Published Nov. 8 & 15 (EPO); Nov. 2 & 9 (WO); Nov. 8& 15 (GB)
Amano Pharma Ascorbate oxidase EPO 682116
Gene for ascorbate oxidase, encoded protein; forexpression in and production from microorganisms.
Appl. Tech. Genetics Resolvase mutation WO95/29251
Malvern, Penn. detection
Detection of mutations in isolated double-stranded DNAusing resolvases.
Aviron Mutant VZV WO 95/29991
Mutant Varicella Zoster virus (VZV) and genes; formaking immunogenic compositions and developingassays.
Biotech. Biol. Res. Counc. Engineered WO95/30000
Swindon, U.K. FactorIX genes
Factor IX genes engineered to reduce aberrant splicingsites; for increased yields and improved gene therapy.
Boehringer Ingelheim B cell WO 95/29935
Ridgefield, Conn. development
Growth of B cells and differentiation of them intoantibody-producing cells.
Bristol-Myers Squibb CTLA4 receptor EPO 682039
Gene for CTLA4 receptor, encoded protein, fusions, andsoluble forms; for regulating T cell interactions.
British Tech. Grp. Gamma- WO 95/29235
Gene for truncated, active version of invertebrate-specificgamma-latroinsectotoxin from black widow spiders.
Cadus Pharma Adenylyl cyclases WO 95/30012
Mammalian adenylyl cyclases functionally expressed inyeast cells; for screening assays.
Calif. Inst. Tech. Ubiquitin fusion WO95/29195
Pasadena, Calif. assay
Ubiquitin fusion proteins in which the two ends are fusedto proteins to be tested for their ability to interact.
CNRS (Ctr. Natl. Rec. Sci.) Leishmania WO95/30006
Gene for a Leishmania major protein, encoded protein;for preparing vaccines.
Children's Hosp. Angiostatin WO 95/29242
Endothelial cell growth inhibitor protein calledangiostatin that is similar to a murine plasminogenfragment.
Chiron PDGF A-chain genes EPO 682 110
Genes for two forms of PDGF A-chain, expressionvectors; for producing homodimers and heterodimers.
Chiron Improved ribozyme WO 95/29241
Emeryville, Calif. catalysis
Ribozymes with catalytic, substrate binding, anddisplaceable antisense arms; for improved catalyticturnover rates.
Ciba-Geigy Fungal PCR assay WO 95/29260
DNA sequences from internal transcribed spacer ofribosomal RNA genes; for PCR-identification of fungalpathogens.
Ciba-Geigy Cell-cell targeting WO 95/30014
Bifunctional protein that allows its producing cell totarget specific cells; for cancer therapy.
Cold Spr. Harbor Labs Protein tyrosine WO95/30008
Cold Spring Harbor, N.Y. phosphatases
Genes for Type III density-enhanced protein tyrosinephosphatases, encoded protein, production methods.
CSIRO (Comm. Sci. Mildew resistant WO95/29238
Ind. Res. Org.) crops
Genes for resistance against rust and mildew; for creatingtransgenic plants and crops.
Cordixa Leishmania immune WO 95/29239
Leishmania homolog of eukaryotic initiation factor 4A;for evaluating Th1 immune response and IL-12production.
Creative Biomolecules Morphogen protein- WO95/30003
Hopkinton, Mass. specific receptors
Genes for morphogen protein-specific receptors, encodedprotein, production methods; for diagnosis.
Cyanamid Iberica PRRS virus vaccine GB 2 289279
Porcine reproductive and respiratory syndrome (PRRS)virus proteins from baculoviruses; for vaccines.
Dade Intl. Fusions to penI WO 95/30016
Synthesis, isolation, and purification of peptides usingfusions to penI protein.
Dana-Farber Cancer Inst. Lymphocyte WO95/29236
Boston activation antigens
Genes for HB15-related lymphocyte activation antigens,encoded proteins, antibodies to them.
DeKalb Genetics Maize water WO 95/30005
DeKalb, Ill. genes
Identification and characterization of genes involved inthe response of maize plants to water.
Eniricerche Stable bacterial EPO 681 027
Milan, Italy plasmid
Plasmid vector with high stability and efficientexpression; for use in Escherichia coli and Bacillussubtilis.
Fatro Pig pseudorabies EPO 682 108
Bologna, Italy vaccine
Pig pseudorabies viral strains used to prepare a wide-spectrum vaccine.
Florida, Univ. of Implants for WO 95/29988
Gainesville, Fla. diabetes
Growth of functional Islets of Langerhans in vitro; fororgan replacement and diabetes therapy.
Freeman, S. Disease-targeted WO 95/29704
New Orleans cells
Cell compositions with properties allowing migration tospecific tissues when injected; for disease treatment.
Gatsby Charitable Fdn. Saponin glycosyl WO95/30009
Proteins with saponin glycosyl hydrolase activity, genesfor these proteins, antibodies against them.
Gene Shears In vivo expression WO 95/29254
Neutral Bay, Australia screen
In vivo gene expression system for screening formodulation of target gene sequence activity.
Genentech Cardiotrophin WO 95/29237
S. San Francisco
Gene encoding cardiotrophin, encoded protein; fortreatment of heart failure and other cardiac disease.
Genetics Inst. P-selectin ligand WO 95/30001
Cambridge, Mass. glycoprotein
Gene for P-selectin ligand glycoprotein, encoded protein,production methods; for treating inflammatory disease.
Genta Papillomavirus WO 95/28942
San Diego oligos
Antisense oligos targeted to human papillomavirus genes;for infection treatment.
Hong Kong Univ. Sci. Tech. Cellobiase GB 2289 050
Gene for cellobiase, encoded protein, yeast and bacterialhost strains; for converting cellobiose to glucose.
Immunex Inhibitory viral WO 95/30015
Viral proteins that bind to Class II MHC antigens; forinhibiting antigen-specific response and EBV infection.
Immuno Poxvirus vector WO 95/30018
Vienna, Austria vaccines
Defective poxviruses containing heterologous genes; forprotein production and vaccination.
Isis Pharma Cytomegalovirus WO 95/28941
Carlsbad, Calif. oligos
Antisense oligo targeted to cytomegalovirus geneproducts; for infection treatment.
Japan Tobacco Plant carbonic EPO 682 117
Gene coding for carbonic anhydrase from monocotyledonplants.
Japan Res. Develop. Corp. Primary liver cells EPO682 106
Identification and long-term growth of liver parenchymalcells; for studying liver disease mechanisms.
Japan Res. Develop. Corp. Dermal papilla EPO682 107
Saltama, Japan cells
Long-term culture of dermal papilla cells using epidermalcell co-culture and conditioned medium.
La Jolla Cancer Res. Fdn. Epitaxin WO95/29695
La Jolla, Calif.
Epitaxin, a tumor cell motility and DNA synthesis factor,and antibodies to it; for cancer therapy.
Eli Lilly Platelet factor-4 EPO 682 114
Gene for platelet factor-4, encoded protein, its precursorand modified forms.
Lipps, B. a-Taipoxin WO 95/29987
a-taipoxin and its preparation; for cell growth promotionand wound treatment.
Ludwig Inst. Cancer Res. Fibroblast activation WO95/29233
New York factor
Identification and isolation of the gene encodingfibroblast activation protein.
Mayo Fdn. Remyelination WO 95/30004
Rochester, Minn. antibodies
Monoclonal IgM antibodies that promote central nervoussystem remyelination.
Merck TNF production GB 2 289 218
Rahway, N.J. inhibition
Inhibition of TNF production by an adenosine receptoragonist; for therapy of autoimmune diseases.
Merck Cephamycin WO 95/29253
Rahway, N.J. production
Genes encoding enzymes involved in the later stages ofcephamycin biosynthesis; for antibiotic production.
Merck Sharp & Dohme GABAA receptor WO95/29234
Hoddesdon, U.K. gamma subunit
Gene for the gamma subunit of the GABAA receptor,host cells that can express the receptor; for therapeuticscreening.
Michigan St. Univ. Prostate WO 95/29990
E. Lansing, Mich. cancer cells & 29994
Immortalized and malignant prostatic cell linestransformed with various viruses; for study of prostatecancer.
Michigan, Univ. of Chromosomes in WO95/29992
Ann Arbor, Mich. muntjac cells
Introduction of chromosomes or fragments into a femalemuntjac cell line; for chromosome purification.
Michigan, Univ. of Adenoviral WO 95/29993
Ann Arbor, Mich. vectors
Expression vectors containing heterologous genes that arebased on adenoviruses; for gene therapy.
Molec. Gen. Res. Assoc. DNA repair WO95/29245
BTF2 complex proteins, especially p34 and p44; fordiagnosing DNA repair process deficiencies.
Mt. Sinai Hosp. Neural receptor WO95/30326
Toronto tyrosine kinase
Gene for neural receptor tyrosine kinase, encoded protein;for screening agonists.
Mycogen Plant Sci. Synthetic crystal EPO 682115
Wilmington, Del. protein genes
Synthetic genes for Bacillus thuringiensis crystal proteinusing preferred codons; for high expression in plants.
Nabel et al. Particle-mediated WO 95/29703
Ann Arbor, Mich. gene transfer
Introduction of an HIV-protective agent intohematopoietic cells using particle-mediated gene transfer.
NIH (Natl. Inst. Hlth.) Melanoma WO 95/29193
Bethesda, Md. antigens
Gene for melanoma antigen recognized by T cells,encoded protein, modified versions; for immunogenicvaccine.
NIH (Natl. Inst. Hlth.) T-cell WO 95/29240
Bethesda, Md. lymphotropic virus
Primate T-cell lymphotropic virus, encoded proteins,antibodies to them; for anti-viral agent screening.
NIH (Natl. Inst. Hlth.) Transplants for WO95/29989
Bethesda, Md. diabetes
Induction of growth and differentiation of fetal pancreaticcells; for making transplantable islets for diabetics.
Novo Nordisk Heparin binding WO 95/28949
Bagsvaerd, Denmark protein
Gene for heparin binding protein, modifications, andfusions; for sepsis treatment.
Ono Pharma Endothelial cell EPO 682 113
Osaka, Japan protein
Gene for a protein from an endothelial cell line, encodedprotein, antibodies; for vascular disease treatment.
Pasteur Inst. Transgenic EPO 682 111
Paris animal screens
Transgenic animal models with inserted genes that can beused to screen pharmaceutical compounds [in French].
Pasteur Inst. Homologous EPO 682 112
Paris recombination vector
Process for obtaining gene expression or improving it byusing a homologous recombination vector system [inFrench].
Pennsylvania, Univ. of Biologically WO95/29690
Philadelphia active protein mimics
Recombinant antibody library to a biologically activeprotein, CDR sequence synthesis; for identifying mimics.
Pioneer Hi-Bred Maize pollen WO 95/29247
Des Moines, Iowa control
Regulatory element that confers anther tapetal cell-specific expression; for controlling maize pollenproduction.
Princeton Univ. Bile acid DNA WO95/29186
Princeton, N.J. carrier
Transfection DNA carrier containing heterologous geneand a bile acid with an amine-containing side chain.
Proctor & Gamble Subtilisin WO 95/30010 &30011
Subtilisin variants and the genes encoding them; forcleaning a variety of surfaces.
Protein Design Labs Humanized EPO 682 040
Mountain View, Calif. antibody production
Humanized immunoglobulins with complementarydetermining regions and consensus sequence framework.
Rhone Merieux Deleted herpes WO95/29248
Lyon, France vectors
Herpes virus vectors with deleted genes; for encodingantigens and making vaccines.
San Diego Reg. Cancer Ctr. Sensitizing WO95/30002
San Diego tumors
Introduction of sensitizing gene activity into tumor cells;for enhanced cancer therapy.
Sapporo Breweries ADP ribosylation EPO 681028
Tokyo factor vector
Vector with ADP ribosylation factor promoter; fordifferential expression in plant seeds and leaves.
Singapore, Natl. Univ. of Mosquito toxin GB 2289 049
Protease-deficient bacterial strain containing a geneencoding a protein that is a mosquito toxin.
Singapore, Natl. Univ. of DNA repair assay GB 2289 125
Assay for human DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) using V8 protease.
Sloan-Kettering Inst. Fc receptor WO 95/28959
New York transgenics
Transgenic animals with human Fc receptor domainreplaces the endogenous one; for treating autoimmunity.
Smith & Nephew Synthetic growth EPO 681846
Anchorage-dependent mammalian cells grown on ahydrophobic, non-growth inhibitory, non-cytotoxicsynthetic substrate.
St. James' Hosp. Mismatch location WO95/29258
Leeds, U.K. assay
Mutation location by strand pairing, addition ofmismatch-binding protein, digestion, and gelelectrophoresis.
Stanford Univ. Selective sequence EPO 682 120
Stanford, Calif. amplification
Selective amplification of target polynucleotidesequences using a promoter-containing primer.
Stratagene Difficult gene hosts EPO 681 025
La Jolla, Calif.
Host organisms deficient in recombination and DNArepair; for cloning genes with superhelical structures.
Sugen Megakaryocyte WO 95/29185
Redwood City, Calif. protein tyrosine kinases
Megakaryocyte protein tyrosine kinase variants; fordiagnosis and therapy.
Taisho Pharma Cyclic nucleosidase EPO 682109
Cyclic nucleosidase isolated from rat brain that belongs toa different isozyme family.
Tanabe, T. Prostacyclin WO 95/30013
Osaka, Japan synthase
Gene for prostacyclin synthase, encoded protein,antibodies to it; for circulatory disease treatment.
Texas, Univ. of Combination cancer WO95/28948
Austin, Tex. therapy
Combination therapy with adenoviral vector containingp53 gene and a chemotherapeutic agent.
Toyo Thermostable EPO 682 121
Osaka, Japan amplification
Thermostable enzymes for amplifying nucleic acidswithout sequential addition of further enzymes.
Unilever Plant nematode WO 95/30017
Gene for protein with collagenase activity linked to aplant promoter sequence; for resistance to nematodeinfection.
Upjohn Leukocyte WO 95/29243
Kalamazoo, Mich. integrin fusion
Bacterially expressed fusion protein of leukocyte a2-integrin Mac-1 domain and glutathione-S-transferase.
Upjohn FIV vaccines WO 95/30019
Genes for feline immunodeficiency virus (FIV) proteinsexpressed in baculoviruses; for making vaccines.
Washington, Univ. of Thymidine kinase WO95/30007
Thymidine kinase mutants from herpes virus that showincreased biological activity.
Whitehead Inst. Mycobacterial EPO 681 026
Cambridge, Mass. vaccine vectors
Recombinant mycobacterial shuttle vectors; fortransferring genes and preparing vaccines.
Wisconsin, Univ. of Enhanced regulator WO95/29244
Madison, Wisc. expression
Mutant genes for cell regulatory molecules that code formore stable mRNA sequences; for enhanced expression.
Wistar Inst. Wilms' tumor WO 95/29995
Philadelphia antigen antibodies
Monoclonal antibodies against a portion of Wilms' tumorantigen; for diagnosis.
Zeneca Plant fatty acid WO 95/29246
Genes for acetyl Coenzyme A carboxylase; for modifyingthe production of fatty acids in plants.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.