Published Oct. 25 & Nov. 2 (EPO); Oct. 19 & 26 (WO);Nov. 1 (GB)
Akzo Nobel Freeze-dried WO 95/27721
Arnhem, Netherlands RNA
Freeze-dried particles of RNA and methods for preparingthem; for long-term reagent storage.
Alabama, Univ. of Optimizing WO 95/28489
Birmingham, Ala. 5-fluorouracil doses
Antibodies to dihydropyrimidine dehydrogenase; forassay to optimize 5-fluorouracil doses for cancer patients.
Alliance Pharma Leukosialin WO 95/28490
San Diego promoter vector
Vector with human leukosialin promoter; for obtaininghigher expression in T cells than with viral promoters.
Amgen Eph tyrosine WO 95/28484
Thousand Oaks, Calif. kinases
Gene sequences for Eph sub-family of receptor proteintyrosine kinases, expression vectors, host cells.
Aviron Non-splicing WO 95/28488
Burlingame, Calif. variant gp350
Non-splicing variant gene sequence for gp350, encodedprotein, expression vectors, host cells.
Baylor Coll. Med. Sulfonylurea WO 95/28411
Houston receptor gene
Gene for mammalian sulfonylurea receptor; for diagnosisof persistent hyperinsulinemic hypoglycemia of infancy.
Biocine Plasmid-encoded WO 95/28487
Siena, Italy protein pgp3
Recombinant form of plasmid-encoded protein pgp3 andpurification method for this protein.
Biotransplant Pig organ donors WO 95/28412
Transgenic pigs in which tissue expression of (1,3)galactosyltransferase is inhibited; for preventingrejection.
British Technol. Grp. Black Widow GB 2 288 807
Gene sequence for delta-latroinsectotoxin from BlackWidow Spiders, encoded protein; for use as aninsecticide.
Calgene Lysophosphatidic WO 95/27791
Davis, Calif. acid acyltransferases
Gene sequence of lysophosphatidic acid acyltransferases,encoded protein; for modifying plant triglycerides.
California, Univ. of CDK4 WO 95/28169
Oakland, Calif. inhibitor
Gene sequence for an inhibitor of CDK4, encodedprotein; for cancer diagnosis and therapy.
CNRS (Ctr. Natl. Rec. Sci.) Cynnamoyl WO95/27790
Paris CoA reductase
Gene sequence for cynnamoyl CoA reductase; forregulating plant lignin biosynthesis.
Chemoserotherapeut. Humanized EPO 678 523
Res. Inst. anti-HIV antibody
Gene sequences for variable regions of an HIV-neutralizing antibody fused to human IgG sequences,encoded antibody.
Cold Spring Harbor Labs Cell cycle WO95/28483
Cold Spring Harbor, N.Y. regulation
Cell cycle regulatory protein family; for regulating cellgrowth and division.
Dainabot Hepatitis B WO 95/27788
Hepatitis B virus variant and gene encoding the Xprotein; for detection and treatment.
Dana-Farber Cancer Inst. Adenovirus WO95/28499
Boston E1A cooperation
Gene sequence of a protein that cooperates withadenovirus E1A proteins in order to cause transformation.
De Novo Cytokine WO 95/27510
Menlo Park, Calif. modulator assay
Stimulation of cellular cytokine production; forevaluating compounds for their cytokine modulatingactivity.
Hoffmann-La Roche Homogeneous -IFN EPO 679718
Process for producing homogeneous, contamination-free -interferon (IFN); for antiviral/antitumor therapy.
Human Genome Sciences Superoxide WO95/27781
Rockville, Md. dismutase-4
Polynucleotides coding for superoxide dismutase-4,encoded polypeptides, antibodies; for disease treatment.
Iatron Labs Soluble fibrin EPO 678 524
Monoclonal antibody specific for human soluble fibrin,hybridoma; for determining plasma fibrin levels.
Immulogic Japanese cedar WO 95/27786
Waltham, Mass. pollen allergen
Peptides from Japanese cedar pollen allergen; fortherapeutic use in allergic reactions.
Immunex Interleukin-15 WO 95/27722
Gene sequence for interleukin-15 or epithelium-derivedT-cell factor, encoded factor; for regulating T-cells.
Joshi-Sukhwal, S. Antisense HIV WO95/27783
Inhibition of HIV production in cells by using antisenseversions of HIV genes.
Krebs Res. Inst. Apoptosis WO 95/27735
Heidelberg, Germany inhibition
Inhibition of apoptosis by antibodies and fragments thatrecognize anti-Apo-1 antibodies.
La Jolla Cancer Res. Fdn. Apoptosis WO95/28497
La Jolla, Calif. protein interaction
Methods for detecting interactions between proteinsinvolved in apoptosis pathway.
Ligand Pharma Cytokine WO 95/28482 &28492
San Diego responsive oligos
Oligonucleotide sequences with regulatory elements thatare responsive to cytokines; for agonist identification.
Eli Lilly Aureobasidium EPO 678 578
Indianapolis drug resistance
Multiple drug resistance gene from Aureobasidiumpullulans, vectors, transformed cells; for assays usingthese cells.
Luminis Frog skin peptides WO 95/27728
Biologically active peptides from frog skins; for use asdisease treatments.
Mass. Gen. Hosp. Disease- WO 95/28423 &28478
Boston resistant plants
Gene for Arabidopsis thaliana Rps2 polypeptide, encodedprotein; for making disease-resistant transgenic plants.
Matsubara et al. mRNA cDNA EPO 679716
Osaka, Japan library
A 3'-directed cDNA library for determining abundance ofcellular mRNA; for cell discrimination or detection.
Merck Adenosine GB 2 288 733
Rahway, N.J. receptor antagonists
Xanthine antagonists of A3 adenosine receptor subtype;for affecting eosinophils and allergic reactions.
Merck Bradykinin B1 WO 95/28474
Rahway, N.J. receptor
Gene sequence for bradykinin B1 receptor; for identifyingreceptor function modulators.
Merck Frosst ICErel-III WO 95/27792 & 27793
Kirkland, Que. precursor gene
Gene for precursor of interleukin-1a converting enzyme-related cysteine protease III (ICErel-III), encoded protein.
Midwest Res. Inst. Pentose WO 95/28476
Kansas City, Mo. fermentation ethanol
Recombinant microorganisms genetically altered withgenes for pentose fermentation enzymes; for ethanolproduction.
NIH (Natl. Inst. Hlth.) ERBB2 binding WO95/28485
Bethesda, Md. protein
ERBB2 promoter binding protein; for assaying thetransition to a cancerous state.
Natl. Jewish Ctr. Immunol. MEKK proteins WO95/28421
Gene sequences for MEKK proteins, encoded proteins;for regulating cell responsiveness to external signals.
New York Soc. Crippled Arthritis WO95/28481
New York T-cell receptors
Highly conserved sequences from the a-chain of the T-cell receptor from a patient with rheumatoid arthritis.
N. Carolina St. Univ. Lytic phage WO 95/28491
Raleigh, N.C. disruption
Identification and disruption of bacterial sequences thatcontribute to the evolution of new lytic bacteriophages.
Pasteur Inst. Bordetella WO 95/28486
Gene sequence for Bordetella pertussis hemagglutinin;for recombinant production.
Pennsylvania, Univ. of Serine WO 95/28422
Philadelphia protease inhibitor
Methods for producing a recombinant serine proteaseinhibitor; for regulating inflammatory processes.
Pharmacia Asparagine-glycine WO 95/28415
Stockholm, Sweden cleavage
Method of cleaving an asparagine-glycine bond by usinglow molecular weight organic compounds.
Pierre Fabre Medicament G protein WO95/27787
Boulogne, France immunogen
Polypeptide from the G protein of human or bovinerespiratory syncytial viruses; for immunogen preparation.
Pola Chemical Tyrosinase EPO 679 660
Shizuoka, Japan antibody
Monoclonal antibody to human tyrosinase, hybridoma;for assaying tyrosinase.
PPL Therapeutics Purifying - WO 95/27782
Edinburgh, U.K. lactalbumin fusions
Peptides fused to lactalbumin and secreted into themammary gland; for ease of purification.
Rockefeller Univ. AAV vector WO 95/28493
New York delivery
Method for delivering adeno-associated viral (AAV)vectors to the central nervous system; for treating neuraldisease.
Sloan-Kettering Inst. p53 cancer WO 95/27494
New York treatment
Defective herpes simplex and adeno-associated virusvectors containing the p53 gene; for cancer treatment.
SmithKline Beecham Template DNA WO95/28496
King of Prussia, Penn. preparation
Simplified method of preparing template DNA from cellcultures for automated sequencing.
Stichting Labs Syncytium- WO 95/28500
Amsterdam, Netherlands inducing HIV
Oligonucleotides for discriminating between syncytiumand non-syncytium inducing forms of HIV; for diagnosis.
Syntex GMP synthetase WO 95/27789
Palo Alto, Calif.
Gene sequence for human GMP synthetase, encodedprotein, expression vectors, and host cells.
Takeda CHO LH-RH EPO 678 577
Osaka, Japan production
CHO cells that produce luteinizing hormone-releasinghormone (LH-RH) and its fragments; for use in ligandscreening.
Targeted Genetics Gene delivery WO 95/28494
Seattle fusion protein
Gene delivery fusion protein with targeted nucleic acidbinding domain and facilitator of gene delivery.
Virogenetics Dog herpesvirus WO 95/26751
Troy, N.Y. vaccine
Genes for dog herpesvirus proteins; for immunoresponseand vaccine preparation.
Virogenetics Recombinant WO 95/27507
Troy, N.Y. immunodeficiency viruses
Attenuated recombinant viruses containing DNAencoding immunodeficiency virus antigens; for probesand treatment.
Virogenetics Recombinant WO 95/27780
Troy, N.Y. measles virus
Attenuated recombinant viruses containing DNAencoding canine distemper and measles viruses; fortherapy.
Yale Univ. Brain hyaluronan- WO 95/27785
New Haven, Conn. binding protein
Gene sequence of brain hyaluronan-binding protein,encoded protein; for diagnostic use.
Yeda Res. & Develop. Interferon /a EPO 676413
Rehovot, Israel binding proteins
Gene sequence of interferon /a binding proteins, encodedproteins, antibodies; for modulating interferon activity.
Yeda Res. & Develop. Soluble -IFN EPO 679717
Rehovot, Israel receptors
Soluble -interferon (IFN) receptors; for use in diagnosisand therapy.
Yeda Res. & Develop. Mast cell WO95/27734
Rehovot, Israel antigen
Gene sequence for mammalian mast cell function-associated antigen, encoded protein; for treating allergy.
Yokoyama, S. Cisplatin WO 95/27784
Tokyo resistance genes
Gene sequences for cisplatin and heavy metal resistanceproteins; for determining resistance to cisplatin.
Zeneca Insecticidal WO 95/26410
Recombinant baculovirus with a gene coding for aninsecticidal protein; for pest control.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.