In 26 scientific categories, from "AIDS" to "VIROLOGY OTHERTHAN HIV," the National Institutes of Health's Office of TechnologyTransfer (NIH/OTT) holds well over 1,000 pending and issued patents,which it offers for commercialization by the biotechnology industry.NIH's 17 National Institutes, plus the Centers for Disease Control &Prevention (CDC) and the Food and Drug Administration (FDA) filetheir patentable findings with OTT for licensure. Many of theirinventors are leading scientists in the arena of pharmaceuticallyoriented biotechnology R&D.At intervals, OTT publishes notices in the Federal Register describingselected inventions that it is putting up for licensing grabs bycompanies. BioWorld Today has arranged with OTT to receiveadvance or current copies of such lists, so we may inform our readersof these intellectual-property opportunities. All of the items are current.As listed below, entries are grouped alphabetically by NIH agency, andkeyed to the individual Licensing Specialist at OTT, who may becontacted for information regarding access to a specific technology.These contacts share a common telephone number, 301-496-7735, andtelefax, 301-402-0220.
C D C (Centers for Disease Control & Prevention)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Hepatitis A Virus (HAV) Detection 07/828/,444 Robertson, B. H.,et al.Fast, specific assay tests stools for general HAV infection, filed5/11/92 Carl C. FLoydusing antibodies, reverse transcription into cDNA, PCR amplification; differentiates genotypes I, II, III.
N C I (National Cancer Institute)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Enrichment of Full-Length cDNAs 08/038,652 Giri, C.P., et alSynthesizing sense and antisense RNAs to generate filed 3/22/93 Carl C. Floydsubtraction probes for enrichment of rare, full-length,human cDNAs of genes selected by phenotype.
Peptide Inhibitors of Protein-Protein Interaction 08/072,946 Roller, P.P., et al.Synthetic peptides that inhibit interaction between proteins filed6/8/93 Carl C. Floydwith src homology and those with phosphorylated tyrosine domainsfor antitumor chemotherapy
Stable Phosphotyrosyl Mimetics 08/073/088 Burke, T. R., etal.Phosphono(difluromethyl)phenylalanine stably mimics filed6/8/93 Carl C. Floydphosphotyrosine; for solid-phase peptide synthesis.
First Immortalized Kaposi's Cell Line 08/110,175 Gallo,R. C., et al.Cell lines for testing anti-Kaposi's sarcoma therapies in filed8/20/93 Carl C. Floydvitro or in animals, and optimizing dosage before human trials.
NHLBI (Natl. Inst. on Alcohol Abuse & Alcoholism)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Attenuation of Alcohol Intoxication #5,109,007 Linnoila, M. et al.Drugs based on alpha-2 adrenoceptor antagonists lack issued4/28/92 Arthur J. Cohnharmful sedative effects of tranquilizers, currently used to treat ethanol intoxication
NIAAA (Natl. Inst. of Allergy & Infectious Diseases)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Atherogenic Apolipoprotein Suppressor 07/601,931 Ross &HoegSuppressor binds transactivating elements, is tissue specific, filed Carol Lavrichinhibits expression of a bacterial enzyme driven by TK gene. For anti-apolipoprotein-B drug discovery.
NIAMSD (Natl. Inst. of Arthritis & Musculoskeletal Diseases)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Diagnosis of Autoimmune Diseases 08/052,404 Raben, N., et al.Detection of auto-antibodies to histydyl tRNA; for diagnosis filed Carol Lavrichof myositis, polymyositis, dermatomyositis, etc. with unique sensitivity. Antigen is highly stable.
NIAID (Natl. Inst. of Allergy & Infectious Diseases)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Avipox Virus Expression Vectors 07/882/,768 Falkner, F. G., etal.Recombinant wild type avipox virus vectors, unlike filed 5/11/92 Girish C. Baruavaccinia, are not pathogenic to humans or animals, but can express foreign DNA in mammalian and aviancell cultures.
NIDDK (Natl. Inst. of Diabetes & Digestive & Kidney Diseases)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
Protecting Genes From Cis-Acting Sequences 08/045,266 Chung, H. J., et al.Insulating functional DNA domains introduced into higher filed4/7/93 Carl C. Floydeukaryotic cells from cis-acting regulatory elements. Forgene therapy, transfer and expression techniques
Cloning of Perilipin Proteins 08/132,649 Londos, C., et al.DNA encoding perilipins; useful as markers to differentiate filed10/4/93 Carl C. Floydtrue adipocytes from other cells, which under pathophysiological states assume adipocyte traits.
NIMH (National Institute of Mental Health)Title and Summary Pat. or App. # Inventors/ Filing date Licensing Contact
DNA Fingerprinting by Microsatellite Markers 08/074,275 Merril, C. R., et al.Polymorphism repeat sequences distinguish nucleotide size filed6/9/93 Carl C. Floyddifferences in human differentiation. For forensic, paternity and prenatal-screening tests.
(c) 1997 American Health Consultants. All rights reserved.