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BioWorld - Friday, June 20, 2025
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Home » Innate immunity can drive radiation-induced abscopal effect
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Cancer

Innate immunity can drive radiation-induced abscopal effect

Nov. 23, 2022
By Anette Breindl
A combination of radiation therapy and CD47 blockade induced an abscopal effect in animal studies even in animals that lacked T cells, researchers reported in the Nov. 21, 2022, online issue of Nature Cancer. The findings are “the first demonstration of T-cell-independent abscopal response,” co-corresponding author Edward Graves told BioWorld. “We’re not trying to say that all abscopal responses are macrophage-mediated. There are plenty that require T cells,” Graves clarified. But “there is another avenue of abscopal responses that has not been reported. ... All the abscopal literature is about stimulating an adaptive response.”
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