Published July 5 & 12 (EPO & GB); June 29 & July 6(WO)
Abbott Labs HEV antibodies WO 95/17501, 502
Abbott Park, Ill.
Monoclonal antibodies to hepatitis E virus (HEV)antigens, hybridomas; for assay kits.
Abbott Labs Prostate cancer WO 95/18381
Abbott Park, Ill. immunoassay
Fractionated polyclonal antibodies to prostate-specificantigen (PSA); for cancer immunoassay.
Abs Global Bovine ES cell WO 95/17500
DeForest, Wisc. donors immunoassay
Bovine embryonic stem (ES) cells; for use as donors ofnuclei in nuclear transfer procedures.
Agresearch New Zealand Mycobacterial WO95/17511
Upper Hutt, New Zealand virulence
Coding sequences for virulence and avirulence inmyocobacteria; for producing modified strains.
Allelix Biopharma Glutamate receptor WO95/17508
Missisauga, Ont. variants
Coding sequence for glutamate receptor and variants,encoded proteins; for screening assays.
Amoco HPV probes EPO 662 518
Nucleic acid probes for detecting human papillomavirus(HPV) genes or transcripts; for cervical cancer diagnosis.
Asahi Breweries DerI allergen WO 95/17424
DerI gene and encoded allergen, expression andproduction using nuclear polyhedrosis virus.
Becton Dickinson Blood stem cells EPO 662512
Franklin Lakes, N.J.
Hematopoietic stem cell preparation that differentiatesinto all blood cell types; for autologous transplantation.
Brussels, Free Univ. of Lipid vesicle WO95/17378
Brussels, Belgium delivery
Lipid compounds that make positively charged vesicles;for intracellular delivery of materials.
California, Univ. of Anti-idiotypic WO 95/17200
Oakland, Calif. antibodies
Enriched populations of anti-idiotypic antibodiesproduced by immunizing animals with an IgG transgene.
California, Univ. of Methionine WO 95/17908
Oakland, Calif. analogue chemotherapy
Chemotherapy for malignant cells that have an absoluterequirement for methionine by using analogues.
Cangene Streptomyces WO 95/17512
Missisauga, Ont. proteases
Streptomyces proteases that degrade exogenouslysecreted proteins, irreversible inhibitor, host cells.
Catholic Univ. Louvain Organ WO 95/17425
Louvain-La-Neuve, Belgium rejection proteins
Coding sequences for proteins that are characteristic oforgan rejection; for diagnosis.
Cell Genesys Universal WO 95/17911
Foster City, Calif. transgenic donors
Homologous recombination to inactivate genes inembryonic stem cells; universal donor cells for transgenicanimals.
Celtrix Pharma Chromosomal WO 95/17499
Santa Clara, Calif. transfer vector
Chromosomal transfer DNA vector; for site-specificrecombination.
CNRS (Ctr. Natl. Rec. Sci.) Expression WO95/18223
Paris control RNA
Coding sequence for an RNA forming a triple helix; forselectively and efficiently controlling gene expression.
Chugai Adseverin genes WO 95/18221
Coding sequences for adseverins, encoded proteins,antibodies, production methods.
Ciba-Geigy Hirustasin EPO 662 514
Antistasin-type serine proteinase inhibitor (Hirustasin)from the medicinal leech, Hirudo medicinalis.
Daikin Industries RecA in situ WO 95/18236
Osaka, Japan hybridization
In situ hybridization method using RecA proteincomplexed with a single-stranded nucleic acid probe.
Dako PNA/DNA WO 95/17430
Glostrup, Denmark antibodies
Antibodies against peptide nucleic acid (PNA)-DNAcomplexes; for recognition and detection.
Evotec Biosystems Combinatorial WO95/17413
Hamburg, Germany functional evolution
Oligomeric or polymeric functional elements produced bycombinations of designer elements.
Forssmann, W.-G. Circulating WO 95/18228
Hannover, Germany cytokine CC-1
Coding sequence for human circulating cytokine CC-1,encoded protein, biologically active fragments.
Gatsby Charitable Fdn. Tomato WO95/18230
London pathogen resistance
Coding sequence for tomato Cf-9 pathogen resistanceprotein, encoded protein; for identifying similar genes.
Gene Pharming Phenylketonuric- WO95/18224
Leiden, Netherlands lactalbumin
Production of -lactalbumin without phenylalanine in themilk of transgenic animals; for phenylketonurics.
Genentech Thrombopoietin GB 2 285 446
S. San Francisco
Coding sequence for thrombopoietin, encoded protein,variants, purification; for treating thrombocytopenia.
Genzyme Transgenics Milk-produced WO95/17085
Framingham, Mass. antibodies
Monoclonal antibody production in mammalian milkusing transgenes expressed in mammary epithelial cells.
Harvard College Allograft WO 95/17506
Cambridge, Mass. rejection proteins
Coding sequences for allograft rejection proteins; fordiagnosis and treatment.
Hoechst Japan Scleroderma WO 95/18218
Human DNA topoisomerase I variant that reacts withautoantibody from scleroderma patients; for diagnosis.
Human Genome Sciences Macrophage WO95/17092
Rockville, Md. inflammatory proteins
Coding sequences for macrophage inflammatory proteins,encoded proteins, production methods.
Icos a2 integrin WO 95/17412
Bothell, Wash. subunit
Coding sequence for a2 integrin subunit, encoded andfusion proteins, production methods.
Immunol. Res. Inst. Thymopoietin WO 95/17205
DNA and amino acid coding sequences for humanthymopoietin, methods of expression; for diagnosis andtherapy.
Innogenetics Tau protein WO 95/17429
Ghent, Belgium antibodies
Monoclonal antibodies against abnormallyphosphorylated tau protein; for detection in cerebrospinalfluid.
Inst. Phys. Chem. Res. Sialyltransferase WO95/18217
Saitama, Japan gene
Coding sequence for N-acetylgalactosaminesialyltransferase, encoded protein, process for production.
Kirin Beer Xanthophyll WO 95/18220
Coding sequences for genes involved in xanthophyllsynthesis; for production in bacteria.
Kirin Beer Plant fatty WO 95/18222
Tokyo acid desaturase
Coding sequence for fatty acid desaturase, encodedprotein; for creating transgenic plants.
Korea Inst. Sci. Tech. Insulinase EPO 662 515
Seoul, Korea secretion
Expression vector for insulinase with yeast signalpeptide; for secretion from yeast.
Krebs Res. Inst. High resolution WO95/18235
Heidelberg, Germany hybridization
Arrangement of nucleic acid sequences allowing highresolution during comparative genomic hybridization.
Max Planck Inst. Fusion WO 95/17509
Berlin protein bacteria
Bacterial strains with specific markers that stably expressfusion proteins on their surfaces.
MRC (Med. Res. Coun.) Polycystic WO95/18225
London kidney disease
Polycystic kidney disease-associated gene located onchromosome 16; for diagnosis and treatment.
Merck Wnt-x growth WO 95/17416
Rahway, N.J. factor
Coding sequence for Wnt-x growth factor, encodedprotein, host cells expressing Wnt-x.
Merck Homologous WO 95/17516
Rahway, N.J. recombination locus
Specific mouse host cell genome locus that causes highlevel recombination of genes following their stableintegration.
Molec. Biol. Diagnostics Inst. c-erbB-2 WO95/17507
Gottingen, Germany antisense
Antisense nucleic acids for the c-erbB-2 gene thatencodes the p185 receptor; for cancer treatment.
New Jersey, Med. Astrocyte WO 95/17203
& Dent. Univ. of neurotrophic factor
Coding sequence for astrocyte-derived neurotrophicfactor, cDNA; for measuring glial cell differentiation.
Nisshin Flour Milling Fused glicentin EPO 662482
Human glicentin preparation using a fused protein andbinding to the chromatographic stationary phase.
Novo Nordisk Bacterial GLP-1 WO 95/17510
Production of glucagon-like peptide 1 (GLP-1) frombacteria using an expression vector for a GLP-1precursor.
Novo Nordisk Fungi production WO 95/17513
Bagsvaerd, Denmark strains
Selection markers and foreign protein genes in expressionvectors designed for filamentous fungi.
Pharmacia Biotech In vitro WO 95/17415
Milwaukee phage packaging
Lyophilized E. coli extract that is stable at roomtemperature; for packaging lambda phage in vitro.
PNA Diagnostics Sequence-specific GB 2 285445
Copenhagen, Denmark protection
Protection of nucleic acids in a sequence-specific mannerusing bound analogues; for PCR analysis.
Shalitin, C. p21 antibodies EPO 662 612
Sandwich ELISA with polyclonal antibodies to p21; forclinical cancer monitoring.
Shintaku, Y. Orange EPO 662 281
Transgenic cauliflower with inserted carotene synthesisgenes; for making the curd orange.
Sloan-Kettering Inst. p53 protein WO 95/17213
New York fragment
Coding sequence for a p53-based polypeptide fragment,encoded protein; for expression in cells.
SS Pharma Band-3 WO 95/18375
Tokyo glycoprotein detection
Detection of blood constituents by reaction of humanerythrocyte band-3 glycoprotein with hemagglutinin.
Sumitomo Pharma CNTF variant WO 95/18150
Coding sequence for human ciliary neurotrophic factor(CNTF) variant with a better side effect profile, encodedprotein.
Synaptic Pharma Y4 receptor WO 95/17906
Coding sequence for neuropeptide Y/peptideYY/pancreatic polypeptide (Y4) receptor, encodedprotein; for screening.
Texas, Univ. of Rb binding WO 95/17198
Austin, Tex. protein
Coding sequence for Rb binding protein, a tumorsuppressor gene; encoded protein; antibodies to Rbprotein.
Tsumura Elastin variant EPO 662 516
Elastin derivative with superior stability to oxidation; foruse as an elastase inhibitor.
U.K. Defense Secretary Yersinia pestis WO95/18231
Live, attenuated bacterial strains for preparation ofvaccines against Yersinia pestis.
University Tech. Intl. Insect-killing proteins WO95/17515
Baculovirus expression of heterologous proteins; forinfection and killing of insects.
Wake Forest Univ. Ileal bile WO 95/17905
Winston-Salem, N.C. cotransporter
Coding sequence for the ileal bile cotransporter, encodedprotein; for detecting human mutations.
Wales, Med. Univ. of Tuberous sclerosis WO95/18226
Tuberous sclerosis-associated gene located onchromosome 16; for diagnosis and treatment.
Washington Univ. RNA virus WO 95/17525
St. Louis detection
Cell lines with vectors containing a reporter gene whoseexpression is activated by RNA virus replication.
Yeda Res. & Develop. Olfactory WO95/18140
Rehovot, Israel receptor genes
Olfactory gene clusters on chromosome 11 that encodegenes for olfactory receptors.
Zeneca Polyprotein plant WO 95/17514
Gene construct for transfection into plants that expressesa polyprotein that is processed into its componentproteins.
Zeneca Plant seed WO 95/18229
Coding sequences for plant seed antimicrobial proteins;for antibacterial/antifungal activity in transgenic plants.
Zymogenetics Glutamate WO 95/18154
Seattle receptor gene
Coding sequence for glutamate receptor, encoded protein,antibodies; for identifying agonists/antagonists.
Zymogenetics Phospholipid WO 95/18227
Seattle transfer proteins
Coding sequences for phospholipid transfer proteins,encoded proteins; for modifying blood lipoprotein profile.
(c) 1997 American Health Consultants. All rights reserved.