Published Dec. 6 & 13 (EPO); Nov. 30 & Dec. 7 (WO)
Ajinomoto Recombinant EPO 685 555
Tokyo L-isoleucine biosynthesis
E. coli transformed with genes for L-isoleucine biosynthetic enzymes;for biosynthesis.
Albert Einstein Coll. Med. Mutated WO 95/32277
New York mycobacteria
Mutated mycobacteria; for transformation with vectors containingheterologous genes.
Amgen Boulder Insulin-like growth WO 95/32003
Boulder, Colo. factor muteins
Insulin-like growth factor muteins and polyethylene glycol-conjugated variants; for improved therapeutics.
Bayer Proteolipid EPO 685 558
Leverkusen, Germany protein transgenics
Transgenic animals that lack proteolipid protein, a major membraneprotein of CNS myelin.
Baylor Coll. Med. DNA synthesis WO 95/31995
Phage display methods for identifying senescent cell-derivedinhibitors of DNA synthesis.
Biopolymer Res. Cellulose from WO 95/32279
Kanagawa, Japan sucrose
Sucrose metabolism genes transfected into cellulose-producingbacteria; for cellulose production from sucrose.
Biotronics Specific detection WO 95/32306
Lowell, Mass. duplex
Detection of a target nucleic acid by amplification using a specificdetection duplex.
Boehringer Ingelheim Apoptosis WO 95/33061 & 33062
Ingelheim, Germany protection for transfectants
Transfection with polycation complexes and protection of transfectedcells from apoptotic response.
Brigham & Women's Hosp. Leukotriene WO 95/32280
Genes for leukotriene C4 and variants, encoded proteins, antibodies;for assays and antagonist identification.
Calgene Plant wax WO 95/33055
Davis, Calif. esters
Production of wax esters and defined oil compositions in transformedplants.
California, Univ, of Leptospirosis WO 95/32220
Oakland, Calif. treatment
Gene for outer membrane protein of Leptospira, encoded protein,antibodies; for infection treatment.
California, Univ. of Nematode-resistant WO 95/32288
Oakland, Calif. plants
Genes from feeding site cells of nematodes; for production ofresistant transgenic plants.
Cancer Res. Camp. Technol. Chromosome WO 95/32297
London fragment vectors
Y chromosome-derived telomeric fragments that control centromerefunction; for use as a vector.
Canji Tumor suppressor EPO 685 493
San Diego fusion
Fusion of cell membrane receptor and tumor suppressor transcriptionfactor; for treating cancer.
Canji Prostate/colon WO 95/32214
San Diego tumor suppressor
Genes for a prostate/colon tumor suppressor gene located onchromosome 8; for detection and cancer treatment.
Chiron HCV asialoglyco- WO 95/33053
Emeryville, Calif. proteins
Hepatitis C virus (HCV) envelope proteins that are not sialated; foraggregation into viral-like particles.
Ciba-Geigy B lymphocyte- WO 95/32284
Basel, Switzerland specific activator
Gene coding for B lymphocyte-specific activator of octamer site-mediated gene transcription.
Columbia Univ. Integrase WO 95/31904
New York interactor
Gene for integrase interactor, encoded protein; for identifyinginhibitors.
Cornell Univ. Identification WO 95/33075
Ithaca, N.Y. by microsatellite repeats
Determination of the origin of a biological sample by usingmicrosatellite repeat sequences.
Dako PNA probes for WO 95/32305
Glostrup, Denmark gonorrhea
Peptide nucleic acid (PNA) probes for the detection of the sexuallytransmitted diseases of gonorrhea and chlamydia.
Fuji Yakuhin Metalloproteinase EPO 685 557
Toyama, Japan gene
Gene for a metalloproteinase, encoded protein, antibodies to it,expression system; for recognizing cancer cells.
Genelabs Technol. Hepatitis G WO 95/32290 &
Redwood City, Calif. 32291
Hepatitis G gene sequences and polypeptide antigens; for diagnosisand treatment.
Genelabs Technol. Reverse reading WO 95/32292
Redwood City, Calif. frames
Reverse reading frame polypeptide antigens; for diagnostic testing forviral infection.
Genentech TNF receptor- WO 95/33051
S. San Francisco associated factors
Tumor necrosis factor (TNF) receptor-associated factors that bind tointracellular domains of TNF and CD40.
Gen. Engin. & Biotech. Ctr. HBV surface EPO 686 696
Havana antigen antibody
Recombinant single chain antibody fragment against hepatitis B virus(HBV) surface antigen; for bacterial production.
Glaxo ATP P2X receptor WO 95/33048
Gene for P2X receptor of ATP, encoded receptor, antibodies to it; fortherapeutic screening.
Human Genome Sciences IL-6 splice WO 95/32282
Rockville, Md. variants
Genes for interleukin-6 (IL-6) splice variants, encoded proteins; fortreating platelet reducing conditions.
Hybridon Cytomegalovirus WO 95/32213
Worcester, Mass. oligos
Oligonucleotides that hybridize to cytomegalovirus; for inhibitinginfection.
Immunex Oncostatin M WO 95/33059
Seattle receptor protein
Protein that functions as the a chain of the oncostatin M receptor.
Indiana Univ. Ribozyme WO 95/32283
Bloomington, Ind. conjugate endonuclease
Conjugates of RNase P and structure-specific ribozymes; for makingsequence-specific endonucleases.
INSERM (Natl. Inst. Transgenic WO 95/32285
Hlth. & Med. Res.) arthritis model
Transgenic animals in which the T cell repertoire is relatively limited;for use as an arthritis model.
INSERM (Natl. Inst. Mycobacterial WO 95/32296
Hlth. & Med. Res.) shuttle vectors
Shuttle vectors for mycobacteria that allow replication and drugselection.
Intl. Murex Technol. HIV gp41 WO 95/32293
Norcross, Ga. antigen
An antigenic peptide from the HIV gp41 glycoprotein; for diagnosisof HIV.
Japan Tobacco Plant EPO 685 559
Tokyo phospholipase D
Gene for plant-derived phospholipase D and cloned DNA for itscontrol region.
Kirin Beer Yeast expression WO 95/32289
Transformed yeast cell lines that can be used to express heterologousgenes.
Ludwig Inst. Cancer Res. Glial WO 95/32724
New York mitogenic factors
Genes for glial mitogenic factors, encoded proteins, antibodies; forglial cell diseases.
Lynxvale Soluble FLT WO 95/33050
Soluble forms of FLT, a FMS-like tyrosine kinase, that binds to andinhibits vascular endothelial growth factor.
Magainin Pharma Defensin WO 95/32287
Plymouth Meeting, Penn.
Gene for an inducible antimicrobial peptide derived from mammalianepithelium that is named defensin.
Max Planck Inst. Tetracycline WO 95/32295
Munich, Germany repressed expression
Prokaryotic vector containing a control sequence that may berepressed by tetracycline.
Mayo Fdn. Rifampin-resistant WO 95/33074
Rochester, Minn. tuberculosis
DNA assay for determination of the presence of rifampin-resistantstrains of tuberculosis.
McGill Univ. MTHFR WO 95/33054
DNA probe for human methylenetetrahydrofolate reductase(MTHFR); for diagnosing MTHFR deficiency.
Menarini Res. GM-CSF/EPO WO 95/33057
Pomesia, Italy hybrids
Hybrids of GM-CSF and EPO and fragments fused with a linker,DNA coding sequences; for hematopoietic stimulation.
Merck Chloride channel WO 95/32302
Rahway, N.J. genes
Genes for glutamate- and avermectin-sensitive chloride channels,encoded proteins; for identifying modulators.
Merck Glucan synthase WO 95/32982
Rahway, N.J. gene
Gene for glucan synthesis; for in vitro assay for modulators of 1,3a-Dglucan synthase activity.
Microgenesys HIV polyprotein WO 95/32000
Meriden, Conn. immunogens
HIV polyprotein immunogens; for detection of infection and vaccinedevelopment.
Microgenesys Carcinoembryonic WO 95/32286
Meriden, Conn. antigen
Carcinoembryonic antigen produced by insect cells; for use as animmunogenic substance for treating cancer.
Mitotix FKBP/rapamycin WO 95/33052
Cambridge, Mass. immunosuppressants
Immunosuppressant proteins that are the immediate downstreamtargets for FKBP/rapamycin complexes.
Mt. Sinai Med. Ctr. Protein interaction WO 95/32310
New York antivirals
Host cell proteins that interact with viral proteins; for identifyinginhibitors of this interaction.
NIH (Natl. Inst. Hlth.) Autotaxin WO 95/32221
Gene for autotaxin, encoded protein, antibodies to it, expressionsystem for it; for cancer diagnosis/therapy.
NIH (Natl. Inst. Hlth.) Ras-related WO 95/32223
Bethesda, Md. oncogenes
Genes for ras-related oncogenes; for the identification and treatmentof cancers.
Nebraska, Univ. of Prokaryotic WO 95/32216
Omaha, Neb. glycoprotein hormones
Biologically active recombinant glycoprotein hormones produced byprokaryotic cells.
New England Biolabs Direct cloning WO 95/32281
Beverly, Mass. of nuclease genes
Direct cloning of restriction endonuclease genes into E. coli,appropriate E. coli strains.
New Jersey, Univ. of Selective WO 95/32300
Med. & Dent. destruction with HIV
Genetically altered HIV which selectively destroys CD4+ T-celllymphocytes.
Nippon Meat Packers Modified BMP WO 95/33058
Osaka, Japan receptor
Gene for a modified bone morphogenic protein (BMP) receptor; foruse as a diagnostic reagent.
N. Carolina, Univ. of Equine WO 95/32733
Chapel Hill, N.C. encephalitis vaccine
Induction of an immune response with live Venezuelan equineencephalitis virus expressing a heterologous immunogen.
N. Carolina St. Univ. Bacillus WO 95/33056
Raleigh, N.C. protease
Gene sequence of a Bacillus keratinase and its variants, all sequencesdiffering from that of Bacillus serine protease.
Oxford Univ. Translation WO 95/32731
Oxford, U.K. shifting mutations
Translation shifting mutations that result in an immune responseagainst the translated protein.
Paravax Parasite protease WO 95/32988
Fort Collins, Colo. therapeutics
Genes for astacin metalloendopeptidase and cysteine protease,encoded proteins, antibodies; for heartworm therapy.
Pasteur Merieux Transferrin WO 95/33049
Lyon, France receptor fragments
Tbp2 fragments of the Neisseria transferrin receptor with deletionsresulting in maximum strain sequence homology.
Perkin-Elmer PCR target EPO 686 699
Norwalk, Conn. concentration
Apparatus and method for determining target nucleic acidconcentration in PCR by using a reporter molecule.
Res. Corp. Technol. Safe gene WO 95/32298
Tucson, Ariz. therapy vectors
Retroviral vectors with direct repeats flanking sequences that are tobe deleted; for making gene therapy vectors.
Rhone-Poulenc Rorer Therapy by WO 95/33060
Antony, France p53 control
Cancer treatment by controlling p53 protein levels by using acompound that modulates calpaine activity.
Sagama Chem. Res. Ctr. Animal WO 95/32224
Kanagawa, Japan antibody vector
Expression vector with a gene for a protein against which an antibodyis to be generated; for injection into animals.
Salk Inst. Site-specific WO 95/32225
San Diego integration
Chimeric proteins that target and then integrate genes, encodingvectors; for site-specific integration.
Soft Gene Ballistic transfer EPO 686 697
Enrichment of cells transfected by ballistic transfer using themagnetic properties of the microprojectile (in German).
Stanford Univ. Episomal EBV WO 95/32299
Stanford, Calif. vector
Autonomously replicating vector system for mammalian cells that isbased on Epstein Barr virus (EBV) sequences.
Suntory Mutant lactose EPO 685 560
Osaka, Japan repressor
Mutant lactose repressor protein that controls expression of desiredgenes by temperature induction.
Takeda Protein kinase C EPO 686 695
Gene for rat protein kinase C, expression vector, host cells; forstudying signal transduction.
Tepnel Medical Solid phase WO 95/33073
Knutsford, U.K. amplification
Amplification of nucleic acids using oligonucleotides bound on solidphase supports; for high copy production.
Texas, Univ. of Psoriasis locus WO 95/32308
Psoriasis susceptibility locus on chromosome 17; for detection anddiagnosis.
Tularik EBV WO 95/32307
S. San Francisco therapeutics
Epstein Barr virus (EBV) transcription factor binding assay; foridentifying therapeutics.
Unisearch Cellular WO 95/32740
Kensington, Australia diabetes therapy
Hepatocytes transformed with insulin gene; for transplantation andtreatment of diabetes.
Vet. Med. Instruments Cryogenic EPO 685 556
l'Aigle, France storage medium
Aqueous solution for maintaining sperm and oocyte viability duringcryogenic storage (in French).
Warwick, Univ. of Recombinant WO 95/32294
Coventry, U.K. carbapenem
Genes involved in the biosynthetic pathway of carbapenem, encodedproteins.
Yeda Res. & Develop. Poor WO 95/31994
Rehovot, Israel immunogenic fusions
Fusion proteins combining poorly immunogenic peptides with animmunogenic T cell epitope; for vaccines.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.