Researchers from the Institute of Zoology Guangdong Academy of Sciences have reported on the discovery and preclinical evaluation of a series of diaryl heterocyclic analogues with antiproliferative activities that led to the identification of [I] as the compound with the highest antiproliferative activity, yielding IC50 values of 2.65 μM against HCT-116 colon cancer cell lines comparable to combretastatin A-4 (Ca-4), a tubulin inhibitor with potent anticancer activities.