Published July 19 & 26 (EPO & GB); July 13 & 20 (WO)
Agricult., Fisheries & Equine arteritis WO95/19438
Food Ministry viral peptides
London
Equine arteritis virus peptides, antibodies; foridentification assays to prevent spontaneous abortion inhorses.
Akzo Nobel Bovine herpes virus EPO 663 403
Arnhem, Netherlands vector
Mutant bovine herpes virus vector for introducingheterologous proteins into a host; for response topathogen.
Alexion Pharma Non-prolifer- WO 95/19368, 428
New Haven, Conn. ating cell transduction
Retroviral vector particles with nuclear localizationsequence; for transduction of non-proliferating cells.
Baylor Coll. Med. Fluid space WO 95/19182
Houston gene therapy
Expression vectors for delivering genes to cells in bodyfluid spaces; for somatic gene therapy.
Behringwerke Yeast infections EPO 664 336
Marburg, Germany
Saccharomyces-specific antigens and antibodies to them;for identifying and quantifying infection [in German].
Biotech. & Genetic Fructosyltrans- EPO 663442
Engin. Inst. ferase
Havana
Coding sequence of extracellular Acetobacterfructosyltransferase; for producing low-caloriesweeteners.
Biotech. & Genetic Dextranase sugar EPO 663443
Engin. Inst. production
Havana
Coding sequence of fungal dextranase; for dextranhydrolysis in sugar cane juice for increased sugarproduction.
California, Univ. of Syphilis therapy WO95/18632
Oakland, Calif.
Amino acid sequences of antigenic rare outer membraneproteins from spirochaetes; for syphilisdetection/treatment.
California, Univ. of MCP receptors WO95/19436
Oakland, Calif.
Coding sequences for monocyte chemoattractant protein(MCP) receptors, encoded proteins; for antagonistidentification.
Calydon Prostate cancer WO 95/19434
Menlo Park, Calif. therapy
Prostate-specific transcriptional regulatory sequencecontrolling toxin gene expression; for cancer therapy.
CNRS (Natl. Ctr. Hematopoietic EPO 663444
Hlth. Res.) stem cells
Paris
Bipotent immature mammalian hematopoietic precursorcells, pure stem cell culture, maturation factors.
Children's Hosp. p53 gene WO 95/18818
Philadelphia polymorphism
Identification of a p53 gene polymorphism; fordetermining lineage, linkage and inheritance.
Ciba-Geigy Synergistic WO 95/18859, 9443
Basel, Switzerland antifungal proteins
Plant proteins that are synergistic with antifungalantibiotics; for treating Candida infections.
CSIRO (Comm. Sci. Enzyme-based WO95/19440
Ind. Res. Org.) bioremediation
Campbell, Australia
Coding sequence of E3 esterase from organophosphateresistant microorganism, encoded protein; forbioremediation.
Cornell Univ. Marek's disease WO 95/18860
Ithaca, N.Y. viral protein
Coding sequence of a protein from Marek's disease virus(MDV); for vaccination and control of MDV infection.
Cytogam Gender selection EPO 664 298
Chandler, Ariz.
Sperm cell sorting using antibodies to sex-associatedmembrane proteins; for controlling offspring gender.
Gene Shears Ribozymes against WO 95/18854
St. Leonards, Australia RNA viruses
Ribozymes directed against the packaging sequence ofRNA viruses; for treating infection by these viruses.
Genentech Thrombopoietin WO 95/18858
South San Francisco
Coding sequence of thrombopoietin, encoded proteins;for treatment of thrombocytopenia.
Genetic Therapy Retroviral vector WO95/19427
Gaithersburg, Md. purification
Purification of retroviral vector particles; for increasedrecovery of particles useful in gene therapy.
Ghent, State Univ. of Viral neuraminidase WO95/18861
Ghent, Belgium vaccine
Coding sequence of flu virus neuraminidase; forrecombinant protein production and vaccine manufacture.
Harvard College Vibrio motility WO95/18633
Cambridge, Mass. genes
Coding sequence of Vibrio cholerae motility genes, agarpenetration mutants, methods for making mutant strains.
Harvard College Herpes virus WO 95/18852
Cambridge, Mass. vaccine
Replication-defective herpes virus; for use as a vaccine inimmunoregulatory diseases.
Harvard College Hedgehog-related WO95/18856
Cambridge, Mass. genes
Coding sequences for hedgehog-related genes, encodedproteins; for modulating tissue development.
Illinois, Univ. of Kinesin and WO 95/18857
Urbana, Ill. cancer drugs
Genetic suppressor elements for chemotherapeutic drugresistance, including human heavy chain kinesin gene.
Immunex Fas ligand WO 95/18819
Seattle
Coding sequence of Fas ligand (Fas-L), expressionvectors producing Fas-L, immunoreactive antibodies.
INSERM (Natl. Inst. Hematopoietic WO95/19432
Hlth. Med. Res.) stem cells
Paris
Bipotent immature mammalian hematopoietic precursorcells, pure stem cell culture, maturation factors.
Jockey Club Non-invasive WO 95/19447
New York DNA sampling
Non-invasive sampling method for obtaining nucleic acidsamples for analysis.
Johns Hopkins Univ. Histologic tissue WO95/19448
Baltimore mutations
Detection of nucleic acid mutations in histologic tissuesections; for cancer treatment targeting.
Julich Res. Ctr. Deregulated WO 95/19442
Julich, Germany recombinant isoleucine
Threonine dehydratase mutated in its allosteric domains;for deregulated recombinant production of isoleucine.
La Jolla Cancer Cell death WO 95/19367
Res. Fdn. gene regulation
La Jolla, Calif.
Regulatory sequences linked to cell death genes; forscreening agents that modulate expression of these genes.
Leeds, Univ. of Cellulase regulatory WO95/19441
Leeds, U.K. sequences
Mold cellulase gene regulatory sequences; for use inexpression vectors.
Manitoba, Univ. of Cross-reactive WO95/19437
Winnipeg, Manitoba pollen allergen
Highly cross-reactive allergen from Kentucky Bluegrass;for wide-spectrum pollen allergy treatment.
Mitotix Ubiquitin-conjugating WO95/18974
Cambridge, Mass. enzymes
Ubiquitin-conjugating enzymes and inhibition ofubiquitin-mediated degradation of cell-cycle regulatoryproteins.
NIH (Natl. Inst. Hlth.) Protein tyrosine WO95/19439
Bethesda, Md. kinase
Coding sequence of a protein tyrosine kinase, encodedprotein; for immunodiagnostics and therapy.
Novo Nordisk Factor VIII WO 95/18827, 828, 829
Bagsvaerd, Denmark derivatives
Factor VIII derivatives and subunit combinations; forgreater yield and extended coagulant activity.
Oswaldo Cruz- Protection from GB 2 285626
Fiocruz Fdn. helminths
Rio de Janeiro, Brazil
Amino acid sequence of antigenic protein fromSchistosoma, encoded protein; for treatment of helminthinfections.
Pasteur Inst. MHC minus cells EPO 664 337
Paris
Cell lacking human MHC class II antigens; for detectingand producing antibodies to selected microorganisms.
Pennsylvania, Univ. of Antisense WO95/19175
Philadelphia STK-1 oligos
Antisense oligos against STK-1 mRNA; for treatingcancer and purging bone marrow of cancerous cells.
Pioneer Hi-Bred Synthetic WO 95/18855
Des Moines, Iowa antimicrobial peptides
Synthetic polypeptides with amphipathic -helices; for cellexpression of antimicrobial activity.
Pittsburgh, Univ. of Hematopoietic WO95/18631
Pittsburgh facilitatory cells
Monoclonal antibodies to hematopoietic facilitatory cells;for isolation from bone marrow.
Promega Mutant luciferases WO 95/18853
Madison, Wis.
Coding sequences of mutant beetle luciferases, encodedproteins; for use in biosensing applications.
Rhone-Poulenc Rorer Lipopolyamine WO95/18863
Antony, France DNA delivery
Lipopolyamine carriers for nucleic acids; for genetransfer and therapy.
Ribozyme Pharma Hepatitis C WO 95/19429
Boulder, Colo. ribozyme
An enzymatic RNA molecule that specifically cleaveshepatitis C virus; for inhibiting replication.
Rogosin Inst. Secretory cell WO 95/19430
New York encapsulation
Encapsulation of secretory cells in hydrophilic gels; forcell preservation and therapeutic use.
Salk Inst. Developing brain WO 95/18822
La Jolla, Calif. factors
Coding sequence of developing brain factors (DBFs),encoded proteins, antibodies; for DBF detection.
Schering CTLA-8 antigen WO 95/18826
Kenilworth, N.J.
Coding sequence of primate CTLA-8 antigen, encodedprotein, antibodies; for diagnostic kits.
Scripps Res. Inst. Herpes simplex WO95/18634
La Jolla, Calif. antibodies
Monoclonal antibodies to herpes simplex virus; fordiagnosis and immunotherapy.
Scripps Res. Inst. Zinc finger WO 95/19431
La Jolla, Calif. proteins
Zinc finger-nucleotide binding polypeptides, assays foridentifying such molecules; for modulating expression.
Singapore, Natl. DNA repair WO 95/19445
Univ. of enzyme assay
Singapore
Assay for distinguishing wild-type and alkylated DNArepair enzymes using V8 protease.
Sloan-Kettering Inst. p27 and WO 95/18824
New York hyperproliferation
Coding sequence of p27; for inhibiting E-Cdk2 complexand treating hyperproliferative disorders.
T Cell Sciences T cell antigen WO 95/19435
Needham, Mass. receptor
Full length T cell antigen receptor V region protein; fordiagnosing immune-related disorders.
Targetech Hepatitis WO 95/19433
Meriden, Conn. B antisense
Antisense oligos against hepatitis B virus; for detectionand treatment of viral infection.
Thomas Jefferson Univ. Targeted gene WO95/19426
Philadelphia insertion
Nucleotide sequence that directs integration of genes; fortargeted DNA insertion.
Union Camp Plant selectable WO 95/18862
Wayne, N.J. markers
Transformation of plants with tfdA gene; for productionof transgenic plants with selectable markers.
Univ. Technol. & Cephalosporin EPO 663445
Sci. Res. Ministry production
Rome
7a-(4-carboxybutanamido)-cephalosporanic acid acylaseisolation; for low-cost production of cephalosporins.
Vanderbilt Univ. Early breast WO 95/19369
Nashville, Tenn. cancer detection
Identification of differentially expressed genes in pre-invasive breast cancer tissue; for early detection.
Vermont, Univ. of Mutator phenotype WO95/19444
Burlington, Vt. lymphocytes
Lymphocytes with different alleles near a selectablemarker gene; for identifying mutator phenotypes.
Virta et al. Metal level assay WO 95/19446
Vaha-Hameenkatu, Finland
Plasmid whose copy number is controlled by metal-regulatable promoter; for determining metal levels insamples.
Wakunaga Variant PCR EPO 664 339
Osaka, Japan detection
PCR amplification and solid-phase binding of nucleicacids; for detecting variants.
Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.