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BioWorld - Monday, May 19, 2025
Breaking News: 100 days of uncertaintySee today's BioWorld Science
Home » TMPRSS3 gene therapy prolongedly restores hearing in mouse model of human recessive deafness DFNB8
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Ear, Nose & Throat

TMPRSS3 gene therapy prolongedly restores hearing in mouse model of human recessive deafness DFNB8

June 9, 2023
Currently, there are no treatments to reverse or prevent genetic hearing loss, which affects 1 in 500 newborns. Several gene replacement and overexpression preclinical studies targeting genetic hearing loss have shown success, as the inner ear can be accessed safely by local injection. However, all these gene therapy studies have been performed in neonatal animals, except one in the Otof gene; therefore, the suitability of the approach in the fully mature adult inner ear remains to be elucidated.
BioWorld Science Ear, nose and throat Gene therapy

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