WTX-712, an IL-21 prodrug, shows strong antitumor activity in preclinical models
May 4, 2023
Cytokines are potent immunomodulators with the potential to amplify cell-based immunity against cancer development. Interleukin-21 (IL-21) generates antitumor immunity by inducing B-cell activation and driving the development of antitumor T-cell response. The use of IL-21 in cancer treatment so far is limited due to inadequate pharmacokinetic properties and toxicity issues.