Previous studies have revealed that the microbiome plays a role in the development and progression of some cancers and gut microbiome has been linked with immune homeostasis as well as antitumor immune responses. In the current study, scientists at the University of California, Davis aimed to evaluate the intratumoral microbiome in patients with nonmetastatic soft tissue sarcoma (STS) undergoing neoadjuvant radiotherapy (RT) and surgery.