Breast cancer (BC) is a prevalent form of cancer among women globally. Recent studies suggest that circular RNA (circRNA) plays a significant role in BC progression, but the biological functions and underlying mechanisms remain unexplored. According to a recent study published in the Journal of Translational Medicine, the interaction between circDNAJC11 and TATA-box-binding protein-associated factor 15 (TAF15) promotes BC progression through the upregulation of MAPK6 expression and activation of the MAPK signaling pathway.