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BioWorld - Tuesday, January 31, 2023
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Home » From mouse to man, UBR2 is target in cancer cachexia
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Cancer

From mouse to man, UBR2 is target in cancer cachexia

Nov. 14, 2022
By W. Todd Penberthy
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Investigators working at University of Texas Health Science Center, Houston, have discovered that the ubiquitin ligase UBR2 is up-regulated and sufficient for targeting the myosin heavy chain protein for the degradation characteristic of cancer cachexia. UBR2 knockout or pharmacological inhibition could prevent cachexia in mice. Confirmatory observations were noted in cancer cachexia patient-derived tissues.
BioWorld Science Cancer Endocrine/Metabolic

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