selection
Preferential stimulation and growth of T cell populations byactivating surface molecules; for immunotherapy.
Urocor Urologic cancer WO 95/34637
Oklahoma City biomarkers
Methods for selectively inducing biomarker expression in urologiccancer; for diagnosis and therapy.
Vanderbilt Univ. Localizing gene WO 95/34647
Nashville, Tenn. delivery
Enhancing delivery of genes to nuclei and mitochondria by usingspecific localization complexes.
Wacker-Nagel, W. Conditional E. coli WO 95/34643
Oldenburg, Germany suicide
Temperature-induced nuclease gene transfected into E. coli strains;for conditional suicide.
(c) 1997 American Health Consultants. All rights reserved.