Published Nov. 8 & 15 (EPO); Nov. 2 & 9 (WO); Nov. 8& 15 (GB)

Amano Pharma Ascorbate oxidase EPO 682116

Aichi, Japan

Gene for ascorbate oxidase, encoded protein; forexpression in and production from microorganisms.

Appl. Tech. Genetics Resolvase mutation WO95/29251

Malvern, Penn. detection

Detection of mutations in isolated double-stranded DNAusing resolvases.

Aviron Mutant VZV WO 95/29991

Burlingame, Calif.

Mutant Varicella Zoster virus (VZV) and genes; formaking immunogenic compositions and developingassays.

Biotech. Biol. Res. Counc. Engineered WO95/30000

Swindon, U.K. FactorIX genes

Factor IX genes engineered to reduce aberrant splicingsites; for increased yields and improved gene therapy.

Boehringer Ingelheim B cell WO 95/29935

Ridgefield, Conn. development

Growth of B cells and differentiation of them intoantibody-producing cells.

Bristol-Myers Squibb CTLA4 receptor EPO 682039

New York

Gene for CTLA4 receptor, encoded protein, fusions, andsoluble forms; for regulating T cell interactions.

British Tech. Grp. Gamma- WO 95/29235

London latroinsectotoxin

Gene for truncated, active version of invertebrate-specificgamma-latroinsectotoxin from black widow spiders.

Cadus Pharma Adenylyl cyclases WO 95/30012

Tarrytown, N.Y.

Mammalian adenylyl cyclases functionally expressed inyeast cells; for screening assays.

Calif. Inst. Tech. Ubiquitin fusion WO95/29195

Pasadena, Calif. assay

Ubiquitin fusion proteins in which the two ends are fusedto proteins to be tested for their ability to interact.

CNRS (Ctr. Natl. Rec. Sci.) Leishmania WO95/30006

Paris vaccine

Gene for a Leishmania major protein, encoded protein;for preparing vaccines.

Children's Hosp. Angiostatin WO 95/29242


Endothelial cell growth inhibitor protein calledangiostatin that is similar to a murine plasminogenfragment.

Chiron PDGF A-chain genes EPO 682 110

Emeryville, Calif.

Genes for two forms of PDGF A-chain, expressionvectors; for producing homodimers and heterodimers.

Chiron Improved ribozyme WO 95/29241

Emeryville, Calif. catalysis

Ribozymes with catalytic, substrate binding, anddisplaceable antisense arms; for improved catalyticturnover rates.

Ciba-Geigy Fungal PCR assay WO 95/29260

Basel, Switzerland

DNA sequences from internal transcribed spacer ofribosomal RNA genes; for PCR-identification of fungalpathogens.

Ciba-Geigy Cell-cell targeting WO 95/30014

Basel, Switzerland

Bifunctional protein that allows its producing cell totarget specific cells; for cancer therapy.

Cold Spr. Harbor Labs Protein tyrosine WO95/30008

Cold Spring Harbor, N.Y. phosphatases

Genes for Type III density-enhanced protein tyrosinephosphatases, encoded protein, production methods.

CSIRO (Comm. Sci. Mildew resistant WO95/29238

Ind. Res. Org.) crops

Campbell, Australia

Genes for resistance against rust and mildew; for creatingtransgenic plants and crops.

Cordixa Leishmania immune WO 95/29239

Seattle response

Leishmania homolog of eukaryotic initiation factor 4A;for evaluating Th1 immune response and IL-12production.

Creative Biomolecules Morphogen protein- WO95/30003

Hopkinton, Mass. specific receptors

Genes for morphogen protein-specific receptors, encodedprotein, production methods; for diagnosis.

Cyanamid Iberica PRRS virus vaccine GB 2 289279

Madrid, Spain

Porcine reproductive and respiratory syndrome (PRRS)virus proteins from baculoviruses; for vaccines.

Dade Intl. Fusions to penI WO 95/30016

Deerfield, Ill.

Synthesis, isolation, and purification of peptides usingfusions to penI protein.

Dana-Farber Cancer Inst. Lymphocyte WO95/29236

Boston activation antigens

Genes for HB15-related lymphocyte activation antigens,encoded proteins, antibodies to them.

DeKalb Genetics Maize water WO 95/30005

DeKalb, Ill. genes

Identification and characterization of genes involved inthe response of maize plants to water.

Eniricerche Stable bacterial EPO 681 027

Milan, Italy plasmid

Plasmid vector with high stability and efficientexpression; for use in Escherichia coli and Bacillussubtilis.

Fatro Pig pseudorabies EPO 682 108

Bologna, Italy vaccine

Pig pseudorabies viral strains used to prepare a wide-spectrum vaccine.

Florida, Univ. of Implants for WO 95/29988

Gainesville, Fla. diabetes

Growth of functional Islets of Langerhans in vitro; fororgan replacement and diabetes therapy.

Freeman, S. Disease-targeted WO 95/29704

New Orleans cells

Cell compositions with properties allowing migration tospecific tissues when injected; for disease treatment.

Gatsby Charitable Fdn. Saponin glycosyl WO95/30009

London hydrolases

Proteins with saponin glycosyl hydrolase activity, genesfor these proteins, antibodies against them.

Gene Shears In vivo expression WO 95/29254

Neutral Bay, Australia screen

In vivo gene expression system for screening formodulation of target gene sequence activity.

Genentech Cardiotrophin WO 95/29237

S. San Francisco

Gene encoding cardiotrophin, encoded protein; fortreatment of heart failure and other cardiac disease.

Genetics Inst. P-selectin ligand WO 95/30001

Cambridge, Mass. glycoprotein

Gene for P-selectin ligand glycoprotein, encoded protein,production methods; for treating inflammatory disease.

Genta Papillomavirus WO 95/28942

San Diego oligos

Antisense oligos targeted to human papillomavirus genes;for infection treatment.

Hong Kong Univ. Sci. Tech. Cellobiase GB 2289 050

Hong Kong

Gene for cellobiase, encoded protein, yeast and bacterialhost strains; for converting cellobiose to glucose.

Immunex Inhibitory viral WO 95/30015

Seattle proteins

Viral proteins that bind to Class II MHC antigens; forinhibiting antigen-specific response and EBV infection.

Immuno Poxvirus vector WO 95/30018

Vienna, Austria vaccines

Defective poxviruses containing heterologous genes; forprotein production and vaccination.

Isis Pharma Cytomegalovirus WO 95/28941

Carlsbad, Calif. oligos

Antisense oligo targeted to cytomegalovirus geneproducts; for infection treatment.

Japan Tobacco Plant carbonic EPO 682 117

Tokyo anhydrase

Gene coding for carbonic anhydrase from monocotyledonplants.

Japan Res. Develop. Corp. Primary liver cells EPO682 106

Saltama, Japan

Identification and long-term growth of liver parenchymalcells; for studying liver disease mechanisms.

Japan Res. Develop. Corp. Dermal papilla EPO682 107

Saltama, Japan cells

Long-term culture of dermal papilla cells using epidermalcell co-culture and conditioned medium.

La Jolla Cancer Res. Fdn. Epitaxin WO95/29695

La Jolla, Calif.

Epitaxin, a tumor cell motility and DNA synthesis factor,and antibodies to it; for cancer therapy.

Eli Lilly Platelet factor-4 EPO 682 114


Gene for platelet factor-4, encoded protein, its precursorand modified forms.

Lipps, B. a-Taipoxin WO 95/29987

Belaire, Tex.

a-taipoxin and its preparation; for cell growth promotionand wound treatment.

Ludwig Inst. Cancer Res. Fibroblast activation WO95/29233

New York factor

Identification and isolation of the gene encodingfibroblast activation protein.

Mayo Fdn. Remyelination WO 95/30004

Rochester, Minn. antibodies

Monoclonal IgM antibodies that promote central nervoussystem remyelination.

Merck TNF production GB 2 289 218

Rahway, N.J. inhibition

Inhibition of TNF production by an adenosine receptoragonist; for therapy of autoimmune diseases.

Merck Cephamycin WO 95/29253

Rahway, N.J. production

Genes encoding enzymes involved in the later stages ofcephamycin biosynthesis; for antibiotic production.

Merck Sharp & Dohme GABAA receptor WO95/29234

Hoddesdon, U.K. gamma subunit

Gene for the gamma subunit of the GABAA receptor,host cells that can express the receptor; for therapeuticscreening.

Michigan St. Univ. Prostate WO 95/29990

E. Lansing, Mich. cancer cells & 29994

Immortalized and malignant prostatic cell linestransformed with various viruses; for study of prostatecancer.

Michigan, Univ. of Chromosomes in WO95/29992

Ann Arbor, Mich. muntjac cells

Introduction of chromosomes or fragments into a femalemuntjac cell line; for chromosome purification.

Michigan, Univ. of Adenoviral WO 95/29993

Ann Arbor, Mich. vectors

Expression vectors containing heterologous genes that arebased on adenoviruses; for gene therapy.

Molec. Gen. Res. Assoc. DNA repair WO95/29245

Paris deficiencies

BTF2 complex proteins, especially p34 and p44; fordiagnosing DNA repair process deficiencies.

Mt. Sinai Hosp. Neural receptor WO95/30326

Toronto tyrosine kinase

Gene for neural receptor tyrosine kinase, encoded protein;for screening agonists.

Mycogen Plant Sci. Synthetic crystal EPO 682115

Wilmington, Del. protein genes

Synthetic genes for Bacillus thuringiensis crystal proteinusing preferred codons; for high expression in plants.

Nabel et al. Particle-mediated WO 95/29703

Ann Arbor, Mich. gene transfer

Introduction of an HIV-protective agent intohematopoietic cells using particle-mediated gene transfer.

NIH (Natl. Inst. Hlth.) Melanoma WO 95/29193

Bethesda, Md. antigens

Gene for melanoma antigen recognized by T cells,encoded protein, modified versions; for immunogenicvaccine.

NIH (Natl. Inst. Hlth.) T-cell WO 95/29240

Bethesda, Md. lymphotropic virus

Primate T-cell lymphotropic virus, encoded proteins,antibodies to them; for anti-viral agent screening.

NIH (Natl. Inst. Hlth.) Transplants for WO95/29989

Bethesda, Md. diabetes

Induction of growth and differentiation of fetal pancreaticcells; for making transplantable islets for diabetics.

Novo Nordisk Heparin binding WO 95/28949

Bagsvaerd, Denmark protein

Gene for heparin binding protein, modifications, andfusions; for sepsis treatment.

Ono Pharma Endothelial cell EPO 682 113

Osaka, Japan protein

Gene for a protein from an endothelial cell line, encodedprotein, antibodies; for vascular disease treatment.

Pasteur Inst. Transgenic EPO 682 111

Paris animal screens

Transgenic animal models with inserted genes that can beused to screen pharmaceutical compounds [in French].

Pasteur Inst. Homologous EPO 682 112

Paris recombination vector

Process for obtaining gene expression or improving it byusing a homologous recombination vector system [inFrench].

Pennsylvania, Univ. of Biologically WO95/29690

Philadelphia active protein mimics

Recombinant antibody library to a biologically activeprotein, CDR sequence synthesis; for identifying mimics.

Pioneer Hi-Bred Maize pollen WO 95/29247

Des Moines, Iowa control

Regulatory element that confers anther tapetal cell-specific expression; for controlling maize pollenproduction.

Princeton Univ. Bile acid DNA WO95/29186

Princeton, N.J. carrier

Transfection DNA carrier containing heterologous geneand a bile acid with an amine-containing side chain.

Proctor & Gamble Subtilisin WO 95/30010 &30011

Cincinnati variants

Subtilisin variants and the genes encoding them; forcleaning a variety of surfaces.

Protein Design Labs Humanized EPO 682 040

Mountain View, Calif. antibody production

Humanized immunoglobulins with complementarydetermining regions and consensus sequence framework.

Rhone Merieux Deleted herpes WO95/29248

Lyon, France vectors

Herpes virus vectors with deleted genes; for encodingantigens and making vaccines.

San Diego Reg. Cancer Ctr. Sensitizing WO95/30002

San Diego tumors

Introduction of sensitizing gene activity into tumor cells;for enhanced cancer therapy.

Sapporo Breweries ADP ribosylation EPO 681028

Tokyo factor vector

Vector with ADP ribosylation factor promoter; fordifferential expression in plant seeds and leaves.

Singapore, Natl. Univ. of Mosquito toxin GB 2289 049


Protease-deficient bacterial strain containing a geneencoding a protein that is a mosquito toxin.

Singapore, Natl. Univ. of DNA repair assay GB 2289 125


Assay for human DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) using V8 protease.

Sloan-Kettering Inst. Fc receptor WO 95/28959

New York transgenics

Transgenic animals with human Fc receptor domainreplaces the endogenous one; for treating autoimmunity.

Smith & Nephew Synthetic growth EPO 681846

London substrate

Anchorage-dependent mammalian cells grown on ahydrophobic, non-growth inhibitory, non-cytotoxicsynthetic substrate.

St. James' Hosp. Mismatch location WO95/29258

Leeds, U.K. assay

Mutation location by strand pairing, addition ofmismatch-binding protein, digestion, and gelelectrophoresis.

Stanford Univ. Selective sequence EPO 682 120

Stanford, Calif. amplification

Selective amplification of target polynucleotidesequences using a promoter-containing primer.

Stratagene Difficult gene hosts EPO 681 025

La Jolla, Calif.

Host organisms deficient in recombination and DNArepair; for cloning genes with superhelical structures.

Sugen Megakaryocyte WO 95/29185

Redwood City, Calif. protein tyrosine kinases

Megakaryocyte protein tyrosine kinase variants; fordiagnosis and therapy.

Taisho Pharma Cyclic nucleosidase EPO 682109


Cyclic nucleosidase isolated from rat brain that belongs toa different isozyme family.

Tanabe, T. Prostacyclin WO 95/30013

Osaka, Japan synthase

Gene for prostacyclin synthase, encoded protein,antibodies to it; for circulatory disease treatment.

Texas, Univ. of Combination cancer WO95/28948

Austin, Tex. therapy

Combination therapy with adenoviral vector containingp53 gene and a chemotherapeutic agent.

Toyo Thermostable EPO 682 121

Osaka, Japan amplification

Thermostable enzymes for amplifying nucleic acidswithout sequential addition of further enzymes.

Unilever Plant nematode WO 95/30017

London resistance

Gene for protein with collagenase activity linked to aplant promoter sequence; for resistance to nematodeinfection.

Upjohn Leukocyte WO 95/29243

Kalamazoo, Mich. integrin fusion

Bacterially expressed fusion protein of leukocyte a2-integrin Mac-1 domain and glutathione-S-transferase.

Upjohn FIV vaccines WO 95/30019

Kalamazoo, Mich.

Genes for feline immunodeficiency virus (FIV) proteinsexpressed in baculoviruses; for making vaccines.

Washington, Univ. of Thymidine kinase WO95/30007

Seattle mutants

Thymidine kinase mutants from herpes virus that showincreased biological activity.

Whitehead Inst. Mycobacterial EPO 681 026

Cambridge, Mass. vaccine vectors

Recombinant mycobacterial shuttle vectors; fortransferring genes and preparing vaccines.

Wisconsin, Univ. of Enhanced regulator WO95/29244

Madison, Wisc. expression

Mutant genes for cell regulatory molecules that code formore stable mRNA sequences; for enhanced expression.

Wistar Inst. Wilms' tumor WO 95/29995

Philadelphia antigen antibodies

Monoclonal antibodies against a portion of Wilms' tumorantigen; for diagnosis.

Zeneca Plant fatty acid WO 95/29246

London modification

Genes for acetyl Coenzyme A carboxylase; for modifyingthe production of fatty acids in plants.

_ Compiled By Chester A. Bisbee

(c) 1997 American Health Consultants. All rights reserved.