Research shows that individuals with schizophrenia have abnormal gene expression patterns in their brains compared with people without the condition. In a study published in PLOS Biology on Jan. 24, 2023, the authors reported that many genes in brain tissue from the dorsolateral prefrontal cortex, a region involved in cognition, have expression patterns that follow a 12-hour cycle. The investigators found that these patterns were largely lost in people with schizophrenia.