Dana-Farber Cancer Institute presents new DOT1L degradation inducers for cancer
May 16, 2023
Dana-Farber Cancer Institute Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising a cereblon (CRBN) binding moiety covalently linked to a histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L) targeting moiety via linker reported to be useful for the treatment of cancer.