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The importance of the stimulator of interferon genes (STING) pathway in orchestrating the body’s innate response to pathogenic, tumor or self-DNA in the cytoplasm has made it a hot target in immunology research and drug discovery, and several biopharma companies have started programs dedicated to that area, spanning infectious and inflammatory diseases as well as cancer. The second part of this feature examines the products undergoing preclinical development as well as the ones that are now in clinical testing.