Published Aug. 2 & 9 (EPO & GB); July 27 & Aug. 3(WO)
Abbott Labs HCV envelope WO 95/20664
Abbott Park, Ill. proteins
Expression vectors that produce hepatitis C virus (HCV)envelope proteins; for diagnosis and treatment.
Ajinomoto Oyster WO 95/20662
Coding sequence for Japanese oyster transglutaminase,encoded protein; for use as a salt-activated food gellingagent.
American Cyanamid Opioid receptor- WO95/19986
Wayne, N.J. related proteins
Coding sequences of opioid receptor-related proteins,encoded proteins, antibodies to the proteins.
Amoco Flu sequence WO 95/20055
Nucleic acid probes that recognize flu RNA and DNAsequences; for detection and diagnosis.
Athena Neurosciences Leukocyte WO 95/19790
S. San Francisco adhesion antibody
Humanized antibodies against leukocyte adhesionmolecule (VLA-4); for treating multiple sclerosis.
Becton Dickinson Tuberculosis WO 95/19781
Franklin Lakes, N.J. antibodies
Monoclonal and monospecific polyclonal antibodies thatbind Mycobacterium tuberculosis; for diagnosticimmunoassay.
Biocem Plant aconitase WO 95/20046
Aubiere, France gene
Coding sequence of plant aconitase, encoded protein,gene fragments and chimeras.
Bionebraska Mercury binding WO 95/20607
Lincoln, Neb. polypeptides
Metal binding polypeptides that have an antibody variableregion that reacts with mercury; for bioremediation.
Boston Univ. Self-assembling WO 95/20320
Boston nucleic acids
Self-assembling nucleic acid constructs with attachedfunctional groups; for tagging or targeting.
Boston Univ. Protein antibody WO 95/20401
Protein libraries of polyclonal antibodies and their codingsequences; for making disease- or patient-specific panels.
Bresatec Transplantation WO 95/20661
Adelaide, Australia antigen elimination
Elimination of tissue epitopes that cause transplantrejection by eliminating sugar residues andxenoantibodies.
British Biotech Thrombin-activated GB 2 286190
Oxford, U.K. plasminogen
Plasminogen analogue that is activatable by thrombin tohave plasmin activity.
California, Univ. of Tumor cell matrix WO95/20041
Immortalized parotid tumor myoepithelial cells producingbasement membrane and extracellular matrix materials.
California, Univ. of Universal WO 95/20317
Oakland, Calif. donor cells
Oligos that bind to transplantation antigen genes; formaking universal donor cells.
California, Univ. of Sequence WO 95/20682
Oakland, Calif. artifact elimination
Elimination of stops/pauses in chain termination DNAsequencing by using nitrogen-containing organiccompounds.
Carlsberg Customized protease WO 95/20039
Copenhagen, Denmark transacylation
Mutant proteases that are customized to performpreselected transacylation reactions that result in specificproducts.
Cheil Pseudomonas GB 2 285 925
Seoul, S. Korea vaccine
Attenuated Pseudomonas aeruginosa strains; forproducing vaccines using cell wall proteins.
Cold Spr. Harbor Labs cAMP/ras-related EPO666 314
Cold Spr. Harbor, N.Y. proteins
Cloned genes coding for proteins involved in cAMP- orras-related pathways; for insertion into microorganisms.
Columbia Univ. Vacuolar WO 95/20043
New York ATPase oligos
Oligonucleotides that bind to the vacuolar ATPase gene;for inhibiting enzyme activity and reducing acidsecretion.
Duke Univ. Protein WO 95/20651
Durham, N.C. prenyltransferase
Coding sequence of a protein prenyltransferase, encodedprotein; for modifying proteins.
Goldsmith Seeds Fungus WO 95/19698
Gilroy, Calif. resistant seeds
Catharanthus and other crop seeds that are resistant tofungal infection; for disease control.
Groningen St. Univ. Thermostable WO 95/20663
Groningen, Netherlands neutral proteases
Coding sequences of thermostable Bacillus neutralproteases, encoded protein, expression vectors containinggene.
Gx Biosystems Recombined WO 95/20657
Holte, Denmark bacterial adhesins
Selected or recombined bacterial adhesins, bacteriaexpressing these adhesins; for specific binding.
Hoechst HSV-1 antisense EPO 666 317
Frankfurt, Germany oligos
Antisense oligonucleotides against Herpes simplex virus(HSV)-1 and their preparation [in German].
Human Genome Sciences Hematopoietic WO95/19985
Rockville, Md. maturation factor
Coding sequence of hematopoietic maturation factor,encoded protein, antibodies to the protein.
Human Genome Sciences Growth hormone WO95/20398
Rockville, Md. variants
Coding sequences of human growth hormone variants,derivatives, and analogues; for disease treatment.
Human Genome Sciences DNA repair WO95/20678
Rockville, Md. proteins
Coding sequences of DNA mismatch repair proteinsmapped to chromosomes 2, 3, and 7; for diagnosis andtreatment.
Hybridon Sequencing WO 95/20680
Worcester, Mass. short oligos
Method for determining the nucleotide sequence of shortoligonucleotides by using gel separation mobilities.
Incyte Pharma Differential WO 95/20681
Palo Alto, Calif. expression assay
Method for quantifying relative abundance of genetranscripts; for measuring differential expression.
Iowa St. Univ. Teleomerase EPO 666 313
Ames, Iowa RNA
Cloning of the RNA component of teleomerase; foridentifying and competing with tumor cell teleomeraseRNA.
INRA (Inst. Natl. Rec. Agron.) Transgenic WO95/20653
Paris embryo reporting
Coding sequence of Vargula luciferase; for detection oftransgenic embryos.
Japanese Agri. Ministry Protoplast EPO 665290
Ibaraki, Japan gene transfer
Plant gene transfer method using protoplasts andpolycation assistance; for making transgenic plants.
Julich Res. Ctr. Gram-negative WO95/20048
Julich, Germany proteins
Vectors for secretion of gram-negative bacteria outermembrane proteins from gram-positive bacteria; forproduction.
Lynxvale Resistance WO 95/20044
Cambridge, U.K. macrophage protein
Macrophage protein having N-terminal src homology thatcontrols natural resistance to microorganisms.
Mass., Univ. Med. Ctr. Immunization WO95/20660
Worcester, Mass. with DNA
Injection of a DNA transcription unit encoding anantigen; for immunization.
Medeva Holdings Attenuated WO 95/20665
Amsterdam, Netherlands htrA bacteria
Attenuated bacterial strains containing vectors with thehtrA promoter; for vaccines.
MRC (Med. Res. Counc.) HSV non-infectious WO95/20049
Virion-free, non-infectious viral particles containingHerpes simplex virus (HSV)-1 or 2.
Medigene Regulatory WO 95/20652
Martinsreid, Germany factor activity
Regulatory factor activity determined by the interaction oftwo regulatory regions on a reporter enzyme gene.
Minnesota, Univ. of Alzheimer's WO 95/20666
Minneapolis transgenic model
Transgenic animals whose cells contain the amyloidprecursor protein gene sequence; for studyingAlzheimer's disease.
Mor Res. Applications Lymphoblastoid WO95/20605
Givat Shrauel, Israel antibody
Immunostimulatory antibody that binds to Blymphoblastoid cells; for lymphocyte growth and tumortreatment.
NIH (Natl. Inst. Hlth.) Human mu WO 95/20667
Bethesda, Md. opiate receptor
Coding sequence of human mu opiate receptor localizedto chromosome 6, encoded protein.
New York, St. Univ. of Affinity WO95/20677
Buffalo, N.Y. DNA capture
Affinity-based method of capturing genes of interest byusing immobilized hapten-linked oligo probes.
New York Univ. Phosphacan WO 95/20397
New York proteoglycan
Coding sequence of phosphacan proteoglycan, encodedprotein; for promoting nerve regeneration.
Nickerson Biochem Modified plants WO95/20668
Cambridge, U.K. from transgenics
Modified plants produced by crossing two lines, one ofwhich is transgenic.
N. Carolina St. Univ. Woody WO 95/19697
Raleigh, N.C. perennial selection
Genetic markers for heritable traits in woody perennials;for selecting and propagating plants.
N. Carolina, Univ. of Peptide WO 95/20601
Chapel Hill, N.C. library fusions
Fusion binding proteins called totally synthetic affinityreagents made from peptide libraries.
Pioneer Hi-Bred Nematode-resistant WO95/20669
Des Moines, Iowa soybean
Introduction of soybean cyst nematode resistance genesinto germplasm; for breeding and identifying resistantplants.
PPL Therapeutics In situ WO 95/20042
Roslin, U.K. ES cells
Embryonic stem (ES) cells isolated in situ from embryoscontaining both ES and differentiated cells.
Proteine Performance Baculovirus WO 95/20672
St.-Christol-les-Ales, France immunoglobulin expression
Baculovirus-based vector; for expression ofimmunoglobulins in insect cells.
Queensland, Univ. of Papilloma WO 95/20659
Parkville, Australia virus-like particles
Modified papilloma virus L2 protein that binds minimalamounts of DNA; for making virus-like particles.
Renner et al. Protein-free EPO 666 312
Muntelier, Switzerland growth
Cell lines that readily grow in serum- and protein-freemedium; for recombinant protein production.
Res. Corp. Technol. Metastatic WO 95/20656
Tucson, Ariz. cancer gene
Coding sequence of the mts-1 gene, encoded protein,antibodies to the protein; for detecting metastatic cancer.
Res. Develop. Fdn. Mosquito WO 95/19990
Carson City, Nev. antiviral protein
Protein from Aedes albopictus cells that is associatedwith lysosomal membranes and induces an antiviral state.
Rhone-Poulenc Rorer AAV vector WO 95/20671
Antony, France preparation
Adeno-associated viral (AAV) vector preparation, cellsand vectors used for preparation; for gene therapy.
Royal Sluis France Defective WO 95/19696
Nimes, France endosperm
Male gametophyte genetic factor causing defectiveendosperm and lack of germination; for producing hybridseeds.
Royal Cancer Hosp. EGF WO 95/20045
London receptor antibodies
Antibodies against epidermal growth factor (EGF)receptor that have antitumor activity; for use in cancertherapy.
Royal Cancer Hosp. Polypeptide WO 95/20654
London folding complex
Coding sequence of polypeptide folding complex,encoded protein, antibodies to the protein.
Salk Inst. Biotech. Indus. Assoc. NMDA GB 2286 188
La Jolla, Calif. receptor subunits
Coding sequence of N-methyl-D-aspartate (NMDA)receptor subunits, encoded protein; for identifyingantagonists.
Salk Inst. Protein WO 95/19993
La Jolla, Calif. kinase mutants
Coding sequences of protein kinase mutants; forscreening DNA double-strand break repair activity.
Schering NK antigen WO 95/20604
Kenilworth, N.J. antibodies
Antibodies specific for natural killer (NK) cell surfaceantigen, coding sequences for genes.
Scotgen Recombinant GB 2 286 189
Aberdeen, U.K. binding proteins
Specific binding proteins containing fragments from morethan one antibody; for bispecific binding.
Scripps Res. Inst. TGF-a WO 95/19987
La Jolla, Calif. assay
Specific, non-radioactive method for detectingtransforming growth factor (TGF)-a using a luciferasereporter gene.
Scripps Res. Inst. Coagulation-related WO95/20655
La Jolla, Calif. receptors
Coding sequence of cellular receptors homologous tocoagulation factors V and VIII, encoded proteins.
Shiseido C-terminal EPO 666 318
Tokyo amidation enzyme
Enzyme participating in C-terminal amidation, codingsequence of enzyme, expression vector.
Solvay Glucose EPO 665 291
Brussels, Belgium oxidase vector
Expression vector designed to code for glucose oxidase;for extracellular production of the enzyme [in French].
Sudzucker Non-caloric WO 95/20047
Mannheim, Germany sugars
Coding sequences of saccharose isomerases, encodedproteins; for production of non-caloric sugars.
Targeted Genetics CD69 WO 95/20670
Seattle regulatory sequences
Transcriptional regulatory sequences from the CD69gene; for controlling cells expressing CD69.
Tonen Organic EPO 666 316
Tokyo solvent resistance
Pseudomonas strains subjected to mutagenesis forincreasing resistance to organic solvents.
Victoria Univ. Bacterial WO 95/20658
Manchester, U.K. infection proteins
Coding sequences of proteins expressed duringstreptococci or enterococci infection, encoded proteins;for therapy.
Yale Univ. Deltex proteins WO 95/19779
New Haven, Conn.
Coding sequences of Drosophila and human deltex genes;for diagnosis and therapy.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.